1,117
Views
0
CrossRef citations to date
0
Altmetric
Original Research

A clinical and economic assessment of adjuvanted trivalent versus standard egg-derived quadrivalent influenza vaccines among older adults in the United States during the 2018-19 and 2019-20 influenza seasons

, , , , , & show all
Pages 124-136 | Received 09 Aug 2023, Accepted 06 Dec 2023, Published online: 19 Dec 2023

References

  • Czaja CA, Miller L, Alden N, et al. Age-related differences in hospitalization rates, clinical presentation, and outcomes among older adults hospitalized with influenza-U.S. Influenza hospitalization surveillance network (FluSurv-NET). Open Forum Infect Dis. 2019;6(7):ofz225. doi: 10.1093/ofid/ofz225
  • Estimated flu-related illnesses, medical visits, hospitalizations, and deaths in the United States — 2018–2019 flu season. Atlanta (GA): Centers for Disease Control and Prevention; 2021 [cited 2022 Dec 13]. Available from: https://www.cdc.gov/flu/about/burden/2018-2019.html
  • Estimated flu-related illnesses, medical visits, hospitalizations, and deaths in the United States — 2019–2020 flu season. Atlanta (GA): Centers for Disease Control and Prevention; 2022 [cited 2022 Dec 13]. Available from: https://www.cdc.gov/flu/about/burden/2019-2020.html
  • Glezen WP, Greenberg SB, Atmar RL, et al. Impact of respiratory virus infections on persons with chronic underlying conditions. JAMA. 2000;283(4):499–505. doi: 10.1001/jama.283.4.499
  • McElhaney JE. The unmet need in the elderly: designing new influenza vaccines for older adults. Vaccine. 2005;23(Suppl 1):S10–S25. doi: 10.1016/j.vaccine.2005.04.019
  • Grohskopf LA, Blanton LH, Ferdinands JM, et al. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices - United States, 2022-23 influenza season. MMWR Recomm Rep. 2022;71(1):1–28. doi: 10.15585/mmwr.rr7101a1
  • Demicheli V, Jefferson T, Di Pietrantonj C, et al. Vaccines for preventing influenza in the elderly. Cochrane Database Syst Rev. 2018;2(2): CD004876. doi: 10.1002/14651858.CD004879.pub5
  • Targonski PV, Jacobson RM, Poland GA. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine. 2007;25(16):3066–3069. doi: 10.1016/j.vaccine.2007.01.025
  • Goronzy JJ, Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nat Immunol. 2013;14(5):428–436. doi: 10.1038/ni.2588
  • Andrew MK, Shinde V, Ye L, et al. The importance of frailty in the assessment of influenza vaccine effectiveness against influenza-related hospitalization in elderly people. J Infect Dis. 2017;216(4):405–414. doi: 10.1093/infdis/jix282
  • Rondy M, El Omeiri N, Thompson MG, et al. Effectiveness of influenza vaccines in preventing severe influenza illness among adults: a systematic review and meta-analysis of test-negative design case-control studies. J Infect. 2017;75(5):381–394. doi: 10.1016/j.jinf.2017.09.010
  • Grohskopf LA, Alyanak E, Broder KR, et al. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices - United States, 2019-20 influenza season. MMWR Recomm Rep. 2019;68(3):1–21. doi: 10.15585/mmwr.rr6803a1
  • Grohskopf LA, Sokolow LZ, Broder KR, et al. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices-United States, 2018-19 influenza season. MMWR Recomm Rep. 2018;67(3):1–20. doi: 10.15585/mmwr.rr6703a1
