1,216
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Synthesis, antitumor screening and cell cycle analysis of novel benzothieno[3,2-b]pyran derivatives

, , , &
Pages 145-153 | Received 19 Apr 2016, Accepted 25 Jul 2016, Published online: 02 Sep 2016

References

  • Kamal A, Mallareddy A, Suresh P. Novel apoptotic regulators in carcinogenesis. Chapter 3: heterocyclics as inducers of apoptosis. 1st ed. Netherlands: Springer; 2012:45–92
  • Vaupel P, Hockel M. Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance. Int J Oncol 2000;17:869–79
  • Bates DJP, Lewis LD. Manipulating the apoptotic pathway: potential therapeutics for cancer patients. Br J Clin Pharmacol 2013;76:381–95
  • Billard C. Apoptosis inducers in chronic lymphocytic leukemia. Oncotarget 2013;5:309–25
  • Zheng D, Ming YX. Essentials of apoptosis: a guide for basic and clinical research. Vol. 2. New York: Humana Press; 2009:239–41
  • Kelly GL, Strasser A. The essential role of evasion from cell death in cancer. Adv Cancer Res 2011;111:39–96
  • Steller H. Mechanisms and genes of cellular suicide. Science 1995;267:1445–9
  • Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis 2000;21:485–95
  • Vyas VK, Chintha C, Pandya MR. Biology and medicinal chemistry approaches towards various apoptosis inducers. Anti-Cancer Agents Med Chem 2013;13:433–55
  • Zornig M, Hueber A, Baum W, Evan G. Apoptosis regulators and their role in tumorigenesis. Biochim Biophys Acta 2001;1551:F1–37
  • Kingston DG, Newman DJ. Taxoids: cancer-fighting compounds from nature. Curr Opin Drug Discov Devel 2007;10:130–44
  • Kingston DG, Newman DJ. Natural products as anticancer agents. Chapter 13: natural products in chemical biology. 1st ed. UK: John Wiley & Sons, Inc., 2012:325–49
  • Nepali K, Sharma S, Sharma M, et al Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids. Eur J Med Chem 2014;77:422–87
  • Nevagi RJ, Dighe SN, Dighe SN. Biological and medicinal significance of benzofuran. Eur J Med Chem 2015;97:561–81
  • Shamsuzzaman KH. Bioactive benzofuran derivatives: a review. Eur J Med Chem 2015;97:483–504
  • Huang W, Liu MZ, Li Y, et al Design, syntheses, and antitumor activity of novel chromone and aurone derivatives. Bioorg Med Chem 2007;15:5191–7
  • Lv L, Zhang X, Lv J, et al Design, synthesis and biological evaluation of the novel antitumor agent 5-bromobenzofuran-3(2H)-one and its derivatives. Proc 2012 Int Conf Appl Biotechnol (ICAB 2012) 2014;2:835–41
  • Kemnitzer W, Kasibhatla S, Jiang S, et al Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions. Bioorg Med Chem 2005;15:4745–51
  • Kemnitzer W, Drewe J, Jiang S, et al Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure–activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions. J Med Chem 2008;51:417–23
  • Kemnitzer W, Jiang S, Wang Y, et al Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: modifications of the 2- and 3-positions. Bioorg Med Chem 2008;18:603–7
  • Guha SK, Mitra AK. Some thioindigoids and related compounds. J Indian Chem Soc 1966;43:597–600
  • Dalgliesh CE, Mann FG. The comparative reactivity of the carbonyl groups in the thionaphthenquinones. Part II. The influence of substituent groups in the thionaphthenquinones. J Chem Soc 1945;893–909
  • Boyd MR, Paull KD. Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Dev Res 1995;34:91–109
  • Boyd MR. Cancer drug discovery and development. In: Teicher BA, ed. Anticancer drug development guide: preclinical screening. Clinical trials and approval. Vol. 2. Totowa, NJ: Humana Press; 1997:23–43
  • Shoemaker RH. The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 2006;6:813–23
  • Skehan P, Storeng R, Scudiero D, et al New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990;82:1107–12
  • NCI-60 Screening Methodology. Available from: https://dtp.cancer.gov/discovery_development/nci-60/methodology.htm
  • Pavia DL, Lampman GM, Kriz GS. Introduction to spectroscopy. 3rd ed. USA: Thomson Learning Inc.; 2001:403
  • Stewart ZA, Westfall MD, Pietenpol JA. Cell-cycle dysregulation and anticancer therapy. Trends Pharmacol Sci 2003;24:139–45
  • Ozdemir O. Flow cytometric mast cell mediated cytotoxicity assay: a three-color flow cytometric approach using monoclonal antibody staining with annexin V/propidium iodide co-labeling to assess human mast cell-mediated cytotoxicity by fluorosphere-adjusted counts. J Immunol Methods 2011;365:166–73

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.