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Review

Management of residual masses in testicular germ cell tumors

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Pages 291-300 | Received 18 Jul 2018, Accepted 05 Feb 2019, Published online: 22 Feb 2019

References

  • Albers P, Albrecht W, Algaba F, et al. European association of urology. Guidelines on testicular cancer: 2015 update. Eur Urol. 2015;68:1054–1068.
  • Honecker F, Aparicio J, Berney D, et al. ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up. Ann Oncol. 2018;29:1658–1686.
  • Daneshmand S, Albers P, Fosså SD, et al. Contemporary management of postchemotherapy testis cancer. Eur Urol. 2012;62:867–876.
  • Woldu SL, Matulay JT, Clinton TN, et al. Impact of hospital case volume on testicular cancer outcomes and practice patterns. Urol Oncol. 2018;36:14.e7-e15.
  • Flechon A, Bompas E, Biron P, et al. Management of post-chemotherapy residual masses in advanced seminoma. J Urol. 1979;168:1975–1979.
  • Friedman EL, Garnick MB, Stomper PC, et al. Therapeutic guidelines and results in advanced seminoma. J Clin Oncol. 1985;3:1325–1332.
  • Schultz SM, Einhorn LH, Conces DJ, et al. Management of postchemotherapy residual mass in patients with advanced seminoma: Indiana University experience. J Clin Oncol. 1989;7:1497–1503.
  • Fosså SD, Borge L, Aass N, et al. The treatment of advanced metastatic seminoma: experience in 55 cases. J Clin Oncol. 1987 Jul;5(7):1071–1077.
  • Ravi R, Rao RR, Shanta V. Integrated approach to the management of patients with advanced germ cell tumors of the testis. J Surg Oncol. 1994 Jan;55(1):47–51.
  • Puc HS, Heelan R, Mazumdar M, et al. Management of residual mass in advanced seminoma: results and recommendations from the Memorial Sloan Kettering Cancer Center. J Clin Oncol. 1996;14:454–460.
  • Mosharafa AA, Foster RS, Leibovich CC, et al. Is post-chemotherapy resection of seminomatous elements associated with higher acute morbidity? J Urol. 2003;169:2126–2128.
  • Pfister D, Porres D, Matveev V, et al. Reduced morbidity in resection of residual tumors after chemotherapy for seminoma. Urologe A. 2015;54:1402–1406.
  • De Santis M, Becherer A, Bokemeyer C, et al. 2-18fluoro-deoxy-D-glucose positron emission tomography is a reliable predictor for viable tumor in postchemotherapy seminoma: an update from the multicenter SEMPET trial. J Clin Oncol. 2004;22:1034–1039.
  • Becherer A, De Santis M, Karanikas G, et al. FDG PET is superior to CT in the prediction of viable tumour in post-chemotherapy seminoma residuals. Eur J Radiol. 2005;54:284–288.
  • Albers P, Weissbach L, Krege S, et al. Prediction of necrosis after chemotherapy of advanced germ cell tumors: results of a prospective multicenter trial of the German Testicular Cancer Study Group. J Urol. 2004;171:1835–1838.
  • Kamat MR, Kulkarni JN, Tongoankar HB, et al. Value of retroperitoneal lymph node dissection in advanced testicular seminoma. J Surg Oncol. 1992;51:65–67.
  • Hofmockel G, Gruss A, Theiss M. Chemotherapy in advanced seminoma and the role of postcytostatic retroperitoneal lymph node dissection. Urol Int. 1996;57:38–42.
  • Herr HW, Sheinfeld J, Puc HS, et al. Surgery for a post-chemotherapy residual mass in seminoma. J Urol. 1997;157:860–862.
  • Ehrlich Y, Brames MJ, Beck SD, et al. Long-term follow-up of Cisplatin combination chemotherapy in patients with disseminated nonseminomatous germ cell tumors: is a postchemotherapy retroperitoneal lymph node dissection needed after complete remission? J Clin Oncol. 2010;28:531–536.
  • Pfister D, Haidl F, Paffenholz P, et al. Metastatic surgery in testis cancer. Curr Opin Urol. 2016 Nov;26(6):590–595.
  • Kollmannsberger C, Daneshmand S, So A, et al. Management of disseminated nonseminomatous germ cell tumors with risk-based chemotherapy followed by response-guided postchemotherapy surgery. J Clin Oncol. 2010;28(4):537–542.
  • Albers P, Höltl W, Heidenreich A, et al. Thoracoabdominal resection of retrocrural residual tumors. Akt Urol. 2004;35:141–150.
  • Fujioka T, Nomura K, Okamoto T, et al. Retroperitoneal lymph node dissection for testicular tumors using the thoracoabdominal approach. Int Surg. 1993;78:154–158.
