Consumption of β-glucans to spice up T cell treatment of tumors: a review

References

• Houot R, Schultz LM, Marabelle A, et al. T-cell-based immunotherapy: adoptive cell transfer and checkpoint inhibition. Cancer Immunol Res. 2015;3(10):1115–1122.
   PubMed Web of Science ®Google Scholar
• Johnson LA, June CH. Driving gene-engineered T cell immunotherapy of cancer. Cell Res. 2017;27(1):38–58.
   PubMed Web of Science ®Google Scholar
• Maude SL, Laetsch TW, Buechner J, et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N Engl J Med. 2018;378(5):439–448.
   PubMed Web of Science ®Google Scholar
• Neelapu SS, Locke FL, Bartlett NL, et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N Engl J Med. 2017;377(26):2531–2544.
   PubMed Web of Science ®Google Scholar
• Debets R, Donnadieu E, Chouaib S, et al. TCR-engineered T cells to treat tumors: seeing but not touching? Semin in Immunol. 2016;28(1):10–21.
   PubMed Web of Science ®Google Scholar
• Porter DL, Hwang WT, Frey NV, et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci Transl Med. 2015;7(303):303ra139.eng.
   Web of Science ®Google Scholar
• Rosenberg SA, Yang JC, Sherry RM, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 2011;17(13):4550–4557.
   PubMed Web of Science ®Google Scholar
• Kumar V, Patel S, Tcyganov E, et al. The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol. 2016;37(3):208–220.
   PubMed Web of Science ®Google Scholar
• Holmgaard RB, Zamarin D, Li Y, et al. Tumor-expressed IDO recruits and activates MDSCs in a treg-dependent manner. Cell Reports. 2015;13(2):412–424.
   PubMed Web of Science ®Google Scholar
• Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19(11):1423–1437.
   PubMed Web of Science ®Google Scholar
• Sakuishi K, Jayaraman P, Behar SM, et al. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 2011;32(8):345–349.
   PubMed Web of Science ®Google Scholar
• Goedegebuure P, Mitchem JB, Porembka MR, et al. Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer. Curr Cancer Drug Targets. 2011;11(6):734–751.
   PubMed Web of Science ®Google Scholar
• Yu J, Du W, Yan F, et al. Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer. J Immunol. 2013;190(11):3783–3797.
   PubMed Web of Science ®Google Scholar
• Jordan KR, Amaria RN, Ramirez O, et al. Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients. Cancer Immunol Immunother. 2013;62(11):1711–1722.
   PubMed Web of Science ®Google Scholar
• Koinis F, Vetsika EK, Aggouraki D, et al. Effect of first-line treatment on myeloid-derived suppressor cells’ subpopulations in the peripheral blood of patients with non–small cell lung cancer. J Thorac Oncol. 2016;11(8):1263–1272.
   PubMed Web of Science ®Google Scholar
• Diaz-Montero CM, Salem M, Nishimura MI, et al. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother. 2009;58(1):49–59.
   PubMed Web of Science ®Google Scholar
• Zhang B, Wang Z, Wu L, et al. Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma. PLoS One. 2013;8(2):e57114.
   PubMed Web of Science ®Google Scholar
• Weide B, Martens A, Zelba H, et al. Myeloid-derived suppressor cells predict survival of patients with advanced melanoma: comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells. Clin Cancer Res. 2014;20(6):1601–1609.
   PubMed Web of Science ®Google Scholar
• Franklin RA, Li MO. Ontogeny of tumor-associated macrophages and its implication in cancer regulation. Trends Cancer. 2016;2(1):20–34.
   PubMed Web of Science ®Google Scholar
• Woo SR, Corrales L, Gajewski TF. Innate immune recognition of cancer. Annu Rev Immunol. 2015;33:445–474.
   PubMed Web of Science ®Google Scholar
• Huang Y, Snuderl M, Jain RK. Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and anti-tumor immunity. Cancer Cell. 2011;19(1):1–2.
   PubMed Web of Science ®Google Scholar
• Yang L, Zhang Y. Tumor-associated macrophages: from basic research to clinical application. J Hematol Oncol. 2017;10(1):58.
   PubMed Web of Science ®Google Scholar
• Komohara Y, Fujiwara Y, Ohnishi K, et al. Tumor-associated macrophages: potential therapeutic targets for anti-cancer therapy. Adv Drug Deliv Rev. 2016;99(Pt B):180–185.
