Unopposed appetite (orexigenic) mechanisms in the near-term ovine fetus: central leptin does not inhibit sucrose ingestion

References

• Bradley RL, Cleveland KA, Cheatham B. The adipocyte as a secretory organ: mechanisms of vesicle transport and secretory pathways. Recent Prog Horm Res 2001;56:329–58
   Google Scholar
• Ioffe E, Moon B, Connolly E, Friedman JM. Abnormal regulation of the leptin gene in the pathogenesis of obesity. Proc Natl Acad Sci USA 1998;95:11852–7
   PubMed Web of Science ®Google Scholar
• Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1: 1155–61
   PubMed Web of Science ®Google Scholar
• Ahima RS, Kelly J, Elmquist JK, Flier JS. Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology 1999;140:4923–31
   PubMed Web of Science ®Google Scholar
• Elias CF, Aschkenasi C, Lee C, et al. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 1999;23:775–86
   PubMed Web of Science ®Google Scholar
• Williams G, Bing C, Cai XJ, et al. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav 2001;74:683–701
   PubMed Web of Science ®Google Scholar
• Cowley MA, Smart JL, Rubinstein M, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001;411:480–4
   PubMed Web of Science ®Google Scholar
• Ninomiya Y, Shigemura N, Yasumatsu K, et al. Leptin and sweet taste. Vitam Harm 2002;64:221–48
   PubMed Web of Science ®Google Scholar
• Blache D, Celi P, Blackberry MA, et al. Decrease in voluntary feed intake and pulsatile luteinizing hormone secretion after intracerebroventricular infusion of recombinant bovine leptin in mature male sheep. Reprod Fertil Dev 2000;12: 373–81
   PubMed Web of Science ®Google Scholar
• Stehling O, Doring H, Ertl J, et al. Leptin reduces juvenile fat stores by altering the circadian cycle of energy expenditure. Am J Physiol 1996;271:R1770–4
   PubMed Web of Science ®Google Scholar
• Wirth JB, Epstein AN. Ontogeny of thirst in the infant rat. Am J Physiol 1976;230:188–98
   PubMed Web of Science ®Google Scholar
• Ahima RS, Hileman SM. Postnatal regulation of hypotha-lamic neuropeptide expression by leptin: implications for energy balance and body weight regulation. Regul Pept 2000;92:1–7
   PubMed Web of Science ®Google Scholar
• Mistry AM, Swick A, Romsos DR. Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice. Am J Physiol 1999;277:R742–7
   Google Scholar
• Ross MG, Kullama LK, Ogundipe A, et al. Ovine fetal swallowing response to intracerebroventricular hypertonic saline. J Appl Physiol 1995;78:2267–71
   PubMed Web of Science ®Google Scholar
• Roberts TJ, Caston-Balderrama A, Nijland MJ, Ross MG. Central neuropeptide Y stimulates ingestive behavior and increases urine output in the ovine fetus. Am J Physiol Endocrinol Metab 2000;279:E494–500
   PubMed Web of Science ®Google Scholar
• El-Haddad MA, Ismail Y, Guerra C, et al. Oral sucrose stimulates ingestive behavior in near term ovine fetus. Am J Obstet Gynecol 2002;187:898–901
   Google Scholar
• Jhanwar-Uniyal M, Beck B, Jhanwar YS, et al. Neuropeptide Y projection from arcuate nucleus to parvocellular division of paraventricular nucleus: specific relation to the ingestion of carbohydrate. Brain Res 1993;631:97–106
   Google Scholar
• Roberts TJ, Nijland MJ, Caston-Balderrama A, Ross MG. Central leptin stimulates ingestive behavior and urine flow in the near term ovine fetus. Horm Metab Res 2001;33:144–50
   Google Scholar
• Fujino Y, Agnew CL, Schreyer P, et al. Amniotic fluid volume response to esophageal occlusion in fetal sheep. Am J Obstet Gynecol 1991;165:1620–6
   PubMed Web of Science ®Google Scholar
• Ross MG, Dodd A, Agnew C, et al. Ovine fetal swallowing and behavioral state responses to sublingual water. Biol Neonate 1993;64:127–33
   PubMedGoogle Scholar
• Robillard JE, Weitzman RE. Developmental aspects of the fetal renal response to exogenous arginine vasopressin. Am J Physiol 1980;238:F407–14
   PubMed Web of Science ®Google Scholar
