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Review

Advances in stem cell therapy for male stress urinary incontinence

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Pages 293-300 | Received 30 Jan 2018, Accepted 31 Jan 2019, Published online: 15 Feb 2019

References

  • Bauer RM, Bastian PJ, Gozzi C, et al. Postoprostatectomy incontinence: all about diagnosis and management. Eur Urol. 2009;55:322–333.
  • McGuire EJ, Lytton B, Pepe V, et al. Stress urinary incontinence. Obstet Gynecol. 1976;47(3):255–264.
  • Kayigil O, Iftekhar Ahmed S, Metin A. The coexistence of intrinsic sphincter deficiency with type II stress incontinence. J Urol. 1999;162(4):1365–1366.
  • Magon N, Kalra B, Malik S. et al. Stress urinary incontinence: what, when, why, and then what? J Mid‐life Health. 2011;2(2):57–64.
  • Kretschmer A, Hübner W, Sandhu JS, et al. Evaluation and management of postprostatectomy incontinence: a systematic review of current literature. Eur Urol Focus. 2016 Aug;2(3):245–259.
  • Chong JT, Simma-Chiang V. A historical perspective and evolution of the treatment of male urinary incontinence. Neurourol Urodyn. 2018 Mar;37(3):1169–1175.
  • McGuire EJ. Urethral bulking agents. Nat Clin Pract Urol. 2006;3:234–235.
  • Lightner DJ, Itano NB, Sweat SD, et al. Injectable agents: present and future. Curr Urol Rep. 2002;3:408–413.
  • Gallo F, Giberti C, Schenone M. Slings in iatrogenic male incontinence: current status. Indian J Urol. 2010;26:279–283.
  • Radadia KD, Farber NJ, Shinder B, et al. Management of postradical prostatectomy urinary incontinence: a review. Urology. 2018 Mar;113:13–19.
  • Chung E. Contemporary surgical devices for male stress urinary incontinence: a review of technological advances in current continence surgery. Transl Androl Urol. 2017 Jul;6(Suppl 2):S112–S121.
  • Chen YC, Lin PH, Jou YY, et al. Surgical treatment for urinary incontinence after prostatectomy: a meta-analysis and systematic review. PLoS One. 2017 May 3;12(5):e0130867.
  • Chung E. Stem-cell-based therapy in the field of urology: a review of stem cell basic science, clinical applications and future directions in the treatment of various sexual and urinary conditions. Expert Opin Biol Ther. 2015;15(11):1623–1632.
  • Amend B, Vaegler M, Fuchs K, et al. Regeneration of degenerated urinary sphincter muscles: improved stem cell-based therapies and novel imaging technologies. Cell Transplant. 2015;24(11):2171–2183.
  • Tran C, Damaser MS. The potential role of stem cells in the treatment of urinary incontinence. Ther Adv Urol. 2015 Feb;7(1):22–40.
  • Giberti C, Gallo F, Schenone M, et al. Stem cell therapy for male urinary incontinence. Urol Int. 2013;90(3):249–252.
  • Martin G. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA. 1981;78:7634–7638.
  • Thomson J, Itskovitz-Eldor J, Shapiro S, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147.
  • Godfrey K, Mathew B, Bulman J, et al. Stem cellbased treatments for type 1 diabetes mellitus: bone marrow, embryonic, hepatic, pancreatic and induced pluripotent stem cells. Diabet Med. 2012;29:14–23.
  • Singla D, Abdelli L. Embryonic stem cells and released factors stimulate c-Kit/Flk-1 progenitor cells and promote neovascularization in doxorubicininduced cardiomyopathy. Cell Transplant. 2015;24(6):1043–1052.
  • Perin L, Sedrakyan S, Giuliani S, et al. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010 Feb 24;5(2):e9357.
  • Moorefield E, Mckee E, Solchaga L, et al. Cloned, CD117 selected human amniotic fluid stem cells are capable of modulating the immune response. PLoS One. 2011;6(10):e26535.
  • Weber B, Emmert M, Behr L, et al. Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation. Biomaterials. 2012;33:4031–4043.
  • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–676.
  • Morris S, Daley G. A blueprint for engineering cell fate: current technologies to reprogram cell identity. Cell Res. 2013;23:33–48.
  • Wang H, Chuang Y, Chancellor M. Development of cellular therapy for the treatment of stress urinary incontinence. Int Urogynecol J. 2011;22:1075–1083.
  • Goldman H, Sievert K, Damaser M. Will we ever use stem cells for the treatment of SUI?—ICI-RS 2011. Neurourol Urodyn. 2012;31:386–389.
  • Kim J, Lee S, Song Y Kim J, Lee S, Song Y, et al. Stem cell therapy in bladder dysfunction: where are we? And where do we have to go? Biomed Res Int. 2013;930713.
  • Friedenstein A, Deriglasova U, Kulagina N, et al. Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol. 1974;2:83–92.
  • Ding D, Shyu W, Lin S. Mesenchymal stem cells. Cell Transplant. 2011;20:5–14.