  • Frey SE, Reyes MR, Reynales H, et al. Comparison of the safety and immunogenicity of an MF59®-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects. Vaccine. 2014;32(39):5027–5034. doi: 10.1016/j.vaccine.2014.07.013
  • Nicolay U, Heijnen E, Nacci P, et al. Immunogenicity of aIIV3, MF59-adjuvanted seasonal trivalent influenza vaccine, in older adults ≥65 years of age: Meta-analysis of cumulative clinical experience. Int J Infect Dis. 2019;85:S1–S9. doi: 10.1016/j.ijid.2019.03.026
  • Boikos C, Fischer L, O’Brien D, et al. Relative effectiveness of adjuvanted trivalent inactivated influenza vaccine versus egg-derived quadrivalent inactivated influenza vaccines and high-dose trivalent influenza vaccine in preventing influenza-related medical encounters in US adults ≥ 65 years during the 2017-2018 and 2018-2019 influenza seasons. Clin Infect Dis. 2021;73(5):816–823. doi: 10.1093/cid/ciab152
  • Boikos C, Imran M, Nguyen VH, et al. Effectiveness of the adjuvanted influenza vaccine in older adults at high risk of influenza complications. Vaccines (Basel). 2021;9(8):862. doi: 10.3390/vaccines9080862
  • Izurieta HS, Chillarige Y, Kelman J, et al. Relative effectiveness of influenza vaccines among the United States elderly, 2018-2019. J Infect Dis. 2020;222(2):278–287. doi: 10.1093/infdis/jiaa080
  • Izurieta HS, Lu M, Kelman J, et al. Comparative effectiveness of influenza vaccines among US medicare beneficiaries ages 65 years and older during the 2019-2020 season. Clin Infect Dis. 2021;73(11):e4251–e4259. doi: 10.1093/cid/ciaa1727
  • Pelton SI, Divino V, Shah D, et al. Evaluating the relative vaccine effectiveness of adjuvanted trivalent influenza vaccine compared to high-dose trivalent and other egg-based influenza vaccines among older adults in the US during the 2017-2018 influenza season. Vaccines (Basel). 2020;8(3):446. doi: 10.3390/vaccines8030446
  • Coleman BL, Sanderson R, Haag MDM, et al. Effectiveness of the MF59-adjuvanted trivalent or quadrivalent seasonal influenza vaccine among adults 65 years of age or older, a systematic review and meta-analysis. Influenza Other Respir Viruses. 2021;15(6):813–823. doi: 10.1111/irv.12871
  • Van Aalst R, Gravenstein S, Mor V, et al. Economic assessment of high-dose versus adjuvanted influenza vaccine: an evaluation of hospitalization costs based on a cohort study. Vaccines (Basel). 2021;9(10):1065. doi: 10.3390/vaccines9101065
  • Austin PC, Stuart EA. Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Stat Med. 2015;34(28):3661–3679. doi: 10.1002/sim.6607
  • Pelton SI, Divino V, Postma MJ, et al. A retrospective cohort study assessing relative effectiveness of adjuvanted versus high-dose trivalent influenza vaccines among older adults in the United States during the 2018-19 influenza season. Vaccine. 2021;39(17):2396–2407. doi: 10.1016/j.vaccine.2021.03.054
  • Levin MJ, Divino V, Shah D, et al. Comparing the clinical and economic outcomes associated with adjuvanted versus high-dose trivalent influenza vaccine among adults aged ≥ 65 years in the US during the 2019-20 influenza season-a retrospective cohort analysis. Vaccines (Basel). 2021;9(10):1146. doi: 10.3390/vaccines9101146
  • Huse D, Russo P, Vasey J. Expanding the evidence base in outcomes research: linking electronic medical records and claims data. ISPOR Connections. 2013;19(3):5–7.
