An updated review of adipose derived-mesenchymal stem cells and their applications in musculoskeletal disorders

References

• Friedenstein AJ, Petrakova KV, Kurolesova AI, et al. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968;6(2): 230–247. PubMed PMID: 5654088.
   PubMed Web of Science ®Google Scholar
• Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284(5411):143–147. PubMed PMID: 10102814.
   PubMed Web of Science ®Google Scholar
• Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9(5):641–650. PubMed PMID: 1870029.
   PubMed Web of Science ®Google Scholar
• Da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006;119(Pt 11):2204–2213. PubMed PMID: 16684817.
   PubMed Web of Science ®Google Scholar
• Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng . 2001;7(2):211–228. PubMed PMID: 11304456.
   PubMedGoogle Scholar
• Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol. 2000;109(1): 235–242. PubMed PMID: 10848804.
   PubMed Web of Science ®Google Scholar
• Roufosse CA, Direkze NC, Otto WR, et al. Circulating mesenchymal stem cells. Int J Biochem Cell Biol. 2004;36(4):585–597. PubMed PMID: 15010325.
   PubMed Web of Science ®Google Scholar
• Jankowski RJ, Deasy BM, Huard J. Muscle-derived stem cells. Gene Ther. 2002;9(10):642–647. PubMed PMID: 12032710.
   PubMed Web of Science ®Google Scholar
• Noort WA, Kruisselbrink AB, In’t Anker PS, et al. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol. 2002;30(8):870–878. PubMed PMID: 12160838.
   PubMed Web of Science ®Google Scholar
• Wenisch S, Trinkaus K, Hild A, et al. Human reaming debris: a source of multipotent stem cells. Bone. 2005;36(1):74–83. PubMed PMID: 15664005.
   PubMed Web of Science ®Google Scholar
• Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000;97(25):13625–13630. PubMed PMID: 11087820; PubMed Central PMCID: PMCPMC17626.
   PubMed Web of Science ®Google Scholar
• Haniffa MA, Wang XN, Holtick U, et al. Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol. 2007;179(3):1595–1604. PubMed PMID: 17641026.
   PubMed Web of Science ®Google Scholar
• Sessarego N, Parodi A, Podesta M, et al. Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical application. Haematologica. 2008;93(3):339–346. PubMed PMID: 18268281.
   PubMed Web of Science ®Google Scholar
• Yan XL, Fu CJ, Chen L, et al. Mesenchymal stem cells from primary breast cancer tissue promote cancer proliferation and enhance mammosphere formation partially via EGF/EGFR/Akt pathway. Breast Cancer Res Treat. 2012;132(1):153–164. PubMed PMID: 21584665.
   PubMed Web of Science ®Google Scholar
• Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. 2004;36(4):568–584. PubMed PMID: 15010324.
   PubMed Web of Science ®Google Scholar
• Baer PC. Adipose-derived mesenchymal stromal/stem cells: an update on their phenotype in vivo and in vitro. World J Stem Cells. 2014;6(3):256–265. PubMed PMID: 25126376; PubMed Central PMCID: PMCPMC4131268.
   PubMedGoogle Scholar
• Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell . 2002;13(12):4279–4295. PubMed PMID: 12475952; PubMed Central PMCID: PMCPMC138633.
   PubMed Web of Science ®Google Scholar
• Tsuji W, Rubin JP, Marra KG. Adipose-derived stem cells: implications in tissue regeneration. World J Stem Cells. 2014;6(3):312–321. PubMed PMID: 25126381; PubMed Central PMCID: PMCPMC4131273.
   PubMedGoogle Scholar
• Bunnell BA, Flaat M, Gagliardi C, et al. Adipose-derived stem cells: isolation, expansion and differentiation. Methods. 2008;45(2):115–120. PubMed PMID: 18593609; PubMed Central PMCID: PMCPMC3668445.
   PubMed Web of Science ®Google Scholar
• Arnhold S, Wenisch S. Adipose tissue derived mesenchymal stem cells for musculoskeletal repair in veterinary medicine. Am J Stem Cells. 2015;4(1): 1–12. PubMed PMID: 25973326; PubMed Central PMCID: PMCPMC4396154.
   PubMed Web of Science ®Google Scholar
• Alt EU, Senst C, Murthy SN, et al. Aging alters tissue resident mesenchymal stem cell properties. Stem Cell Res. 2012;8(2):215–225. PubMed PMID: 22265741.