  • Krause D, Theise N, Collector M, et al. Multi-organ, multi-lineage engraftment by a single bone marrowderived stem cell. Cell. 2011;105:369–377.
  • Patel A, Park E. Kuzman M, et al. Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation. Cell Transplant. 2008;17:303–311.
  • Zhang Y, Atala A. Urothelial cell culture, wound regeneration and repair. Methods Mol Biol. 2013;1037:27–43.
  • Zhang Y, Mcneill E, Tian H, et al. Urine derived cells are a potential source for urological tissue reconstruction. J Urol. 2008;180:2226–2233.
  • Bharadwaj S, Liu G, Shi Y, et al. Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering. Tissue Eng Part A. 2011;17:2123–2132.
  • Liu G, Pareta R, Wu R, et al. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials. 2012;34:1311–1326.
  • Lang R, Liu G, Shi Y, et al. Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS One. 2013;8:e53980.
  • Bharadwaj S, Liu G, Shi Y, et al. Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. Stem Cells. 2013;31:1840–1856.
  • Turksen K. Stem cells: current challenges and new directions. New York: Springer; 2013.
  • Vaegler M, Lenis A, Daum L, et al. Stem cell therapy for voiding and erectile dysfunction. Nat Rev Urol. 2012;9:435–447.
  • Yang F, Green J, Dinio T, et al. Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors. Gene Ther. 2009;16:533–546.
  • Deans R, Moseley A. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000;28:875–884.
  • Sohni A, Verfaillie C. Mesenchymal stem cells migration homing and tracking. Stem Cells Int. 2013;130763.
  • Wynn R, Hart C, Corradi-Perini C, et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood. 2004;104:2643–2645.
  • Docheva D, Popov C, Mutschler W, et al. Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system. J Cel Mol Med. 2007;11:21–38.
  • Wood H, Kuang M, Woo L, et al. Cytokine expression after vaginal distention of different durations in virgin sprague-dawley rats. J Urol. 2008;180:753–759.
  • Lenis A, Kuang M, Woo L, et al. Impact of parturition on chemokine homing factor expression in the vaginal distension model of stress urinary incontinence. J Urol. 2012;189:1588–1594.
  • Fischer U, Harting M, Jimenez F, et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev. 2009;18:683–692.
  • Ghionzoli M, Cananzi M, Zani A, et al. Amniotic fluid stem cell migration after intraperitoneal injection in pup rats: implication for therapy. Pediatr Surg Int. 2010;26:79–84.
  • Chermansky C, Tarin T, Kwon D, et al. Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency. Urology. 2004b;63:780–785.
  • Cruz M, Dissaranan C, Cotleur A, et al. Pelvic organ distribution of mesenchymal stem cells injected intravenously after simulated childbirth injury in female rats. Obstet Gynecol Int. 2012;612946.
  • Fu Q, Song X, Liao G, et al. Myoblasts differentiated from adipose-derived stem cells to treat stress urinary incontinence. Urology. 2010;75:718–723.
  • Lin G, Wang G, Banie L, et al. Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Cytotherapy. 2010;12:88–95.
  • Dissaranan C, Cruz M, Kiedrowski M, et al. Rat mesenchymal stem cell secretome promotes elastogenesis and facilitates recovery from simulated childbirth injury. Cell Transplant. 2014;23(11):1395–1406.
  • Eberli D, Aboushwareb T, Soker S, et al. Muscle precursor cells for the restoration of irreversibly damaged sphincter function. Cell Transplant. 2012;21(9):2089–2098.
  • Burdzińska A, Crayton R, Dybowski B, et al. The effect of endoscopic administration of autologous porcine muscle-derived cells into the urethral sphincter. Urology. 2013;82(3):743–748.
  • Chancellor MB, Yokoyama T, Tirney S, et al. Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor contractility. Neurourol Urodyn. 2000;19:279–287.
  • Cannon TW, Lee JY, Somogyi G, et al. Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra. Urology. 2003;62:958–963.
  • Kwon D, Minnery B, Kim Y, et al. Neurologic recovery and improved detrusor contractility using muscle-derived cells in rat model of unilateral pelvic nerve transection. Urology. 2005;65:1249–1253.
  • Jack G, Almeida F, Zhang R, et al. Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol. 2005;174:2041–2045.
  • Kanematsu A, Yamamoto S, Iwai-Kanai E, et al. Induction of smooth muscle cell-like phenotype in marrow-derived cells among regenerating urinary bladder smooth muscle cells. Am J Pathol. 2005;166:565–573.
  • Mitterberger M, Pinggera GM, Marksteiner R, et al. Functional and histological changes after myoblast injections in the porcine rhabdosphincter. Eur Urol. 2007;52:1736–1743. (Published erratum appears in Eur Urol 2008; 54:1208.).
