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Original Article

Dysregulation of maternal serum adiponectin in preterm labor

, , , , , , , , , , , , , , & show all
Pages 887-904 | Received 31 Dec 2008, Accepted 23 Apr 2009, Published online: 15 Sep 2009

References

  • Romero R, Mazor M, Wu Y K, Sirtori M, Oyarzun E, Mitchell M D, Hobbins J C. Infection in the pathogenesis of preterm labor. Semin Perinatol 1988; 12: 262–279
  • Romero R, Mazor M. Infection and preterm labor. Clin Obstet Gynecol 1988; 31: 553–584
  • Romero R, Brody D T, Oyarzun E, Mazor M, Wu Y K, Hobbins J C, Durum S K. Infection and labor. III. Interleukin-1: a signal for the onset of parturition. Am J Obstet Gynecol 1989; 160: 1117–1123
  • Romero R, Manogue K R, Mitchell M D, Wu Y K, Oyarzun E, Hobbins J C, Cerami A. Infection and labor. IV. Cachectin-tumor necrosis factor in the amniotic fluid of women with intraamniotic infection and preterm labor. Am J Obstet Gynecol 1989; 161: 336–341
  • Gibbs R S, Romero R, Hillier S L, Eschenbach D A, Sweet R L. A review of premature birth and subclinical infection. Am J Obstet Gynecol 1992; 166: 1515–1528
  • Gomez R, Ghezzi F, Romero R, Munoz H, Tolosa J E, Rojas I. Premature labor and intra-amniotic infection. Clinical aspects and role of the cytokines in diagnosis and pathophysiology. Clin Perinatol 1995; 22: 281–342
  • Goldenberg R L, Hauth J C, Andrews W W. Intrauterine infection and preterm delivery. N Engl J Med 2000; 342: 1500–1507
  • Romero R, Espinoza J, Mazor M, Chaiworapongsa T. The preterm parturition syndrome. Preterm birth, H Critchely, P Bennett, S Thornton. RCOG Press, London 2004; 28–60
  • Romero R, Espinoza J, Kusanovic J P, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M. The preterm parturition syndrome. BJOG 2006; 113(Suppl 3)17–42
  • Mazaki-Tovi S, Romero R, Kusanovic J P, Erez O, Pineles B L, Gotsch F, Mittal P, Than N G, Espinoza J, Hassan S S. Recurrent preterm birth. Semin Perinatol 2007; 31: 142–158
  • Gotsch F, Romero R, Kusanovic J P, Mazaki-Tovi S, Pineles B L, Erez O, Espinoza J, Hassan S S. The fetal inflammatory response syndrome. Clin Obstet Gynecol 2007; 50: 652–683
  • Romero R, Nien J K, Espinoza J, Todem D, Fu W, Chung H, Kusanovic J P, Gotsch F, Erez O, Mazaki-Tovi S, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med 2008; 21: 9–23
  • Hirsch E, Wang H. The molecular pathophysiology of bacterially induced preterm labor: insights from the murine model. J Soc Gynecol Investig 2005; 12: 145–155
  • Cassell G H, Davis R O, Waites K B, Brown M B, Marriott P A, Stagno S, Davis J K. Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fluid at 16–20 weeks of gestation: potential effect on outcome of pregnancy. Sex Transm Dis 1983; 10: 294–302
  • Romero R, Kadar N, Hobbins J C, Duff G W. Infection and labor: the detection of endotoxin in amniotic fluid. Am J Obstet Gynecol 1987; 157: 815–819
  • Romero R, Quintero R, Oyarzun E, Wu Y K, Sabo V, Mazor M, Hobbins J C. Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. Am J Obstet Gynecol 1988; 159: 661–666
  • Romero R, Sirtori M, Oyarzun E, Avila C, Mazor M, Callahan R, Sabo V, Athanassiadis A P, Hobbins J C. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989; 161: 817–824
  • Romero R, Shamma F, Avila C, Jimenez C, Callahan R, Nores J, Mazor M, Brekus C A, Hobbins J C. Infection and labor. VI. Prevalence, microbiology, and clinical significance of intraamniotic infection in twin gestations with preterm labor. Am J Obstet Gynecol 1990; 163: 757–761
  • Romero R, Avila C, Brekus C A, Morotti R. The role of systemic and intrauterine infection in preterm parturition. Ann N Y Acad Sci 1991; 622: 355–375
  • Romero R, Ceska M, Avila C, Mazor M, Behnke E, Lindley I. Neutrophil attractant/activating peptide-1/interleukin-8 in term and preterm parturition. Am J Obstet Gynecol 1991; 165: 813–820
