1,439
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Synthesis and evaluation of novel N–H and N-substituted indole-2- and 3-carboxamide derivatives as antioxidants agents

, , &
Pages 457-462 | Received 03 Nov 2006, Accepted 06 Dec 2006, Published online: 04 Oct 2008

References

  • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-Biol Interac 2006; 160: 1–40
  • Iemma F, Trombino S, Puoci F, Cirillo G, Spizzirri UG, Muzzalupo R, Picci N. Synthesis and antioxidant efficiency of a new copolymer containing phosphorylated myo-inositol. Macromol Biosci 2005; 5: 1049–1056
  • Gonenc A, Erten D, Aslan S, Akıncı M, Simsek B, Torun M. Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease. Cell Biol Internat 2006; 30: 376–380
  • Reiter RJ, Acuna CD, Tan DX. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann N Y Acad Sci 2001; 939: 200–215
  • Bendheim PE, Poeggeler B, Neria E, Ziv V, Pappolla M, Chain DG. Development of indole-3-propionic acid (Oxigon) for alzheimer's diseses. J Mol Nurosci 2002; 19: 213–217
  • Ames NB, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative disease of aging. Proc Natl Acad Sci USA 1993; 90: 7915–7922
  • Collins AR. Antioxidant intervention as a route to cancer prevention. Eur J Cancer 2005; 41: 1923–1930
  • Organesian A, Hendricks JD, Williams DE. Long term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infant mouse model. Cancer Lett 1997; 118: 87–94
  • Andreadou I, Tsantili-Kakoulidou A, Spyropoulou E, Siatra T. Reactions of indole derivatives with cardioprotective activity with reactive oxygen species. Comparison with melatonin. Chem Pharm Bull 2003; 51: 1128–1131
  • Kim DS, Jeon SE, Park KC. Oxidation of indole-3-acetic acid by horsedish peroxidase induces apoptosis in G361 human melanoma cells. Cell Signal 2004; 16: 81–88
  • Benanadhi SH, Zheng JB, Dong XC, Yuan SG. Anticarcinogenic and antioxidant activity of diindolylmethane derivatives. Acta Pharmacol Sin 2004; 25: 666–671
  • Antosiewich E, Damiani E, Jassem W, Wozniak M, Orena M, Greci L. Influence of structure on the antioxidant activity of indolinic nitroxide radicals. Free Rad Biol Med 1997; 22: 249–255
  • Spadoni G, Diamantini G, Bendini A, Tarzia G, Vacondio F, Silva C, Rivara M, Mor M, Plazzi PV, Zusso M, Franceschini D, Giusti P. Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity. J Pineal Res 2006; 40: 259–269
  • Ates-Alagoz Z, Kus C, Coban T. Synthesis and antioxidant properties of novel benzimidazoles containing substituted indole or 1, 1, 4, 4-tetramethyl-1, 2, 3, 4-tetrahydro-naphthalene fragments. J Enz Inhib Med Chem 2005; 20: 325–331
  • Ates-Alagoz Z, Coban T, Buyukbingol E. Synthesis and antioxidant activity of new tetrahydro-napthalene-indole derivatives as retinoid and melatonin analogues. Arch Pharm Life Sci 2006; 339: 193–200
  • Olgen S, Coban T. Antioxidant activity of N-substituted indole-2- and 3-carboxamides. J Fac Pharmacy Ankara 2004; 33: 109–116
  • Aboul-Enein HY, Kruk I, Lichszteld K, Michalska T, Kladna A, Marczynski S, Olgen S. Scavenging of reactive species by N-substituted indole-2- and 3-carboxamides. Luminescence 2004; 19: 1–7
  • Olgen S, Coban T. Antioxidant evaluation of novel N-H and N-substituted indole esters. Biol Pharm Bull 2003; 26: 736–738
  • Aboul-Enein HY, Kruk I, Lichszteld K, Michalska T, Kladna A, Marczynski S, Olgen S. Scavenging of reactive oxgen species by novel 3 (substituted-benzylidine)-1, 3-dihydro-indoline-2-one and 3-(substituted-benzylidine)-1, 3-dihydro-indoline-2-thione derivatives. Biopolymers 2005; 78: 171–178
  • Mihara M, Uchiyama MS, Fukuzawa K. Thiobarbituric acid value on fresh homogenate of rat as a parameter of lipid peroxidation in aging, CCl4 intoxication, and vitamin E deficiency. Biochem Med 1980; 23: 303–311
  • McCord JM, Fridovich JM. Preparation and assay of superoxide dismutases. Meth Enzymol 1978; 53: 382–393
  • Battaglia S, Boldrini E, Da Settimo F, Dondio G, La Motta C, Marini AM, Primofiore G. Indole amide derivatives: Synthesis, structure-activity relationships and molecular modelling studies of a new series of histamine H1-receptor antagonists. Eur J Med Chem 1999; 34: 93–105
  • Olgen S, Guner E, Fabregat MA, Crespo MI, Nebioglu D. Syntheses and biological evaluation of indole-2 and 3-carboxamides: New selective cyclooxygenase-2 inhibitors. Pharmazie 2002; 57(4)238–242

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.