   PubMed Web of Science ®Google Scholar
• Duscher D, Rennert RC, Januszyk M, et al. Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells. Sci Rep. 2014;4:7144. PubMed PMID: 25413454; PubMed Central PMCID: PMCPMC4239576.
   PubMed Web of Science ®Google Scholar
• Kornicka K, Marycz K, Maredziak M, et al. The effects of the DNA methyltranfserases inhibitor 5-Azacitidine on ageing, oxidative stress and DNA methylation of adipose derived stem cells. J Cell Mol Med. 2017;21(2):387–401. PubMed PMID: 27998022; PubMed Central PMCID: PMCPMC5264131.
   PubMed Web of Science ®Google Scholar
• Kornicka K, Marycz K, Tomaszewski KA, et al. The effect of age on osteogenic and adipogenic differentiation potential of human adipose derived stromal stem cells (hASCs) and the impact of stress factors in the course of the differentiation process. Oxid Med Cell Longev. 2015;2015:309169. PubMed PMID: 26246868; PubMed Central PMCID: PMCPMC4515302.
   PubMed Web of Science ®Google Scholar
• Rodbell M. Metabolism of isolated fat cells. II. The similar effects of phospholipase C (Clostridium perfringens alpha toxin) and of insulin on glucose and amino acid metabolism. J Biol Chem. 1966;241(1): 130–139. PubMed PMID: 4379054.
   PubMed Web of Science ®Google Scholar
• Chen J, Tang Y-X, Liu Y-M, et al. Transplantation of adipose-derived stem cells is associated with neural differentiation and functional improvement in a rat model of intracerebral hemorrhage. CNS Neurosci Ther. 2012;18(10):847–854. PubMed PMID: 22934896.
   PubMed Web of Science ®Google Scholar
• Sherman LS, Conde-Green A, Kotamarti VS, et al. Enzyme-free isolation of adipose-derived mesenchymal stem cells. Methods Mol Biol. 2018;1842:203–206. PubMed PMID: 30196411.
   PubMedGoogle Scholar
• Rodbell M, Jones AB. Metabolism of isolated fat cells. 3. The similar inhibitory action of phospholipase C (Clostridium perfringens alpha toxin) and of insulin on lipolysis stimulated by lipolytic hormones and theophylline. J Biol Chem. 1966;241(1): 140–142. PubMed PMID: 4285132.
   PubMed Web of Science ®Google Scholar
• Aust L, Devlin B, Foster SJ, et al. Yield of human adipose-derived adult stem cells from liposuction aspirates. Cytotherapy. 2004;6(1):7–14. PubMed PMID: 14985162.
   PubMed Web of Science ®Google Scholar
• Guilak F, Lott KE, Awad HA, et al. Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. J Cell Physiol. 2006;206(1):229–237. PubMed PMID: 16021633.
   PubMed Web of Science ®Google Scholar
• Mitchell JB, McIntosh K, Zvonic S, et al. Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells. 2006;24(2):376–385. PubMed PMID: 16322640.
   PubMed Web of Science ®Google Scholar
• Dai R, Wang Z, Samanipour R, et al. Adipose-derived stem cells for tissue engineering and regenerative medicine applications. Stem Cells Int. 2016;2016:6737345. PubMed PMID: 27057174; PubMed Central PMCID: PMCPMC4761677.
   PubMedGoogle Scholar
• Marycz K, Krzak-Ros J, Donesz-Sikorska A, et al. The morphology, proliferation rate, and population doubling time factor of adipose-derived mesenchymal stem cells cultured on to non-aqueous SiO2, TiO2, and hybrid sol-gel-derived oxide coatings. J Biomed Mater Res A. 2014;102(11):4017–4026. PubMed PMID: 24408867.
   PubMed Web of Science ®Google Scholar
• Chang YW, Wu YC, Huang SH, et al. Autologous and not allogeneic adipose-derived stem cells improve acute burn wound healing. PLoS One. 2018;13(5):e0197744. PubMed PMID: 29787581; PubMed Central PMCID: PMCPMC5963767.
   PubMed Web of Science ®Google Scholar
• Li H, Zimmerlin L, Marra KG, et al. Adipogenic potential of adipose stem cell subpopulations. Plast Reconstr Surg. 2011;128(3):663–672. PubMed PMID: 21572381; PubMed Central PMCID: PMCPMC4167367.
   PubMed Web of Science ®Google Scholar
• Gonda K, Shigeura T, Sato T, et al. Preserved proliferative capacity and multipotency of human adipose-derived stem cells after long-term cryopreservation. Plast Reconstr Surg. 2008;121(2):401–410. PubMed PMID: 18300956.
