Rapid travel to a Zika vaccine: are we heading towards success or more questions?

References

• Plourde AR, Bloch EM. A literature review of Zika virus. Emerg Infect Dis. 2016;22:1185–1192.
   PubMed Web of Science ®Google Scholar
• Gautret P, Simon F. Dengue, chikungunya and Zika and mass gatherings: what happened in Brazil, 2014. Travel Med Infect Dis. 2018;14:7–8.
   Web of Science ®Google Scholar
• Drebot M, MacDonald J, Lindsay R, et al. First case of Zika virus infection in a returning Canadian traveler. Am J Trop Med Hyg. 2014;91:1035–1038.
   PubMed Web of Science ®Google Scholar
• Cavalheiro S, Lopez A, Serra S, et al. Microcephaly and Zika virus: neonatal neuroradiological aspects. Child’s Nerv Syst. 2016;32:1057–1060.
   PubMed Web of Science ®Google Scholar
• Duffy M, Chen T, Hancock W, et al. Zika virus outbreak on yap island, federated states of micronesia. N Engl J Med. 2009;360:2536–2543.
   PubMed Web of Science ®Google Scholar
• Musso D, Nhan T, Robin E, et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro Surveill. 2014;19.
   Google Scholar
• Calvet GA, Filippis AMB, Mendonca MCL, et al. First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil. J Clin Virol. 2016;74:1–3.
   PubMed Web of Science ®Google Scholar
• Musso D, Cao-Lormeau VM, Gubler DJ. Zika virus: following the path of dengue and chikungunya? Lancet. 2015;386:243–244.
   PubMed Web of Science ®Google Scholar
• Villamil-Gómez WE, González-Camargo O, Rodriguez-Ayubi J, et al. Dengue, chikungunya and Zika co-infection in a patient from Colombia. J Infect Public Health. 2015;10. DOI:10.1016/j.jiph.2015.12.002
   Web of Science ®Google Scholar
• Dupont-Rouzeyrol M, O'Connor O, Calvez E, et al. Co-infection with Zika and dengue viruses in 2 patients, new caledonia, 2014. Emerg Infect Dis. 2015 Feb;21(2):381-2. doi: 10.3201/eid2102.141553.PMID:25625687;21:381–382.
   Google Scholar
• Cao-Lormeau V-M, Roche C, Teissier A, et al. Zika virus, French polynesia, South pacific, 2013. Emerg Infect Dis. 2014;20:1085–1086.
   PubMed Web of Science ®Google Scholar
• Cauchemez S, Besnard M, Bompard P, et al. Association between Zika virus and microcephaly in French Polynesia, 2013 – 15 : a retrospective study. Lancet. 2016;6736:1–8.
   Google Scholar
• Nunes ML, Carlini CR, Marinowic D, et al. Microcephaly and Zika virus: a clinical and epidemiological analysis of the current outbreak in Brazil. J Pediatr (Rio J). 2016 published online Apr. DOI:10.1016/j.jped.2016.02.009
   PubMed Web of Science ®Google Scholar
• Mlakar J, Korva M, Tul N, et al. Zika virus associated with microcephaly. N Engl J Med. 2016;374:951–958.
   PubMed Web of Science ®Google Scholar
• Simmins CH Establishing base levels of microcephaly in Brazil prior to the arrival of Zika viral illnesses. 2016.
   Google Scholar
• Schuler-Faccini L, Ribeiro EM, Feitosa IML, et al. Possible association between Zika virus infection and microcephaly — Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65:59–62.
   PubMed Web of Science ®Google Scholar
• Tetro JA. Zika and microcephaly: causation, correlation, or coincidence?. Microbes Infect. 2016 Mar;18(3):167-168. doi: 10.1016/j.micinf.2015.12.010. PMID:26774330.
   PubMed Web of Science ®Google Scholar
• Oehler E, Watrin L, Larre P, et al. Zika virus infection complicated by Guillain-Barré syndrome – case report, French Polynesia, December 2013. Euro Surveill. 2014 Mar 6;19(9). pii: 20720.PMID:24626205.
   Google Scholar
• Cao-Lormeau V, Blake A, Mons S, et al. Guillain-barré syndrome outbreak caused by ZIKA virus infection in French Polynesia. Lancet. 2016;387:1531–1539.
   PubMed Web of Science ®Google Scholar
• Brito C. Zika virus : a new chapter in the history of medicine. Acta Paediatr Port. 2015;28:679–680.
   Google Scholar
• Petersen LR, Jamieson DJ, Powers AM, et al. Zika virus. N Engl J Med. 2016;374:1552–1563.