   PubMed Web of Science ®Google Scholar
• Chanmee T, Ontong P, Konno K, et al. Tumor-associated macrophages as major players in the tumor microenvironment. Cancers. 2014;6(3):1670–1690.
   PubMed Web of Science ®Google Scholar
• Zhu Q, Wu X, Wang X. Differential distribution of tumor-associated macrophages and Treg/Th17 cells in the progression of malignant and benign epithelial ovarian tumors. Oncol Lett. 2017;13(1):159–166.
   PubMed Web of Science ®Google Scholar
• Pedersen MB, Danielsen AV, Hamilton-Dutoit SJ, et al. High intratumoral macrophage content is an adverse prognostic feature in anaplastic large cell lymphoma. Histopathology. 2014;65(4):490–500.
   PubMed Web of Science ®Google Scholar
• Fridlender ZG, Albelda SM. Tumor-associated neutrophils: friend or foe? Carcinogenesis. 2012;33(5):949–955.
   PubMed Web of Science ®Google Scholar
• Powell DR, Huttenlocher A. Neutrophils in the tumor microenvironment. Trends Immunol. 2016;37(1): 41–52. PubMed PMID: PMC4707100.
   PubMed Web of Science ®Google Scholar
• Shaul ME, Levy L, Sun J, et al. Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs. OncoImmunology. 2016;5(11):e1232221.
   PubMed Web of Science ®Google Scholar
• Hagerling C, Casbon AJ, Werb Z. Balancing the innate immune system in tumor development. Trends Biol. 2015;25(4):214–220.
   PubMed Web of Science ®Google Scholar
• Singel KL, Segal BH. Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal. Immunol Rev. 2016;273(1):329–343.
   PubMed Web of Science ®Google Scholar
• Wang TT, Zhao YL, Peng LS, et al. Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway. Gut. 2017;66(11):1900–1911.
   PubMed Web of Science ®Google Scholar
• Travar M, Petkovic M, Type VA. I, II, and III interferons: regulating immunity to mycobacterium tuberculosis infection. Arch Immunol Ther Exp (Warsz). 2016;64(1):19–31.
   PubMed Web of Science ®Google Scholar
• Parker BS, Rautela J, Hertzog PJ. Antitumour actions of interferons: implications for cancer therapy. Nat Rev Cancer. 2016;16(3):131–144.
   PubMed Web of Science ®Google Scholar
• Jablonska J, Leschner S, Westphal K, et al. Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest. 2010;120(4):1151–1164.
   PubMed Web of Science ®Google Scholar
• Woo SR, Corrales L, Gajewski TF. The STING pathway and the T cell-inflamed tumor microenvironment. Trends Immunol. 2015 Apr;36(4):250–256.
   PubMed Web of Science ®Google Scholar
• Sanchez-Paulete AR, Teijeira A, Cueto FJ, et al. Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy. Ann Oncol. 2017;1(28):xii44–xii55.
   Google Scholar
• Corrales L, Matson V, Flood B, et al. Innate immune signaling and regulation in cancer immunotherapy. Cell Res. 2017;27(1):96–108.
   PubMed Web of Science ®Google Scholar
• Xu M, Liu M, Du X, et al. Intratumoral delivery of IL-21 overcomes anti-Her2/Neu resistance through shifting tumor-associated macrophages from M2 to M1 phenotype. J Immunol. 2015;194(10):4997–5006.
   PubMed Web of Science ®Google Scholar
• Lee S, Margolin K. Cytokines in cancer immunotherapy. Cancers (Basel). 2011;3(4):3856–3893.
   PubMedGoogle Scholar
• Steding CE, Wu ST, Zhang Y, et al. The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis. Immunology. 2011;133(2):221–238.
   PubMed Web of Science ®Google Scholar
• Otles S, Ozgoz S. Health effects of dietary fiber. Acta Sci Pol Technol Aliment. 2014;13(2):191–202.
   PubMedGoogle Scholar
• DeVries JW. On defining dietary fibre. Proc Nutr Soc. 2003;62(1):37–43.
   PubMed Web of Science ®Google Scholar
• Wong C, Harris PJ, Ferguson LR. Potential benefits of dietary fibre intervention in inflammatory bowel disease. Int J Mol Sci. 2016;17(6):pii:E919.
   Web of Science ®Google Scholar
• Otaegui-Arrazola A, Amiano P, Elbusto A, et al. Diet, cognition, and Alzheimer’s disease: food for thought. Eur J Nutr. 2014;53(1):1–23.
