β-CA-specific inhibitor dithiocarbamate Fc14–584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis

References

• Gai CS, Lu J, Brigham CJ, et al. Insights into bacterial CO2 metabolism revealed by the characterization of four carbonic anhydrases in Ralstonia eutropha H16. AMB Express 2014;4:2.
   PubMed Web of Science ®Google Scholar
• WHO. Global Tuberculosis Report 2016. ISBN 978 92 4 156539 4 2016:1-214.
   Google Scholar
• Cole ST, Brosch R, Parkhill J, et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998;393:537–44.
   PubMed Web of Science ®Google Scholar
• Lew JM, Kapopoulou A, Jones LM, et al. TubercuList–10 years after. Tuberculosis (Edinb) 2011;91:1–7.
   PubMed Web of Science ®Google Scholar
• Rose SJ, Bermudez LE. Identification of Bicarbonate as a Trigger and Genes Involved with Extracellular DNA Export in Mycobacterial Biofilms. mBio 2016;7:e01597–16.
   PubMed Web of Science ®Google Scholar
• Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008;7:168–81.
   PubMed Web of Science ®Google Scholar
• Nishimori I, Onishi S, Takeuchi H, et al. The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets. Curr Pharm Design 2008;14:622–30.
   PubMed Web of Science ®Google Scholar
• Supuran CT. Bacterial carbonic anhydrases as drug targets: toward novel antibiotics? Front Pharmacol 2011;2:34.
   PubMed Web of Science ®Google Scholar
• Morishita S, Nishimori I, Minakuchi T, et al. Cloning, polymorphism, and inhibition of beta-carbonic anhydrase of Helicobacter pylori. J Gastroenterol 2008;43:849–57.
   PubMed Web of Science ®Google Scholar
• Johnson BK, Colvin CJ, Needle DB, et al. The carbonic anhydrase inhibitor ethoxzolamide inhibits the mycobacterium tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence. Antimicrobial Agents Chemother 2015;59:4436–45.
   PubMed Web of Science ®Google Scholar
• Bjarnsholt T, Ciofu O, Molin S, et al. Applying insights from biofilm biology to drug development - can a new approach be developed? Nat Rev Drug Discov 2013;12:791–808.
   PubMed Web of Science ®Google Scholar
• Covarrubias AS, Bergfors T, Jones TA, et al. Structural mechanics of the pH-dependent activity of beta-carbonic anhydrase from Mycobacterium tuberculosis. J Biol Chem 2006;281:4993–9.
   PubMed Web of Science ®Google Scholar
• Maresca A, Carta F, Vullo D, et al. Dithiocarbamates strongly inhibit the beta-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Med Chem 2013;28:407–11.
   PubMed Web of Science ®Google Scholar
• Maresca A, Scozzafava A, Vullo D, et al. Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three beta-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Medicinal Chem 2013;28:384–7.
   PubMed Web of Science ®Google Scholar
• Cronan MR, Tobin DM. Fit for consumption: zebrafish as a model for tuberculosis. Disease Models Mech 2014;7:777–84.
   PubMed Web of Science ®Google Scholar
• Myllymaki H, Bauerlein CA, Ramet M. The Zebrafish Breathes New Life into the Study of Tuberculosis. Front Immunol 2016;7:196.
   PubMed Web of Science ®Google Scholar
• Parikka M, Hammaren MM, Harjula SK, et al. Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish. PLoS Pathog 2012;8:e1002944.
   PubMed Web of Science ®Google Scholar
• Hammaren MM, Oksanen KE, Nisula HM, et al. Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathogens 2014;10:e1004190.
   PubMed Web of Science ®Google Scholar
• Cosma CL, Humbert O, Ramakrishnan L. Superinfecting mycobacteria home to established tuberculous granulomas. Nat Immunol 2004;5:828–35.
   PubMed Web of Science ®Google Scholar
• Davis JM, Ramakrishnan L. The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell 2009;136:37–49.
   PubMed Web of Science ®Google Scholar
• Takaki K, Davis JM, Winglee K, et al. Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish. Nature Protocols 2013;8:1114–24.
   PubMed Web of Science ®Google Scholar
• Slater GS, Birney E. Automated generation of heuristics for biological sequence comparison. BMC Bioinform 2005;6:31.
   PubMed Web of Science ®Google Scholar
• Team RC. R: A language and environment for statistical computing. R Foundation for Statistical Computing Vienna, Austria 2013; 2014.
   Google Scholar
• Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45
   PubMed Web of Science ®Google Scholar
• Hall L, Jude KP, Clark SL, et al. Antimicrobial susceptibility testing of Mycobacterium tuberculosis complex for first and second line drugs by broth dilution in a microtiter plate format. J Visualized Exp JoVE 2011;52:e3094.
   Google Scholar
• Del Prete S, Isik S, Vullo D, et al. DNA cloning, characterization, and inhibition studies of an alpha-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. J Med Chem 2012;55:10742–8.
   PubMed Web of Science ®Google Scholar
• Nüsslein-Volhard C, Dahm R. Zebrafish: a practical approach. New York: Oxford University Press; 2002. 303p.
   Google Scholar
• Benard EL, van der Sar AM, Ellett F, et al. Infection of zebrafish embryos with intracellular bacterial pathogens. J Visual Exp JoVE 2012;61:e3781.
   Google Scholar
• Suarez Covarrubias A, Larsson AM, Hogbom M, et al. Structure and function of carbonic anhydrases from Mycobacterium tuberculosis. J Biol Chem 2005;280:18782–9.
   PubMed Web of Science ®Google Scholar
• Takaki K, Cosma CL, Troll MA, et al. An in vivo platform for rapid high-throughput antitubercular drug discovery. Cell Rep 2012;2:175–84.
   PubMed Web of Science ®Google Scholar