   PubMed Web of Science ®Google Scholar
• Mambelli LI, Santos EJ, Frazao PJ, et al. Characterization of equine adipose tissue-derived progenitor cells before and after cryopreservation. Tissue Eng Part C Methods. 2009;15(1):87–94. PubMed PMID: 19196122.
   PubMed Web of Science ®Google Scholar
• Reich CM, Raabe O, Wenisch S, et al. Isolation, culture and chondrogenic differentiation of canine adipose tissue- and bone marrow-derived mesenchymal stem cells–a comparative study. Vet Res Commun. 2012;36(2):139–148. PubMed PMID: 22392598.
   PubMed Web of Science ®Google Scholar
• Vieira NM, Brandalise V, Zucconi E, et al. Isolation, characterization, and differentiation potential of canine adipose-derived stem cells. Cell Transplant. 2010;19(3):279–289. PubMed PMID: 19995482.
   PubMed Web of Science ®Google Scholar
• Raabe O, Reich C, Wenisch S, et al. Hydrolyzed fish collagen induced chondrogenic differentiation of equine adipose tissue-derived stromal cells. Histochem Cell Biol. 2010;134(6):545–554. PubMed PMID: 21076963.
   PubMed Web of Science ®Google Scholar
• Salgado AJ, Reis RL, Sousa NJ, et al. Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine. Curr Stem Cell Res Ther. 2010;5(2): 103–110. PubMed PMID: 19941460.
   PubMed Web of Science ®Google Scholar
• Lee EY, Xia Y, Kim WS, et al. Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen. 2009;17(4):540–547. PubMed PMID: 19614919.
   PubMed Web of Science ®Google Scholar
• Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004;109(10):1292–1298. PubMed PMID: 14993122.
   PubMed Web of Science ®Google Scholar
• Muthukrishnan L, Warder E, McNeil PL. Basic fibroblast growth factor is efficiently released from a cytolsolic storage site through plasma membrane disruptions of endothelial cells. J Cell Physiol. 1991;148(1):1–16. PubMed PMID: 1860889.
   PubMed Web of Science ®Google Scholar
• Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83(3):835–870. PubMed PMID: 12843410.
   PubMed Web of Science ®Google Scholar
• Hauner H, Rohrig K, Petruschke T. Effects of epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) on human adipocyte development and function. Eur J Clin Invest. 1995;25(2): 90–96. PubMed PMID: 7737268.
   PubMed Web of Science ®Google Scholar
• Kakudo N, Shimotsuma A, Kusumoto K. Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells. Biochem Biophys Res Commun. 2007;359(2):239–244. PubMed PMID: 17543283.
   PubMed Web of Science ®Google Scholar
• Kang YJ, Jeon ES, Song HY, et al. Role of c-Jun N-terminal kinase in the PDGF-induced proliferation and migration of human adipose tissue-derived mesenchymal stem cells. J Cell Biochem. 2005;95(6):1135–1145. PubMed PMID: 15962287.
   PubMed Web of Science ®Google Scholar
• Quarto N, Longaker MT. FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential state. Tissue Eng. 2006;12(6):1405–1418. PubMed PMID: 16846339.
   PubMedGoogle Scholar
• Serrero G. EGF inhibits the differentiation of adipocyte precursors in primary cultures. Biochem Biophys Res Commun. 1987;146(1): 194–202. PubMed PMID: 3496882.
   PubMed Web of Science ®Google Scholar
• Kaewsuwan S, Song SY, Kim JH, et al. Mimicking the functional niche of adipose-derived stem cells for regenerative medicine. Expert Opin Biol Ther. 2012;12(12):1575–1588. PubMed PMID: 22953993.
   PubMed Web of Science ®Google Scholar
• Song SY, Chung HM, Sung JH. The pivotal role of VEGF in adipose-derived-stem-cell-mediated regeneration. Expert Opin Biol Ther. 2010;10(11):1529–1537. PubMed PMID: 20860536.
   PubMed Web of Science ®Google Scholar
• Seo MJ, Suh SY, Bae YC, et al. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun. 2005;328(1):258–264. PubMed PMID: 15670778.
   PubMed Web of Science ®Google Scholar
• Dubey NK, Mishra VK, Dubey R, et al. Revisiting the advances in isolation, characterization and secretome of adipose-derived stromal/stem cells. Int J Mol Sci. 2018;19(8). PubMed PMID: 30060511; PubMed Central PMCID: PMCPMC6121360. doi:10.3390/ijms19082200
   Web of Science ®Google Scholar
• Choi EW, Seo MK, Woo EY, et al. Exosomes from human adipose-derived stem cells promote proliferation and migration of skin fibroblasts. Exp Dermatol. 2018;27(10): 1170–1172. PubMed PMID: 28940813.