   PubMed Web of Science ®Google Scholar
• Pedersen C, Gallagher E, Horton F, et al. Host-microbiome interactions in human type 2 diabetes following prebiotic fibre (galacto-oligosaccharide) intake. Br J Nutr. 2016;116(11):1869–1877.
   PubMed Web of Science ®Google Scholar
• Hong F, Yan J, Baran JT, et al. Mechanism by which orally administered β-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol. 2004;173(2):797–806.
   PubMed Web of Science ®Google Scholar
• Kerperien J, Jeurink PV, Wehkamp T, et al. Non-digestible oligosaccharides modulate intestinal immune activation and suppress cow’s milk allergic symptoms. Pediatr Allergy Immunol. 2014;25(8):747–754.
   PubMed Web of Science ®Google Scholar
• Correa-Oliveira R, Fachi JL, Vieira A, et al. Regulation of immune cell function by short-chain fatty acids. Clin Transl Immunol. 2016 Apr;5(4):e73.
   PubMedGoogle Scholar
• Zhu F, Du B, Xu B. A critical review on production and industrial applications of beta-glucans. Food Hydrocolloids. 2016;52:275–288.
   Web of Science ®Google Scholar
• Batbayar S, Lee DH, Kim HW. Immunomodulation of fungal β-glucan in host defense signaling by dectin-1. Biomol Ther. 2012;20(5):433–445.
   PubMed Web of Science ®Google Scholar
• Rice PJ, Adams EL, Ozment-Skelton T, et al. Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther. 2005;314(3):1079–1086.
   PubMed Web of Science ®Google Scholar
• Adams EL, Rice PJ, Graves B, et al. Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching. J Pharmacol Exp Ther. 2008;325(1):115–123.
   PubMed Web of Science ®Google Scholar
• Goodridge HS, Reyes CN, Becker CA, et al. Activation of the innate immune receptor dectin-1 upon formation of a ‘phagocytic synapse’. Nature. 2011 Apr 28;472(7344):471–475.
   PubMed Web of Science ®Google Scholar
• Sandvik A, Wang Y, Morton H, et al. Oral and systemic administration of beta-glucan protects against lipopolysaccharide-induced shock and organ injury in rats. Clin Exp Immunol. 2007;148(1):168–177.
   PubMed Web of Science ®Google Scholar
• Adachi Y, Ishii T, Ikeda Y, et al. Characterization of beta-glucan recognition site on C-type lectin, dectin 1. Infect Immun. 2004;72(7):4159–4171.
   PubMed Web of Science ®Google Scholar
• Kim HS, Park KH, Lee HK, et al. Curdlan activates dendritic cells through dectin-1 and toll-like receptor 4 signaling. Int Immunopharmacol. 2016;39:71–78.
   PubMed Web of Science ®Google Scholar
• Herre J, Gordon S, Brown GD. Dectin-1 and its role in the recognition of β-glucans by macrophages. Mol Immunol. 2004;40(12):869–876.
   PubMed Web of Science ®Google Scholar
• Bao H, Sun L, Zhu Y, et al. Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal dectin-1/AMPA receptor signaling pathway. Behav Brain Res. 2017;317:263–271.
   PubMed Web of Science ®Google Scholar
• Taylor PR, Brown GD, Reid DM, et al. The β-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J Immunol. 2002;169(7):3876–3882.
   PubMed Web of Science ®Google Scholar
• Stier H, Ebbeskotte V, Gruenwald J. Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan. Nutr J. 2014;13:38.
   PubMed Web of Science ®Google Scholar
• Evans SE, Hahn PY, McCann F, et al. Pneumocystis cell wall beta-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factor-kappaB-dependent mechanisms. Am J Respir Cell Mol Biol. 2005 Jun;32(6):490–497.
   PubMed Web of Science ®Google Scholar
• Rice PJ, Kelley JL, Kogan G, et al. Human monocyte scavenger receptors are pattern recognition receptors for (1→3)-β-D-glucans . J Leukoc Biol. 2002;72(1):140–146.
   PubMed Web of Science ®Google Scholar
• Taylor PR, Brown GD, Herre J, et al. The role of SIGNR1 and the β-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. J Immunol. 2004;172(2):1157–1162.
   PubMed Web of Science ®Google Scholar
• Vetvicka V, Thornton BP, Ross GD. Soluble B-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells. J Clin Invest. 1996;98(1):50–61.