  • Gray D J, Robinson H B, Malone J, Thomson R B, Jr. Adverse outcome in pregnancy following amniotic fluid isolation of Ureaplasma urealyticum. Prenat Diagn 1992; 12: 111–117
  • Romero R, Gonzalez R, Sepulveda W, Brandt F, Ramirez M, Sorokin Y, Mazor M, Treadwell M C, Cotton D B. Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. Am J Obstet Gynecol 1992; 167: 1086–1091
  • Romero R, Mazor M, Morrotti R, Avila C, Oyarzun E, Insunza A, Parra M, Behnke E, Montiel F, Cassell G H. Infection and labor. VII. Microbial invasion of the amniotic cavity in spontaneous rupture of membranes at term. Am J Obstet Gynecol 1992; 166: 129–133
  • Romero R, Salafia C M, Athanassiadis A P, Hanaoka S, Mazor M, Sepulveda W, Bracken M B. The relationship between acute inflammatory lesions of the preterm placenta and amniotic fluid microbiology. Am J Obstet Gynecol 1992; 166: 1382–1388
  • Saito S, Kato Y, Ishihara Y, Ichijo M. Amniotic fluid granulocyte colony-stimulating factor in preterm and term labor. Clin Chim Acta 1992; 208: 105–109
  • Watts D H, Krohn M A, Hillier S L, Eschenbach D A. The association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor. Obstet Gynecol 1992; 79: 351–357
  • Gomez R, Romero R, Galasso M, Behnke E, Insunza A, Cotton D B. The value of amniotic fluid interleukin-6, white blood cell count, and gram stain in the diagnosis of microbial invasion of the amniotic cavity in patients at term. Am J Reprod Immunol 1994; 32: 200–210
  • Gravett M G, Witkin S S, Haluska G J, Edwards J L, Cook M J, Novy M J. An experimental model for intraamniotic infection and preterm labor in rhesus monkeys. Am J Obstet Gynecol 1994; 171: 1660–1667
  • Hirsch E, Saotome I, Hirsh D. A model of intrauterine infection and preterm delivery in mice. Am J Obstet Gynecol 1995; 172: 1598–1603
  • Horowitz S, Mazor M, Romero R, Horowitz J, Glezerman M. Infection of the amniotic cavity with Ureaplasma urealyticum in the midtrimester of pregnancy. J Reprod Med 1995; 40: 375–379
  • Mazor M, Hershkovitz R, Ghezzi F, Maymon E, Horowitz S, Leiberman J R. Intraamniotic infection in patients with preterm labor and twin pregnancies. Acta Obstet Gynecol Scand 1996; 75: 624–627
  • Romero R, Gomez R, Mazor M, Ghezzi F, Yoon B H. The preterm labor syndrome. Preterm labor, M G Elder, R Romero, R F Lamont. Churchill Livingstone, New York, NY 1997; 29–49
  • Yoon B H, Romero R, Jun J K, Park K H, Park J D, Ghezzi F, Kim B I. Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1997; 177: 825–830
  • Romero R, Gomez R, Ghezzi F, Yoon B H, Mazor M, Edwin S S, Berry S M. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol 1998; 179: 186–193
  • Ghezzi F, Gomez R, Romero R, Yoon B H, Edwin S S, David C, Janisse J, Mazor M. Elevated interleukin-8 concentrations in amniotic fluid of mothers whose neonates subsequently develop bronchopulmonary dysplasia. Eur J Obstet Gynecol Reprod Biol 1998; 78: 5–10
  • Gomez R, Romero R, Ghezzi F, Yoon B H, Mazor M, Berry S M. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998; 179: 194–202
  • Yoon B H, Romero R, Kim M, Kim E C, Kim T, Park J S, Jun J K. Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction. Am J Obstet Gynecol 2000; 183: 1130–1137
  • Romero R, Maymon E, Pacora P, Gomez R, Mazor M, Yoon B H, Berry S M. Further observations on the fetal inflammatory response syndrome: a potential homeostatic role for the soluble receptors of tumor necrosis factor alpha. Am J Obstet Gynecol 2000; 183: 1070–1077
  • Pacora P, Romero R, Maymon E, Gervasi M T, Gomez R, Edwin S S, Yoon B H. Participation of the novel cytokine interleukin 18 in the host response to intra-amniotic infection. Am J Obstet Gynecol 2000; 183: 1138–1143
  • Challis J R, Lye S J, Gibb W, Whittle W, Patel F, Alfaidy N. Understanding preterm labor. Ann N Y Acad Sci 2001; 943: 225–234