   PubMed Web of Science ®Google Scholar
• Liuzzi G, Puro V, Lanini S, et al. Zika virus and microcephaly: is the correlation causal or coincidental? New Microbiol. 2016;39:83–85.
   PubMed Web of Science ®Google Scholar
• Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika Virus and. Birth defects–reviewing the evidence for causality. N Engl J Med. 2016;374:1981–1987.
   PubMed Web of Science ®Google Scholar
• Sirohi D, Chen Z, Sun L, et al. The 3.8 Å resolution cryo-EM structure of Zika virus. Science. 2016;352:467–470.
   PubMed Web of Science ®Google Scholar
• Stettler K, Beltramello M, Espinosa DA, et al. Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection. Science (80-). 2016;353:823–826.
   PubMed Web of Science ®Google Scholar
• Darton TC, Blohmke CJ, Moorthy VS, et al. Design, recruitment, and microbiological considerations in human challenge studies. Lancet Infect Dis. 2015;15:840–851.
   PubMed Web of Science ®Google Scholar
• Barzon L, Palù G. Current views on Zika virus vaccine development. Expert Opin Biol Ther. 2017;17:1185–1192.
   PubMed Web of Science ®Google Scholar
• Search of: NCT03110770 - List Results - ClinicalTrials.gov. [updated 2018 Jan 12] Available from: https://clinicaltrials.gov/ct2/results?cond=&term=NCT03110770&cntry=&state=&city=&dist=
   Google Scholar
• Sanofi quietly pulls the plug on its Zika vaccine project. [updated 2018 Jan 12] Available from: https://www.statnews.com/2017/09/02/sanofi-zika-vaccine/
   Google Scholar
• Barouch DH, Thomas SJ, Michael NL. Prospects for a Zika virus vaccine. Immunity. 2017;46:176–182.
   PubMed Web of Science ®Google Scholar
• Blackman MA, Kim I-J, Lin J-S, et al. Challenges of vaccine development for Zika virus. Viral Immunol. 2017;31:1–7.
   PubMed Web of Science ®Google Scholar
• WHO/UNICEF Zika Virus Vaccine Target Product Profile for Emergency/Outbreak Use WHO/UNICEF Zika Virus (ZIKV) Vaccine Target Product Profile (TPP): Vaccine to protect against congenital Zika syndrome for use during an emergency. 2017.
   Google Scholar
• Lanciotti RS, Kosoy OL, Laven JJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14:1232–1239.
   PubMed Web of Science ®Google Scholar
• Xu X, Vaughan K, Weiskopf D, et al. Identifying candidate targets of immune responses in Zika virus based on homology to epitopes in other flavivirus species. PLoS Curr. 2016;8. DOI:10.1371/currents.outbreaks.9aa2e1fb61b0f632f58a098773008c4b
   PubMedGoogle Scholar
• Waggoner JJ, Pinsky BA. Zika virus: diagnostics for an emerging pandemic threat. J Clin Microbiol. 2016;54:860–867.
   PubMed Web of Science ®Google Scholar
• Díaz-Quiñonez JA, López-Martínez I, Torres-Longoria B, et al. Evidence of the presence of the Zika virus in Mexico since early 2015. Virus Genes. 2016;52:855–857.
   PubMed Web of Science ®Google Scholar
• PAHO WHO | regional Zika epidemiological update (Americas) August 25, 2017. [updated 2018 Jan 15] Available from: http://www.paho.org/hq/index.php?option=com_content&view=article&id=11599%3Aregional-zika-epidemiological-update-americas
   Google Scholar
• Munoz-Jordan JL. Diagnosis of Zika virus infections: challenges and opportunities. J Infect Dis. 2017;216:S951–6.
   PubMed Web of Science ®Google Scholar
• Testing for Zika Virus | Zika Virus | CDC. [updated 2017 Dec 17]. Available from: https://www.cdc.gov/zika/hc-providers/testing-for-zikavirus.html .
   Google Scholar
• Tappe D, Rissland J, Gabriel M, et al. First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013. Eurosurveillance. 2014;19:20685.
   Web of Science ®Google Scholar
• Korhonen EM, Huhtamo E, Smura T, et al. Zika virus infection in a traveller returning from the Maldives, June 2015. Eurosurveillance. 2016;21:30107.
   Web of Science ®Google Scholar
• Premkumar L, Collins M, Graham S, et al. Development of envelope protein antigens to serologically differentiate Zika virus infection from dengue virus infection. J Clin Microbiol. 2018;56:e01504–17.
   PubMed Web of Science ®Google Scholar
• Balmaseda A, Stettler K, Medialdea-Carrera R, et al. Antibody-based assay discriminates Zika virus infection from other flaviviruses. Proc Natl Acad Sci U S A. 2017;114:8384–8389.