   PubMed Web of Science ®Google Scholar
• Gantner BN, Simmons RM, Canavera SJ, et al. Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2. J Exp Med. 2003 May 05;197(9):1107–1117. PubMed PMID: 12719479; PubMed Central PMCID: PMC2193968.
   PubMed Web of Science ®Google Scholar
• Călugăru A, Cremer L, Lupu AR, et al. Recognition and modulation of dectin-1 and TLR-2 receptors by curdlan derivatives and purified natural extracts. Roum Arch Microbiol Immunol. 2009;68(3):119–124.
   PubMedGoogle Scholar
• Sato M, Sano H, Iwaki D, et al. Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A. J Immunol. 2003;171(1):417–425.
   PubMed Web of Science ®Google Scholar
• Cardone M, Dzutsev AK, Li H, et al. Interleukin-1 and interferon-γ orchestrate β-glucan-activated human dendritic cell programming via IκB-ζ modulation. PLoS One. 2014;9(12):e114516.
   PubMed Web of Science ®Google Scholar
• Muramatsu D, Kawata K, Aoki S, et al. Stimulation with the Aureobasidium pullulans-produced β-glucan effectively induces interferon stimulated genes in macrophage-like cell lines. Sci Rep. 2014;4:4777.
   PubMed Web of Science ®Google Scholar
• Mahla RS, Reddy MC, Prasad DVR, et al. Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology. Front Immunol. 2013;4:248, PubMed PMID: PMC3759294
   PubMed Web of Science ®Google Scholar
• Kankkunen P, Teirilä L, Rintahaka J, et al. (1,3)-β-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages. J Immunol. 2010;184(11):6335–6342.
   PubMed Web of Science ®Google Scholar
• Kerrigan AM, Brown GD. Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. Immunol Rev. 2010;234:335–352.
   PubMed Web of Science ®Google Scholar
• Lin YL, Liang YC, Lee SS, et al. Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-κB and p38 mitogen-activated protein kinase pathways. J Leukoc Biol. 2005;78(2):533–543.
   PubMed Web of Science ®Google Scholar
• Ali MF, Driscoll CB, Walters PR, et al. Beta-glucan activated human B-lymphocytes participate in innate immune responses by releasing pro-inflammatory cytokines and stimulating neutrophil chemotaxis. J Immunol. 2015;195(11):5318–5326.
   PubMed Web of Science ®Google Scholar
• Wakshull E, Brunke-Reese D, Lindermuth J, et al. PGG-glucan, a soluble β-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-κB-like factor in human PMN: evidence for a glycosphingolipid β-(1,3)-glucan receptor. Immunopharmacology. 1999;41(2):89–107.
   PubMedGoogle Scholar
• Tian J, Ma J, Ma K, et al. Beta-glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells. Eur J Immunol. 2013;43(5):1220–1230.
   PubMed Web of Science ®Google Scholar
• Liu M, Luo F, Ding C, et al. Dectin-1 activation by a natural product beta-glucan converts immunosuppressive macrophages into an M1-like phenotype. J Immunol. 2015;195(10):5055–5065.
   PubMed Web of Science ®Google Scholar
• Liu J, Gunn L, Hansen R, et al. Combined yeast-derived β-glucan with anti-tumor monoclonal antibody for cancer immunotherapy. Exp Mol Pathol. 2009;86(3):208–214.
   PubMed Web of Science ®Google Scholar
• McFarlin BK, Carpenter KC, Davidson T, et al. Baker’s yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171–183.
   PubMedGoogle Scholar
• Fuller R, Butt H, Noakes PS, et al. Influence of yeast-derived 1,3/1,6 glucopolysaccharide on circulating cytokines and chemokines with respect to upper respiratory tract infections. Nutrition. 2012;28(6):665–669.
   PubMed Web of Science ®Google Scholar
• Cosola C, De Angelis M, Rocchetti MT, et al. Beta-glucans supplementation associates with reduction in P-cresyl sulfate levels and improved endothelial vascular reactivity in healthy individuals. PLoS One. 2017;12(1):e0169635.
   PubMed Web of Science ®Google Scholar
• Bergendiova K, Tibenska E, Pleuran MJ. (β-glucan from pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur J Appl Physiol. 2011;111(9):2033–2040.
