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Research Papers

A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathway in vivo and in vitro

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Pages 202-210 | Received 25 Aug 2021, Accepted 17 Oct 2021, Published online: 11 Dec 2021

References

  • Guerini D. Calcineurin: not just a simple protein phosphatase. Biochem Biophys Res Commun 1997;235:271–5.
  • Perrino BA. Regulation of calcineurin phosphatase activity by its autoinhibitory domain. Arch Biochem Biophys 1999;372:159–65.
  • Li H, Rao A, Hogan PG. Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol 2011;21:91–103.
  • Macián F, López-Rodríguez C, Rao A. Partners in transcription: NFAT and AP-1. Oncogene 2001;20:2476–89.
  • Klee CB, Ren H, Wang X. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem 1998;273:13367–70.
  • Li SJ, Wang J, Ma L, et al. Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. Cell Res 2016;26:336–49.
  • Shou J, Jing J, Xie J, et al. Nuclear factor of activated T cells in cancer development and treatment. Cancer Lett 2015;361:174–84.
  • Medyouf H, Ghysdael J. The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors. Cell Cycle 2008;7:297–303.
  • Kipanyula MJ, Kimaro WH, Seke Etet PF. The emerging roles of the calcineurin-nuclear factor of activated T-lymphocytes pathway in nervous system functions and diseases. J Aging Res 2016;2016:5081021.
  • Sitara D, Aliprantis AO. Transcriptional regulation of bone and joint remodeling by NFAT. Immunol Rev 2010;233:286–300.
  • Aramburu J, Yaffe MB, López-Rodríguez C, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 1999;285:2129–33.
  • Grigoriu S, Bond R, Cossio P, et al. The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. PLoS Biol 2013;11:e1001492.
  • Granja AG, Nogal ML, Hurtado C, et al. The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway. J Biol Chem 2004;279:53736–46.
  • Wang L, Cheng N, Wang P, et al. A novel peptide exerts potent immunosuppression by blocking the two-site interaction of NFAT with calcineurin. J Biol Chem 2020;295:2760–70.
  • Noguchi H, Matsushita M, Okitsu T, et al. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat Med 2004;10:305–9.
  • Kahan BD. Cyclosporine: a revolution in transplantation. Transplant Proc 1999;31:14S–5S.
  • Kiani A, Rao A, Aramburu J. Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity 2000;12:359–72.
  • Benigni A, Bruzzi I, Mister M, et al. Nature and mediators of renal lesions in kidney transplant patients given cyclosporine for more than one year. Kidney Int 1999;55:674–85.
  • Ganesan V, Milford DV, Taylor CM, et al. Cyclosporin-related nephrotoxicity in children with nephrotic syndrome[J]. Pediatr Nephrol 2002;17:225–6.
  • Mihatsch MJ, Kyo M, Morozumi K, et al. The side-effects of ciclosporine-A and tacrolimus. Clin Nephrol 1998;49:356–63.
  • Wang H, Zhou CL, Lei H, Wei Q. Inhibition of calcineurin by quercetin in vitro and in Jurkat cells. J Biochem 2010;147:185–90.
  • Wang H, Zhou CL, Lei H, et al. Kaempferol: a new immunosuppressant of calcineurin. IUBMB Life 2008;60:549–54.
  • Wang M, Xie Y, Zhong Y, et al. Amelioration of Experimental Autoimmune Encephalomyelitis by Isogarcinol Extracted from Garcinia mangostana L. Mangosteen. J Agric Food Chem 2016;64:9012–21.
  • Cen J, Wang M, Jiang G, et al. The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus. Biochimie 2015;111:119–24.
  • Uvebrant K, da Graça Thrige D, Rosén A, et al. Discovery of selective small-molecule CD80 inhibitors. J Biomol Screen 2007;12:464–72.
  • Ganeshpurkar A, Swetha R, Kumar D, et al. Protein-Protein Interactions and Aggregation Inhibitors in Alzheimer’s Disease. Curr Top Med Chem 2019;19:501–33.
  • Sharma SK, Ramsey TM, Bair KW. Protein-protein interactions: lessons learned. Curr Med Chem Anticancer Agents 2002;2:311–30.
  • Cheng AC, Coleman RG, Smyth KT, et al. Structure-based maximal affinity model predicts small-molecule druggability. Nat Biotechnol 2007;25:71–5.
  • Futaki S. Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms. Int J Pharm 2002;245:1–7.
  • Mitchell DJ, Kim DT, Steinman L, et al. Polyarginine enters cells more efficiently than other polycationic homopolymers. J Pept Res 2000;56:318–25.
  • Gonçalves E, Kitas E, Seelig J. Binding of oligoarginine to membrane lipids and heparan sulfate: structural and thermodynamic characterization of a cell-penetrating peptide. Biochemistry 2005;44:2692–702.