Synthesis and Anti-HIV Activity of Some [Nucleoside Reverse Transcriptase Inhibitor]-C5′-Linker-[Integrase Inhibitor] Heterodimers as Inhibitors of HIV Replication

References

• Anderson, P.S., Kenyon, G.L. and Marshall, G.R., eds (1993) Perspectives in Drug Discovery and Design 1, 1–250.
   Google Scholar
• Johnson, V.A. (1996) Antiviral Res. 29, 35–39.
   Google Scholar
• De Clercq, E. (1995) J. Med. Chem. 38, 2491–2517.
   Google Scholar
• De Clercq, E. (2001) Current Med. Chem. 8, 1543–1572.
   Google Scholar
• Fischl, M.A., Richman, D.D., Grieco, M.H., Gottlieb, M.S., Volberding, P.A., Laskin, O.L., Leedom, J.M., Mildvan, D., Schooley, R.T., Jackson, G.C., Durack, D.T. and King, D. (1987) N. Engl. J. Med. 317, 185–191.
   Google Scholar
• Volberding, P.A., Lagakos, S.W., Koch, M.A., Pettinelli, C., Myers, M.W., Booth, D.K., Balfour, H.H., Reichman, R.C., Bartlett, J.A., Hirch, M.S., Murphy, R.L., Hardy, W.D. Soeiro, R., Fischl, M.A., Bartlett, J.G., Merigan, T.C., Hyslop, N.E., Richman, D.D., Valentine, F.T. and Corey, L. (1990) N. Engl. J. Med. 322, 941–949.
   Google Scholar
• Mitsuya, H., Weinhold, K.J., Furman, P.A., St. Clair, M.H., Nusinoff-Lehrman, S., Gallo, R.C., Bolognesi, D., Barry, D.W. and Broder, S. (1985) Proc. Natl Acad. Sci. USA 82, 7096–7100.
   PubMed Web of Science ®Google Scholar
• Yarchoan, R., Mitsuya, H., Thomas, H., Pluda, R.V., Hartman, J.M., Perno, N.R., Marczyk, C.F., Allain, K.S., Johns, J.P. and Broder, D.G. (1989) Science 245, 412–415.
   PubMed Web of Science ®Google Scholar
• Yarchoan, R., Thomas, R.V., Allain, J.P., McAter, N., Dubinsky, R., Mitsuya, H., Lawley, T.J., Safai, B., Myers, C.E., Perno, C.F., Klecker, R.W., Wills, R.W., Fischl, M.A., McNeili, M.C., Pluda, J.M., Leuther, M., Collins, J.M. and Broder, S. (1988) Lancet, 76–81.
   Google Scholar
• Mansuri, M.M., Starrett, J.E., Ghazzouli, I., Hitchcock, M.J.M., Sterzycki, R.Z., Brankovan, V., Lin, T., August, E.M., Prusoff, W.H., Sommadossi, J. and Martin, J.C. (1989) J. Med. Chem. 32, 461–466.
   Web of Science ®Google Scholar
• Shiragami, H., Uchida, Y. and Izawa, K. (1996) Nucleosides and Nucleotides 15, 47–58.
   Web of Science ®Google Scholar
• Lin, T., Schinazi, R.F. and Prusoff, W.H. (1987) Biochem. Pharmacol. 36, 2713–2718.
   Google Scholar
• Balzarini, J., Kang, G.J., Dalal, M., Herdewijn, P., De Clercq, E., Broder, S. and Johns, D.G. (1987) Mol. Pharmacol. 32, 162–167.
   PubMed Web of Science ®Google Scholar
• Browne, M.J., Mayer, K.H., Chafee, S.B., Dudley, M.N., Posner, M.R., Steinberg, S.M., Graham, K.K., Geletko, S.M., Zinner, S.H., Denman, S.L., Dunkle, L.M., Kaul, S., Mc Laren, C., Skowron, G., Kontlab, N.M., Kennedy, T.A., Weitberg, A.B. and Curt, G.A. (1993) J. Infect. Dis. 167, 21–29.
   Google Scholar
• Riddler, S.A., Anderson, R.E. and Mellors, J.W. (1995) Antiviral Res. 27, 189–203.
   PubMed Web of Science ®Google Scholar
• Mitsuya, H., Yarchoan, R. and Broder, S. (1990) Science 249, 1533–1544.
   PubMed Web of Science ®Google Scholar
• Belleau, B., Dixit, N., Nguyen-Ba, N. and Kraus, J.L. (1989) 5th Int. Conf. Aids Montreal, Canada 4-6 June 1989, Abstr. T.C. 01, pp. 515.