  • Dawood FS, Chung JR, Kim SS, et al. Interim estimates of 2019-20 seasonal influenza vaccine effectiveness - United States, February 2020. MMWR Morb Mortal Wkly Rep. 2020;69(7):177–182. doi: 10.15585/mmwr.mm6907a1
  • Xu X, Blanton L, Elal AIA, et al. Update: influenza activity in the United States during the 2018-19 season and composition of the 2019-20 influenza vaccine. MMWR Morb Mortal Wkly Rep. 2019;68(24):544–551. doi: 10.15585/mmwr.mm6824a3
  • Influenza-like illness, code set B. Falls Church (VA): US Armed Forces health Surveillance center; 2015 [cited 2023 Jul 25]. Available from: https://health.mil/Reference-Center/Publications/2015/10/01/Influenza-Like-Illness
  • Romano PS, Roos LL, Jollis JG. Presentation adapting a clinical comorbidity index for use with ICD-9-CM administrative data: differing perspectives. J Clin Epidemiol. 1993;46(10):1075–1079. discussion 1081–1090. doi: 10.1016/0895-4356(93)90103-8
  • Nuttall M, van der Meulen J, Emberton M. Charlson scores based on ICD-10 administrative data were valid in assessing comorbidity in patients undergoing urological cancer surgery. J Clin Epidemiol. 2006;59(3):265–273. doi: 10.1016/j.jclinepi.2005.07.015
  • Cost-to-charge ratio for inpatient files. Rockville (MD): Agency for Healthcare Research and Quality; 2021 [cited 2023 Jul 25]. Available from: https://hcup-us.ahrq.gov/db/ccr/ip-ccr/ip-ccr.jsp.
  • Centers for Medicare and Medicaid Services. Medicare CY 2019 outpatient prospective payment system (OPPS) final rule claims accounting. (MD) United States: Centers for Medicare and Medicaid Services; 2019.
  • Thoemmes F, Ong AD. A primer on inverse probability of treatment weighting and marginal structural models. Emerg Adulthood. 2015;4(1):40–59. doi: 10.1177/2167696815621645
  • Austin PC. Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med. 2009;28(25):3083–3107. doi: 10.1002/sim.3697
  • ReimbursementCodes features. RJ Health; [cited 2022 Dec 14]. Available from: https://www.reimbursementcodes.com/
  • Lozalojo/Mem: second release of the MEM R library (v2.0). Lozano J. 2016 [cited 2022 Dec 14]. Available from. 10.5281/zenodo.165983
  • Malosh RE, McGovern I, Monto AS. Influenza during the 2010-2020 decade in the United States: seasonal outbreaks and vaccine interventions. Clin Infect Dis. 2023;76(3):540–549. doi: 10.1093/cid/ciac653
  • Loong D, Pham B, Amiri M, et al. Systematic review on the cost-effectiveness of seasonal influenza vaccines in older adults. Value Health. 2022;25(8):1439–1458. doi: 10.1016/j.jval.2022.03.011
  • Olsen SJ, Azziz-Baumgartner E, Budd AP, et al. Decreased influenza activity during the COVID-19 pandemic-United States, Australia, Chile, and South Africa, 2020. Am J Transplant. 2020;20(12):3681–3685. doi: 10.1111/ajt.16381
  • Ansaldi F, Zancolli M, Durando P, et al. Antibody response against heterogeneous circulating influenza virus strains elicited by MF59- and non-adjuvanted vaccines during seasons with good or partial matching between vaccine strain and clinical isolates. Vaccine. 2010;28(25):4123–4129. doi: 10.1016/j.vaccine.2010.04.030
  • O’Hagan DT, Ott GS, De Gregorio E, et al. The mechanism of action of MF59 - an innately attractive adjuvant formulation. Vaccine. 2012;30(29):4341–4348. doi: 10.1016/j.vaccine.2011.09.061
  • Grohskopf LA, Alyanak E, Broder KR, et al. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices - United States, 2020-21 influenza season. MMWR Recomm Rep. 2020;69(8):1–24. doi: 10.15585/mmwr.rr6908a1
  • Ambrose CS, Levin MJ. The rationale for quadrivalent influenza vaccines. Hum Vaccin Immunother. 2012;8(1):81–88. doi: 10.4161/hv.8.1.17623