  • Skinner DG, Melamud A, Lieskovsky G. Complications of thoracoabdominal retroperitoneal lymph node dissection. J Urol. 1982;127:1107–1110.
  • Wood DP, Herr HW, Heller G, et al. Distribution of retroperitoneal metastases after chemotherapy in patients with nonseminomatous germ cell tumors. J Urol. 1992;148:1812–1816.
  • Heidenreich A, Haidl F, Paffenholz P, et al. Surgical management of complex residual masses following systemic chemotherapy for metastatic testicular germ cell tumours. Ann Oncol. 2017;28:362–367.
  • Beck SD, Foster RS, Bihrle R, et al. Aortic replacement during post-chemotherapy retroperitoneal lymph node dissection. J Urol. 2001;165:1517–1520.
  • Winter C, Pfister D, Busch J, et al. Residual tumor size and IGCCCG risk classification predict additional vascular procedures in patients with germ cell tumors and residual tumor resection: a multicenter analysis of the German Testicular Cancer Study Group. Eur Urol. 2012;6:403–409.
  • Johnston P, Beck SD, Cheng L, et al. Incidence, histology and management of intraluminal thrombus at post-chemotherapy retroperitoneal lymph node dissection. J Urol. 2013;190:874–878.
  • Sonneveld DJ, Sleijfer DT, Koops HS, et al. Mature teratoma identified after postchemotherapy surgery in patients with disseminated nonseminomatous testicular germ cell tumors: a plea for an aggressive surgical approach. Cancer. 1998;82:1343–1351.
  • Hendry WF, Norman AR, Dearnaley DP, et al. Metastatic nonseminomatous germ cell tumors of the testis: results of elective and salvage surgery for patients with residual retroperitoneal masses. Cancer. 2002;94:1668–1676.
  • Qvist HL, Fossa SD, Ous S, et al. Post-chemotherapy tumor residuals in patients with advanced nonseminomatous testicular cancer. Is it necessary to resect all residual masses? J Urol. 1991;145:300–302.
  • Rabbani F, Goldenberg SL, Gleave ME, et al. Retroperitoneal lymphadenectomy for post-chemotherapy residual masses: is a modified dissection and resection of the residual mass sufficient? Br J Urol. 1998;81:295–300.
  • Aprikian AG, Herr HW, Bajorin DF, et al. Resection of postchemotherapy residual masses and limited retroperitoneal lymphadenectomy in patients with metastatic testicular nonseminomatous germ cell tumors. Cancer. 1994;74:1329–1334.
  • Herr HW. Does necrosis on frozen-section analysis of a mass after chemotherapy justify a limited retroperitoneal resection in patients with advanced testis cancer? Br J Urol. 1997;80:653–657.
  • Beck SD, Foster RS, Bihrle R, et al. Is full bilateral retroperitoneal lymph node dissection always necessary for postchemotherapy residual tumor? Cancer. 2007;110:1235–1240.
  • Cho JS, Kaimakliotis HZ, Cary C, et al. Modified retroperitoneal lymph node dissection for post-chemotherapy residual tumour: a long-term update. BJU Int. 2017;120:104–108.
  • Heidenreich A, Pfister D, Witthuhn R, et al. Postchemotherapy retroperitoneal lymph node dissection in advanced testicular cancer: radical or modified template resection. Eur Urol. 2009;55:217–224.
  • Vallier C, Savoie PH, Delpero JR, et al. External validation of the Heidenreich criteria for patient selection for unilateral or bilateral retroperitoneal lymph node dissection for post-chemotherapy residual masses of testicular cancer. World J Urol. 2014;32:1573–1578.
  • Ehrlich Y, Yossepovitch O, Kedar D, et al. Distribution of nodal metastases after chemotherapy in nonseminomatous testis cancer: a possible indication for limited dissection. BJU Int. 2006;97:1221–1224.
  • Krege S, Beyer J, Souchon R, et al. European consensus conference ondiagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. Eur Urol. 2008;53:478–496.
  • Besse B, Grunenwald D, Flechon A, et al. Nonseminomatous germ cell tumors: assessing the need for postchemotherapy contralateral pulmonary resection in patients with ipsilateral complete necrosis. J Thoracic Cardiovasc Surg. 2009;137:448–452.
  • Masterson TA, Carver BS, Shayegan B, et al. Outcomes in patients with clinical stage III NSGCT who achieve complete clinical response to chemotherapy at extraretroperitoneal disease site. Urology. 2012;79:1079–1084.
  • Hahn T, Jacobson L, Einhorn L, et al. Hepatic resection of metastatic testicular carcinoma: a further update. Ann Surg Oncol. 1999;6:640–644.
