1,082
Views
0
CrossRef citations to date
0
Altmetric
Research Paper

Different chemical proteomic approaches to identify the targets of lapatinib

, , , , , & show all
Article: 2183809 | Received 02 Dec 2022, Accepted 19 Feb 2023, Published online: 01 Mar 2023

References

  • Conradt L, Godl K, Schaab C, Tebbe A, Eser S, Diersch S, Michalski CW, Kleeff J, Schnieke A, Schmid RM, et al. Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma. Neoplasia. 2011;13(11):1026–1034.
  • Bantscheff M, Scholten A, Heck AJR. Revealing promiscuous drug–target interactions by chemical proteomics. Drug Discov Today. 2009;14(21–22):1021–1029.
  • Bantscheff M, Drewes G. Chemoproteomic approaches to drug target identification and drug profiling. Bioorg Med Chem. 2012;20(6):1973–1978.
  • Wang K, Yang T, Wu Q, Zhao X, Nice EC, Huang C. Chemistry-based functional proteomics for drug target deconvolution. Expert Rev Proteomics. 2012;9(3):293–310.
  • Sutton CW. The role of targeted chemical proteomics in pharmacology. Br J Pharmacol. 2012;166(2):457–475.
  • Leslie BJ, Hergenrother PJ. Identification of the cellular targets of bioactive small organic molecules using affinity reagents. Chem Soc Rev. 2008;37(7):1347–1360.
  • Hatanaka Y. Development and leading-edge application of innovative photoaffinity labeling. Chem Pharm Bull. 2015;63(1):1–12.
  • Robinette D, Neamati N, Tomer KB, Borchers CH. Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics. Expert Rev Proteomics. 2006;3(4):399–408.
  • Lapinsky DJ. Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry. Bioorg Med Chem. 2012;20(21):6237–6247.
  • Kool J, Jonker N, Irth H, Niessen WMA. Studying protein-protein affinity and immobilized ligand-protein affinity interactions using MS-based methods. Anal Bioanal Chem. 2011;401(4):1109–1125.
  • Petrov KG, Zhang Y-M, Carter M, Cockerill GS, Dickerson S, Gauthier CA, Guo Y, Mook RA, Rusnak DW, Walker AL, et al. Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series. Bioorg Med Chem Lett. 2006;16(17):4686–4691.
  • Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Therapeut. 2001;1:85–94.
  • Yamaura K, Kuwata K, Tamura T, Kioi Y, Takaoka Y, Kiyonaka S, Hamachi I. Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry. Chem Commun. 2014;50(91):14097–14100.
  • Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, et al. A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib). Cancer Res. 2004;64(18):6652–6659.
  • Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature. 1984;309(5967):418–425.
  • Wiley SH. Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system. J Cell Biol. 1988;107(2):801–810.
  • Rix U, Superti-Furga G. Target profiling of small molecules by chemical proteomics. Nat Chem Biol. 2009;5(9):616–624.
  • Hwang H‐Y, Kim TY, Szász MA, Dome B, Malm J, Marko‐Varga G, Kwon HJ. Profiling the protein targets of unmodified bio‐active molecules with drug affinity responsive target stability and liquid chromatography/tandem mass spectrometry. Proteomics. 2020;20(9):1900325.
  • Meissner F, Geddes-McAlister J, Mann M, Bantscheff M. The emerging role of mass spectrometry-based proteomics in drug discovery. Nat Rev Drug Discov. 2022;21(9):637–654.
  • Nujić K, Smith M, Lee M, Belamarić D, Tomašković L, Alihodžić S, Malnar I, Polančec D, Schneider K, Eraković Haber V, et al. Valosin containing protein (VCP) interacts with macrolide antibiotics without mediating their anti-inflammatory activities. Eur J Pharmacol. 2012;677(1–3):163–172.
  • Shevchenko A, Wilm M, Vorm O, Mann M. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Anal Chem. 1996;68(5):850–858.