   PubMed Web of Science ®Google Scholar
• Gaullier J, Nurminiemi M, Sleboda J, et al. Supplementation with a soluble beta-glucan exported from shiitake medicinal mushroom, lentinus edodes (Berk.) singer mycelium: a crossover, placebo-controlled study in healthy elderly. Int J Med Mushrooms. 2011;13(4):319–326.
   PubMed Web of Science ®Google Scholar
• Lehne G, Haneberg B, Gaustad P, et al. Oral administration of a new soluble branched beta-1,3-D-glucan is well tolerated and can lead to increased salivary concentrations of immunoglobulin A in healthy volunteers. Clin Exp Immunol. 2006;143(1):65–69.
   PubMed Web of Science ®Google Scholar
• Dai X, Stanilka JM, Rowe CA, et al. Consuming lentinula edodes (Shiitake) mushrooms daily improves human immunity: a randomized dietary intervention in healthy young adults. J Am Coll Nutr. 2015;34(6):478–487.
   PubMed Web of Science ®Google Scholar
• Jafarzadeh A, Sadeghi M, Karam GA, et al. Salivary IgA and IgE levels in healthy subjects: relation to age and gender. Braz Oral Res. 2010;24(1):21–27.
   PubMedGoogle Scholar
• Lee YJ, Paik DJ, Kwon DY, et al. Agrobacterium sp.-derived beta-1,3-glucan enhances natural killer cell activity in healthy adults: a randomized, double-blind, placebo-controlled, parallel-group study. Nutr Res Pract. 2017;11(1):43–50.
   PubMed Web of Science ®Google Scholar
• Bobovčák M, Kuniaková R, Gabriž J, et al. Effect of pleuran (β-glucan from pleurotus ostreatus) supplementation on cellular immune response after intensive exercise in elite athletes. Appl Physiol Nutr Metab. 2010;35(6):755–762.
   PubMed Web of Science ®Google Scholar
• Carpenter KC, Breslin WL, Davidson T, et al. Baker’s yeast beta-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk? Br J Nutr. 2013;109(3):478–486.
   PubMed Web of Science ®Google Scholar
• Terakawa N, Matsui Y, Satoi S, et al. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. Nutr Cancer. 2008;60(5):643–651.
   PubMed Web of Science ®Google Scholar
• Yin Z, Fujii H, Walshe T. Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-gamma and/or tumor necrosis factor-alpha in healthy adults. Hum Immunol. 2010;71(12):1187–1190.
   PubMed Web of Science ®Google Scholar
• Routy B, Le Chatelier E, Derosa L, et al. Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors. Science. 2018;359(6371):91–97.
   PubMed Web of Science ®Google Scholar
• Karaca H, Inanc M, Bozkurt O, et al. Positive effects of oral β-glucan on mucositis and leukopenia in colorectal cancer patients receiving adjuvant FOLFOX-4 combination chemotherapy. Asian Pac J Cancer Prev. 2014;15(8):3641–3644.
   PubMedGoogle Scholar
• Nagashima Y, Maeda N, Yamamoto S, et al. Evaluation of host quality of life and immune function in breast cancer patients treated with combination of adjuvant chemotherapy and oral administration of lentinula edodes mycelia extract. Onco Targets Ther. 2013;6:853–859.
   PubMed Web of Science ®Google Scholar
• Suzuki N, Takimoto Y, Suzuki R, et al. Efficacy of oral administration of lentinula eododes mycelia extract for breast cancer patients undergoing postoperative hormone therapy. Asian Pacific J Cancer Prev. 2013;14(6):3469–3472.
   PubMedGoogle Scholar
• Hazam S, Watanabe S, Ohashi M, et al. Efficacy of orally administered superfine dispersed lentinan (β-1,3-glucan) for the treatment of advanced colorectal cancer. Anticancer Res. 2009;29(7):2611–2618.
   PubMed Web of Science ®Google Scholar
• Albeituni SH, Ding C, Liu M, et al. Yeast-derived particulate beta-glucan treatment subverts the suppression of myeloid-derived suppressor cells (MDSC) by inducing polymorphonuclear MDSC apoptosis and monocytic MDSC differentiation to APC in cancer. J Immunol. 2016;196(5):2167–2180.
   PubMed Web of Science ®Google Scholar
• Okuno K, Uno K. Efficacy of orally administered lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot stud. Asian Pac J Cancer Prev. 2011;12(7):1671–1674.
   PubMedGoogle Scholar
• Magnani M, Catro-Gomez RH, Aoki MN, et al. Effects of carboxymethyl-glucan from saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer. Exp Ther Med. 2010;1:859–862.