   PubMed Web of Science ®Google Scholar
• Li X, Xie X, Lian W, et al. Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med. 2018;50(4):29. PubMed PMID: 29651102; PubMed Central PMCID: PMCPMC5938041.
   PubMedGoogle Scholar
• Hu L, Wang J, Zhou X, et al. Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep. 2016;6:32993. PubMed PMID: 27615560; PubMed Central PMCID: PMCPMC5018733.
   PubMed Web of Science ®Google Scholar
• Wang L, Hu L, Zhou X, et al. Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling. Sci Rep. 2017;7(1):13321. PubMed PMID: 29042658; PubMed Central PMCID: PMCPMC5645460.
   PubMed Web of Science ®Google Scholar
• Assuncao-Silva RC, Mendes-Pinheiro B, Patricio P, et al. Exploiting the impact of the secretome of MSCs isolated from different tissue sources on neuronal differentiation and axonal growth. Biochimie. 2018. PubMed PMID: 30077816. doi:10.1016/j.biochi.2018.07.026
   Web of Science ®Google Scholar
• Lee M, Liu T, Im W, et al. Exosomes from adipose-derived stem cells ameliorate phenotype of Huntington’s disease in vitro model. Eur J Neurosci. 2016;44(4):2114–2119. PubMed PMID: 27177616.
   PubMed Web of Science ®Google Scholar
• Niada S, Giannasi C, Gualerzi A, et al. Differential proteomic analysis predicts appropriate applications for the secretome of adipose-derived mesenchymal stem/stromal cells and dermal fibroblasts. Stem Cells Int. 2018;2018:7309031. PubMed PMID: 30158987; PubMed Central PMCID: PMCPMC6109467.
   PubMed Web of Science ®Google Scholar
• Brayfield C, Marra K, Rubin JP. Adipose stem cells for soft tissue regeneration. Handchir Mikrochir Plast Chir. 2010;42(2):124–128. PubMed PMID: 20352575.
   PubMed Web of Science ®Google Scholar
• Gentile P, Orlandi A, Scioli MG, et al. Concise review: adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical implications for tissue engineering therapies in regenerative surgery. Stem Cells Transl Med. 2012;1(3):230–236. PubMed PMID: 23197782; PubMed Central PMCID: PMCPMC3659840.
   PubMed Web of Science ®Google Scholar
• Aksu AE, Rubin JP, Dudas JR, et al. Role of gender and anatomical region on induction of osteogenic differentiation of human adipose-derived stem cells. Ann Plast Surg. 2008;60(3):306–322. PubMed PMID: 18443514.
   PubMed Web of Science ®Google Scholar
• Stockl S, Gottl C, Grifka J, et al. Sox9 Modulates proliferation and expression of osteogenic markers of adipose-derived stem cells (ASC). Cell Physiol Biochem. 2013;31(4–5):703–717. PubMed PMID: 23711496.
   PubMed Web of Science ®Google Scholar
• Wei Y, Sun X, Wang W, et al. Adipose-derived stem cells and chondrogenesis. Cytotherapy. 2007;9(8):712–716. PubMed PMID: 17917888.
   PubMed Web of Science ®Google Scholar
• Musumeci G, Mobasheri A, Trovato FM, et al. Biosynthesis of collagen I, II, RUNX2 and lubricin at different time points of chondrogenic differentiation in a 3D in vitro model of human mesenchymal stem cells derived from adipose tissue. Acta Histochem. 2014;116(8):1407–1417. PubMed PMID: 25307495.
   PubMed Web of Science ®Google Scholar
• Beigi MH, Atefi A, Ghanaei HR, et al. Activated platelet-rich plasma improves cartilage regeneration using adipose stem cells encapsulated in a 3D alginate scaffold. J Tissue Eng Regen Med. 2018;12(6):1327–1338. PubMed PMID: 29522657.
   PubMed Web of Science ®Google Scholar
• Huang L, Yi L, Zhang C, et al. Synergistic effects of FGF-18 and TGF-beta3 on the chondrogenesis of human adipose-derived mesenchymal stem cells in the pellet culture. Stem Cells Int. 2018;2018:7139485. PubMed PMID: 29861742; PubMed Central PMCID: PMCPMC5971284.
