Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice

References

• Gatenby RA, Gillies RJ. A microenvironmental model of carcinogenesis. Nat Rev Cancer 2008;8:56–61.
   PubMed Web of Science ®Google Scholar
• Fais S, Venturi G, Gatenby B. Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy. Cancer Metastasis Rev 2014;33:1095–108.
   PubMed Web of Science ®Google Scholar
• Damaghi M, Tafreshi NK, Lloyd MC, et al. Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane. Nat Commun 2015;6:8752.
   PubMed Web of Science ®Google Scholar
• Spugnini EP, Sonveaux P, Stock C, et al. Proton channels and exchangers in cancer. Biochim Biophys Acta 2015;1848:2715–26.
   PubMed Web of Science ®Google Scholar
• Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004;4:891–9.
   PubMed Web of Science ®Google Scholar
• Lardner A. The effects of extracellular pH on immune function. J Leuk Biol 2001;69:522–30.
   PubMed Web of Science ®Google Scholar
• Xu L, Fukumura D, Jain RK. Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem 2002;277:11368–74.
   PubMed Web of Science ®Google Scholar
• Moellering RE, Black KC, Krishnamurty C, et al. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis 2008;25:411–25.
   PubMed Web of Science ®Google Scholar
• Estrella V, Chen T, Lloyd M, et al. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res 2013;73:1524–35.
   PubMed Web of Science ®Google Scholar
• Damaghi M, Wojtkowiak JW, Gillies RJ. pH sensing and regulation in cancer. Front Physiol 2013;4:370.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646–74.
   PubMed Web of Science ®Google Scholar
• Spugnini EP, Buglioni S, Carocci F, et al. High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors. J Transl Med 2014;12:225.
   PubMed Web of Science ®Google Scholar
• Ferrari S, Perut F, Fagioli F, et al. Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed. J Transl Med 2013;11:268.
   PubMed Web of Science ®Google Scholar
• Wang BY, Zhang J, Wang JL, et al. Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer. J Exp Clin Cancer Res: CR 2015;34:85.
   PubMed Web of Science ®Google Scholar
• Robey IF, Baggett BK, Kirkpatrick ND, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res 2009;69:2260–8.
   PubMed Web of Science ®Google Scholar
• Ibrahim-Hashim A, Wojtkowiak JW, de Lourdes Coelho Ribeiro M, et al. Free base lysine increases survival and reduces metastasis in prostate cancer model. J Cancer Sci Ther 2011:Suppl 1(4).
   PubMedGoogle Scholar
• Azzarito T, Lugini L, Spugnini EP, et al. Effect of modified alkaline supplementation on syngenic melanoma growth in CB57/BL mice. PLoS One 2016;11:e0159763.
   PubMed Web of Science ®Google Scholar
• Gingrich JR, Barrios RJ, Kattan MW, et al. Androgen-independent prostate cancer progression in the TRAMP model. Cancer Res 1997;57:4687–91.
   PubMed Web of Science ®Google Scholar
• Greenberg NM, DeMayo F, Finegold MJ, et al. Prostate cancer in a transgenic mouse. Proc Natl Acad Sci USA 1995;92:3439–43.
   PubMed Web of Science ®Google Scholar
• Pannellini T, Iezzi M, Liberatore M, et al. A dietary tomato supplement prevents prostate cancer in TRAMP mice. Cancer Prev Res (Philadelphia, PA) 2010;3:1284–91.
   PubMed Web of Science ®Google Scholar
• Singh SV, Powolny AA, Stan SD, et al. Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice. Cancer Res 2008;68:9503–11.
   PubMed Web of Science ®Google Scholar
• Gupta S, Hastak K, Ahmad N, et al. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc Natl Acad Sci USA 2001;98:10350–5.
   PubMed Web of Science ®Google Scholar
• Pannellini T, Iezzi M, Liberatore M, et al. A dietary tomato supplement prevents prostate cancer in TRAMP mice. Cancer Prev Res (Phila) 2010;3:1284–91.
   PubMed Web of Science ®Google Scholar
• Raina K, Singh RP, Agarwal R, Agarwal C. Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. Cancer Res 2007;67:5976–82.
   PubMed Web of Science ®Google Scholar
• Singh SV, Warin R, Xiao D, et al. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Res 2009;69:2117. 25.
   PubMed Web of Science ®Google Scholar
• Vene R, Benelli R, Minghelli S, et al. Xanthohumol impairs human prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice. Mol Med 2012;18:1292–302.
   PubMed Web of Science ®Google Scholar
• Ibrahim-Hashim A, Cornnell HH, Abrahams D, et al. Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol 2012;188:624–31.
   PubMed Web of Science ®Google Scholar
• Chiaverotti T, Couto SS, Donjacour A, et al. Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. Am J Pathol 2008;172:236–46.
   PubMed Web of Science ®Google Scholar
• Parimi V, Goyal R, Poropatich K, Yang XJ. Neuroendocrine differentiation of prostate cancer: a review. Am J Clin Exp Urol 2014;2:273–85.
   PubMedGoogle Scholar
• Kaplan-Lefko PJ, Chen TM, Ittmann MM, et al. Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model. The Prostate 2003;55:219–37.
   PubMed Web of Science ®Google Scholar
• Foster BA, Gingrich JR, Kwon ED, et al. Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Cancer Res 1997;57:3325–30.
   PubMed Web of Science ®Google Scholar
• Bostwick DG, Hossain D, Qian J, et al. Phyllodes tumor of the prostate: long-term follow up study of 23 cases. J Urol 2004;172:894–9.
   PubMed Web of Science ®Google Scholar
• Fais S, O'Driscoll L, Borras FE, et al. Evidence-based clinical use of nanoscale extracellular vesicles in nanomedicine. ACS Nano 2016;10:3886–99.
   PubMed Web of Science ®Google Scholar
• Taylor S, Spugnini EP, Assaraf YG, et al. Microenvironment acidity as a major determinant of tumor chemoresistance: proton pump inhibitors (PPIs) as a novel therapeutic approach. Drug Resist Updat 2015;23:69–78.
   PubMed Web of Science ®Google Scholar