977
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Potent inhibition of fatty acid synthase by parasitic loranthus [Taxillus chinensis (DC.) Danser] and its constituent avicularin

, , &
Pages 87-93 | Received 05 Aug 2005, Accepted 09 Oct 2005, Published online: 04 Oct 2008

References

  • Wakil SJ, Stoops JK, Joshi VC. Fatty acid synthesis and its regulation. Annu Rev Biochem 1983; 52: 537–579
  • Joshi AK, Witkowski A, Smith S. The malonyl/acetyltransferase and beta-ketoacyl synthase domains of the animal fatty acid synthase can cooperate with the acyl carrier protein domain of either subunit. Biochemistry 1998; 37(8)2515–2523
  • Smith S. The animal fatty acid synthase: One gene, one polypeptide, seven enzymes. FASEB J 1994; 8(15)1248–1259
  • Kuhajda FP, Pizer ES, Li JN, Mani NS, Frehywot GL, Townsend CA. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA 2000; 97(7)3450–3454
  • Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000; 288(5475)2379–2381
  • Bouchard C. Inhibition of food intake by inhibitors of fatty acid synthase. New Engl J Med 2000; 21: 1888–1889
  • Mobbs CV, Makimura H. Block the FAS, lose the fat. Nat Med 2002; 8(4)335–336
  • Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD, Pasternack GR. Fatty acid synthesis: A potential selective target for antineoplastic therapy. Proc Natl Acad Sci USA 1994; 91(14)6379–6383
  • Kuhajda FP. Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 2000; 16(3)202–208
  • Vance D, Goldberg I, Mitsuhashi O, Bloch K. Inhibition of fatty acid synthatase by the antibiotic cerulenin. Biochem Biophys Res Commun 1972; 48: 649–655
  • Shu IW, Lindenberg DL, Mizuno TM, Roberts JL, Mobbs CV. The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons. Brain Res 2003; 985(1)1–12
  • Wang X, Tian W. Green tea epigallocatechin gallate: A natural inhibitor of fatty-acid synthase. Biochem Biophys Res Commun 2001; 288(5)1200–1206
  • Wang X, Song KS, Guo QX, Tian WX. The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase. Biochem Pharmacol 2003; 66(10)2039–2047
  • Li BH, Tian WX. Inhibitory effects of flavonoids on animal fatty acid synthase. J Biochem (Tokyo) 2004; 135(1)85–91
  • Tian WX, Li LC, Wu XD, Chen CC. Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase. Life Sci 2004; 74(19)2389–2399
  • Xie YM, Wong WL. Reducing fat with traditional Chinese medicine. Symposium International Conference of Weight Reducing, Beijing 2000; 132
  • National Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China2nd ed. Chemical Industry Press, Beijing 2000; 246
  • Tian WX, Hsu RY, Wang YS. Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty acid synthetase of chicken liver. Inactivation by 5,5′-dithiobis-(2-nitrobenzoic acid) and intersubunit cross-linking of the inactivated enzyme. J Biol Chem 1985; 260(20)11375–11387
  • Soulie JM, Sheplock GJ, Tian WX, Hsu RY. Transient kinetic studies of fatty acid synthetase. A kinetic self-editing mechanism for the loading of acetyl and malonyl residues and the role of coenzyme A. J Biol Chem 1984; 259(1)134–140
  • Tian WX, Cai H. The denaturation and inactivation of fatty acid synthase from duck liver in guanidine hydrochloride. Acta Biophys Sinica (Chinese) 1994; 10(1)6–12
  • Wakil SJ. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 1989; 28(11)4523–4530
  • Zhou HH, Wu JR. Preliminary studies of Sang Ji Sheng and Hu Ji Sheng. J Guiyang Col Trad Chin Med 1999; 21(4)59–60
  • Li BH, Tian WX. Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance. J Enz Inhib Med Chem 2003; 18(4)349–356
  • Du YT, Wang X, Wu XD, Tian WX. Keemun Black tea extract contains potent fatty acid synthase inhibitor and reduces food intake and body weight of rats via oral intubation. J Enz Inhib Med Chem 2005, in press
  • A Dictionary of Chinese Traditional Medicines. Shanghai Science and Technology Publishing House. 1997; Vol 3: 1970–1973

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.