References
- Ling, Y.-Z., Li, J.-S., Liu, Y., Kato, K., Klus, G.T. and Brodie, A. (1997) J. Med. Chem. 40, 3297.
- Njar, V.C.O., Kato, K., Nname, I.P., Grigoryev, D.N., Long, B.J. and Brodie, A.M.H. (1998) J. Med. Chem. 41, 902.
- Wachall, B.G., Hector, M., Zhuang, Y. and Hartmann, R.W. (1999) Bioorg. Med. Chem. 7, 1913.
- Hartmann, R.W., Frotscher, M., Ledergerber, D., Wa¨chter, G.A., Gru¨ n, G.L. and Sergejew, T. (1996) Arch. Pharm. Pharm. Med. Chem. 329, 251.
- Jacobs, C., Frotscher, M., Dannhardt, G. and Hartmann, R.W. (2000) J. Med. Chem. 43, 1841.
- Schlosser, M. (1999) “The Chemical and Physiological Size of Fluorine”, In: Soloshonok, V.A., eds, Enantiocontrolled Syn- thesis of Fluoro-Organic Compounds: Stereochemical Challenges and Biomedical Targets (John Wiley & Sons Ltd, Chichester).
- See for example in Studies in Organic Chemistry 48 Filler, R., Kobayashi, Y., Yagupolskii, L.M., eds, (1993) “Organofluorine Compounds in Medicinal Chemistry and Biomedical Appli- cations”, (Elsevier).
- Gourve`s, J.-P., Ruzziconi, R. and Vilarroig, L. (2001) J. Org. Chem. 66(2), 617- 619.
- Reetz, M.T. and Kindler, A. (1995) J. Organomet. Chem. 502, C5- C7.
- Baciocchi, E., Casu, A. and Ruzziconi, R. (1990) Synlett, 679.
- Baciocchi, E., Civitarese, G. and Ruzziconi, R. (1987) Tetrahedron Lett. 28, 5357, Diethyl (2,2-dimetoxyethyl)- malonate (DMEM) was conveniently prepared in 75% yield by CAN-promoted oxidative addition of dimethyl malonate to vinyl acetate in methanol at room tempera- ture. This procedure, leading to the mono-acetal exclusively, is certainly preferable to that involving bromine replacement of a-bromoacetaldehyde diethyl acetal by sodium dimethyl malonate which leads inevitably to a mixture of mono- and dialkylmalonate with consequent separation nuisance.
- Thompson, E.A. and Siiteri, P.K. (1974) J. Biol. Chem. 249, 5364.
- Hartmann, R.W. and Batzl, C. (1986) J. Med. Chem. 29, 1362.
- Sergejew, T. and Hartmann, R.W. (1994) J. Enz. Inhib. 8, 113.