   PubMedGoogle Scholar
• Radtke C, Schmitz B, Spies M, et al. Peripheral glial cell differentiation from neurospheres derived from adipose mesenchymal stem cells. Int J Dev Neurosci. 2009;27(8):817–823. PubMed PMID: 19699793.
   PubMed Web of Science ®Google Scholar
• Yu JM, Bunnell BA, Kang SK. Neural differentiation of human adipose tissue-derived stem cells. Methods Mol Biol. 2011;702:219–231. PubMed PMID: 21082405.
   PubMedGoogle Scholar
• Bonora-Centelles A, Jover R, Mirabet V, et al. Sequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved, and expression of new key marker genes. Cell Transplant. 2009;18(12):1319–1340. PubMed PMID: 19660180.
   PubMed Web of Science ®Google Scholar
• Okura H, Komoda H, Fumimoto Y, et al. Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters. J Artif Organs. 2009;12(2):123–130. PubMed PMID: 19536630.
   PubMed Web of Science ®Google Scholar
• Grzesiak J, Marycz K, Szarek D, et al. Polyurethane/polylactide-based biomaterials combined with rat olfactory bulb-derived glial cells and adipose-derived mesenchymal stromal cells for neural regenerative medicine applications. Mater Sci Eng C Mater Biol Appl. 2015;52:163–170. PubMed PMID: 25953554.
   PubMed Web of Science ®Google Scholar
• Choi JH, Gimble JM, Lee K, et al. Adipose tissue engineering for soft tissue regeneration. Tissue Eng Part B Rev. 2010;16(4):413–426. PubMed PMID: 20166810; PubMed Central PMCID: PMCPMC2946881.
   PubMed Web of Science ®Google Scholar
• Tsuji W, Inamoto T, Yamashiro H, et al. Adipogenesis induced by human adipose tissue-derived stem cells. Tissue Eng Part A. 2009;15(1):83–93. PubMed PMID: 18759663.
   PubMed Web of Science ®Google Scholar
• Ito R, Morimoto N, Liem PH, et al. Adipogenesis using human adipose tissue-derived stromal cells combined with a collagen/gelatin sponge sustaining release of basic fibroblast growth factor. J Tissue Eng Regen Med. 2014;8(12):1000–1008. PubMed PMID: 22997068.
   PubMed Web of Science ®Google Scholar
• Zanetti AS, Sabliov C, Gimble JM, et al. Human adipose-derived stem cells and three-dimensional scaffold constructs: a review of the biomaterials and models currently used for bone regeneration. J Biomed Mater Res B Appl Biomater. 2013;101(1):187–199. PubMed PMID: 22997152.
   PubMedGoogle Scholar
• Fan L, Fan J, Liu Y, et al. miR-450b Promotes osteogenic differentiation in vitro and enhances bone formation in vivo by targeting BMP3. Stem Cells Dev. 2018;27(9):600–611. PubMed PMID: 29649414.
   PubMed Web of Science ®Google Scholar
• Awad HA, Wickham MQ, Leddy HA, et al. Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials. 2004;25(16):3211–3222. PubMed PMID: 14980416.
   PubMed Web of Science ®Google Scholar
• Wei Y, Hu Y, Hao W, et al. A novel injectable scaffold for cartilage tissue engineering using adipose-derived adult stem cells. J Orthop Res. 2008;26(1):27–33. PubMed PMID: 17853485.
   PubMed Web of Science ®Google Scholar
• Marycz K, Grzesiak J, Wrzeszcz K, et al. Adipose stem cell combined with plasma-based implant bone tissue differentiation in vitro and in a horse with a phalanx digitalis distalis fracture: a case report. Vet Med. 2012;610–617.
   Web of Science ®Google Scholar
• Marycz K, Toker N, Grzesiak J, et al. The therapeutic effect of autogenic adipose derived stem cells combined with autogenic platelet rich plasma in tendons disorders in horses in vitro and in vivo research. J Anim Vet Adv. 2012;11(23):4324–4331.
   Google Scholar
• Feisst V, Meidinger S, Locke MB. From bench to bedside: use of human adipose-derived stem cells. Stem Cells Cloning. 2015;8:149–162. PubMed PMID: 26586955; PubMed Central PMCID: PMCPMC4636091.
   PubMed Web of Science ®Google Scholar
• Houtgraaf JH, Den Dekker WK, van Dalen BM, et al. First experience in humans using adipose tissue-derived regenerative cells in the treatment of patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012;59(5):539–540. PubMed PMID: 22281257.