  • Yoon B H, Oh S Y, Romero R, Shim S S, Han S Y, Park J S, Jun J K. An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery. Am J Obstet Gynecol 2001; 185: 1162–1167
  • Gibbs R S, Davies J K, McDuffie R S, Jr, Leslie K K, Sherman M P, Centretto C A, Wolf D M. Chronic intrauterine infection and inflammation in the preterm rabbit, despite antibiotic therapy. Am J Obstet Gynecol 2002; 186: 234–239
  • Romero R, Espinoza J, Chaiworapongsa T, Kalache K. Infection and prematurity and the role of preventive strategies. Semin Neonatol 2002; 7: 259–274
  • Yoon B H, Romero R, Lim J H, Shim S S, Hong J S, Shim J Y, Jun J K. The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor. Am J Obstet Gynecol 2003; 189: 919–924
  • Elovitz M A, Mrinalini C. Animal models of preterm birth. Trends Endocrinol Metab 2004; 15: 479–487
  • Keelan J A, Yang J, Romero R J, Chaiworapongsa T, Marvin K W, Sato T A, Mitchell M D. Epithelial cell-derived neutrophil-activating peptide-78 is present in fetal membranes and amniotic fluid at increased concentrations with intra-amniotic infection and preterm delivery. Biol Reprod 2004; 70: 253–259
  • Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization. Fertil Steril 2004; 82: 799–804
  • Chaiworapongsa T, Romero R, Espinoza J, Kim Y M, Edwin S, Bujold E, Gomez R, Kuivaniemi H. Macrophage migration inhibitory factor in patients with preterm parturition and microbial invasion of the amniotic cavity. J Matern Fetal Neonatal Med 2005; 18: 405–416
  • Esplin M S, Romero R, Chaiworapongsa T, Kim Y M, Edwin S, Gomez R, Mazor M, Adashi E Y. Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra-amniotic infection. J Matern Fetal Neonatal Med 2005; 17: 365–373
  • Lindstrom T M, Bennett P R. The role of nuclear factor kappa B in human labour. Reproduction 2005; 130: 569–581
  • Mazaki-Tovi S, Romero R, Kusanovic J P, Erez O, Gotsch F, Mittal P, Than N G, Nhan-Chang C L, Hamill N, Vaisbuch E, et al. Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturition. J Perinat Med 2008; 36: 485–496
  • Kusanovic J P, Romero R, Mazaki-Tovi S, Chaiworapongsa T, Mittal P, Gotsch F, Erez O, Vaisbuch E, Edwin S S, Than N G, et al. Resistin in amniotic fluid and its association with intra-amniotic infection and inflammation. J Matern Fetal Neonatal Med 2008; 21: 902–916
  • Fidel P L, Jr, Romero R, Wolf N, Cutright J, Ramirez M, Araneda H, Cotton D B. Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice. Am J Obstet Gynecol 1994; 170: 1467–1475
  • Romero R, Mazor M, Tartakovsky B. Systemic administration of interleukin-1 induces preterm parturition in mice. Am J Obstet Gynecol 1991; 165: 969–971
  • Romero R, Tartakovsky B. The natural interleukin-1 receptor antagonist prevents interleukin-1-induced preterm delivery in mice. Am J Obstet Gynecol 1992; 167: 1041–1045
  • Gilles H M, Lawson J B, Sibelas M, Voller A, Allan N. Malaria, anaemia and pregnancy. Ann Trop Med Parasitol 1969; 63: 245–263
  • Herd N, Jordan T. An investigtion of malaria during pregnancy in Zimbabwe. Afr J Med 1981; 27: 62
  • Wren B G. Subclinical renal infection and prematurity. Med J Aust 1969; 2: 596–600
  • Cunningham F G, Morris G B, Mickal A. Acute pyelonephritis of pregnancy: a clinical review. Obstet Gynecol 1973; 42: 112–117
  • Kaul A K, Khan S, Martens M G, Crosson J T, Lupo V R, Kaul R. Experimental gestational pyelonephritis induces preterm births and low birth weights in C3H/HeJ mice. Infect Immunol 1999; 67: 5958–5966
  • Benedetti T J, Valle R, Ledger W J. Antepartum pneumonia in pregnancy. Am J Obstet Gynecol 1982; 144: 413–417
  • Madinger N E, Greenspoon J S, Ellrodt A G. Pneumonia during pregnancy: has modern technology improved maternal and fetal outcome. Am J Obstet Gynecol 1989; 161: 657–662
  • Khader Y S, Ta'ani Q. Periodontal diseases and the risk of preterm birth and low birth weight: a meta-analysis. J Periodontol 2005; 76: 161–165
