Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
Submit an article Journal homepage
2,114
Views
12
CrossRef citations to date
0
Altmetric
Brief Report

First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors

Chiara Testaa Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology”, Department of Chemistry “Ugo Schiff”, University of Florence, Sesto Fiorentino, ItalyView further author information
,
Anna Maria Papinia Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology”, Department of Chemistry “Ugo Schiff”, University of Florence, Sesto Fiorentino, ItalyORCID Iconhttps://orcid.org/0000-0002-2947-7107View further author information
ORCID Icon,
Reinhard Zeidlerb Research Group Therapeutic Antibodies, Helmholtz Centre Munich German Research Centre for Environmental Health, Munich, Germany;c Department of Otorhinolaryngology, Klinikum der Universitaet, Munich, GermanyView further author information
,
Daniela Vullod NEUROFARBA Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, via Ugo Schff 6, Sesto Fiorentino (Florence), 50019ItalyView further author information
,
Fabrizio Cartad NEUROFARBA Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, via Ugo Schff 6, Sesto Fiorentino (Florence), 50019ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1141-6146View further author information
ORCID Icon,
Claudiu T. Supurand NEUROFARBA Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, via Ugo Schff 6, Sesto Fiorentino (Florence), 50019ItalyORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
ORCID Icon &
Paolo Roveroa Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology”, Department of Chemistry “Ugo Schiff”, University of Florence, Sesto Fiorentino, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9577-5228View further author information
ORCID Icon show all
Pages 592-596 | Received 13 Oct 2021, Accepted 04 Nov 2021, Published online: 20 Jan 2022

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics. CA Cancer J. Clin 2020;70:7–30.
  • https://www.who.int/health-topics/cancer#tab=tab_3 (Last access 10/10/2021).
  • https://gco.iarc.fr/today/home (Last access 10/10/2021).
  • Cazzamalli S, Dal Corso A, Widmayer F, Neri D. Chemically defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: a comparative analysis. J Am Chem Soc 2018;140:1617–21.
  • do Pazo C, Nawaz K, Webster RM. The oncology market for antibody-drug conjugates. Nat Rev Drug Discov 2021; 20:583–4.
  • Pysz I, Jackson PJM, Thurston DE, Introduction to antibody–drug conjugates (ADCs), In Cytotoxic Payloads for Antibody–Drug Conjugates, 2019, 1–30.
  • Peters C, Brow S. Antibody–drug conjugates as novel anti-cancer chemotherapeutics. Biosci Rep 2015;4:e00225.
  • Dal Corso A, Gébleux R, Murer P, et al. A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo. J Control Release 2017; 264:211–8.
  • Quintieri L, Geroni C, Fantin M, et al. Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. Clin Cancer Res 2005; 11:1608–17.
  • Lv P-C, Putt KS, Low PS. Low Evaluation of nonpeptidic ligand conjugates for SPECT imaging of hypoxic and carbonic anhydrase IX-expressing cancers. Bioconjug Chem 2016;27:1762–9.
  • Krall N, Pretto F, Mattarella M, et al. A 99mTc-labeled ligand of carbonic anhydrase IX selectively targets renal cell carcinoma in vivo. J Nucl Med 2016;57:943–9.
  • Le Chevalier-Isaad A, Papini AM, Chorev M, Rovero P. Side chain-to-side chain cyclization by click reaction. J Pept Sci 2009;15:451–4.
  • Testa C, Scrima M, Grimaldi M, et al. 1,4-Disubstituted-[1,2,3]triazolyl-containing analogs of MTII – design, synthesis, conformational analysis, and biological activity. J Med Chem 2014;57:9424–34.
  • Battke C, Kremmer E, Mysliwietz J, et al. Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII. Cancer Immunol Immunother 2011;60:649–58.
  • Carta F, Vullo D, Osman SM, et al. Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs. Bioorg Med Chem 2017;25:2569–76.
  • Vullo D, Durante M, Di Leva FS, et al. Monothiocarbamates strongly inhibit carbonic anhydrases in vitro and possess intraocular pressure lowering activity in an animal model of glaucoma. J Med Chem 2016;59:5857–67.
  • Ratto F, Witort E, Tatini F, et al. Plasmonic particles that hit hypoxic cells. Adv Funct Mater 2015;25:316–23.
  • Khalifah RG. The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. J Biol Chem 1971;246:2561–73.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.