• Schwartz MW, Seeley RJ, Campfield LA, et al. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996;98:1101–6
   PubMed Web of Science ®Google Scholar
• Meek JL, Neff NH. Is cerebrospinal fluid the major avenue for the removal of 5-hydroxyindoleacetic acid from the brain? Neuropharmacology 1973;12:497–9
   PubMed Web of Science ®Google Scholar
• Evans, CAN, Reynolds JM, Reynolds ML, et al. The development of a blood-brain barrier mechanism in foetal sheep. J Physiol (Lond) 1974;238:371–8
   Google Scholar
• El-Haddad MA, Ismail Y, Guerra C, et al. Neuropeptide Y administered into cerebral ventricles stimulates sucrose ingestion in the near-term ovine fetus. Am J Obstet Gynecol 2003;189:949–52
   Google Scholar
• Sherman DJ, Ross MG, Day L, Ervin MG. Fetal swallowing: correlation of electromyography and esophageal fluid flow. Am J Physiol 1990;258:R1386–94
   PubMedGoogle Scholar
• Sivitz I, Walsh A, Morgan DA, et al. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997;138:3395–401
   PubMed Web of Science ®Google Scholar
• Chan K, Dodd PA, Day L, et al. Fetal catecholamine, cardiovascular, and neurobehavioral responses to cocaine. Am J Obstet Gynecol 1992;167:1616–23
   PubMed Web of Science ®Google Scholar
• Lin J, Barb CR, Kraeling RR, Rampacek GB. Developmental changes in the long form leptin receptor and related neuropeptide gene expression in the pig brain. Biol Reprod 2001;64:1614–18
   PubMed Web of Science ®Google Scholar
• Matsuda J, Ichiro Y, Yoshihiro T, et al. Developmental changes in long-form leptin receptor expression and localiza-tion in rat brain. Endocrinology 1999;140:5233–8
   PubMed Web of Science ®Google Scholar
• Henry BA, Goding JW, Alexander WS, et al. Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function. J End ocrinol 1999;140:1175–82
   Google Scholar
• Tang-Christensen M, Havel PJ, Jacobs RR, et al. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab 1999;84:711–17
   Google Scholar
• Levin N, Nelson C, Gurney A, et al. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 1996;93:1726–30
   PubMed Web of Science ®Google Scholar
• Dunbar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997;46:2040–3
   Google Scholar
• Shek E, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998;31:409–14
   Google Scholar
• Casto RM, VanNess JM, Overton JM. Effects of central leptin administration on blood pressure in normotensive rats. Neurosci Lett 1998;246:29–32
   Google Scholar
• Mitchell JL. Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation? Hypertension 2001;38:1081–6
   PubMed Web of Science ®Google Scholar
• Buchbinder A, Lang U, Baker RS, et al. Leptin in the ovine fetus correlates with fetal and placental size. Am J Obstet Gynecol 2001;185:786–91
   PubMed Web of Science ®Google Scholar
• Yuen BS, McMillen IC, Symonds ME, Owens PC. Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight. J Endocrinol 1999;163:R1–4
   PubMed Web of Science ®Google Scholar
• Yuen BS, Owens PC, McFarlane JR, et al. Circulating leptin concentrations are positively related to leptin messenger RNA expression in the adipose tissue of fetal sheep in the pregnant ewe fed at or below maintenance energy require-ments during late gestation. Biol Reprod 2002;67:911–16
   PubMed Web of Science ®Google Scholar
• Jaquet D, Leger J, Levy-Marchal C, et al. Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations. J Clin Endocrinol Metab 1998;83:1243–6
   Google Scholar
• Schubring C, Keiss W, Englaro P, et al. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J Clin Endocrinol Metab 1997;82:1480–3
   PubMed Web of Science ®Google Scholar
• Legradi G, Emerson CH, Ahima RS, et al. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hor-mone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997;138:2569–76
   PubMed Web of Science ®Google Scholar
• Ahima RS, Bjorbaek C, Osei S, Flier JS. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 1999;140:2755–62
   PubMed Web of Science ®Google Scholar