240
Views
11
CrossRef citations to date
0
Altmetric
Review

Stand alone or join forces? Stem cell therapy for stroke

, , & ORCID Icon
Pages 25-33 | Received 05 Oct 2018, Accepted 20 Nov 2018, Published online: 13 Dec 2018

References

  • Janyou A, Wicha P, Jittiwat J, et al. Dihydrocapsaicin attenuates blood brain barrier and cerebral damage in focal Cerebral ischemia/reperfusion via oxidative stress and inflammatory. Sci Rep. 2017;7(1): 1–11. Springer US.
  • Morimoto J, Yasuhara T, Kameda M, et al. Electrical stimulation enhances migratory ability of transplanted bone marrow stromal cells in a rodent ischemic stroke model. Cell Physiol Biochem. 2018;46(1):57–68.
  • Wang J, Gao L, Yang YL, et al. Low serum levels of brain-derived neurotrophic factor were associated with poor short-term functional outcome and mortality in acute ischemic stroke. Mol Neurobiol. 2017;54(9):7335–7342.
  • Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart disease and stroke statistics—2017 update. Circulation. 2017;135:1120–1122.
  • Saposnik G, Cohen LG, Mamdani M, et al. Efficacy and safety of non-immersive virtual reality exercising in stroke rehabilitation (EVREST): a randomised, multicentre, single-blind, controlled trial. Lancet Neurol. 2016;15(10):1019–1027. Elsevier Ltd.
  • Stonesifer C, Corey S, Ghanekar S, et al. Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms. Prog Neurobiol. 2017;158(November):94–131. Elsevier Ltd.
  • George PM, Steinberg GK. Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments. Neuron. 2015;87(2): 297–309. Elsevier Inc.
  • Napoli E, Borlongan CV. Recent advances in stem cell-based therapeutics for stroke. Transl Stroke Res. 2016;7(6):452–457.
  • Liska MG, Crowley MG, Borlongan CV. Regulated and unregulated clinical trials of stem cell therapies for stroke. Transl Stroke Res. 2017 Apr 26; 8(2):93–103.
  • Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature. 2006;441(7097):1094–1096.
  • Tajiri N, Lee JY, Acosta S, et al. Breaking the blood–brain barrier with mannitol to aid stem cell therapeutics in the chronic stroke brain. Cell Transplant. 2016;25(8):1453–1460.
  • Garbuzova-Davis S, Haller E, Lin R, et al. Intravenously transplanted human bone marrow endothelial progenitor cells engraft within brain capillaries, preserve mitochondrial morphology, and display pinocytotic activity toward blood-brain barrier repair in ischemic stroke rats. Lerman J, editor. Stem Cells. 2017 May;35(5):1246–1258.
  • Boese AC, Le QSE, Pham D, et al. Neural stem cell therapy for subacute and chronic ischemic stroke. Stem Cell Res Ther. 2018;9(1):1–17.
  • Cheng Z, Wang L, Qu M, et al. Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice. J Neuroinflammation. 2018;15(1):1–11.
  • Pantcheva P, Reyes S, Hoover J, et al. Treating non-motor symptoms of Parkinson’s disease with transplantation of stem cells. Expert Rev Neurother. 2015 Oct 3;15(10):1231–1240.
  • Duncan T, Valenzuela M. Alzheimer’s disease, dementia, and stem cell therapy. Stem Cell Res Ther. 2017;8(1):1–9.
  • Reidling JC, Relaño-Ginés A, Holley SM, et al. Human neural stem cell transplantation rescues functional deficits in R6/2 and Q140 huntington’s disease mice. Stem Cell Reports. 2018;10(1):58–72.
  • Lee JY, Xu K, Nguyen H, et al. Stem cell-induced biobridges as possible tools to aid neuroreconstruction after CNS injury. Front Cell Dev Biol. 2017;5(May).
  • Lippert T, Gelineau L, Napoli E, et al. Harnessing neural stem cells for treating psychiatric symptoms associated with fetal alcohol spectrum disorder and epilepsy. Prog Neuro Psychopharmacol Biol Psychiatry. 2018 Jan;80(February):10–22. Elsevier.