  • Offenbacher S, Boggess K A, Murtha A P, Jared H L, Lieff S, McKaig R G, Mauriello S M, Moss K L, Beck J D. Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol 2006; 107: 29–36
  • Johnson M J, Petri M, Witter F R, Repke J T. Evaluation of preterm delivery in a systemic lupus erythematosus pregnancy clinic. Obstet Gynecol 1995; 86: 396–399
  • Le H D, Wechsler B, Vauthier-Brouzes D, Seebacher J, Lefebvre G, Bletry O, Darbois Y, Godeau P, Piette J C. Outcome of planned pregnancies in systemic lupus erythematosus: a prospective study on 62 pregnancies. Br J Rheumatol 1997; 36: 772–777
  • Dominitz J A, Young J C, Boyko E J. Outcomes of infants born to mothers with inflammatory bowel disease: a population-based cohort study. Am J Gastroenterol 2002; 97: 641–648
  • Norgard B, Fonager K, Pedersen L, Jacobsen B A, Sorensen H T. Birth outcome in women exposed to 5-aminosalicylic acid during pregnancy: a Danish cohort study. Gut 2003; 52: 243–247
  • Elbaz G, Fich A, Levy A, Holcberg G, Sheiner E. Inflammatory bowel disease and preterm delivery. Int J Gynaecol Obstet 2005; 90: 193–197
  • Kallen B, Rydhstroem H, Aberg A. Asthma during pregnancy – a population based study. Eur J Epidemiol 2000; 16: 167–171
  • Dombrowski M P, Schatz M, Wise R, Momirova V, Landon M, Mabie W, Newman R B, McNellis D, Hauth J C, Lindheimer M, et al. Asthma during pregnancy. Obstet Gynecol 2004; 103: 5–12
  • Adams M M, Sarno A P, Harlass F E, Rawlings J S, Read J A. Risk factors for preterm delivery in a healthy cohort. Epidemiology 1995; 6: 525–532
  • Nohr E A, Bech B H, Vaeth M, Rasmussen K M, Henriksen T B, Olsen J. Obesity, gestational weight gain and preterm birth: a study within the Danish National Birth Cohort. Paediatr Perinat Epidemiol 2007; 21: 5–14
  • Bhattacharya S, Campbell D M, Liston W A, Bhattacharya S. Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Public Health 2007; 7: 168
  • Matsuzawa Y, Funahashi T, Nakamura T. Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci 1999; 892: 146–154
  • Montague C T, O'Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes 2000; 49: 883–888
  • Catalano P M, Hoegh M, Minium J, Huston-Presley L, Bernard S, Kalhan S, Hauguel-De M S. Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Diabetologia 2006; 49: 1677–1685
  • Vidal H. Gene expression in visceral and subcutaneous adipose tissues. Ann Med 2001; 33: 547–555
  • Wang B, Jenkins J R, Trayhurn P. Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha. Am J Physiol Endocrinol Metab 2005; 288: E731–E740
  • Uysal K T, Wiesbrock S M, Marino M W, Hotamisligil G S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997; 389: 610–614
  • Friedman J M, Halaas J L. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763–770
  • Farooqi I S, Keogh J M, Kamath S, Jones S, Gibson W T, Trussell R, Jebb S A, Lip G Y, O'Rahilly S. Partial leptin deficiency and human adiposity. Nature 2001; 414: 34–35
  • Scherer P E, Williams S, Fogliano M, Baldini G, Lodish H F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746–26749
  • Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79–83
  • Berg A H, Combs T P, Scherer P E. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002; 13: 84–89
  • Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocrinol Rev 2005; 26: 439–451
  • Holcomb I N, Kabakoff R C, Chan B, Baker T W, Gurney A, Henzel W, Nelson C, Lowman H B, Wright B D, Skelton N J, et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 2000; 19: 4046–4055
  • Steppan C M, Bailey S T, Bhat S, Brown E J, Banerjee R R, Wright C M, Patel H R, Ahima R S, Lazar M A. The hormone resistin links obesity to diabetes. Nature 2001; 409: 307–312
  • Savage D B, Sewter C P, Klenk E S, Segal D G, Vidal-Puig A, Considine R V, O'Rahilly S. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 2001; 50: 2199–2202
  • Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307: 426–430
  • Hug C, Lodish H F. Medicine. Visfatin: a new adipokine. Science 2005; 307: 366–367