  • Hoshi A, Tamaki T, Tono K, et al. Reconstruction of radical prostatectomy-induced urethral damage using skeletal musclederived multipotent stem cells. Transplantation. 2008;85:1617–1624.
  • Drost AC, Weng S, Feil G, et al. In vitro myogenic differentiation of human bone marrow-derived mesenchymal stem cells as apotential treatment for urethral sphincter muscle repair. Ann N Y Acad Sci. 2009;1176:135–143.
  • Kinebuchi Y, Aizawa N, Imamura T, et al. Autologous bone marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter. Int J Urol. 2010;17:359–368.
  • Zhang Y, Luo H, Zhang Z, et al. A nerve graft constructed with xenogeneic acellular nerve matrix and autologous adipose-derived mesenchymal stem cells. Biomaterials. 2010;31:5312–5324.
  • Turco MP, de Souza AB, de Campos Sousa I, et al. Periurethral muscle-derived mononuclear cell injection improves urethral sphincter restoration in rats. Neurourol Urodyn. 2017 Nov;36(8):2011–2018.
  • Ni J, Li H, Zhou Y, et al. Therapeutic potential of human adipose-derived stem cell exosomes in stress urinary incontinence. An in vitro and in vivo study. Cell Physiol Biochem. 2018;48:1710–1722.
  • Lin A, Carrier S, Morgan D, et al. Effect of simulated birth trauma on the urinary continence mechanism in the rat. Urology. 1998;52:143–151.
  • Mitterberger M, Marksteiner R, Margreiter E, et al. Autologous myoblasts and fibroblasts for female stress incontinence: a 1‐year follow‐up in 123 patients. BJU Int. 2007;100(5):1081–1085.
  • Mitterberger M, Marksteiner R, Margreiter E, et al. Myoblast and fibroblast therapy for post-prostatectomy urinary incontinence: 1-year followup of 63 patients. J Urol. 2008;179:226–231.
  • Yamamoto T, Gotoh M, Kato M, et al. Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence: report of three initial cases. Int J Urol. 2012;19(7):652–659.
  • Gerullis H, Eimer C, Georgas E, et al. Muscle-derived cells for treatment of iatrogenic sphincter damage and urinary incontinence in men. Scientific World J. 2012;1–6.
  • Carr L, Steele D, Steele S, et al. 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int Urogynecol J. 2008;19:881–883.
  • Carr L, Robert M, Kultgen P, et al. Autologous muscle derived cell therapy for stress urinary incontinence: a prospective, dose ranging study. J Urol. 2013;189:595–601.
  • Kuismanen K, Sartoneva R, Haimi S, et al. Autologous adipose stem cells in treatment of female stress urinary incontinence: results of a pilot study. Stem Cells Transl Med. 2014 Aug;3(8):936–941.
  • Gotoh M, Yamamoto T, Kato M, et al. Regenerative treatment of male stress urinary incontinence by periurethral injection of autologous adipose-derived regenerative cells: 1-year outcomes in 11 patients. Int J Urol. 2014;21:294–300.
  • Choi JY, Kim TH, Yang JD, et al. Adipose-derived regenerative cell injection therapy for postprostatectomy incontinence: a phase i clinical study. Yonsei Med J. 2016 Sep;57(5):1152–1158.
  • Fischbach GD, Fischbach RL. Stem cells: science, policy, and ethics. J Clin Invest. 2004;111(10):1364–1370.
  • Bongso A, Fong CY, Gauthaman K. Taking stem cells to the clinic: major challenges. J Cell Biochem. 2008;105:1352–1360.
  • Choumerianou DM, Dimitriou H, Kalmanti M. Stem Cells: promises versus limitations. Tissue Eng Part B Rev. 2008;14:53–60.
  • Preti RA. Bringing safe and effective cell therapies to the bedside. Nat Biotechnol. 2005;23:801–804.
  • Lo B, Kriestein A, Grady D. Clinical trials in stem cell transplantation: guidelines for scientific and ethical review. Clin Trials. 2008;5:517–522.
  • Aragón IM, Imbroda BH, Lara MF. Cell therapy clinical trials for stress urinary incontinence: current status and perspectives. Int J Med Sci. 2018 Jan 1;15(3):195–204.
  • Halme DG, Kessler DA. FDA regulation on stem cell based therapies. N Eng J Med. 2006;355(16):1730–1735.
  • von Tigerstrom BJ. The challenges of regulating stem cell-based products. Cell. 2008;26(12):653–658.
  • Pittenger M, Mackay A, Beck S, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–147.
  • Ranganath S, Levy O, Inamdar M, et al. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell. 2012;10:244–258.
  • Fan M, Chen W, Liu W, et al. The effect of age on the efficacy of human mesenchymal stem cell transplantation after a myocardial infarction. Rejuvenation Res. 2010;13:429–438.
  • Hare J, Fishman J, Gerstenblith G, et al. Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA. 2012;308:2369–2379.

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