  • Rivoire M, Elias D, De Cian F, et al. Multimodality treatment of patients with liver metastases from germ cell tumours. Cancer. 2001;92:578–587.
  • Jacobsen N, Beck S, Jacobsen L, et al. Is retroperitoneal History predictive of liver histology at concurrent postchemotherapy retroperitoneal lymph node dissection and hepatic resection. J Urol. 2010;184:949–953.
  • Copson E, McKendrick J, Hennessey N, et al. Liver metastases in germ cell cancer: defining a role for surgery after chemotherapy. BJU Int. 2004;94:552–558.
  • Uygun K, Karagol H, Kocak Z, et al. Isolated bone metastasis in testicular germ cell tumors: a case report and review of the literature. Onkologie. 2006;29:93–95.
  • Berglund R, Lyden S, Tsai E, et al. Nonesminomatous germ cell tumor after chemotherapy with residual mass invading the spine. Eur Urol. 2006;50:372–374.
  • Hitchins R, Philip P, Wignall B, et al. Bone disease in testicular and extragonadal germ cell tumours. Br J Cancer. 1988;58:793–796.
  • Oing C, Oechsle K, Necchi A, et al. Impact of primary metastatic bone disease in germ cell tumors: results of an International Global Germ Cell Tumor Collaborative Group G3 registry study. Ann Oncol. 2017;28:576–582.
  • Oechsle K, Bokemeyer C. Treatment of brain metastases from germ cell tumors. Hematol Oncol Clin North Am. 2011;25:605–613.
  • Fizazi K, Tjulandin S, Salvioni R, et al. Viable malignant cells after primary chemotherapy for disseminated nonseminatous germ cell tumors: prognostic factors and role of postsurgery chemotherapy results from an international study. J Clin Oncol. 2001;19:2647–2657.
  • Iida K, Naiki T, Kawai N, et al. Metastasectomy as optimal treatment for late relapsing solitary brain metastasis from testicular germ cell tumor: a case report. BMC Res Notes. 2014;7:865.
  • Loriot Y, Pagliaro L, Fléchon A, et al. Patterns of relapse in poor-prognosis germ-cell tumours in the GETUG 13 trial: implications for assessment of brain metastases. Eur J Cancer. 2017;87:140–146.
  • Girones R, Aparicio J, Roure P, et al. Synchronous versus metachronous brain metastasis from testicular germ cell tumors (TGCT): an analysis from the Spanish Germ Cell Cancer Group data base. Clin Transl Oncol. 2014;16:959–965.
  • Eggener S, Carver BS, Loeb S, et al. Pathologic findings and clinical outcome of patients undergoing retroperitoneal lymph node dissection after multiple chemotherapy regimes for metastatic testicular germ cell tumors. Cancer. 2007;109:528–535.
  • Waples MJ, Messing EM. Redo retroperitoneal lymphadenectomy for germ cell tumor. Urology. 1993;42:1–4.
  • Cespedes RD, Peretsman SJ. Retroperitoneal recurrences after retroperitoneal lymph node dissection for low-stage nonseminomatous germ cell tumors. Urology. 1999;54:548–552.
  • Sexton WJ, Wood CG, Kim R, et al. Repeat retroperitoneal lymph node dissection for metastatic testis cancer. J Urol. 2003;169:1353–1356.
  • McKiernan JM, Motzer RJ, Bajorin DF, et al. Reoperative retroperitoneal surgery for nonseminomatous germ cell tumor: clinical presentation, patterns of recurrence and outcome. Urology. 2003;62:732–736.
  • Heidenreich A, Ohlmann C, Hegele A, et al. Repeat retroperitoneal lymphadenectomy in advanced testicular cancer. Eur Urol. 2005;47:64–71.
  • Albers P, Ganz A, Hannig E, et al. Salvage surgery of chemorefractory germ cell tumors with elevated markers. J Urol. 2000;164:381–384.
  • Beck SD, Foster RS, Bihrle R, et al. Outcome analysis for patients with elevated serum tumor markers at postchemotherapy retroperitoneal lymph node dissection. J Clin Oncol. 2005;23:6149–6156.
  • Heidenreich A, Albers P, Hartmann M, et al. Complications of primary nerve-sparing lymph node dissection for clinical stage I nonseminomatous germ cell tumors of the testis: experience of the German Testicular Cancer Study Group. J Urol. 2003;169:1710–1714.
  • Mosharafa AA, Foster RS, Koch MO, et al. Complications of post-chemotherapy retroperitoneal lymph node dissection for testis cancer. J Urol. 2004;171:1839–1841.
  • Fizazi K, Oldenburg J, Dunant A, et al. Assessing prognosis and optimizing treatment in patients with postchemotherapy viable nonseminomatous germ-cell tumors (NSGCT): results of the sCR2 international study. Ann Oncol. 2008 Feb;19(2):259–64.

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