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Original Article

Methylenetetrahydrofolate reductase 677 C→T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women

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Pages 337-344 | Received 10 Sep 2003, Accepted 29 Dec 2003, Published online: 24 May 2010

  • Rajkovic A, Catalano PM, Malinow MR. Elevated homocyst(e)ine levels with preeclampsia. Obstet Gynecol 1997;90:168–71
  • Rajkovic A, Mahomed K, Malinow MR, et al. Plasma homocyst(e)ine concentrations in eclamptic and preeclamptic African women postpartum. Obstet Gynecol 1999;94: 355–60
  • Sorensen TK, Malinow MR, Williams MA, et al. Elevated second-trimester serum homocyst(e)ine levels and subsequent risk of preeclampsia. Gynecol Obstet Invest 1999;48: 98–103
  • Powers RW, Evans RW, Majors AK, et al. Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am J Obstet Gynecol 1998;179:1605–11
  • Dekker GA, de Vries JIP, Doelitzsch PM, et al. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 1995;173:1042–8
  • Malinow MR. Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis. Circulation 1990;81:2004–6
  • Den Heijer M, Koster T, Blom HJ, et al. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. New Engl J Med 1996;334:759–62
  • Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease. J Am Med Assoc 1997;277:1775–81
  • Moghadasian MH, McManus BM, Frohlich JJ. Homocysteine and coronary artery disease. Arch Intern Med 1997;157:2299–308
  • Heinecke JW, Rosen H, Suzuki LA, Chait A. The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. J Biol Chem 1987;262:10098–103
  • Welch GN, Upchurch GR Jr, Farivar RS, et al. Homocysteineinduced nitric oxide production in vascular smooth muscle cells by NF-kb dependent transcriptional activation of Nos2. Proc Assoc Am Physicians 1998;110:22–31
  • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111–13
  • Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase and plasma homocysteine concentrations. Circulation 1996;93:7–9
  • Kluijtmans LA, van den Heuvel LP, Boers GH, et al. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 1996;58:35–41
  • Gallagher PM, Meleady R, Shields DC, et al. Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation. Circulation 1996;94:2154–8
  • Sohda S, Arinami T, Hamada H, et al. Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet 1997;34:525–6
  • Grandone E, Margaglione M, Colaizzo D, et al. Factor V Leiden, C?T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost 1997;77:1052–4
  • Powers RW, Minich LA, Lykins DL, et al. Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia. J Soc Gynecol Investig 1999;6:74–9
  • Rajkovic A, Mahomed K, Rozen R, et al. Methylenetetrahydrofolate reductase 677 C?T polymorphism, plasma folate, vitamin B12 concentrations, and risk of preeclampsia among Black African women from Zimbabwe. Mol Genet Metab 2000;69:33–9
  • Chikosi AB, Moodley J, Pegoraro RJ, et al. 5,10 Methylenetetrahydrofolate reductase polymorphism in black South African women with pre-eclampsia. Br J Obstet Gynaecol 1999;106:1219–20
  • Kaiser T, Brennecke SP, Moses EK. C677T methylenetetrahydrofolate reductase polymorphism is not a risk factor for pre-eclampsia/eclampsia among Australian women. Hum Hered 2001;51: 20–2
  • Kaiser T, Brennecke SP, Moses EK. Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for preeclampsia/ eclampsia in Australian women. Gynecol Obstet Invest 2000;50:100–2
  • Kim YJ, Williamson RA, Murray JC, et al. Genetic susceptibility to preeclampsia: roles of cytosineto-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathionine beta-synthase, and factor V Leiden mutation. Am J Obstet Gynecol 2001;184:1211–17
  • Kobashi G, Yamada H, Asano T, et al. Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women. Am J Med Genet 2000;93:122–5
  • Murakami S, Matsubara N, Saitoh M, et al. The relation between plasma homocysteine concentration and methylenetetrahydrofolate reductase gene polymorphism in pregnant women. J Obstet Gynaecol Res 2001;27:349–52
  • Murphy RP, Donoghue C, Nallen RJ, et al. Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy. Arterioscler Thromb Vasc Biol 2000;20:266–70
  • O’Shaughnessy KM, Fu B, Ferraro F, et al. Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort. Hypertension 1999;33:1338–41
  • Prasmusinto D, Skrablin S, Hofstaetter C, et al. The methylenetetrahydrofolate reductase 677 C?T polymorphism and preeclampsia in two populations. Obstet Gynecol 2002;99:1085–92
  • Raijmakers MT, Zusterzeel PL, Steegers EA, Peters WH. Hyperhomocysteinaemia: a risk factor for preeclampsia? Eur J Obstet Gynecol Reprod Biol 2001;95:226–8
  • Rigo J Jr, Nagy B, Fintor L, et al. Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase. Hypertens Pregnancy 2000;19:163–72
  • Zusterzeel PL, Visser W, Blom HJ, et al. Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome. Hypertens Pregnancy 2000;19: 299–307
  • Ware-Jauregui S, Sanchez SE, Zhang C, et al. Plasma lipid concentrations in preeclamptic and normotensive Peruvian women. Int J Gynecol Obstet 1999;67:147–55
  • Sanchez SE, Zhang C, Malinow MR, et al. Plasma folate, vitamin B12 and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women. Am J Epidemiol 2001;153:474–80
  • Zhang C, Williams MA, Sanchez SE, et al. Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women. Am J Epidemiol 2001;153:572–80.
  • American College of Obstetricians and Gynecologists .Hypertension in pregnancy. ACOG Tech Bull 1996;219:1–8
  • Rothman KJ, Greenland S. Modern Epidemiology, 2nd edn. Philadelphia, PA: Lippincott-Raven, 1998
  • Tiret L, Cambien F. Departure from Hardy-Weinberg equilibrium should be systematically tested in studies of association between genetic markers and disease. Circulation 1995;92:3364–5
  • Speer MC. Basics concepts in genetic. In Haines JL, Pericak MA, eds. Approaches to Gene Mapping in Complex Human Diseases. New York, NY: John Wiley & Sons, Inc., 1998:17–52
  • Schaid DJ, Jacobsen SJ. Biased tests of association: comparison of allele frequencies when departing from Hardy- Weinberg proportions. Am J Epidemiol 1999;149:706–11
  • Pepe G, Camacho Vanegas O, et al. Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10- methylenetetrahydrofolate reductase. Am J Hum Genet 1998;63:917–20
  • Schneider JA, Rees DC, Liu YT, Clegg JB. Worldwide distribution of a common methylenetetrahydrofolate reductase mutation. Am J Hum Genet 1998;62:1258–60
  • Stevenson RE, Schwartz CE, Du YZ, Adams MJ Jr. Differences in methylenetetrahydrofolate reductase genotype frequencies, between Whites and Blacks. Am J Hum Genet 1997;60:229–30
  • Chesley LC, Annitto JE, Cosgrove RA. The remote prognosis of eclamptic women. Am J Obstet Gynecol 1976;124:446–59
  • Fisher K, Luger K, Spargo BH, Lindheimer MD. Hypertension in pregnancy: clinical-pathological correlations and late prognosis. Medicine (Baltimore) 1981;60:267–76
  • Jonsdottir LS, Arngrimsson R, Geirsson RT, et al. Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstet Gynecol Scand 1995;74:772–6

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