Synthesis and cytotoxic and analgesic activities of some 1, 5-diaryl-3-ethoxycarbonylpyrrole derivatives

References

• Talley JJ. Selective inhibitors of cyclooxygenase-2 (COX-2). Progr Med Chem 1999; 36: 201–234
   PubMed Web of Science ®Google Scholar
• Dannhardt G, Kiefer W. Cyclooxygenase inhibitors – current status and future prospects. Eur J Med Chem 2001; 36: 109–126
   PubMed Web of Science ®Google Scholar
• Gauthier JY, Lablanc Y, Black WC, Chan C, Cromlish WA, Gordon R, Kennedey BP, Lau CK, Leger S, Wang Z, Ethier D, Guay J, Mancini J, Riendeau D, Tagari P, Vickers P, Wong E, Xu L, Prasit P. Synthesis and biological evaluation of 2,3-diarylthiophenes as selective COX-2 inhibitors. Part II: Replacing the heterocycle. Bioorg Med Chem Lett 1996; 6: 87–92
   Google Scholar
• Tsuji K, Nakamura K, Ogino T, Konushi N, Tojo T, Ochi T, Seki N, Matsuo M. Studies on anti-inflammatory agents. VI. Synthesis and pharmacological properties of 2,3-diarylthiophenes. Chem Pharm Bull 1998; 46: 279–286
   PubMedGoogle Scholar
• Portevin B, Tordjman C, Pastoureau P, Bonnet J, De Nanteuil G. 1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: A new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite. J Med Chem 2000; 43: 4582–4593
   PubMed Web of Science ®Google Scholar
• Puig C, Crespo MI, Godessart N, Feixas J, Ibarzo J, Jimenez JM, Soca L, Cardelus I, Heredia A, Miralpeix M, Puig J, Beleta J, Huerta JM, Lopez M, Segarra V, Ryder H, Palacios JM. Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxgenase-2 inhibitors. J Med Chem 2000; 43: 214–223
   PubMed Web of Science ®Google Scholar
• Habeeb AG, Rao PNP, Knaus EE. Design and synthesis of 4,5-diphenyl-4-isoxazolines: Novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity. J Med Chem 2001; 44: 2921–2927
   PubMedGoogle Scholar
• Laufer SA, Wagner GK. From imidazole to pyrimidines: New inhibitors of cytokine release. J Med Chem 2002; 45: 2733–2740
   PubMed Web of Science ®Google Scholar
• Hashimoto H, Imamura K, Haruta J, Wakitani K. 4-(4-Cyclooalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: Enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522. J Med Chem 2002; 45: 1511–1517
   PubMed Web of Science ®Google Scholar
• Palomer A, Cabre F, Pascual J, Campos J, Trujillo MA, Entrena A, Gallo MA, Garcia L, Mauleon D, Espinosa A. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem 2002; 45: 1402–1411
   PubMed Web of Science ®Google Scholar
• Balsamo A, Coletta I, Guglielmotti A, Landolfi C, Mancini F, Martinelli A, Milanese C, Minutolo F, Nencetti S, Orlandini E, Pinza M, Rapposelli S, Rossello A. Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring. Eur. J Med Chem 2003; 38: 157–168
   PubMedGoogle Scholar
• Almansa C, Alfon J, de Arriba AF, Cavalcanti FL, Escamilla I, Gomez LA, Miralles A, Soliva R, Bartroli J, Carceller E, Merlos M, Garcia-Rafanell J. Synthesis and structure - activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles. J Med Chem 2003; 46: 3463–3475
   PubMed Web of Science ®Google Scholar
• Pal M, Veeramaneni VR, Nagabelli M, Kalleda SR, Misra P, Casturi SR, Yeleswarapu KR. Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 2003; 13: 1639–1643
   PubMed Web of Science ®Google Scholar
• Joo YH, Kim JK, Kang S, Noh M, Ha J, Choi JK, Lim KM, Lee CH, Chung S. 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxgenase-2 inhibitors. Bioorg Med Chem Lett 2003; 13: 413–417
   PubMedGoogle Scholar
• Demirayak S, Karaburun AC, Kiraz N. Synthesis and antibacterial activities of some 1-[2-(substituted pyrrole1-yl)ethyl]-2-methyl-5-nitroimidazole derivatives. Eur J Med Chem 1999; 34: 275–278
   Web of Science ®Google Scholar
• Green LM, Reade JL, Ware CF. Rapid colormetric assay for cell viability: Application to the quantitation of cytotoxic and growth inhibitory lymphokines. J Immunol Met 1984; 70: 257–268
   PubMed Web of Science ®Google Scholar
• Kumi-Diaka J. Chemo sensitivity of human prostate cancer cells PC3 and LNCaP to genistein isoflavone and beta-lapachone. Biology of The Cell. 2002; 94: 37–44
   PubMed Web of Science ®Google Scholar
• D'Amour FE, Smith DL. A method for determining loss of pain sensation. J Pharmacol Exp Ther 1941; 72: 74–79
   Google Scholar
• Schmauss C, Yaksh TL. In vivo studies on spinal receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat. J Pharmacol Exp Ther 1984; 228: 1–12
   PubMed Web of Science ®Google Scholar