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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Research Papers

Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer’s disease

Gaofeng Zhua State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, ChinaView further author information
,
Ping Baib Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USAView further author information
,
Keren Wangc College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, ChinaView further author information
,
Jing Mic College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, ChinaView further author information
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Jing Yangc College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, ChinaView further author information
,
Jiaqi Hua State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, ChinaView further author information
,
Yujuan Bana State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, ChinaView further author information
,
Ran Xua State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, ChinaView further author information
,
Rui Chena State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, ChinaView further author information
,
Changning Wangb Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USACorrespondence[email protected]
View further author information
,
Lei Tanga State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, ChinaCorrespondence[email protected]
View further author information
&
Zhipei Sanga State Key Laboratory of Functions and Applications of Medicinal Plants, School of Basic Medical Sciences, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, China;c College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, ChinaCorrespondence[email protected]
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Pages 1375-1388 | Received 07 Jan 2022, Accepted 28 Apr 2022, Published online: 13 May 2022

References

  • Barnett R. Alzheimer's disease. Lancet 2019;393:1589.
  • Citron M. Alzheimer's disease: strategies for disease modification. Nat Rev Drug Discov 2010;9:387–98.
  • Viña J, Sanz-Ros J. Alzheimer's disease: only prevention makes sense. Eur J Clin Invest 2018;48:e13005.
  • Jagust W. Imaging the evolution and pathophysiology of Alzheimer disease. Nat Rev Neurosci 2018;19:687–700.
  • Schedin-Weiss S, Inoue M, Hromadkova L, et al. Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels. Alzheimers Res Ther 2017;9:57.
  • Available from: https://www.alzforum.org/therapeutics/rasagiline
  • Calsolaro V, Edison P. Neuroinflammation in Alzheimer's disease: current evidence and future directions. Alzheimers Dement 2016;12:719–32.
  • Tamagno E, Guglielmotto M, Vasciaveo V, Tabaton M. Oxidative stress and beta amyloid in Alzheimer's disease. Which comes first: the chicken or the egg? Antioxidants 2021;10:1479.
  • de Freitas Silva M, Dias KST, Gontijo VS Jr., et al. Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update. Curr Med Chem 2018;25:3491–525.
  • Cavalli A, Bolognesi ML, Minarini A, et al. Multi-target-directed ligands to combat neurodegenerative diseases. J Med Chem 2008;51:347–72.
  • Zhang P, Xu S, Zhu Z, Xu J. Multi-target design strategies for the improved treatment of Alzheimer's disease. Eur J Med Chem 2019;176:228–47.
  • Available from: http://integrity.thomson-pharma.com
  • Sgarbossa A, Giacomazza D, di Carlo M. Ferulic acid: a hope for Alzheimer's disease therapy from plants. Nutrients 2015;7:5764–82.
  • Nabavi SF, Devi KP, Malar DS, et al. Ferulic acid and Alzheimer's disease: promises and pitfalls. Mini Rev Med Chem 2015;15:776–88.
  • Legoabe LJ, Petzer A, Petzer JP. 2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors. Drug Des Devel Ther 2015;9:3635–44.
  • Li T, Pan W, Wang K, et al. Novel ferulic acid-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease with butyrylcholinesterase, amyloid-β, antioxidant and neuroprotective properties. Lett Drug Des Discov 2017;14:918–29.
  • Bai P, Wang K, Zhang P, et al. Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease. Eur J Med Chem 2019;183:111737.
  • Sang Z, Wang K, Zhang P, et al. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. Eur J Med Chem 2019;180:238–52.
  • Knez D, Colettis N, Iacovino LG, et al. Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and B. J Med Chem 2020;63:1361–87.
  • Wang XB, Yin FC, Huang M, et al. Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. RSC Med Chem 2020;11:225–33.
  • Tian C, Qiang X, Song Q, et al. Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: design, synthesis and biological evaluation. Bioorg Chem 2020;94:103477.
  • Sang Z, Wang K, Shi J, et al. The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem 2020;192:112180.
  • Sang Z, Wang K, Shi J, et al. Apigenin-rivastigmine hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem 2020;187:111958.
  • Cao Z, Yang J, Xu R, et al. Design, synthesis and evaluation of 4′-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. Bioorg Med Chem 2018;26:1102–15.
  • Sang Z, Wang K, Bai P, et al. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem 2020;194:112265.
  • Tong Y, Bai L, Gong R, et al. Shikonin protects PC12 cells against β-amyloid peptide-induced cell injury through antioxidant and antiapoptotic activities. Sci Rep 2018;8:26.
  • Di L, Kerns EH, Fan K, et al. High throughput artificial membrane permeability assay for blood-brain barrier. Eur J Med Chem 2003;38:223–32.
  • Available from: https://www.molinspiration.com/cgi-bin/properties
  • Wang C, Schroeder FA, Hooker JM. Development of new positron emission tomography radiotracer for BET imaging. ACS Chem Neurosci 2017;8:17–21.
  • Wang C, Schroeder FA, Wey HY, et al. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. J Med Chem 2014;57:7999–8009.
  • Loening AM, Gambhir SS. AMIDE: a free software tool for multimodality medical image analysis. Mol Imaging 2003;2:131–7.

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