606
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Design, synthesis and pharmacological screening of a series of N1-(substituted)aryl-5,7-dimethyl-2-(substituted)pyrido(2,3-d)pyrimidin-4(3H)-ones as potential histamine H1-receptor antagonists

Pages 681-691 | Received 03 Apr 2006, Accepted 17 May 2006, Published online: 04 Oct 2008

References

  • Silvia F, Montse M, Lluis P. Synthesis and SAR relationships of novel histamine H1-receptor antagonists. Indolypiperidinyl benzoic acid derivatives. J Med Chem 2004; 47: 6326–6337
  • Bousquet J, Vignola AM, Campbell AM. Pathophysiology of allergic rhinitis. Int Arch Allergy Immunol 1996; 110: 207–218
  • Berger WE. Overview of allergic rhinitis. Ann Allergy Asthma Immunol 2003; 90: 7–12
  • Scadding GK. Clinical assessment of antihistamines in rhinitis. Clin Exp Allergy 1999; 29: 77
  • Walsh GM. The clinical relevance of anti-inflammatory properties of antihistamines. Allergy 2000; 55: 53–61
  • Kay GG. The effect of antihistamines on cognition and performance. J Allergy Clin Immunol 2000; 105: 622–627
  • DuBuske LM. Second generation antihistamines: The risk of ventricular arrhythmias. Clin Ther 1999; 21: 281–295
  • Nicolas JM. The metabolic profile of second generation antihistamines. Allergy 2000; 55: 6–52
  • Leusen JE, Gommerren WJ, Janssen PFM, Tanssen PAT. Comparative study of central and peripheral histamine H1-receptor binding in vitro and ex vivo of non sedating antihistamines and of nerebastine, a new agent. Drug Dev Rev 1991; 22: 165–178
  • Simons F, Fraser TG, Reggin JD, Simons KJ. Comparision of the central nervous system effect produced by six H1-receptor: Antagonists. Clin Exp Allergy 1996; 26: 1092–1097
  • Kumar R, Nanda S, Suresh T, Mohan PS. Synthesis and antibacterial activities of newer derivatives of pyrido[2,3-d; 6,5-d]dipyrimidines. Indian J Chem 2003; 42B(7), [Chem Abstr (2004), 140: 59592g]
  • Dhanak D, Knight M, David S, Pu-ping L, Morgans T, David J. Aminoallkyl-substituted derivatives useful as inhibitors of the mitotic kinesin KSP, for the treatment of cellular proliferative disesases, their preparation and methods of their use. PCT Int Appl, WO 2003, 03,103, 575 [Chem Abstr (2004), 140: 42200e]
  • Yong WJ, Shuanghua H, Paul M, Yazhong HG, Young AK. Preparation of pyridopyrimidines as 5-HT6 antagonists. US Pat Appl Publ US, 2004, 19, 064 [Chem Abstr (2004), 140: 146152g]
  • Matthias G, Corinna M, Jagusch UP. Preparation of 3,4-dihydropyrido[1,2-a]pyrimidines as analgesics. PCT Int Appl WO, 2001, 02 30, 933 [Chem Abstr (2002), 136: 309934x]
  • Pitts J, William J, Barbosa J, Janqing G. Synthesis of fused heterocyclic inhibitors of cAMP phosphodiesterase and their use in treatment of Tcell-mediated diseases. US 2002 Appl 137, 508 [Chem Abstr (2003), 139: 307784m].
  • Borea PA, Bertolasi V, Gill G. Crystallographic and conformational studies on histamine H1 receptor antagonists. Arzneim Forsch/ Drug Res 1986; 36: 895
  • Kurzer E. 5-substituted 3-nitroamino-1,2,4-thiadiazole. J Chem soc 1963; 4: 180, (1949), 3033; Org Syn
  • Jain S. Gujarat University. 1988, Ph D Thesis
  • Saxena M, Agrawal SK, Patkaik AK, Saxena AK. Synthesis, biological evaluation and quantitative structure activity relationship analysis of [β-(aroylamino)ethyl]piperazines and piperidines and [2-[(arylamino)carbonyl]ethyl]piperazines and piperidines and pyrazinoisoquinolines. A new class of potent H1-antagonists. J Med Chem 1990; 33: 2970
  • Shah GB, Parmar NS. Antiasthmatic property of polyherbal preparation E-721 B. Phytother Res 2003; 17: 1092–1097
  • Zhang MQ, Leurs R, Timmerman H. Histamine H1-receptor antagonists. Burger's medicinal chemistry and drug discovery5th ed., ME Wolf. Interscience, New York 1995; 495–559

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.