   PubMed Web of Science ®Google Scholar
• Joswig AJ, Mitchell A, Cummings KJ, et al. Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model. Stem Cell Res Ther. 2017;8(1):42. PubMed PMID: 28241885; PubMed Central PMCID: PMCPMC5329965.
   PubMed Web of Science ®Google Scholar
• Toyserkani NM, Jorgensen MG, Tabatabaeifar S, et al. Concise review: a safety assessment of adipose-derived cell therapy in clinical trials: a systematic review of reported adverse events. Stem Cells Transl Med. 2017;6(9):1786–1794. PubMed PMID: 28722289; PubMed Central PMCID: PMCPMC5689766.
   PubMed Web of Science ®Google Scholar
• Alvaro-Gracia JM, Jover JA, Garcia-Vicuna R, et al. Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial. Ann Rheum Dis. 2017;76(1):196–202. PubMed PMID: 27269294.
   PubMed Web of Science ®Google Scholar
• Panes J, Garcia-Olmo D, Van Assche G, et al. Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: a phase 3 randomised, double-blind controlled trial. Lancet. 2016;388(10051):1281–1290. PubMed PMID: 27477896.
   PubMed Web of Science ®Google Scholar
• Chen HT, Lee MJ, Chen CH, et al. Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. J Cell Mol Med. 2012;16(3):582–593. PubMed PMID: 21545685; PubMed Central PMCID: PMCPMC3822933.
   PubMed Web of Science ®Google Scholar
• Lendeckel S, Jodicke A, Christophis P, et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg. 2004;32(6):370–373. PubMed PMID: 15555520.
   PubMed Web of Science ®Google Scholar
• Berdasco M, Melguizo C, Prados J, et al. DNA methylation plasticity of human adipose-derived stem cells in lineage commitment. Am J Pathol. 2012;181(6):2079–2093. PubMed PMID: 23031258.
   PubMed Web of Science ®Google Scholar
• Papakostidis C, Tosounidis TH, Jones E, et al. The role of “cell therapy” in osteonecrosis of the femoral head. A systematic review of the literature and meta-analysis of 7 studies. Acta Orthop. 2016;87(1):72–78. PubMed PMID: 26220203; PubMed Central PMCID: PMCPMC4940596.
   PubMed Web of Science ®Google Scholar
• Wyles CC, Houdek MT, Crespo-Diaz RJ, et al. Adipose-derived mesenchymal stem cells are phenotypically superior for regeneration in the setting of osteonecrosis of the femoral head. Clin Orthop Relat Res. 2015;473(10):3080–3090. PubMed PMID: 26070774; PubMed Central PMCID: PMCPMC4562944.
   PubMed Web of Science ®Google Scholar
• Mirsaidi A, Genelin K, Vetsch JR, et al. Therapeutic potential of adipose-derived stromal cells in age-related osteoporosis. Biomaterials. 2014;35(26):7326–7335. PubMed PMID: 24933514.
   PubMed Web of Science ®Google Scholar
• Cho SW, Sun HJ, Yang JY, et al. Human adipose tissue-derived stromal cell therapy prevents bone loss in ovariectomized nude mouse. Tissue Eng Part A . 2012;18(9–10):1067–1078. PubMed PMID: 22220675.
   PubMed Web of Science ®Google Scholar
• Cheng A, Hardingham TE, Kimber SJ. Generating cartilage repair from pluripotent stem cells. Tissue Eng Part B Rev. 2014;20(4):257–266. PubMed PMID: 23957872; PubMed Central PMCID: PMCPMC4123466.
   PubMed Web of Science ®Google Scholar
• Khan WS, Hardingham TE. Cartilage tissue engineering approaches applicable in orthopaedic surgery: the past, the present, and the future. J Stem Cells. 2012;7(2): 97–104. PubMed PMID: 23550348.
   PubMedGoogle Scholar
• Akpancar S, Tatar O, Turgut H, et al. The current perspectives of stem cell therapy in orthopedic surgery. Arch Trauma Res. 2016;5(4):e37976. PubMed PMID: 28144608; PubMed Central PMCID: PMCPMC5253188.
   PubMed Web of Science ®Google Scholar
• Pak J. Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. J Med Case Rep. 2011;5:296. PubMed PMID: 21736710; PubMed Central PMCID: PMCPMC3154169.
   PubMedGoogle Scholar
• Desando G, Cavallo C, Sartoni F, et al. Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model. Arthritis Res Ther. 2013;15(1):R22. PubMed PMID: 23360790; PubMed Central PMCID: PMCPMC3672720.