  • Scolding NJ, Pasquini M, Reingold SC, et al. Cell-based therapeutic strategies for multiple sclerosis. Brain. 2017;140(11):2776–2796.
  • Eve DJ, Steiner G, Mahendrasah A, et al. Reduction of microhemorrhages in the spinal cord of symptomatic ALS mice after intravenous human bone marrow stem cell transplantation accompanies repair of the blood-spinal cord barrier. Oncotarget. 2018;9(12):10621–10634.
  • Ruzicka J, Machova-Urdzikova L, Gillick J, et al. A comparative study of three different types of stem cells for treatment of rat spinal cord injury. Cell Transplant. 2017;26(4):585–603.
  • Wang W, Li M, Chen Q, et al. Hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke: mechanisms, models, and biomarkers. Mol Neurobiol. 2015 Dec 4;52(3):1572–1579.
  • Dela Peña IC, Yang S, Shen G, et al. Extension of tissue plasminogen activator treatment window by granulocyte-colony stimulating factor in a thromboembolic rat model of stroke. Int J Mol Sci. 2018;19:6.
  • Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2017;378:NEJMoa1706442.
  • Borlongan CV, Glover LE, Tajiri N, et al. The great migration of bone marrow-derived stem cells toward the ischemic brain. Prog Neurobiol. 2012;95(2):213–228.
  • Steinberg GK, Kondziolka D, Wechsler LR, et al. Clinical outcomes of transplanted modified bone marrow–derived mesenchymal stem cells in stroke. Stroke. 2016 Jul;47(7):1817–1824.
  • Napoli E, Borlongan CV. Stem cell recipes of bone marrow and fish: just what the stroke doctors ordered. Stem Cell Rev Rep. 2017;13(2):192–197.
  • Dela Peña I, Borlongan CV. Translating G-CSF as an adjunct therapy to stem cell transplantation for stroke. Transl Stroke Res. 2015 Dec 20;6(6):421–429.
  • Bang OY, Moon GJ, Kim DH, et al. Stroke induces mesenchymal stem cell migration to infarcted brain areas via CXCR4 and C-Met signaling. Transl Stroke Res. 2017;8(5):449–460.
  • Marei HE, Hasan A, Rizzi R, et al. Potential of stem cell-based therapy for ischemic stroke. Front Neurol. 2018;9(FEB).
  • Duncan K, Gonzales-Portillo GS, Acosta SA, et al. Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy. Brain Res. 2015 Oct;1623:160–165.
  • Vu Q, Xie K, Eckert M, et al. Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke. Neurology. 2014 Apr 8;82(14):1277–1286.
  • Rodrigues MCO, Lippert T, Nguyen H, et al. Menstrual blood-derived stem cells: in vitro and in vivo characterization of functional effects. Adv Exp Med Biol. 2016; 111–121.
  • Lee JS, Hong JM, Moon GJ, et al. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells. 2010;28(6):1099–1106.
  • Gonzales-Portillo GS, Sanberg PR, Franzblau M, et al. Mannitol-enhanced delivery of stem cells and their growth factors across the blood-brain barrier. Cell Transplant. 2014;23(4–5):531–539.
  • Savitz SI, Misra V, Kasam M, et al. Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann Neurol. 2011;70(1):59–69.
  • Prasad K, Sharma A, Garg A, et al. Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: A multicentric, randomized trial. Stroke. 2014;45(12):3618–3624.
  • Banerjee S, Bentley P, Hamady M, et al. Intra-arterial immunoselected CD34+ stem cells for acute ischemic stroke. Stem Cells Transl Med. 2014;3(11):1322–1330.
  • Kalladka D, Sinden J, Pollock K, et al. Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet. 2016;388(10046):787–796. Elsevier Ltd.
  • Omori Y, Honmou O, Harada K, et al. Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult rats. Brain Res. 2008 Oct 21;1236:30–38.
