Dasatinib ameliorates thioacetamide-induced liver fibrosis: modulation of miR-378 and miR-17 and their linked Wnt/β-catenin and TGF-β/smads pathways

References

• Marcellin P, Kutala BK. Liver diseases: a major, neglected global public health problem requiring urgent actions and large‐scale screening. Liver Int 2018;38:2–6.
   PubMed Web of Science ®Google Scholar
• Huang YH, Chen MH, Guo QL, et al. Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis. Cell Signal 2020;66:109445.
   PubMed Web of Science ®Google Scholar
• Duval F, Moreno-Cuevas JE, González-Garza MT, et al. Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis. Chinese Med 2014;9:27.
   PubMed Web of Science ®Google Scholar
• Gomaa A, Allam N, Elsharkawy A, et al. Hepatitis C infection in Egypt: prevalence, impact and management strategies. Hepat Med 2017;9:17–25.
   PubMed Web of Science ®Google Scholar
• Tang PM-K, Zhang Y-Y, Lan H-Y. LncRNAs in TGF-β-driven tissue fibrosis. Non-Coding RNA 2018;4:26.
   PubMedGoogle Scholar
• Nishikawa K, Osawa Y, Kimura K. Wnt/β-catenin signaling as a potential target for the treatment of liver cirrhosis using antifibrotic drugs. Int J Mol Sci 2018;19:3103.
   PubMed Web of Science ®Google Scholar
• Baarsma H, Königshoff M. ‘WNT-er is coming’: WNT signalling in chronic lung diseases. Thorax 2017;72:746–59.
   PubMed Web of Science ®Google Scholar
• Kruglikov IL. Interfacial adipose tissue in systemic sclerosis. Curr Rheumatol Rep 2017;19:4.
   PubMed Web of Science ®Google Scholar
• Zeng X, Zhang Y, Xu H, et al. Secreted frizzled related protein 2 modulates epithelial-mesenchymal transition and stemness via Wnt/β-catenin signaling in choriocarcinoma. Cell Physiol Biochem 2018;50:1815–31.
   PubMedGoogle Scholar
• Zaafan MA, Abdelhamid AM. The cardioprotective effect of microRNA-103 inhibitor against isoprenaline-induced myocardial infarction in mice through targeting FADD/RIPK pathway. Eur Rev Med Pharmacol Sci 2021;25:837–44.
   PubMed Web of Science ®Google Scholar
• Shaker OG, Ayeldeen G, Abdelhamid AM. Circulating microRNA-944 and its target gene EPHA7 as a potential biomarker for colorectal cancer. Arch Physiol Biochem 2020:1–7.
   PubMed Web of Science ®Google Scholar
• Lambrecht J, Mannaerts I, van Grunsven LA. The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis. Front Physiol 2015;6:209.
   PubMed Web of Science ®Google Scholar
• Dituri F, Cossu C, Mancarella S, Giannelli G. The interactivity between tgfβ and bmp signaling in organogenesis, fibrosis, and cancer. Cells 2019;8:1130.
   PubMed Web of Science ®Google Scholar
• Yu F, Guo Y, Chen B, et al. MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7. Lab Invest 2015;95:781–9.
   PubMed Web of Science ®Google Scholar
• Yu F, Lu Z, Huang K, et al. MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis. Oncotarget 2016;7:81–93.
   PubMedGoogle Scholar
• Ganguly N, Chakrabarti S. Role of long non‑coding RNAs and related epigenetic mechanisms in liver fibrosis. Int J Mol Med 2021;47:1.
   Web of Science ®Google Scholar
• Vallée A, Lecarpentier Y, Guillevin R, Vallée J-N. Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis. Oncotarget 2017;8:90579–604.
   PubMedGoogle Scholar
• Yu F, Fan X, Chen B, et al. Activation of hepatic stellate cells is inhibited by microRNA-378a-3p via Wnt10a. Cell Physiol Biochem 2016;39:2409–20.
   PubMedGoogle Scholar
• Machado IF, Teodoro JS, Palmeira CM, Rolo AP. miR-378a: a new emerging microRNA in metabolism. Cell Mol Life Sci 2020;77:1947–58.
   PubMed Web of Science ®Google Scholar
• Araujo JC, Mathew P, Armstrong AJ, et al. Dasatinib combined with docetaxel for castration-resistant prostate cancer: results from a phase 1-2 study. Cancer 2012;118:63–71.