   PubMed Web of Science ®Google Scholar
• Target Product Profiles for better diagnostic tests for Zika Virus Infection. 2016.
   Google Scholar
• Doherty M, Buchy P, Standaert B, et al. Vaccine impact: benefits for human health. Vaccine. 2016;34:6707–6714.
   PubMed Web of Science ®Google Scholar
• Abbink P, Larocca RA, Visitsunthorn K, et al. Durability and correlates of vaccine protection against Zika virus in rhesus monkeys. Sci Transl Med. 2017;9. DOI:10.1126/scitranslmed.aao4163
   Web of Science ®Google Scholar
• Aliota MT, Caine EA, Walker EC, et al. Characterization of lethal Zika virus infection in AG129 mice. PLoS Negl Trop Dis. 2016;10:e0004682.
   PubMed Web of Science ®Google Scholar
• Abbink P, Larocca RA, De La Barrera RA, et al. Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys. Science. 2016;353:1129–1132.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Gorman MJ, McKenzie LD, et al. Zika virus has oncolytic activity against glioblastoma stem cells. J Exp Med. 2017;214:314.
   Web of Science ®Google Scholar
• Richner JM, Jagger BW, Shan C, et al. Vaccine mediated protection against Zika virus- induced congenital disease . Cell. 2017;17018:273–283.
   Google Scholar
• Castanha PMS, Nascimento EJM, Braga C, et al. Dengue virus-specific antibodies enhance Brazilian Zika virus infection. J Infect Dis. 2017;215:781–785.
   PubMed Web of Science ®Google Scholar
• Parra B, Lizarazo J, Jiménez-Arango JA, et al. Guillain–Barré syndrome associated with Zika virus infection in colombia. N Engl J Med. 2016;375:1513–1523.
   PubMed Web of Science ®Google Scholar
• Roze B, Najioullah F, Ferge J-L, et al. Guillain-Barre syndrome associated with Zika virus infection in martinique in 2016: a prospective study. Clin Infect Dis. 2017;65:1462–1468.
   PubMed Web of Science ®Google Scholar
• Anaya J-M, Ramirez-Santana C, Salgado-Castaneda I, et al. Zika virus and neurologic autoimmunity: the putative role of gangliosides. BMC Med. 2016;14:49.
   PubMed Web of Science ®Google Scholar
• Lucchese G, Kanduc D. Zika virus and autoimmunity: from mycrocephaly to Guillain-Barré syndrome, and beyond. Autoimmun Rev. 2016  Aug;15(8):801-8. doi: 10.1016/j.autrev.2016.03.020.PMID:27019049.
   Web of Science ®Google Scholar
• Nachamkin I, Shadomy SV, Moran AP, et al. Anti‐ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine‐associated Guillain‐Barré syndrome. J Infect Dis. 2008;198:226–233.
   PubMed Web of Science ®Google Scholar
• Tang H, Hammack C, Ogden SC, et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell. 2016 May 5;18(5):587-90. doi: 10.1016/j.stem.2016.02.016.PMID:26952870;1–4.
   Google Scholar
• Richner JM, Himansu S, Dowd KA, et al. Modified mRNA vaccines protect against Zika virus infection. Cell. 2017;168:1114–1125.e10.
   PubMed Web of Science ®Google Scholar
• Plotkin SA, Starr SE, Friedman HM, et al. Comparison of vaccine-induced and natural immunity to cytomegalovirus (CMV). Pediatr Res. 1987;21:332A–332A.
   Web of Science ®Google Scholar
• Shah SK, Associate JD Ethical considerations for zika virus human challenge trials report & recommendations. 2017.
   Google Scholar
• Halstead SB. Dengue antibody-dependent enhancement: knowns and unknowns. Microbiol Spectr. 2014;2. DOI:10.1128/microbiolspec.AID-0022-2014
   PubMedGoogle Scholar
• Katzelnick LC, Gresh L, Halloran ME, et al. Antibody-dependent enhancement of severe dengue disease in humans. Science (80-). 2017;358:929–932.
   PubMed Web of Science ®Google Scholar
• Halstead SB. Achieving safe, effective, and durable Zika virus vaccines: lessons from dengue. Lancet Infect Dis. 2017;17:e378–82.
   PubMed Web of Science ®Google Scholar
• Hadinegoro SR, Arredondo-García JL, Capeding MR, et al. Efficacy and long-term safety of a dengue vaccine in regions of endemic disease. N Engl J Med. 2015;373:1195–1206.
   PubMed Web of Science ®Google Scholar
• Londono-Renteria B, Troupin A, Cardenas JC, et al. A relevant in vitro human model for the study of Zika virus antibody-dependent enhancement. J Gen Virol. 2017;98:1702–1712.