  • Qiao L-Y, Huang F-J, Zhao M, et al. A two-year follow-up study of cotransplantation with neural stem/progenitor cells and mesenchymal stromal cells in ischemic stroke patients. Cell Transplant. 2014;23(1_suppl):65–72.
  • Chen F, Qi Z, Luo Y, et al. Non-pharmaceutical therapies for stroke: mechanisms and clinical implications. Prog Neurobiol. 2014;115:246–269.
  • Flint AC, Conell C, Ren X, et al. Statin adherence is associated with reduced recurrent stroke risk in patients with or without atrial fibrillation. Stroke. 2017;48(7):1788–1794.
  • Kim J, Lee HS, Nam CM, et al. Effects of statin intensity and adherence on the long-term prognosis after acute ischemic stroke. Stroke. 2017;48(10):2723–2730.
  • Lee M, Saver JL, Wu YL, et al. Utilization of statins beyond the initial period after stroke and 1-year risk of recurrent stroke. J Am Heart Assoc. 2017;6(8):1–12.
  • Xu T, Yu X, Ou S, et al. Adherence and the risk of stroke: a dose-response meta-analysis. CNS Drugs. 2017;31(4): 263–271. Springer International Publishing.
  • Venkat P, Shen Y, Chopp M, et al. Cell-based and pharmacological neurorestorative therapies for ischemic stroke. Neuropharmacology. 2017;134: 310–322. Elsevier Ltd.
  • Peña IDL, Borlongan C, Shen G, et al. Strategies to extend thrombolytic time window for ischemic stroke treatment: an unmet clinical need. J Stroke. 2017;19(1):50–60.
  • Dela Peña IC, Yoo A, Tajiri N, et al. Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis. J Cereb Blood Flow Metab. 2015;35(2):338–346.
  • Huang X, Liu Y, Bai S, et al. Granulocyte colony stimulating factor therapy for stroke: A pairwise meta-analysis of randomized controlled trial. PLoS One. 2017;12(4):1–10.
  • Wang R, Zhao H, Li J, et al. Erythropoietin attenuates axonal injury after middle cerebral artery occlusion in mice. Neurol Res. 2017;39(6):545–551. Taylor & Francis.
  • Wang R, Li J, Duan Y, et al. Effects of erythropoietin on gliogenesis during cerebral ischemic/reperfusion recovery in adult mice. Aging Dis. 2017;8(4):410–419.
  • Knecht T, Story J, Liu J, et al. Adjunctive therapy approaches for ischemic stroke: innovations to expand time window of treatment. Int J Mol Sci. 2017;18:12.
  • Arbeláez-Quintero I, Palacios M. To use or not to use metformin in cerebral ischemia: a review of the application of metformin in stroke rodents. Stroke Res Treat. 2017;2017:1–13. (Hindawi).
  • Guo JM, Zhang L, Niu XC, et al. Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats. Eur J Pharmacol. 2017;798:1–8. Elsevier B.V.
  • Matsukawa N, Yasuhara T, Hara K, et al. Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke. BMC Neurosci. 2009;10:126.
  • Yang JL, Chen WY, Chen YP, et al. Activation of GLP-1 receptor enhances neuronal base excision repair via PI3K-AKT-induced expression of apurinic/apyrimidinic endonuclease 1. Theranostics. 2016;6(12):2015–2027.
  • Sato K, Kameda M, Yasuhara T, et al. Neuroprotective effects of liraglutide for stroke model of rats. Int J Mol Sci. 2013;14(11):21513–21524.
  • Kim S, Jeong J, Jung H-S, et al. Anti-inflammatory effect of glucagon like peptide-1 receptor agonist, exendin-4, through modulation of IB1/JIP1 expression and JNK signaling in stroke. Exp Neurobiol. 2017;26(4):227–239.
  • Liraz-Zaltsman S, Yaka R, Shabashov D, et al. Neuroinflammation-induced memory deficits are amenable to treatment with d-cycloserine. J Mol Neurosci. 2016;60(1):46–62.
  • Hawkins KE, DeMars KM, Alexander JC, et al. Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4analog: protective mechanisms and long-term effects on neurological recovery. Brain Behav. 2017;7(5):1–14.