   Web of Science ®Google Scholar
• Demir G, Klein HO, Mandel-Molinas N, et al. Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. Int Immunopharmacol. 2007;7(1):113–116.
   PubMed Web of Science ®Google Scholar
• Ostadrahimi A, Ziaei JE, Esfahani A, et al. Effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial. Asian Pac J Cancer Prev. 2014;15(14):5733–5739.
   PubMedGoogle Scholar
• Iglesias JL, Prathikanti R, Ma B, et al. A multicenter, open-label, phase II study of PGG beta-glucan and pembrolizumab in patients (pts) with advanced melanoma (MEL) following progression on treatment with checkpoint inhibitors (CPI) or triple negative breast cancer (TNBC) failing front-line chemotherapy for metastatic disease [abstract]. J Clin Oncol. 2017. TPS3105.
   Google Scholar
• Ishikawa S, Matsui Y, Wachi S, et al. Age-associated impairment of antitumor immunity in carcinoma-bearing mice and restoration by oral administration of Lentinula edodes mycelia extract. Cancer Immunol Immunother. 2016 Aug;65(8):961–972.
   PubMed Web of Science ®Google Scholar
• Harnack U, Eckert K, Pecher G. Beta-(1-3),(1-6)-D-glucan enhances the effect of low-dose cyclophosphamide treatment on A20 lymphoma in mice. Anticancer Res. 2011;31(4):1169–1172.
   PubMed Web of Science ®Google Scholar
• Tanaka K, Matsui Y, Ishikawa S, et al. Oral ingestion of Lentinula edodes mycelia extract can restore the antitumor T cell response of mice inoculated with colon-26 cells into the subserosal space of the cecum. Oncol Rep. 2012;27(2):325–332.
   PubMed Web of Science ®Google Scholar
• Byun EB, Park SH, Jang BS, et al. Gamma-irradiated beta-glucan induces immunomodulation and anticancer activity through MAPK and NF-kappaB pathways. J Sci Food Agric. 2016;96(2):695–702.
   PubMed Web of Science ®Google Scholar
• Li B, Cai Y, Qi C, et al. Orally administered particulate beta-glucan modulates tumor-capturing dendritic cells and improves antitumor T-cell responses in cancer. Clin Cancer Res. 2010;16(21):5153–5164.
   PubMed Web of Science ®Google Scholar
• Masuda Y, Inoue H, Ohta H, et al. Oral administration of soluble beta-glucans extracted from grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice. Int J Cancer. 2013;133(1):108–119.
   PubMed Web of Science ®Google Scholar
• Baran J, Allendorf DJ, Hong F, et al. Oral β-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary tumor-bearing mice. Folia Histochem Cytobiol. 2007;45(2):107–114.
   PubMed Web of Science ®Google Scholar
• Qi C, Cai Y, Gunn L, et al. Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived beta-glucans. Blood. 2011;117(25):6825–6836.
   PubMed Web of Science ®Google Scholar
• Tanaka K, Ishikawa S, Matsui Y, et al. Combining a peptide vaccine with oral ingestion of lentinula edodes mycelia extract enhances anti-tumor activity in B16 melanoma-bearing mice. Cancer Immunol Immunother. 2012;61(11):2143–2152.
   PubMed Web of Science ®Google Scholar
• Rui K, Tian J, Tang X, et al. Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden. Immunol Res. 2016;64(4):931–939.
   PubMed Web of Science ®Google Scholar
• Mueller A, Raptis J, Rice PJ, et al. The influence of glucan polymer structure and solution conformation on binding to (1→3)-β-d-glucan receptors in a human monocyte-like cell line. Glycobiology. 2000;10(4):339–346.
   PubMed Web of Science ®Google Scholar
• Beattie A, Hirst EL, Percival E. Studies on the metabolism of the Chrysophyceae. Comparative structural investigations on leucosin (chrysolaminarin) separated from diatoms and laminarin from the brown algae. Biochem J. 1961;79(3):531–537.
   PubMed Web of Science ®Google Scholar
• Noss I, Doekes G, Thorne PS, et al. Comparison of the potency of a variety of beta-glucans to induce cytokine production in human whole blood. Innate Immun. 2013;19(1):10–19.
   PubMed Web of Science ®Google Scholar
• Vetvicka V, Vetvickova J. Immune-enhancing effects of maitake (grifola frondosa) and shiitake (lentinula edodes) extracts. Ann of Transl Med. 2014;2(2):14.
