Magnesium sulfate effectively reduces blood pressure in an animal model of preeclampsia

References

• Roberts J M, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI Working Group on Research in Hypertension During Pregnancy. Hypertension 2003; 41: 437–445
   PubMed Web of Science ®Google Scholar
• The Eclampsia Trial Collaborative Group. Which anticonvulsant for women with eclampsia? Evidence from the collaborative eclampsia trial. Lancet 1995; 345: 1455–1463
   PubMed Web of Science ®Google Scholar
• Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J, Smith D, Magpie Trial Collaboration Group. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: A randomized placebo-controlled trial. Lancet 2002; 359: 1877–1890
   PubMed Web of Science ®Google Scholar
• Alexander B T, Bennett W A, Khalil R A, Granger J P. Preeclampsia: Linking placental ischemia with cardiovascular- renal dysfunction. News Physiol Sci 2001; 16: 282–286
   PubMedGoogle Scholar
• Khalil R A, Crews J K, Novak J, Kassab S, Granger J P. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats. Hypertension 1998; 31: 1065–1069
   PubMed Web of Science ®Google Scholar
• Buhimschi I A, Shi S Q, Saade G R, Garfield R E. Marked variation in responses to long-term nitric oxide inhibition during pregnancy in outbred rats from two different colonies. Am J Obstet Gynecol 2001; 184: 686–693
   PubMed Web of Science ®Google Scholar
• Molnar M, Suto T, Toth T, Hertelendy F. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia and intrauterine growth retardation. Am J Obstet Gynecol 1994; 170: 1458–1466
   PubMed Web of Science ®Google Scholar
• Zhang Y, Kaufman S. Effect of nitric oxide synthase inhibition on cardiovascular and hormonal regulation during pregnancy in the rat. Can J Physiol Pharmacol 2000; 78: 423–427
   PubMed Web of Science ®Google Scholar
• Standley C A, Whitty J E, Mason B A, Cotton D B. Serum ionized magnesium levels in normal and preeclamptic gestation. Obstet Gynecol 1997; 89: 24–27
   Google Scholar
• Resnick L M. Cellular calcium and magnesium metabolism in the pathophysiology and treatment of hypertension and related metabolic disorders. Am J Med 1992; 93: 11S–20S
   PubMed Web of Science ®Google Scholar
• Walker J J. Pre-eclampsia. Lancet 2000; 356: 1260–1265
   PubMed Web of Science ®Google Scholar
• Dekker G A, Sibai B M. Etiology and pathogenesis of preeclampsia: Current concepts. Am J Obstet Gynecol 1998; 179: 1359–1375
   PubMed Web of Science ®Google Scholar
• Zuspan F P. Preeclampsia. Current therapy in obstetrics and gynecology. 5th ed., E J Quilligan, F R Zuspan. WB Saunders, Philadelphia, USA 2000; 322–325
   Google Scholar
• Roberts J M, Taylor R N, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens 1991; 4: 700–708
   PubMed Web of Science ®Google Scholar
• Roggesnsack A M, Zhang Y, Davidge S T. Evidence for peroxynitrite formation in the vasculature of women with preeclampsia. Hypertension 1999; 33: 83–89
   Google Scholar
• Paller M S. Hypertension in pregnancy. J Am Soc Nephrol 1998; 9: 314–321
   Web of Science ®Google Scholar
• Scardo J A, Hogg B B, Newman R B. Favorable hemodynamic effects of magnesium sulfate in preeclampsia. Am J Obstet Gynecol 1995; 173: 1249–1253
   PubMed Web of Science ®Google Scholar
• Belfort M A, Anthony J, Carrillo J F, DeGrado L, Saade G, Varner M, Dildy G, the Nimodipine Study Group. MgSO4 is an effective antihypertensive agent in preeclampsia. Am J Obstet Gynecol 1999; 180: S56
   Google Scholar
• Lu J, Pfister M, Ferrari P, Chen G, Sheiner L. Pharmacokinetic–pharmacodynamic modeling of magnesium plasma concentration and blood pressure in preeclamptic women. Clin Pharmacokinet 2002; 41: 1105–1113
   PubMed Web of Science ®Google Scholar
• Kh R, Khullar M, Kashyap M, Pandhi P, Uppal R. Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate-induced hypertension in rats. J Hypertens 2000; 18: 919–926
   PubMed Web of Science ®Google Scholar
• Touyz R M, Milne F J. Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats. Am J Hypertens 1999; 12: 757–765
   PubMed Web of Science ®Google Scholar
• Wolf J P, Luthringer C, Berthelot A, Berthelay S. Blood pressure and plasma renin activity after magnesium supplementation in the spontaneously hypertensive rat: A study during development and established hypertension. Magnesium 1987; 6: 243–248
   PubMedGoogle Scholar
• Pandhi P, Saha L, Malhotra S. Effect of oral magnesium supplementation on experimental pre-eclampsia induced by prolonged blockade of nitric oxide synthesis in pregnant rats. Indian J Exp Biol 2002; 40: 349–351
   Google Scholar
• Senturk U K, Kaputlu I, Gunduz F, Kuru O, Gokalp O. Tissue and blood levels of zinc, copper, and magnesium in nitric oxide synthase blockade-induced hypertension. Biol Trace Elem Res 2000; 77: 97–106
   PubMed Web of Science ®Google Scholar
• Altura B M, Altura B T. Role of magnesium in the pathogenesis of hypertension. Relationship to its actions on cardiac and vascular smooth muscle. Hypertension: Pathophysiology, diagnosis and management. 2nd ed., J H Laragh, B M Brenner. Raven Press, New York, NY 1995; 1213–1242
   Google Scholar
• Barton J R, Sibai B M, Ahokas R A, Whybrew W D, Mercer B M. Magnesium sulfate therapy in preeclampsia is associated with increased urinary cyclic guanosine monophosphate excretion. Am J Obstet Gynecol 1992; 167: 931–934
   PubMed Web of Science ®Google Scholar
• Fantel A G, Stamps L D, Tran T T, Mackler B, Person R E, Nekahi N. Role of free radicals in the limb teratogenicity of L-NAME (N G-nitro-l-arginine methyl ester): A new mechanistic model of vascular disruption. Teratol 1999; 60: 151–160
   PubMedGoogle Scholar
• Fantel A G, Nekahi N, Shepard T H, Cornel L M, Unis A S, Lemire R J. The teratogenicity of N(omega)-nitro-l-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, in rats. Reprod Toxicol 1997; 11: 709–717
   PubMed Web of Science ®Google Scholar
• Walsh S W, Romney A D, Wang Y, Walsh M D. Magnesium sulfate attenuates peroxide-induced vasoconstriction in the human placenta. Am J Obstet Gynecol 1998; 178: 7–12
   Google Scholar