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Research Article

Carbonic anhydrase inhibitory properties of some uracil derivatives

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Pages 74-77 | Received 15 Aug 2016, Accepted 07 Sep 2016, Published online: 18 Jan 2017

References

  • Martinz Z, Botta O, Fogel ML, et al. Extraterrestrial nucleobases in the Murchison meteorite. Earth Planet Sci Lett 2008;270:130–6.
  • Pałasz A, Cież D. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem 2015;97:582–611.
  • Arutyunyan AA, Mamyan SS, Stepanyan HM, Paronikyan RV. Synthesis and Antitumor and Antibacterial Properties of New N-Alkylated Pyrimidines. Pharm Chem J 2013;47:303–6.
  • Smith NF, Figg WD, Sparreboom A. Recent advances in pharmacogenetic approaches to anticancer drug development. Drug Dev Res 2004;62:233–53.
  • Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008;7:168–81.
  • Almajan GL, Barbuceanu S-F, Innocenti A, et al. Carbonic anhydrase inhibitors. Inhibiton of the cytosolic and tumor-associated carbonic anhydrase iszymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols. J Enzyme Inhib Med Chem 2008;23:101–7.
  • Morgan PE, Supuran CT, Casey JR. Carbonic anhydrase inhibitors that directly inhibit anion transport by the human Cl-/HCO3- exchanger, AE1. Mol Membr Biol 2004;21:423–33.
  • Uygun M, Karagözler AA, Denizli A. Molecularly imprinted cryogels for carbonic anhydrase purification from bovine erythrocyte. Artif Cells Nanomed Biotechnol 2014;42:128–37.
  • Del Prete S, Vullo D, De Luca V, et al. Cloning, expression, purification and sulfoamide inhibition profile of the complyete domain of the η-carbonic anhydrasefrom plasmodium falciparum. Bioorg Med Chem Lett 2016;26:4184–4190.
  • Le Darz A, Mingot A, Bouazza F, et al. Fluorinated pyrrolidines and piperidines incorporating tertiary benzenesulfonamide moieties are selective carbonic anhydrase II inhibitors. J Enzyme Inhib Med Chem 2015;30:737–45.
  • Masini E, Carta F, Scozzafava A, Supuran CT. Antiglaucoma carbonic anhydrase inhibitors: a patent review. Expert Opin Ther Patents 2013;23:705–16.
  • Orhan F, Senturk M, Supuran CT. Interaction of anions with a newly characterized alpha carbonic anhydrase from Halomonas sp. J Enzyme Inhib Med Chem 2015. [Epub ahead of print]. http://dx.doi.org/10.3109/14756366.2015.1100177.
  • Arslan T, Celik G, Celik H, et al. Synthesis and biological evaluation of novel bischalcone derivatives as carbonic anhydrase inhibitors. Arch Pharm (Weinheim) 2016;349:741–8.
  • Karatas MO, Alici B, Cakir U, et al. Syhthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives. J Enzyme Inhib Med Chem 2013;28:299–304.
  • Yaseen R, Ekinci D, Senturk M, et al. Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors. Bioorg Med Chem Lett 2016;26:1337–41.
  • Isık S, Vullo D, Durdagi S, et al. Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives. Bioorg Med Chem Lett 2015;25:5636–41.
  • Guney M, Cavdar H, Senturk M, Ekinci D. Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives. Bioorg Med Chem Lett 2015;25:3261–3.
  • Ozdemir ZO, Senturk M, Ekinci D. Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules. J Enzyme Inhib Med Chem 2013;28:316–19.
  • Balaydin HT, Senturk M, Menzek A. Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives. Bioorg Med Chem Lett 2012;22:1352–7.
  • Cavdar H, Ekinci D, Talaz O, et al. α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters. J Enzyme Inhib Med Chem 2012;27:148–54.
  • Senturk E, Senturk M, Ekinci D. Comparison of inhibition effects of some anions on carbonic anhydrase isoenzymes from mammalian kidney tissues. Acta Physiol 2015;52:1101–6.
  • Ekinci D, Senturk M, Senturk E. Purification and characterization of carbonic anhydrase enzyme from bovine heart tissue and investigation of inhibition effects of some sulfonamide derivative drugs. Acta Physiol 2015;215:99.
  • Ekinci D, Cavdar H, Durdagi S, et al. Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI. Eur J Med Chem 2012;49:68–73.
  • Ekinci D, Al-Rashida M, Abbas G, et al. Chromone containing sulfonamides as potent carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem 2012;27:744–7.
  • Cheng Y, Prusoff WH. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 1973;22:3099–108.
  • Lineweaver H, Burk D. The determination of enzyme dissociation constants. J Am Chem Soc 1934;56:658–66.
  • Innocenti A, Vullo D, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I–XIV). Bioorg Med Chem Lett 2008;18:1583–7.
  • Polat Kose L, Gulcin I, Ozdemir H, et al. The effects of some avermectins on bovine carbonic anhydrase enzyme. J Enzyme Inhib Med Chem 2016;31:773–8.
  • Ozgeriş B, Goksu S, Kose Polat L, et al. Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds. Bioorg Med Chem 2016;24:2318–29.
  • Artunç T, Cetinkaya Y, Gocer H, et al. Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2- dimethoxybenzene derivatives and evaluations of their carbonic anhydrase isoenzymes inhibitory effects. Chem Biol Drug Design 2016;87:594–607.
  • Goksu H, Topal M, Keskin A, et al. 9,10-Dibromo-N-aryl-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-diones: synthesis and ınvestigation of their effects on carbonic anhydrase ısozymes I, II, IX, and XII. Arch Der Pharm 2016;349:466–74.
  • Urcar H, Senturk E, Senturk M, Gul M, Yildirim S. Investigation of the effects of some catecholamines on the activity of carbonic anhydrase enzyme purified from bovine kidney tissue. Acta Physiol 2016;218:57.
  • Demirdag R, Comakli V, Senturk M, et al. Characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity. Bioorg Med Chem 2013;21:1522–5.
  • Balaydin HT, Senturk M, Goksu S, Menzek A. Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B. Eur J Med Chem 2012;54:423–8.
  • Glavas-Obrovac L, Karner I, Pavlak M, et al. Synthesis and antitumor activity of 5-bromo-1-mesyluracil. Nucleosides Nucleotides Nucleic Acids 2005;24:557–69.
  • Visnjevac A, Zinic M, Luic M, et al. Conformational chirality and chiral crystallization of N-sulfonylpyrimidine derivatives. Tetrahedron 2007;63:86–92.