Recent advances in gelatin-based therapeutics

References

• Tibbitt MW, Langer R. Living Biomaterials. Acc.Chem.Res. 2017;50(3):508–513.
   PubMed Web of Science ®Google Scholar
• Darnell M, Mooney DJ. Leveraging advances in biology to design biomaterials. Nat.Mater. 2017;16(12):1178–1185.
   PubMed Web of Science ®Google Scholar
• Santos E, Hernandez RM, Pedraz JL, et al. Novel advances in the design of three-dimensional bio-Scaffolds to control cell fate: translation from 2D to 3D. Trends Biotechnol. 2012;30(6):331–341.
   PubMed Web of Science ®Google Scholar
• Li L, Eyckmans J, Chen CS. Designer biomaterials for mechanobiology. Nat.Mater. 2017;16(12):1164–1168.
   PubMed Web of Science ®Google Scholar
• Kolesky DB, Homan KA, Skylar-Scott MA, et al. Three-dimensional bioprinting of thick vascularized tissues. Proc.Natl.Acad.Sci.U.S.A. 2016;113(12):3179–3184.
   PubMed Web of Science ®Google Scholar
• Young S, Wong M, Tabata Y, et al. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J.Control.Release. 2005;109(1–3):256–274.
   PubMed Web of Science ®Google Scholar
• Zhang M, Ding C, Yang J, et al. Study of interaction between water-soluble collagen and carboxymethyl cellulose in neutral aqueous solution. Carbohydr.Polym. 2016;137:410–417.
   PubMed Web of Science ®Google Scholar
• Larsen M, Artym VV, Green JA, et al. the matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr.Opin.Cell Biol. 2006;18( 5):463–471.
   Google Scholar
• Diba M, Pape B, Klymov A, et al. Nanostructured raspberry-like gelatin microspheres for local delivery of multiple biomolecules. Acta Biomater. 2017;58:67–79.
   PubMed Web of Science ®Google Scholar
• Karim AA, Fish Gelatin: BR, Properties C. Prospects as an alternative to mammalian gelatins. Food Hydrocoll. 2009;23(3):563–576.
   Web of Science ®Google Scholar
• Li F, Truong VX, Thissen H, et al. Microfluidic encapsulation of human mesenchymal stem cells for articular cartilage tissue regeneration. ACS Appl.Mater.Interfaces. 2017;9( 10):8589–8601.
   Google Scholar
• Nichol JW, Koshy ST, Bae H, et al. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials. 2010;31(21):5536–5544.
   PubMed Web of Science ®Google Scholar
• Lim TC, Rokkappanavar S, Toh WS, et al. Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained sdf-1alpha release and compatible structural support. FASEB J. 2013;27(3):1023–1033.
   PubMed Web of Science ®Google Scholar
• Zhou M, Lee BH, Tan YJ, et al. Microbial transglutaminase induced controlled crosslinking of gelatin methacryloyl to tailor rheological properties for 3D Printing. Biofabrication. 2019.
   Web of Science ®Google Scholar
• Wang LS, Du C, Toh WS, et al. Modulation of chondrocyte functions and stiffness-dependent cartilage repair using an injectable enzymatically crosslinked hydrogel with tunable mechanical properties. Biomaterials. 2014;35(7):2207–2217.
   PubMed Web of Science ®Google Scholar
• Lim TC, Toh WS, Wang LS, et al. The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cells. Biomaterials. 2012;33(12):3446–3455.
   PubMed Web of Science ®Google Scholar
• Rizwan M, Peh GS, Ang HP, et al. Sequentially-crosslinked bioactive hydrogels as nano-patterned substrates with customizable stiffness and degradation for corneal tissue engineering applications. Biomaterials. 2017;120:139–154.
   PubMed Web of Science ®Google Scholar
• Uz M, Buyukoz M, Sharma AD, et al. Gelatin-based 3D conduits for transdifferentiation of mesenchymal stem cells into schwann cell-like phenotypes. Acta Biomater. 2017;53:293–306.
   PubMed Web of Science ®Google Scholar
• Boere KW, Visser J, Seyednejad H, et al. Covalent attachment of a three-dimensionally printed thermoplast to a gelatin hydrogel for mechanically enhanced cartilage constructs. Acta Biomater. 2014;10(6):2602–2611.