   PubMed Web of Science ®Google Scholar
• Pers Y-M, Rackwitz L, Ferreira R, et al. Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial. Stem Cells Transl Med. 2016;5(7):847–856. PubMed PMID: 27217345; PubMed Central PMCID: PMCPMC4922848.
   PubMed Web of Science ®Google Scholar
• Centeno CJ, Al-Sayegh H, Freeman MD, et al. A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions. Int Orthop. 2016;40(8):1755–1765. PubMed PMID: 27026621.
   PubMed Web of Science ®Google Scholar
• Freitag J, Ford J, Bates D, et al. Adipose derived mesenchymal stem cell therapy in the treatment of isolated knee chondral lesions: design of a randomised controlled pilot study comparing arthroscopic microfracture versus arthroscopic microfracture combined with postoperative mesenchymal stem cell injections. BMJ Open. 2015;5(12):e009332. PubMed PMID: 26685030; PubMed Central PMCID: PMCPMC4691736.
   PubMed Web of Science ®Google Scholar
• Spasovski D, Spasovski V, Bascarevic Z, et al. Intra-articular injection of autologous adipose-derived mesenchymal stem cells in the treatment of knee osteoarthritis. J Gene Med. 2018;20(1). PubMed PMID: 29243283. doi:10.1002/jgm.3002
   PubMed Web of Science ®Google Scholar
• Koh YG, Kwon OR, Kim YS, et al. Adipose-derived mesenchymal stem cells with microfracture versus microfracture alone: 2-year follow-up of a prospective randomized trial. Arthroscopy. 2016;32(1):97–109. PubMed PMID: 26585585.
   PubMed Web of Science ®Google Scholar
• Song Y, Du H, Dai C, et al. Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections. Regen Med. 2018;13(3):295–307. PubMed PMID: 29417902.
   PubMed Web of Science ®Google Scholar
• Hurley ET, Yasui Y, Gianakos AL, et al. Limited evidence for adipose-derived stem cell therapy on the treatment of osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2018. PubMed PMID: 29713784. doi:10.1007/s00167-018-4955-x
   Web of Science ®Google Scholar
• Verhoekx JS, Mudera V, Walbeehm ET, et al. Adipose-derived stem cells inhibit the contractile myofibroblast in Dupuytren’s disease. Plast Reconstr Surg. 2013;132(5):1139–1148. PubMed PMID: 23924646.
   PubMed Web of Science ®Google Scholar
• James R, Kumbar SG, Laurencin CT, et al. Tendon tissue engineering: adipose-derived stem cell and GDF-5 mediated regeneration using electrospun matrix systems. Biomed Mater. 2011;6(2):025011. PubMed PMID: 21436509; PubMed Central PMCID: PMCPMC3206634.
   PubMed Web of Science ®Google Scholar
• Canapp SO Jr., Canapp DA, Ibrahim V, et al. The use of adipose-derived progenitor cells and platelet-rich plasma combination for the treatment of supraspinatus tendinopathy in 55 dogs: a retrospective study. Front Vet Sci. 2016;3:61. PubMed PMID: 27668218; PubMed Central PMCID: PMCPMC5016533.
   PubMed Web of Science ®Google Scholar
• Lee SY, Kim W, Lim C, et al. Treatment of lateral epicondylosis by using allogeneic adipose-derived mesenchymal stem cells: a pilot study. Stem Cells. 2015;33(10):2995–3005. PubMed PMID: 26202898.
   PubMed Web of Science ®Google Scholar
• Rybalko V, Hsieh PL, Ricles LM, et al. Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair.Regen Med. 2017;12(2):153–167. PubMed PMID: 28244825; PubMed Central PMCID: PMCPMC5348723.
   PubMed Web of Science ®Google Scholar
• Carstens MH, Gómez A, Cortés R, et al. Non-reconstructable peripheral vascular disease of the lower extremity in ten patients treated with adipose-derived stromal vascular fraction cells. Stem Cell Res. 2017;18:14–21. PubMed PMID: 27984756.
   PubMed Web of Science ®Google Scholar
• Jo CH, Chai JW, Jeong EC, et al. Intratendinous injection of autologous adipose tissue derived mesenchymal stem cells for the treatment of rotator cuff disease: a first-in-human trial. Stem Cells. 2018. PubMed PMID: 29790618. doi:10.1002/stem.2855
   PubMed Web of Science ®Google Scholar
• Follin B, Tratwal J, Haack-Sorensen M, et al. Identical effects of VEGF and serum-deprivation on phenotype and function of adipose-derived stromal cells from healthy donors and patients with ischemic heart disease. J Transl Med. 2013;11:219. PubMed PMID: 24047149; PubMed Central PMCID: PMCPMC3852830.
