Dihydroartemisinin enhances the anti-tumour effect of photodynamic therapy by targeting PKM2-mediated glycolysis in oesophageal cancer cell

References

• Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48.
   PubMed Web of Science ®Google Scholar
• Ma L, Yao N, Chen P, Zhuang Z. TRIM27 promotes the development of esophagus cancer via regulating PTEN/AKT signaling pathway. Cancer Cell Int. 2019;19(1):283.
   PubMed Web of Science ®Google Scholar
• Wang L, Zhang Z, Yu X, Li Q, Wang Q, Chang A, Huang X, Han X, Song Y, Hu J, et al. SOX9/miR-203a axis drives PI3K/AKT signaling to promote esophageal cancer progression. Cancer Lett. 2020;468:14–26.
   PubMed Web of Science ®Google Scholar
• Valli F, García Vior MC, Roguin LP, Marino J. Crosstalk between oxidative stress-induced apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma. Free Radic Biol Med. 2020;152:743–754.
   PubMed Web of Science ®Google Scholar
• Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, et al. Photodynamic therapy of cancer: An update. CA Cancer J Clin. 2011;61(4):250–281.
   PubMed Web of Science ®Google Scholar
• Wu H, Minamide T, Yano T. Role of photodynamic therapy in the treatment of esophageal cancer. Dig Endosc. 2019;31(5):508–516.
   PubMed Web of Science ®Google Scholar
• Li X, Lovell JF, Yoon J, Chen X. Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol. 2020;17(11):657–674.
   PubMed Web of Science ®Google Scholar
• Li L-b, Xie J-m, Zhang X-n, Chen J-z, Luo Y-l, Zhang L-y, Luo R-c. Retrospective study of photodynamic therapy vs photodynamic therapy combined with chemotherapy and chemotherapy alone on advanced esophageal cancer. Photodiagnosis Photodyn Ther. 2010;7(3):139–143.
   PubMed Web of Science ®Google Scholar
• Weijer R, Clavier S, Zaal EA, Pijls MME, van Kooten RT, Vermaas K, Leen R, Jongejan A, Moerland PD, van Kampen AHC, et al. Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy. Cell Mol Life Sci. 2017;74(6):1133–1151.
   PubMed Web of Science ®Google Scholar
• Tang Y, Bisoyi HK, Chen X‐M, Liu Z, Chen X, Zhang S, Li Q. Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer. Adv Mater. 2023;35(25):2300232.
   Web of Science ®Google Scholar
• Gan J, Li S, Meng Y, Liao Y, Jiang M, Qi L, Li Y, Bai Y. The influence of photodynamic therapy on the Warburg effect in esophageal cancer cells. Lasers Med Sci. 2020;35(8):1741–1750.
   PubMed Web of Science ®Google Scholar
• Guo J, Xue Q, Liu K, Ge W, Liu W, Wang J, Zhang M, Li Q-Y, Cai D, Shan C, et al. Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis. Front Oncol. 2019;9:993.
   PubMed Web of Science ®Google Scholar
• Graham TA, Sottoriva A. Measuring cancer evolution from the genome: Measuring cancer evolution. J Pathol. 2017;241(2):183–191.
   PubMed Web of Science ®Google Scholar
• Li S, Huang P, Gan J, Ling X, Du X, Liao Y, Li L, Meng Y, Li Y, Bai Y, et al. Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2. Eur J Pharmacol. 2019;854:232–239.
   PubMed Web of Science ®Google Scholar
• Zhang X, Cai L, He J, Li X, Li L, Chen X, Lan P. Influence and mechanism of 5-aminolevulinic acid-photodynamic therapy on the metastasis of esophageal carcinoma. Photodiagnosis Photodyn Ther. 2017;20:78–85.
   PubMed Web of Science ®Google Scholar
• Bose S, Le A. Glucose Metabolism in Cancer. The Heterogeneity of Cancer Metabolism vol. 1063 p. 3–12. Springer International Publishing, 2018.
   Google Scholar
• Ganapathy-Kanniappan S, Geschwind J-FH. Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer. 2013;12:152.
   PubMed Web of Science ®Google Scholar
• Hu Q, Qin Y, Ji S, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X, et al. UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer. Cancer Lett. 2019;452:226–236.
   PubMed Web of Science ®Google Scholar
• Wiese EK, Hitosugi T. Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect. Front Cell Dev Biol. 2018;6:79.
   PubMed Web of Science ®Google Scholar
• Pustylnikov S, Costabile F, Beghi S, Facciabene A. Targeting mitochondria in cancer: current concepts and immunotherapy approaches. Transl Res. 2018;202:35–51.
   PubMed Web of Science ®Google Scholar
• Zhao X, Liu J, Fan J, Chao H, Peng X. Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application. Chem Soc Rev. 2021;50(6):4185–4219.
   PubMed Web of Science ®Google Scholar
• Xu J, Yu S, Wang X, Qian Y, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, et al. High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy. ACS Nano. 2019;13(9):10242–10260.
   PubMed Web of Science ®Google Scholar
• Li YJ, Zhou JH, Du XX, Jia DX, Wu CL, Huang P, Han Y, Sui H, Wei XL, Liu L, et al. Dihydroartemisinin Accentuates the Anti-Tumor Effects of Photodynamic Therapy via Inactivation of NF-κB in Eca109 and Ec9706 Esophageal Cancer Cells. Cell Physiol Biochem. 2014;33(5):1527–1536.
   PubMedGoogle Scholar
• Li X, Ba Q, Liu Y, Yue Q, Chen P, Li J, Zhang H, Ying H, Ding Q, Song H, et al. Dihydroartemisinin selectively inhibits PDGFRα-positive ovarian cancer growth and metastasis through inducing degradation of PDGFRα protein. Cell Discov. 2017;3(1):17042.
   PubMedGoogle Scholar
• Tennant DA. PK-M2 Makes Cells Sweeter on HIF1. Cell. 2011;145(5):647–649.
   PubMed Web of Science ®Google Scholar
• Dayton TL, Jacks T, Vander Heiden MG. PKM 2, cancer metabolism, and the road ahead. EMBO Rep. 2016;17(12):1721–1730.
   PubMed Web of Science ®Google Scholar
• Dong G, Mao Q, Xia W, Xu Y, Wang J, Xu L, Jiang F. PKM2 and cancer: The function of PKM2 beyond glycolysis. Oncol Lett. 2016;11(3):1980–1986.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Deng X, Liu Y, Liu Y, Sun L, Chen F. PKM2, function and expression and regulation. Cell Biosci. 2019;9(1):52.
   PubMedGoogle Scholar
• Xu Q, Tu J, Dou C, Zhang J, Yang L, Liu X, Lei K, Liu Z, Wang Y, Li L, et al. HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma. Mol Cancer. 2017;16(1):178.
   PubMedGoogle Scholar
• Tamada M, Suematsu M, Saya H. Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells. Clin Cancer Res. 2012;18(20):5554–5561.
   PubMed Web of Science ®Google Scholar
• Liu F, Ma F, Wang Y, Hao L, Zeng H, Jia C, Wang Y, Liu P, Ong IM, Li B, et al. PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis. Nat Cell Biol. 2017;19(11):1358–1370.
   PubMed Web of Science ®Google Scholar
• Israelsen WJ, Vander Heiden MG. Pyruvate kinase: Function, regulation and role in cancer. Semin Cell Dev Biol. 2015;43:43–51.
   PubMed Web of Science ®Google Scholar