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Original Article

Placental growth hormone is increased in the maternal and fetal serum of patients with preeclampsia

, , , , , , , , , & , MD show all
Pages 651-659 | Received 02 Feb 2007, Accepted 27 Apr 2007, Published online: 07 Jul 2009

References

  • Lacroix M C, Guibourdenche J, Fournier T, Laurendeau I, Igout A, Goffin V, Pantel J, Tsatsaris V, Evain-Brion D. Stimulation of human trophoblast invasion by placental growth hormone. Endocrinology 2005; 146: 2434–2444
  • Caufriez A, Frankenne F, Hennen G, Copinschi G. Regulation of maternal IGF-I by placental GH in normal and abnormal human pregnancies. Am J Physiol 1993; 265: E572–577
  • Chellakooty M, Skibsted L, Skouby S O, Andersson A M, Petersen J H, Main K M, Skakkebaek N E, Juul A. Longitudinal study of serum placental GH in 455 normal pregnancies: Correlation to gestational age, fetal gender, and weight. J Clin Endocrinol Metab 2002; 87: 2734–2739
  • Chellakooty M, Vangsgaard K, Larsen T, Scheike T, Falck-Larsen J, Legarth J, Andersson A M, Main K M, Skakkebaek N E, Juul A. A longitudinal study of intrauterine growth and the placental growth hormone (GH)–insulin-like growth factor I axis in maternal circulation: Association between placental GH and fetal growth. J Clin Endocrinol Metab 2004; 89: 384–391
  • Coutant R, de Boux C F, Douay O, Mathieu E, Rouleau S, Beringue F, Gillard P, Limal J M, Descamps P. Relationships between placental GH concentration and maternal smoking, newborn gender, and maternal leptin: Possible implications for birth weight. J Clin Endocrinol Metab 2001; 86: 4854–4859
  • McIntyre H D, Serek R, Crane D I, Veveris-Lowe T, Parry A, Johnson S, Leung K C, Ho K K, Bougoussa M, Hennen G, et al. Placental growth hormone (GH), GH-binding protein, and insulin-like growth factor axis in normal, growth-retarded, and diabetic pregnancies: Correlations with fetal growth. J Clin Endocrinol Metab 2000; 85: 1143–1150
  • Takata K, Kasahara T, Kasahara M, Ezaki O, Hirano H. Localization of erythrocyte/HepG2-type glucose transporter (GLUT1) in human placental villi. Cell Tissue Res 1992; 267: 407–412
  • Barbour L A, Shao J, Qiao L, Pulawa L K, Jensen D R, Bartke A, Garrity M, Draznin B, Friedman J E. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol 2002; 186: 512–517
  • Lacroix M C, Bolifraud P, Durieux D, Pauloin A, Vidaud M, Kann G. Placental growth hormone and lactogen production by perfused ovine placental explants: Regulation by growth hormone-releasing hormone and glucose. Biol Reprod 2002; 66: 555–561
  • Goodman H M, Tai L R, Ray J, Cooke N E, Liebhaber S A. Human growth hormone variant produces insulin-like and lipolytic responses in rat adipose tissue. Endocrinology 1991; 129: 1779–1783
  • MacLeod J N, Worsley I, Ray J, Friesen H G, Liebhaber S A, Cooke N E. Human growth hormone-variant is a biologically active somatogen and lactogen. Endocrinology 1991; 128: 1298–1302
  • Ray J, Okamura H, Kelly P A, Cooke N E, Liebhaber S A. Human growth hormone-variant demonstrates a receptor binding profile distinct from that of normal pituitary growth hormone. J Biol Chem 1990; 265: 7939–7944
  • Selden R F, Wagner T E, Blethen S, Yun J S, Rowe M E, Goodman H M. Expression of the human growth hormone variant gene in cultured fibroblasts and transgenic mice. Proc Natl Acad Sci U S A 1988; 85: 8241–8245
  • Liebhaber S A, Urbanek M, Ray J, Tuan R S, Cooke N E. Characterization and histologic localization of human growth hormone-variant gene expression in the placenta. J Clin Invest 1989; 83: 1985–1991
