1,151
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Lipid lowering activity of novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats

, , , , &
Pages 138-144 | Received 11 Apr 2016, Accepted 25 Jul 2016, Published online: 25 Aug 2016

References

  • Fruchart JC, Sacks FM, Hermans MP, et al The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient. Diab Vasc Dis Res 2008;5:319–35
  • Griffin BA. Lipoprotein atherogenicity: an overview of current mechanisms. Proc Nutr Soc 1999;58:163–9
  • Mozaffarian D, Benjamin EJ, Go AS, et al Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation 2015;131:e29–322
  • Chapman MJ, Ginsberg HN, Amarenco P, et al Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 2011;32:1345–61
  • Anandhi R, Annadurai T, Anitha TS, et al Antihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom, Pleurotus ostreatus, and its major constituent, chrysin, in Triton WR-1339-induced hypercholesterolemic rats. J Physiol Biochem 2013;69:313–23
  • Awasthi VK, Mahdi F, Chander R, et al Hypolipidemic activity of Cassia tora seeds in hyperlipidemic rats. Indian J Clin Biochem 2015;30:78–83
  • da Rocha JT, Speranca A, Nogueira CW, Zeni G. Hypolipidaemic activity of orally administered diphenyl diselenide in Triton WR-1339-induced hyperlipidemia in mice. J Pharm Pharmacol 2009;61:1673–9
  • Viswanatha GL, Janaki Priyadarshini B, Hanumanthappa S, et al Synthesis and anti-hyperlipidemic activity of 3H-benzo [4, 5] thieno [2, 3-d][1, 2, 3] triazin-4-ones: possible mechanism of altered lipid metabolism. Oman Med J 2012;27:388
  • Sudha S, Karthic R, Naveen JR. Anti hyperlipidemic activity of Spirulina platensis in Triton x-100 induced hyperlipidemic rats. Hygeria JD Med 2011;3:32–7
  • Venkadeswaran K, Muralidharan AR, Annadurai T, et al Antihypercholesterolemic and antioxidative potential of an extract of the plant, piper betle, and its active constituent, eugenol, in Triton WR-1339-induced hypercholesterolemia in experimental rats. Evid Based Complement Alternat Med 2014;2014:478973
  • Al-Hiari Y, Shattat G, Al-Qirim T, et al Antihyperlipidemic properties of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-induced hyperlipidemic rats. Molecules 2011;16:8292–304
  • Shattat G, Al-Qirim R, Al-Hiari Y, et al Synthesis and anti-hyperlipidemic evaluation of N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats. Molecules 2010;15:5840–9
  • Garlick DG, Courtice FC. The composition of the lipoproteins in the plasma of rabbits with hypercholesterolaemia or triton WR-1339-induced hyperlipaemia. Q J Exp Physiol Cogn Med Sci 1962;47:211–20
  • Vijayaraj P, Muthukumar K, Sabarirajan J, Nachiappan V. Antihyperlipidemic activity of Cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats. Exp Toxicol Pathol 2013;65:135–41
  • Scanu A, Page IH. Plasma transport of lipids and lipoprotein proteins in dogs treated with triton WR-1339. J Clin Invest 1962;41:495–504
  • Al-Qirim T, Shattat G, Sheikha G, et al Synthesis of novel N-(4-benzoylphenyl)-2-furamide derivatives and their pharmacological evaluation as potent antihyperlipidemic agents in rats. Drug Res 2015;65:158–63
  • Al-Qirim T, Shattat G, Sweidan K, et al In vivo antihyperlipidemic activity of a new series of N-(benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2-carboxamides in rats. Arch Pharm (Weinheim) 2012;345:401–6
  • Schurr PE, Schultz JR, Parkinson TM. Triton-induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs. Lipids 1972;7:68–74
  • Kamanna VS, Kashyap ML. Mechanism of action of niacin. Am J Cardiol 2008;101:S20–6
  • Gille A, Bodor ET, Ahmed K, Offermanns S. Nicotinic acid: pharmacological effects and mechanisms of action. Annu Rev Pharmacol Toxicol 2008;48:79–106
  • Bodor ET, Offermanns S. Nicotinic acid: an old drug with a promising future. Br J Pharmacol 2008;153 Suppl 1:S68–75
  • Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract 2009;63:1369–77
  • Shahwan M, Shattat G, Al-Qirim T, et al Synthesis and pharmacological evaluation of novel substituted and unsubstituted N-(benzoylphenyl)-1H-indole-2-carboxamides as potent antihypertriglyceridemic agents. Zeitschrift für Naturforschung C 2010;65:309–16
  • Al-Najdawi M, Hiari Y, Qirim T, et al Synthesis and pharmacological evaluation of novel unsubstituted indole-anthraquinone carboxamide derivatives as potent antihyperlipidemic agents. Zeitschrift Für Naturforschung C 2014;69:21–8
  • Fararjeh M, Mohammad MK, Bustanji Y, et al Evaluation of immunosuppression induced by metronidazole in Balb/c mice and human peripheral blood lymphocytes. Int Immunopharmacol 2008;8:341–50
  • Kumar G, Srivastava A, Sharma SK, Gupta YK. The hypolipidemic activity of Ayurvedic medicine, Arogyavardhini vati in Triton WR-1339-induced hyperlipidemic rats: a comparison with fenofibrate. J Ayurveda Integr Med 2013;4:165–70
  • Majithiya J, Parmar A, Balaraman R. Effect of curcumin on Triton WR 1339 induced hypercholesterolemia in mice. Indian J Pharmacol 2004;36:382
  • Reed LJ, Muench H. A simple method of estimating fifty per cent endpoints. Am J Epidemiol 1938;27:493–7
  • Parasuraman S. Toxicological screening. J Pharmacol Pharmacother 2011;2:74
  • Gouda M, Berghot M, Shoeib A, Khalil A. Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety. Eur J Med Chem 2010;45:1843–8
  • Oliveira HC, dos Santos MP, Grigulo R, et al Antidiabetic activity of Vatairea macrocarpa extract in rats. J Ethnopharmacol 2008;115:515–19
  • Jeyabalan S, Palayan M. Antihyperlipidemic activity of Sapindus emarginatus in Triton WR-1339 induced albino rats. Res J Pharm Tech 2009;2:319–23
  • Subbarao PG, Ashok P. Antihyperlipidemic effect of Trichilia connaroides in hypercholesterolemic rats and its possible mechanism. J Pharm Bioall Sci 2011;3:230
  • Zeb Shah T, Ali AB, Ahmad Jafri S, Qazi MH. Effect of nicotinic acid (vitamin b3 or niacin) on the lipid profile of diabetic and non-diabetic rats. Pak J Med Sci 2013;29:1259–64
  • Chapman MJ. Review: fibrates: therapeutic review. Br J Diabetes Vasc Dis 2006;6:11–19

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.