   PubMed Web of Science ®Google Scholar
• Yu L, Wang R, Gao F, et al. Delineating antibody recognition against Zika virus during natural infection. JCI Insight. 2017 Jun 15;2(12). pii: 93042. doi: 10.1172/jci.insight.93042.PMID:28614803.
   Web of Science ®Google Scholar
• Dejnirattisai W, Supasa P, Wongwiwat W, et al. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with Zika virus. Nat Publ Gr. 2016;17. DOI:10.1038/ni.3515
   Google Scholar
• Halstead SB. Biologic evidence required for Zika disease enhancement by dengue antibodies. Emerg Infect Dis. 2017;23:569–573.
   PubMed Web of Science ®Google Scholar
• Sanofi updates information on dengue vaccine | Sanofi. [updated 2018 Jun 17]. Available from: http://mediaroom.sanofi.com/sanofi-updates-information-on-dengue-vaccine/.
   Google Scholar
• Sridhar S, Luedtke A, Langevin E, et al. Effect of dengue serostatus on dengue vaccine safety and efficacy. N Engl J Med. 2018;379:327–340.
   PubMed Web of Science ®Google Scholar
• Boigard H, Alimova A, Martin GR, et al. Zika virus-like particle (VLP) based vaccine. PLoS Negl Trop Dis. 2017;11:e0005608.
   PubMed Web of Science ®Google Scholar
• Yang M, Lai H, Sun H, et al. Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice. Sci Rep. 2017;7:7679.
   PubMed Web of Science ®Google Scholar
• Boonnak K, Slike BM, Burgess TH, et al. Role of dendritic cells in antibody-dependent enhancement of dengue virus infection. J Virol. 2008;82:3939–3951.
   PubMed Web of Science ®Google Scholar
• Ubol S, Halstead SB. How innate immune mechanisms contribute to antibody-enhanced viral infections. Clin Vaccine Immunol. 2010;17:1829–1835.
   PubMed Web of Science ®Google Scholar
• Lima NS, Rolland M, Modjarrad K, et al. T cell immunity and Zika virus vaccine development. Trends Immunol. 2017;38:594–605.
   PubMed Web of Science ®Google Scholar
• Porterfield JS. Antibody-dependent enhancement of viral infectivity. Adv Virus Res. 1986;31:335–355.
   PubMed Web of Science ®Google Scholar
• Bardina SV, Bunduc P, Tripathi S, et al. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science (80-). 2017;356:175–180.
   PubMed Web of Science ®Google Scholar
• McCracken MK, Gromowski GD, Friberg HL, et al. Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques. PLoS Pathog. 2017;13:e1006487.
   PubMed Web of Science ®Google Scholar
• Pantoja P, Perez-Guzman EX, Rodriguez IV, et al. Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus. Nat Commun. 2017;8:15674.
   PubMed Web of Science ®Google Scholar
• George J, Valiant WG, Mattapallil MJ, et al. Prior exposure to Zika virus significantly enhances peak dengue-2 viremia in rhesus macaques. Sci Rep. 2017;7:10498.
   PubMed Web of Science ®Google Scholar
• Barba-Spaeth G, Dejnirattisai W, Rouvinski A, et al. Structural basis of potent Zika–dengue virus antibody cross-neutralization.
   Google Scholar
• Collins MH, McGowan E, Jadi R, et al. Lack of durable cross-neutralizing antibodies against Zika virus from dengue virus infection. Emerg Infect Dis. 2017;23:773–781.
   PubMed Web of Science ®Google Scholar
• Montoya M, Collins M, Dejnirattisai W, et al. Longitudinal analysis of antibody cross-neutralization following Zika virus and dengue virus infection in Asia and the Americas. J Infect Dis. 2018 published online Apr 2. DOI:10.1093/infdis/jiy164
   Web of Science ®Google Scholar
• Ribeiro GS, Kikuti M, Tauro LB, et al. Does immunity after Zika virus infection cross-protect against dengue?
   Google Scholar
• Goncalves A, Peeling RW, Chu MC, et al. Innovative and new approaches to laboratory diagnosis of Zika and dengue: a meeting report. J Infect Dis. 2018;217:1060–1068.
   PubMed Web of Science ®Google Scholar
• Muthumani K, Griffin BD, Agarwal S, et al. In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine. NPJ Vaccines. 2016;1:16021.
   PubMed Web of Science ®Google Scholar
• Chibueze EC, Tirado V, Da Silva Lopes K, et al. Zika virus infection in pregnancy: a systematic review of disease course and complications. Reprod Health. 2017;14:28.
   PubMed Web of Science ®Google Scholar