  • Pan J, Palmateer J, Schallert T, et al. Novel humanized recombinant T cell receptor ligands protect the female brain after experimental stroke. Transl Stroke Res. 2014;5(5):577–585.
  • England TN. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346(8):549–556.
  • Wang B, Wu D, Dornbos D, et al. Local cerebral hypothermia induced by selective infusion of cold lactated ringer’s: A feasibility study in rhesus monkeys. Neurol Res. 2016;38(6):545–552.
  • Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002 Feb 21;346(8):557–563.
  • Mattingly TK, Denning LM, Siroen KL, et al. Catheter based selective hypothermia reduces stroke volume during focal cerebral ischemia in swine. J Neurointerv Surg. 2016;8(4):418–422.
  • Van Der Worp HB, Sena ES, Donnan GA, et al. Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis. Brain. 2007;130(12):3063–3074.
  • Wu D, Shi J, Elmadhoun O, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017;1671:18–25.
  • Kaneko Y, Tajiri N, Su TP, et al. Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro: role of the opioid system. PLoS One. 2012;7(10).
  • Nih LR, Carmichael ST, Segura T. Hydrogels for brain repair after stroke: an emerging treatment option. Curr Opin Biotechnol. 2016 Aug;40:155–163.
  • Harris JP, Struzyna LA, Murphy PL, et al. Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain. J Neural Eng. 2016 Feb 1;13(1):016019.
  • Zhang Y, Ying G, Ren C, et al. Administration of human platelet-rich plasma reduces infarction volume and improves motor function in adult rats with focal ischemic stroke. Brain Res. 2015;1594(45):267–273. Elsevier.
  • Ghuman H, Massensini AR, Donnelly J, et al. ECM hydrogel for the treatment of stroke: characterization of the host cell infiltrate. Biomaterials. 2016 Jun 22;91(05):166–181.
  • Moshayedi P, Nih LR, Llorente IL, et al. Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. Biomaterials. 2016 Oct 22;105(05):145–155.
  • Jendelová P, Kubinová Š, Sandvig I, et al. Current developments in cell- and biomaterial-based approaches for stroke repair. Expert Opin Biol Ther. 2016;16(1): 43–56. Informa UK, Ltd.
  • Dimyan MA, Cohen LG. Neuroplasticity in the context of motor rehabilitation after stroke. Nat Rev Neurol. 2011 Feb 18;7(2):76–85.
  • Trounson A, McDonald C. Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell. 2015;17(1): 11–22. Elsevier Inc.
  • Hyun I. Review series the bioethics of stem cell research and therapy. J Clin Invest. 2010;120(1):71–75.
  • Borlongan CV, McWhirter C, Fultz-Carver C, et al. The case for an ethics research consortium for emerging technologies: public perception of stem cell research and development. Technol Innov. 2010;12(1):21–28.
  • Son B, Lee S, Youn H, et al. The role of tumor microenvironment in therapeutic resistance. Oncotarget. 2017;8(3):3933–3945.
  • Bernhardt J, Dewey H, Thrift A, et al. A very early rehabilitation trial for stroke (AVERT): phase II safety and feasibility. Stroke. 2008;39(2):390–396.
  • Cumming TB, Thrift AG, Collier JM, et al. Very early mobilization after stroke fast-tracks return to walking: further results from the phase II AVERT randomized controlled trial. Stroke. 2011;42(1):153–158.
  • Langhorne P, Stott D, Knight A, et al. Very early rehabilitation or intensive telemetry after stroke: a pilot randomised trial. Cerebrovasc Dis. 2010;29(4):352–360.
  • Craig LE, Bernhardt J, Langhorne P, et al. Early mobilization after stroke: an example of an individual patient data meta-analysis of a complex intervention. Stroke. 2010;41(11):2632–2636.
  • Langhorne P, Wu O, Rodgers H, et al. A very early rehabilitation trial after stroke (AVERT): a Phase III, multicentre, randomised controlled trial. Health Technol Assess (Rockv). 2017;21(54):1–119.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.