   Google Scholar
• Sonderns, H., Yao, Q., Belleau, B., Kraus, J.L., Nguyen-Ba, N., Spira, B. and Wainberg, M.A. (1991) Antimicrob. Agents Chemother. 35, 1386–1390.
   PubMedGoogle Scholar
• Hazuda, D., Blau, C.U., Felock, P., Hastings, J., Pramanik, B., Wolfe, A., Bushman, F., Farnet, C., Goetz, M., Williams, M., Silverman, K., Lingham, R. and Singh, S. (1999) Antiviral Chem. Chemother. 10, 63–70.
   Google Scholar
• Neamati, N., Turpin, J.A., Winslow, H.E., Christensen, J.L., Williamson, K., Orr, A., Rice, W.G., Pommier, Y., Garofalo, A., Brizzi, A., Campiani, G., Fiorini, I. and Nacci, V. (1999) J. Med. Chem. 42, 3334–3341.
   Google Scholar
• Neamati, N., Hong, H., Sunder, S., Milne, G.W. and Pommier, Y. (1997) Mol. Pharmacol. 52, 1041–1055.
   PubMed Web of Science ®Google Scholar
• Robinson, W.E., Cordeiro, M., Abdel-Malek, S., Jia, Q., Chow, S.A., Reinecke, M.G. and Mitchell, W.M. (1996) Mol. Pharmacol. 50, 846–855.
   PubMed Web of Science ®Google Scholar
• Zhao, H., Neamati, N., Sunder, S., Hong, H., Wang, S., Milne, G.W., Pommier, Y. and Burke, T.R. (1997) J. Med. Chem. 40, 937–941.
   Google Scholar
• Neamati, N., Hong, H., Owen, J.M., Sunder, S., Winslow, H.E., Christensen, J.L., Zhao, H., Burke, T.R., Milne, G.W. and Pommier, Y. (1998) J. Med. Chem. 41, 3202–3209.
   Google Scholar
• Fesen, M.R., Pommier, Y., Leteurtre, F., Hiroguchi, S., Yung, J. and Kohn, K.W. (1994) Biochem. Pharmacol. 48, 595–608.
   Google Scholar
• Goldgur, Y., Craigie, R., Cohen, G.H., Fujiwara, T., Yoshinaga, T., Fujishita, T., Sugimoto, H., Endo, T., Murai, H. and Davies, D.R. (1999) Proc. Natl Acad. Sci. USA 96, 13040–13043.
   PubMed Web of Science ®Google Scholar
• Hazuda, D.J., Felock, P., Witmer, M., Wolfe, A., Stillmock, K., Grobler, J.A., Espeseth, A., Gabryelski, L., Schleif, W., Blau, C. and Miller, M.D. (2000) Science 287, 646–650.
   PubMed Web of Science ®Google Scholar
• Debyser, Z., Cherepanov, P., Van Maele, B., De Clercq, E. and Witvrouw, M. (2002) Antiviral Chem. Chemother. 13, 1–15.
   Google Scholar
• Sugeac, E., Fossey, C., Ladure´e, D., Schmidt, S., Laumond, G. and Aubertin, A.M. (2003) J. Enz. Inhib. Med. Chem. 18, 175–186.
   Google Scholar
• Moog, C., Wick, A., Le Ber, P., Kirn, A. and Aubertin, A.M. (1994) Antiviral Res. 24, 275–288.
   PubMed Web of Science ®Google Scholar
• Chou, J. and Chou, T.C. (1985) Computer Software for Apple II Series and IBM-PC and Instruction Manual (Elsevier-Biosoft, Cambridge), pp. 19–28.
   Google Scholar
• Mosmann, T. (1983) J. Immunol. Meth. 65, 55–63.
   Google Scholar
• Lefebvre, I., Perigaud, C., Pompon, A., Aubertin, A.M., Girardet, J.L., Kirn, A., Gosselin, G. and Imbach, J.L. (1995) J. Med. Chem. 38, 3941–3950.
   Google Scholar
• Matsumoto, H., Kimura, T., Hamawaki, T., Kumagai, A., Goto, T., Sano, K., Hayashi, Y. and Kiso, Y. (2001) Bioorg. Med. Chem. 9, 1589–1600.
   Google Scholar
• Camplo, M., Niddam, V., Barthelemy, P., Faury, P., Mourier, N., Simon, V., Sharvet, A.S., Trabaund, C., Graciet, J.C., Chermann, J.C. and Kraus, J.L. (1995) Eur. J. Med. Chem. 30, 789–800.
   Google Scholar