   PubMed Web of Science ®Google Scholar
• Henry TD, Pepine CJ, Lambert CR, et al. The Athena trials: autologous adipose-derived regenerative cells for refractory chronic myocardial ischemia with left ventricular dysfunction. Catheter Cardiovasc Interv. 2017;89(2):169–177. PubMed PMID: 27148802.
   PubMed Web of Science ®Google Scholar
• Joo HJ, Kim JH, Hong SJ. Adipose tissue-derived stem cells for myocardial regeneration. Korean Circ J. 2017;47(2):151–159. PubMed PMID: 28382066; PubMed Central PMCID: PMCPMC5378017.
   PubMed Web of Science ®Google Scholar
• Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum. 2009;52(1):79–86. PubMed PMID: 19273960.
   PubMed Web of Science ®Google Scholar
• Garcia-Olmo D, Garcia-Arranz M, Herreros D. Expanded adipose-derived stem cells for the treatment of complex perianal fistula including Crohn’s disease. Expert Opin Biol Ther. 2008;8(9):1417–1423. PubMed PMID: 18694359.
   PubMed Web of Science ®Google Scholar
• Stillaert FB, Di Bartolo C, Hunt JA, et al. Human clinical experience with adipose precursor cells seeded on hyaluronic acid-based spongy scaffolds. Biomaterials. 2008;29(29):3953–3959. PubMed PMID: 18635258.
   PubMed Web of Science ®Google Scholar
• Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Dermatol Surg. 2008;34(9):1178–1185. PubMed PMID: 18513295.
   PubMed Web of Science ®Google Scholar
• Yoshimura K, Asano Y, Aoi N, et al. Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications. Breast J. 2010;16(2):169–175. PubMed PMID: 19912236.
   PubMed Web of Science ®Google Scholar
• Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409–22; discussion 23–4. PubMed PMID: 17415234.
   PubMedGoogle Scholar
• Zack-Williams SD, Butler PE, Kalaskar DM. Current progress in use of adipose derived stem cells in peripheral nerve regeneration. World J Stem Cells. 2015;7(1):51–64. PubMed PMID: 25621105; PubMed Central PMCID: PMCPMC4300936.
   PubMed Web of Science ®Google Scholar
• Zavan B, Vindigni V, Gardin C, et al. Neural potential of adipose stem cells. Discov Med. 2010;10(50):37–43. PubMed PMID: 20670597.
   PubMed Web of Science ®Google Scholar
• Erba P, Terenghi G, Kingham PJ. Neural differentiation and therapeutic potential of adipose tissue derived stem cells. Curr Stem Cell Res Ther. 2010;5(2): 153–160. PubMed PMID: 19941451.
   PubMed Web of Science ®Google Scholar
• Franco Lambert AP, Fraga Zandonai A, Bonatto D, et al. Differentiation of human adipose-derived adult stem cells into neuronal tissue: does it work? Differentiation. 2009;77(3):221–228. PubMed PMID: 19272520.
   PubMed Web of Science ®Google Scholar
• Lam PK, Lo AW, Wang KK, et al. Transplantation of mesenchymal stem cells to the brain by topical application in an experimental traumatic brain injury model. J Clin Neurosci. 2013;20(2):306–309. PubMed PMID: 23219830.
   PubMed Web of Science ®Google Scholar
• Gao S, Zhao P, Lin C, et al. Differentiation of human adipose-derived stem cells into neuron-like cells which are compatible with photocurable three-dimensional scaffolds. Tissue Eng Part A. 2014;20(7–8):1271–1284. PubMed PMID: 24251600; PubMed Central PMCID: PMCPMC3993073.
   PubMed Web of Science ®Google Scholar
• Zimmerlin L, Park TS, Zambidis ET, et al. Mesenchymal stem cell secretome and regenerative therapy after cancer. Biochimie. 2013;95(12):2235–2245. PubMed PMID: 23747841; PubMed Central PMCID: PMCPMC3825748.
   PubMed Web of Science ®Google Scholar
• Petit JY, Rietjens M, Botteri E, et al. Evaluation of fat grafting safety in patients with intraepithelial neoplasia: a matched-cohort study. Ann Oncol. 2013;24(6):1479–1484. PubMed PMID: 23393126.
   PubMed Web of Science ®Google Scholar