  • Scippo M L, Frankenne F, Hooghe-Peters E L, Igout A, Velkeniers B, Hennen G. Syncytiotrophoblastic localization of the human growth hormone variant mRNA in the placenta. Mol Cell Endocrinol 1993; 92: R7–13
  • Lacroix M C, Guibourdenche J, Frendo J L, Muller F, Evain-Brion D. Human placental growth hormone—a review. Placenta 2002; 23(Suppl A)S87–94
  • Eriksson L, Frankenne F, Eden S, Hennen G, Von Schoultz B. Growth hormone 24-h serum profiles during pregnancy—lack of pulsatility for the secretion of the placental variant. Br J Obstet Gynaecol 1989; 96: 949–953
  • Caufriez A, Frankenne F, Englert Y, Golstein J, Cantraine F, Hennen G, Copinschi G. Placental growth hormone as a potential regulator of maternal IGF-I during human pregnancy. Am J Physiol 1990; 258: E1014–1019
  • Frankenne F, Closset J, Gomez F, Scippo M L, Smal J, Hennen G. The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant. J Clin Endocrinol Metab 1988; 66: 1171–1180
  • Mirlesse V, Frankenne F, Alsat E, Poncelet M, Hennen G, Evain-Brion D. Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation. Pediatr Res 1993; 34: 439–442
  • Wu Z, Bidlingmaier M, Friess S C, Kirk S E, Buchinger P, Schiessl B, Strasburger C J. A new nonisotopic, highly sensitive assay for the measurement of human placental growth hormone: Development and clinical implications. J Clin Endocrinol Metab 2003; 88: 804–811
  • Evain-Brion D. Hormonal regulation of fetal growth. Horm Res 1994; 42: 207–214
  • Sibai B M, Ewell M, Levine R J, Klebanoff M A, Esterlitz J, Catalano P M, Goldenberg R L, Joffe G. Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group. Am J Obstet Gynecol 1997; 177: 1003–1010
  • Alexander G R, Himes J H, Kaufman R B, Mor J, Kogan M. A United States national reference for fetal growth. Obstet Gynecol 1996; 87: 163–168
  • Hennen G, Frankenne F, Pirens G, Gomez F, Closset J, Schaus C, el Khayat N. New chorionic GH-like antigen revealed by monoclonal antibody radioimmunoassays. Lancet 1985; 1: 399
  • George D L, Phillips J A, III, Francke U, Seeburg P H. The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter. Hum Genet 1981; 57: 138–141
  • Fuglsang J, Ovesen P. Aspects of placental growth hormone physiology. Growth Horm IGF Res 2006; 16: 67–85
  • Cooke N E, Ray J, Emery J G, Liebhaber S A. Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins. J Biol Chem 1988; 263: 9001–9006
  • Struman I, Bentzien F, Lee H, Mainfroid V, D'Angelo G, Goffin V, Weiner R I, Martial J A. Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: An efficient mechanism for the regulation of angiogenesis. Proc Natl Acad Sci U S A 1999; 96: 1246–1251
  • Aggarwal P K, Jain V, Sakhuja V, Karumanchi S A, Jha V. Low urinary placental growth factor is a marker of pre-eclampsia. Kidney Int 2006; 69: 621–624
  • Boutsikou T, Malamitsi-Puchner A, Economou E, Boutsikou M, Puchner K P, Hassiakos D. Soluble vascular endothelial growth factor receptor-1 in intrauterine growth restricted fetuses and neonates. Early Hum Dev 2006; 82: 235–239
  • Chaiworapongsa T, Romero R, Espinoza J, Bujold E, Mee K Y, Goncalves L F, Gomez R, Edwin S. Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Young Investigator Award. Am J Obstet Gynecol 2004; 190: 1541–1547
  • Chaiworapongsa T, Romero R, Kim Y M, Kim G J, Kim M R, Espinoza J, Bujold E, Goncalves L, Gomez R, Edwin S, et al. Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia. J Matern Fetal Neonatal Med 2005; 17: 3–18
  • Crispi F, Dominguez C, Llurba E, Martin-Gallan P, Cabero L, Gratacos E. Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction. Am J Obstet Gynecol 2006; 195: 201–207