   PubMedGoogle Scholar
• Sasaki T, Takasuka N. Further study of the structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes. Carbohydr Res. 1976;47(1):99–104.
   PubMed Web of Science ®Google Scholar
• Fisher M, Yang LX. Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy. Anticancer Res. 2002;22(3):1737–1754.
   PubMed Web of Science ®Google Scholar
• Bae AH, Lee SW, Ikeda M, et al. Rod-like architecture and helicity of the poly(C)/schizophyllan complex observed by AFM and SEM. Carbohydr Res. 2004;339(2):251–258.
   PubMed Web of Science ®Google Scholar
• Bacon JS, Farmer VC, Jones D, et al. The glucan components of the cell wall of baker’s yeast (saccharomyces cerevisiae) considered in relation to its ultrastructure. Biochem J. 1969;114(3):557–567.
   PubMed Web of Science ®Google Scholar
• Błaszczyk K, Wilczak J, Harasym J, et al. Impact of low and high molecular weight oat beta-glucan on oxidative stress and antioxidant defense in spleen of rats with LPS induced enteritis. Food Hydrocolloids. 2015;51:272–280.
   Web of Science ®Google Scholar
• Rubin-Bejerano I, Abeijon C, Magnelli P, et al. Phagocytosis by human neutrophils is stimulated by a unique fungal cell wall component. Cell Host Microbe. 2007;2(1):55–67.
   PubMed Web of Science ®Google Scholar
• Bose N, Chan ASH, Guerrero F, et al. Binding of soluble yeast β-glucan to human neutrophils and monocytes is complement-dependent. Front Immunol. 2013;4:230.
   PubMed Web of Science ®Google Scholar
• Chanput W, Reitsma M, Kleinjans L, et al. β-Glucans are involved in immune-modulation of THP-1 macrophages. Mol Nutr Food Res. 2012;56(5):822–833.
   PubMed Web of Science ®Google Scholar
• Tang Y, Govers C, Wichers HJ, et al. Macrophages treated with non-digestible polysaccharides reveal a transcriptionally unique phenotype. J Funct Foods. 2017;36:280–289.
   Web of Science ®Google Scholar
• Ding J, Feng T, Ning Y, et al. β-Glucan enhances cytotoxic T lymphocyte responses by activation of human monocyte-derived dendritic cells via the PI3K/AKT pathway. Hum Immunol. 2015;76(2–3):146–154.
   PubMed Web of Science ®Google Scholar
• Elder MJ, Webster SJ, Chee R, et al. β-Glucan size controls dectin-1-mediated immune responses in human dendritic cells by regulating IL-1β Production. Front Immunol. 2017;8:791.
   PubMed Web of Science ®Google Scholar
• Leentjens J, Quintin J, Gerretsen J, et al. The effects of orally administered Beta-glucan on innate immune responses in humans, a randomized open-label intervention pilot-study. PLoS One. 2014;9(9):e108794.
   PubMed Web of Science ®Google Scholar
• Araujo VB, de Melo AN, de Souza NT, et al. Oral intake of carboxymethyl-glucan (CM-G) from yeast (Saccharomyces uvarum) reduces malondialdehyde levels in healthy men. Molecules. 2015;20(8):14950–14958.
   PubMed Web of Science ®Google Scholar
• Nieman DC, Henson DA, McMahon M, et al. Beta-glucan, immune function, and upper respiratory tract infections in athletes. Med Sci Sports Exerc. 2008;40(8):1463–1471.
   PubMed Web of Science ®Google Scholar
• Tian J, Ma J, Ma K, et al. Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma. PLoS One. 2012;7(10):e46936.
   PubMed Web of Science ®Google Scholar
• Harnack U, Eckert K, Fichtner I, et al. Oral administration of a soluble 1-3, 1-6 beta-glucan during prophylactic survivin peptide vaccination diminishes growth of a B cell lymphoma in mice. Int Immunopharmacol. 2009;9(11):1298–1303.
   PubMed Web of Science ®Google Scholar
• Tanaka K, Ishikawa S, Matsui Y, et al. Oral ingestion of Lentinula edodes mycelia extract inhibits B16 melanoma growth via mitigation of regulatory T cell-mediated immunosuppression. Cancer Sci. 2011;102(3):516–521.
   PubMed Web of Science ®Google Scholar