   PubMed Web of Science ®Google Scholar
• Koshy ST, Desai RM, Joly P, et al. Click-crosslinked injectable gelatin hydrogels. Adv.Healthc.Mater. 2016;5(5):541–547.
   PubMed Web of Science ®Google Scholar
• Jia W, Gungor-Ozkerim PS, Zhang YS, et al. Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. Biomaterials. 2016;106:58–68.
   PubMed Web of Science ®Google Scholar
• Zhao X, Sun X, Yildirimer L, et al. Cell infiltrative hydrogel fibrous scaffolds for accelerated wound healing. Acta Biomater. 2017;49:66–77.
   PubMed Web of Science ®Google Scholar
• Wang L, Yang J, Ran B, et al. Small molecular TGF-Beta1-inhibitor-loaded electrospun fibrous scaffolds for preventing hypertrophic scars. ACS Appl.Mater.Interfaces. 2017;9( 38):32545–32553.
   Google Scholar
• Lv F, Wang J, Xu P, et al. A conducive bioceramic/polymer composite biomaterial for diabetic wound healing. Acta Biomater. 2017;60:128–143.
   PubMed Web of Science ®Google Scholar
• Dhand C, Venkatesh M, Barathi VA, et al. Bio-inspired crosslinking and matrix-drug interactions for advanced wound dressings with long-term antimicrobial activity. Biomaterials. 2017;138:153–168.
   PubMed Web of Science ®Google Scholar
• Lee Y, Choi KH, Park KM, et al. In situ forming and H2O2-releasing hydrogels for treatment of drug-resistant bacterial infections. ACS Appl.Mater.Interfaces. 2017;9( 20):16890–16899.
   Google Scholar
• Oh E, Oh JE, Hong J, et al. Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy. J.Control.Release. 2017;259:115–127.
   PubMed Web of Science ®Google Scholar
• Kim ID, Sawicki E, Lee HK, et al. Robust neuroprotective effects of intranasally delivered iNOS siRNA encapsulated in gelatin nanoparticles in the postischemic brain. Nanomedicine. 2016;12(5):1219–1229.
   PubMed Web of Science ®Google Scholar
• Sabet S, George MA, El-Shorbagy HM, et al. Gelatin nanoparticles enhance delivery of hepatitis C virus recombinant NS2 gene. PLoS One. 2017;12(7):e0181723.
   PubMed Web of Science ®Google Scholar
• Eke G, Mangir N, Hasirci N, et al. Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering. Biomaterials. 2017;129:188–198.
   PubMed Web of Science ®Google Scholar
• Oryan A, Alidadi S, Bigham-Sadegh A, et al. Effectiveness of tissue engineered chitosan-gelatin composite scaffold loaded with human platelet gel in regeneration of critical sized radial bone defect in rat. J.Control.Release. 2017;254:65–74.
   PubMed Web of Science ®Google Scholar
• Kang H, Shih YV, Hwang Y, et al. Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. Acta Biomater. 2014;10(12):4961–4970.
   PubMed Web of Science ®Google Scholar
• Feng Q, Wei K, Lin S, et al. Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration. Biomaterials. 2016;101:217–228.
   PubMed Web of Science ®Google Scholar
• Heo DN, Castro NJ, Lee SJ, et al. Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel. Nanoscale. 2017;9(16):5055–5062.
   PubMed Web of Science ®Google Scholar
• He X, Feng B, Huang C, et al. Electrospun gelatin/polycaprolactone nanofibrous membranes combined with a coculture of bone marrow stromal cells and chondrocytes for cartilage engineering. Int.J.Nanomedicine. 2015;10:2089–2099.
   PubMed Web of Science ®Google Scholar
• Levato R, Webb WR, Otto IA, et al. The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells. Acta Biomater. 2017;61:41–53.
   PubMed Web of Science ®Google Scholar
• Brancato V, Comunanza V, Imparato G, et al. Bioengineered tumoral microtissues recapitulate desmoplastic reaction of pancreatic cancer. Acta Biomater. 2017;49:152–166.
   PubMed Web of Science ®Google Scholar
• Lee S, Serpooshan V, Tong X, et al. Contractile force generation by 3d hipsc-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness. Biomaterials. 2017;131:111–120.
   PubMed Web of Science ®Google Scholar
• Agrawal G, Aung A, Skeletal Muscle-on-a-Chip: VS. An in vitro model to evaluate tissue formation and injury. Lab.Chip. 2017;17(20):3447–3461.
   PubMed Web of Science ®Google Scholar