  • Espinoza J, Romero R, Nien J K, Kusanovic J P, Richani K, Gomez R, Kim C J, Mittal P, Gotsh F, Erez O, et al. A role of the anti-angiogenic factor sVEGFR-1 in the ‘mirror syndrome’ (Ballantyne's syndrome). J Matern Fetal Neonatal Med 2006; 19: 607–613
  • Espinoza J, Romero R, Nien J K, Gomez R, Kusanovic J P, Goncalves L F, Medina L, Edwin S, Hassan S, Carstens M, et al. Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor. AM J Obstet Gynecol 2007; 196: 326, E1–13
  • Girardi G, Yarilin D, Thurman J M, Holers V M, Salmon J E. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med 2006; 203: 2165–2175
  • Koga K, Osuga Y, Yoshino O, Hirota Y, Ruimeng X, Hirata T, Takeda S, Yano T, Tsutsumi O, Taketani Y. Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J Clin Endocrinol Metab 2003; 88: 2348–2351
  • Krauss T, Pauer H U, Augustin H G. Prospective analysis of placenta growth factor (PlGF) concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia. Hypertens Pregnancy 2004; 23: 101–111
  • Kupferminc M J, Daniel Y, Englender T, Baram A, Many A, Jaffa A J, Gull I, Lessing J B. Vascular endothelial growth factor is increased in patients with preeclampsia. Am J Reprod Immunol 1997; 38: 302–306
  • Levine R J, Maynard S E, Qian C, Lim K H, England L J, Yu K F, Schisterman E F, Thadhani R, Sachs B P, Epstein F H, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350: 672–683
  • Levine R J, Thadhani R, Qian C, Lam C, Lim K H, Yu K F, Blink A L, Sachs B P, Epstein F H, Sibai B M, et al. Urinary placental growth factor and risk of preeclampsia. JAMA 2005; 293: 77–85
  • Levine R J, Karumanchi S A. Circulating angiogenic factors in preeclampsia. Clin Obstet Gynecol 2005; 48: 372–386
  • Levine R J, Lam C, Qian C, Yu K F, Maynard S E, Sachs B P, Sibai B M, Epstein F H, Romero R, Thadhani R, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006; 355: 992–1005
  • Lyall F, Greer I A, Boswell F, Fleming R. Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre-eclampsia. Br J Obstet Gynaecol 1997; 104: 223–228
  • Malamitsi-Puchner A, Boutsikou T, Economou E, Sarandakou A, Makrakis E, Hassiakos D, Creatsas G. Vascular endothelial growth factor and placenta growth factor in intrauterine growth-restricted fetuses and neonates. Mediators Inflamm 2005; 2005: 293–297
  • Maynard S E, Min J Y, Merchan J, Lim K H, Li J, Mondal S, Libermann T A, Morgan J P, Sellke F W, Stillman I E, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649–658
  • Maynard S E, Venkatesha S, Thadhani R, Karumanchi S A. Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia. Pediatr Res 2005; 57: 1R–7R
  • McKeeman G C, Ardill J E, Caldwell C M, Hunter A J, McClure N. Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop. Am J Obstet Gynecol 2004; 191: 1240–1246
  • Padavala S, Pope N, Baker P, Crocker I. An imbalance between vascular endothelial growth factor and its soluble receptor in placental villous explants of intrauterine growth-restricted pregnancies. J Soc Gynecol Investig 2006; 13: 40–47
  • Rajakumar A, Michael H M, Rajakumar P A, Shibata E, Hubel C A, Karumanchi S A, Thadhani R, Wolf M, Harger G, Markovic N. Extra-placental expression of vascular endothelial growth factor receptor-1 (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. Placenta 2005; 26: 563–573
  • Robinson C J, Johnson D D, Chang E Y, Armstrong D M, Wang W. Evaluation of placenta growth factor and soluble Fms-like tyrosine kinase 1 receptor levels in mild and severe preeclampsia. Am J Obstet Gynecol 2006; 195: 255–259
  • Sibai B M. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): Much ado about nothing?. Am J Obstet Gynecol 1990; 162: 311–316
  • Staff A C, Braekke K, Harsem N K, Lyberg T, Holthe M R. Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 2005; 122: 33–39