   PubMed Web of Science ®Google Scholar
• McCafferty EH, Dhillon S, Deeks ED. Dasatinib: a review in pediatric chronic myeloid leukemia. Paediatr Drugs 2018;20:593–600.
   PubMed Web of Science ®Google Scholar
• Zeng X-P, Wang L-J, Guo H-L, et al. Dasatinib ameliorates chronic pancreatitis induced by caerulein via anti-fibrotic and anti-inflammatory mechanism. Pharmacol Res 2019;147:104357.
   PubMed Web of Science ®Google Scholar
• Choi S, Jung HJ, Kim MW, et al. A novel STAT3 inhibitor, STX-0119, attenuates liver fibrosis by inactivating hepatic stellate cells in mice. Biochem Biophys Res Commun 2019;513:49–55.
   PubMed Web of Science ®Google Scholar
• Yang HY, Kim KS, Lee YH, et al. Dendropanax morbifera ameliorates thioacetamide-induced hepatic fibrosis via TGF-β1/Smads pathways. Int J Biol Sci 2019;15:800–11.
   PubMed Web of Science ®Google Scholar
• Bancroft JD, Gamble M. Theory and practice of histological techniques. Amsterdam, The Netherlands: Elsevier Health Sciences; 2008.
   Google Scholar
• Zaafan MA, Haridy AR, Abdelhamid AM. Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2. Naunyn-Schmiedeberg’s Arch Pharmacol 2019;392:279–86.
   Google Scholar
• Stoline M. The status of multiple comparisons: simultaneous estimation of all pairwise comparisons in one-way ANOVA designs. J Am Stat Assoc. 1981;35:134–41.
   Web of Science ®Google Scholar
• Samarakoon R, Overstreet JM, Higgins PJ. TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities. Cell Signal 2013;25:264–68.
   PubMed Web of Science ®Google Scholar
• Cao H, Wang C, Chen X, et al. Inhibition of Wnt/β-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis. Scientific Rep 2018;8:13644.
   PubMed Web of Science ®Google Scholar
• Xiao W, Jiang W, Shen J, et al. Retinoic acid ameliorates pancreatic fibrosis and inhibits the activation of pancreatic stellate cells in mice with experimental chronic pancreatitis via suppressing the Wnt/β-catenin signaling pathway. PLoS One 2015;10:e0141462.
   PubMed Web of Science ®Google Scholar
• Krejci P, Aklian A, Kaucka M, et al. Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation. PLoS One 2012;7:e35826.
   PubMed Web of Science ®Google Scholar
• Martyanov V, Kim G-HJ, Hayes W, et al. Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease. PLoS One 2017;12:e0187580.
   PubMed Web of Science ®Google Scholar
• Abdalla M, Thompson L, Gurley E, et al. Dasatinib inhibits TGFβ-induced myofibroblast differentiation through Src-SRF Pathway. Eur J Pharmacol 2015;769:134–42.
   PubMed Web of Science ®Google Scholar
• He Y, Huang C, Zhang S-P, et al. The potential of microRNAs in liver fibrosis. Cell Signal 2012;24:2268–72.
   PubMed Web of Science ®Google Scholar
• Shaker O, Ayeldeen G, Abdelhamid A. The impact of single nucleotide polymorphism in the long non-coding MEG3 gene on microRNA-182 and microRNA-29 expression levels in the development of breast cancer in Egyptian women. Front Genet 2021;12:683809.
   PubMed Web of Science ®Google Scholar
• Kim KK, Wei Y, Szekeres C, et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 2009;119:213–24.
   PubMed Web of Science ®Google Scholar
• Kordes C, Sawitza I, Häussinger D. Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun 2008;367:116–23.
   PubMed Web of Science ®Google Scholar
• Cheng JH, She H, Han YP, et al. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 2008;294:G39–49.
   PubMed Web of Science ®Google Scholar
• Peng H, Wan LY, Liang JJ, et al. The roles of lncRNA in hepatic fibrosis. Cell and Biosci 2018;8:1–8.
   PubMed Web of Science ®Google Scholar
• Hu HH, Chen DQ, Wang YN, et al. New insights into TGF-β/Smad signaling in tissue fibrosis. Chemico-Biol Inter 2018;292:76–83.
   PubMed Web of Science ®Google Scholar
• Meng X-m, Nikolic-Paterson DJ, Lan HY. TGF-β: the master regulator of fibrosis. Nature Rev Nephrol 2016;12:325–38.
   PubMed Web of Science ®Google Scholar