735
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Aromatic esters of progesterone as 5α-reductase and prostate growth inhibitors

, , , , , & show all
Pages 655-662 | Received 26 Feb 2008, Accepted 19 May 2008, Published online: 01 Jun 2009

References

  • N Bruchovsky, JD Wilson. The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem 1968; 243:2012–2022.
  • MK Anderson, S Liao. Selective retention of dihydrotestosterone by prostatic nuclei. Nature 1968; 219:277–279.
  • J Imperato-McGinley, L Guerrero, T Gautier, RE Peterso. Steroid 5α-reductase deficiency in man: An inherited form of male pseudohermaphroditism. Science 1974; 186:1213–1215.
  • F Machetti, A Guarna. Novel inhibitors of 5α-reductase. Expert Opin Ther Patents 2002; 12:201–215.
  • T Liang, CE Heiss, AH Cheung, GF Reynolds, GH Rasmusson. 4-azasteroidal 5α-reductase inhibitors without affinity for the androgen receptor. J Biol Chem 1984; 259:734–739.
  • M Brandt, A Levy. 3-Beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase from bovine adrenals: Mechanism of inhibition by 3-oxo-4-aza steroids and kinetic mechanism of the dehydrogenase. Biochemistry 1989; 281:40–148.
  • D Russell, JD Wilson. Steroid 5 alpha-reductase: Two genes/two enzymes. Annu Rev Biochem 1994; 63:25–61.
  • V Pérez-Ornelas, M Cabeza, E Bratoeff, I Heuze, M Sánchez, E Ramírez, E Naranjo. New 5α-reductase inhibitors: In vitro and in vivo effects. Steroids 2005; 70:217–224.
  • PWJ Hendry, BJ Danzo. Structural conversion of cytosolic steroid receptors by an age-dependent epididymal protease. J Steroid Biochem 1985; 21:883–893.
  • M Cabeza, F Vilchis, AE Lemus, L Díaz de León, G Pérez-Palacios. Molecular interactions of levonorgestrel and its 5α-reduced derivative with androgen receptors in hamster flanking organs. Steroids 1995; 60:630–635.
  • MM Bradford. A rapid and sensitive method for the quantization of micograms quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1986; 72:248–254.
  • J Hirosumi, O Nakayama, T Fagan, K Sawada, N Chida, M Inami, S Takahashi, H Kojo, Y Notsu, MJA Okuhara. FK143, a novel non steroidal inhibition of steroid 5α-reductase: In vitro effects of human and animal prostatic enzymes. J Steroid Biochem Mol Biol 1995; 52:357–363.
  • T Liang, MA Cascieri, AH Cheung, GF Reynolds, GH Rasmusson. Species differences in prostatic steroid 5 alpha-reductases of rat, dog, and human. Endocrinology 1985; 117:571–579.
  • T Liang, EJ Heiss. Inhibition of 5α-reductase, receptor binding, and nuclear uptake of androgens in the prostate by a 4-methyl-4-aza-steroid. Biol Chem 1981; 256:7998–8005.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.