  • Stepan H, Faber R. Elevated sFlt1 level and preeclampsia with parvovirus-induced hydrops. N Engl J Med 2006; 354: 1857–1858
  • Thadhani R, Mutter W P, Wolf M, Levine R J, Taylor R N, Sukhatme V P, Ecker J, Karumanchi S A. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab 2004; 89: 770–775
  • Tidwell S C, Ho H N, Chiu W H, Torry R J, Torry D S. Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia. Am J Obstet Gynecol 2001; 184: 1267–1272
  • Torry D S, Wang H S, Wang T H, Caudle M R, Torry R J. Preeclampsia is associated with reduced serum levels of placenta growth factor. Am J Obstet Gynecol 1998; 179: 1539–1544
  • Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim Y M, Bdolah Y, Lim K H, Yuan H T, Libermann T A, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 2006; 12: 642–649
  • Wallner W, Sengenberger R, Strick R, Strissel P L, Meurer B, Beckmann M W, Schlembach D. Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction. Clin Sci (Lond) 2007; 112: 51–57
  • Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher S J. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol 2002; 160: 1405–1423
  • Barbour L A, Shao J, Qiao L, Leitner W, Anderson M, Friedman J E, Draznin B. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology 2004; 145: 1144–1150
  • Curran A J, Peacey S R, Shalet S M. Is maternal growth hormone essential for a normal pregnancy?. Eur J Endocrinol 1998; 139: 54–58
  • Fuglsang J, Lauszus F, Orskov H, Ovesen P. Placental growth hormone during pregnancy in a growth hormone deficient woman with type 1 diabetes compared to a matching diabetic control group. Growth Horm IGF Res 2004; 14: 66–70
  • Verhaeghe J, Bougoussa M, Van Herck E, de Zegher F, Hennen G, Igout A. Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency. Clin Endocrinol (Oxf) 2000; 53: 645–647
  • Eriksson L. Growth hormone in human pregnancy. Maternal 24-hour serum profiles and experimental effects of continuous GH secretion. Acta Obstet Gynecol Scand Suppl 1989; 147: 1–38
  • Alsat E, Guibourdenche J, Luton D, Frankenne F, Evain-Brion D. Human placental growth hormone. Am J Obstet Gynecol 1997; 177: 1526–1534
  • Eriksson L, Frankenne F, Eden S, Hennen G, Von Schoultz B. Growth hormone secretion during termination of pregnancy. Further evidence of a placental variant. Acta Obstet Gynecol Scand 1988; 67: 549–552
  • Lonberg U, Damm P, Andersson A M, Main K M, Chellakooty M, Lauenborg J, Skakkebaek N E, Juul A. Increase in maternal placental growth hormone during pregnancy and disappearance during parturition in normal and growth hormone-deficient pregnancies. Am J Obstet Gynecol 2003; 188: 247–251
  • Moghadam S, Engel W, Bougoussa M, Hennen G, Igout A, Sancken U. Maternal serum placental growth hormone and insulin-like growth factor binding proteins 1 and 3 in pregnancies affected by fetal aneuploidy and other abnormalities: Implications for prenatal diagnosis of trisomy 21. Fetal Diagn Ther 1998; 13: 291–297
  • Papadopoulou E, Sifakis S, Giahnakis E, Fragouli Y, Karkavitsas N, Koumantakis E, Kalmanti M. Increased human placental growth hormone at midtrimester pregnancies may be an index of intrauterine growth retardation related to preeclampsia. Growth Horm IGF Res 2006; 16: 290–296
  • Evain-Brion D, Alsat E, Igout A, Frankenne F, Hennen G. Placental growth hormone variant: Assay and clinical aspects. Acta Paediatr Suppl 1994; 399: 49–51
  • Fisker S, Ebdrup L, Orskov H. Influence of growth hormone binding protein on growth hormone estimation in different immunoassays. Scand J Clin Lab Invest 1998; 58: 373–381

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