Discovery of benzochalcone derivative as a potential antigastric cancer agent targeting signal transducer and activator of transcription 3 (STAT3)

References

• Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209–49.
   PubMed Web of Science ®Google Scholar
• Feng Y, Lu Y, Li J, et al. Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo. Eur J Med Chem 2022;227:113888.
   PubMed Web of Science ®Google Scholar
• Hu S, Niu J, Zhang R, et al. Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients. Gastroenterol Hepatol 2020;43:240–7.
   PubMed Web of Science ®Google Scholar
• Mao Z, Wang Z, Zhang S, et al. LRP4 promotes migration and invasion of gastric cancer under the regulation of microRNA-140-5p. Cancer Biomark 2020;29:245–53.
   PubMed Web of Science ®Google Scholar
• Van Cutsem E, Sagaert X, Topal B, et al. Gastric cancer. Lancet 2016;388:2654–64.
   PubMed Web of Science ®Google Scholar
• Wang S, Ma X-B, Yuan X-H, et al. Discovery of new [1,2,4] Triazolo[1,5-a]pyrimidine derivatives that kill gastric cancer cells via the mitochondria pathway. Eur J Med Chem 2020;203:112630.
   PubMed Web of Science ®Google Scholar
• Davidson M, Okines AFC, Starling N. Current and future therapies for advanced gastric cancer. Clin Colorectal Cancer 2015;14:239–50.
   PubMed Web of Science ®Google Scholar
• Zhuang C, Zhang W, Sheng C, et al. Chalcone: a privileged structure in medicinal chemistry. Chem Rev 2017;117:7762–810.
   PubMed Web of Science ®Google Scholar
• Dong J, Huang G, Cui Q, et al. Discovery of heterocycle-containing α-naphthoflavone derivatives as water-soluble, highly potent and selective CYP1B1 inhibitors. Eur J Med Chem 2021;209:112895.
   PubMed Web of Science ®Google Scholar
• Dong J, Wang Z, Cui J, et al. Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors. Eur J Med Chem 2020;187:111938.
   PubMed Web of Science ®Google Scholar
• Lee JM, Lee MS, Koh D, et al. A new synthetic 2'-hydroxy-2,4,6-trimethoxy-5',6'-naphthochalcone induces G2/M cell cycle arrest and apoptosis by disrupting the microtubular network of human colon cancer cells. Cancer Lett 2014;354:348–54.
   PubMed Web of Science ®Google Scholar
• Shin SY, Kim JH, Yoon H, et al. Novel antimitotic activity of 2-hydroxy-4-methoxy-2',3'-benzochalcone (HymnPro) through the inhibition of tubulin polymerization. J Agric Food Chem 2013;61:12588–97.
   PubMed Web of Science ®Google Scholar
• Dong J, Huang G, Zhang Q, et al. Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents. Medchemcomm 2019;10:1606–14.
   PubMed Web of Science ®Google Scholar
• Giraud AS, Menheniott TR, Judd LM. Targeting STAT3 in gastric cancer. Expert Opin Ther Targets 2012;16:889–901.
   PubMed Web of Science ®Google Scholar
• He S, Liao G, Liu Y, et al. Overexpression of STAT3/pSTAT3 was associated with poor prognosis in gastric cancer: a meta-analysis. Int J Clin Exp Med 2015;8:20014–23.
   PubMed Web of Science ®Google Scholar
• Kanda N, Seno H, Konda Y, et al. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene 2004;23:4921–9.
   PubMed Web of Science ®Google Scholar
• Dong J, Cheng XD, Zhang WD, et al. Recent update on development of small-molecule STAT3 inhibitors for cancer therapy: from phosphorylation inhibition to protein degradation. J Med Chem 2021;64:8884–915.
   PubMed Web of Science ®Google Scholar
• Cui J, Zhou W, Li S. A convenient and efficient synthesis of 2-acetyl-5,8-dimethoxy-1,4-naphthoquinone. J Chem Res 2012;36:264–5.
   Google Scholar
• Sana S, Reddy VG, Srinivasa Reddy T, et al. Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: synthesis, in silico and cell growth inhibition studies. Bioorg Chem 2021;110:104765.
   PubMed Web of Science ®Google Scholar
• Sana S, Reddy VG, Bhandari S, et al. Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect. Eur J Med Chem 2020;200:112457.
   PubMed Web of Science ®Google Scholar
• Wang L, Wang X, Jiang X. miR-127 suppresses gastric cancer cell migration and invasion via targeting Wnt7a. Oncol Lett 2019;17:3219–26.
   PubMed Web of Science ®Google Scholar
• Sultana F, Reddy Bonam S, Reddy VG, et al. Synthesis of benzo[d]imidazo[2,1-b]thiazole-chalcone conjugates as microtubule targeting and apoptosis inducing agents. Bioorg Chem 2018;76:1–12.
   PubMed Web of Science ®Google Scholar
• Wang X, He Q, Wu K, et al. Design, synthesis and activity of novel 2,6-disubstituted purine derivatives, potential small molecule inhibitors of signal transducer and activator of transcription 3. Eur J Med Chem 2019;179:218–32.
   PubMed Web of Science ®Google Scholar
• Ivanova T, Zouridis H, Wu Y, et al. Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer. Gut 2013;62:22–33.
   PubMed Web of Science ®Google Scholar
• Kawk SH, Kang YR, Kim YH. 1,2,3,4,6-Penta-O-galloyl-β-d-glucose suppresses colon cancer through induction of tumor suppressor. Bioorg Med Chem Lett 2018;28:2117–23.
   PubMed Web of Science ®Google Scholar
• Huang G, Dong JY, Zhang QJ, et al. Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. Eur J Med Chem 2019;165:160–71.
   PubMed Web of Science ®Google Scholar
• Huang X, Zhang Z, Jia L, et al. Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. Cancer Lett 2010;296:123–31.
   PubMed Web of Science ®Google Scholar
• Wang S, Liu Q, Zhang Y, et al. Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol Cancer 2009;8:81.
   PubMed Web of Science ®Google Scholar
• Cao Q, Li YY, He WF, et al. Interplay between microRNAs and the STAT3 signaling pathway in human cancers. Physiol Genomics 2013;45:1206–14.
   PubMed Web of Science ®Google Scholar
• Becker S, Groner B, Müller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998;394:145–51.
   PubMed Web of Science ®Google Scholar