  • Sethi J K, Vidal-Puig A. Visfatin: the missing link between intra-abdominal obesity and diabetes. Trends Mol Med 2005; 11: 344–347
  • Shoelson S E, Lee J, Goldfine A B. Inflammation and insulin resistance. J Clin Invest 2006; 116: 1793–1801
  • Tilg H, Moschen A R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772–783
  • Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F. Leptin: does it have any role in childhood asthma. J Allergy Clin Immunol 2004; 114: 254–259
  • Tuzun A, Uygun A, Yesilova Z, Ozel A M, Erdil A, Yaman H, Bagci S, Gulsen M, Karaeren N, Dagalp K. Leptin levels in the acute stage of ulcerative colitis. J Gastroenterol Hepatol 2004; 19: 429–432
  • Schaffler A, Ehling A, Neumann E, Herfarth H, Tarner I, Scholmerich J, Muller-Ladner U, Gay S. Adipocytokines in synovial fluid. JAMA 2003; 290: 1709–1710
  • Bernotiene E, Palmer G, Talabot-Ayer D, Szalay-Quinodoz I, Aubert M L, Gabay C. Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. Arthritis Res Ther 2004; 6: R256–R263
  • Matarese G, Sanna V, Di G A, Lord G M, Howard J K, Bloom S R, Lechler R I, Fontana S, Zappacosta S. Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males. Eur J Immunol 2001; 31: 1324–1332
  • Batocchi A P, Rotondi M, Caggiula M, Frisullo G, Odoardi F, Nociti V, Carella C, Tonali P A, Mirabella M. Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta. J Neuroimmunol 2003; 139: 150–154
  • Ahima R S, Flier J S. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 2000; 11: 327–332
  • Yang W S, Lee W J, Funahashi T, Tanaka S, Matsuzawa Y, Chao C L, Chen C L, Tai T Y, Chuang L M. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 2001; 86: 3815–3819
  • Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R, Giugliano D. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003; 289: 1799–1804
  • Nien J K, Mazaki-Tovi S, Romero R, Erez O, Kusanovic J P, Gotsch F, Pineles B L, Gomez R, Edwin S, Mazor M, et al. Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women. J Perinat Med 2007; 35: 522–531
  • Nien J K, Mazaki-Tovi S, Romero R, Kusanovic J P, Erez O, Gotsch F, Pineles B L, Friel L A, Espinoza J, Goncalves L, et al. Resistin: a hormone which induces insulin resistance is increased in normal pregnancy. J Perinat Med 2007; 35: 513–521
  • Nien J K, Mazaki-Tovi S, Romero R, Erez O, Kusanovic J P, Gotsch F, Pineles B L, Gomez R, Edwin S, Mazor M, et al. Adiponectin in severe preeclampsia. J Perinat Med 2007; 35: 503–512
  • Mazaki-Tovi S, Romero R, Kusanovic J P, Erez O, Vaisbuch E, Gotsch F, Mittal P, Than G N, Nhan-Chang C, Chaiworapongsa T, et al. Adiponectin multimers in maternal plasma. J Matern Fetal Neonatal Med 2008; 21: 796–815
  • Mazaki-Tovi S, Romero R, Kusanovic J P, Vaisbuch E, Erez O, Than G N, Chaiworapongsa T, Nhan-Chang C, Pacora P, Gotsch F, et al. Maternal visfatin concentration in normal pregnancy. J Perinat Med 2009; 37: 206–217
  • Mazaki-Tovi S, Romero R., Kusanovic J P, Vaisbuch E, Erez O, Than G N, Chaiworapongsa T, Nhan-Chang C, Pacora P, Gotsch F, et al. Visfatin in human pregnancy: maternal gestational diabetes vis-a-vis neonatal birthweight. J Perinat Med 2009; 37: 218–231
  • Verma S, Li S H, Wang C H, Fedak P W, Li R K, Weisel R D, Mickle D A. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation 2003; 108: 736–740
  • Jia S H, Li Y, Parodo J, Kapus A, Fan L, Rotstein O D, Marshall J C. Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest 2004; 113: 1318–1327
  • Ognjanovic S, Bryant-Greenwood G D. Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes. Am J Obstet Gynecol 2002; 187: 1051–1058
  • Matarese G, Moschos S, Mantzoros C S. Leptin in immunology. J Immunol 2005; 174: 3137–3142
  • Zhao T, Hou M, Xia M, Wang Q, Zhu H, Xiao Y, Tang Z, Ma J, Ling W. Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways. Cell Immunol 2005; 238: 19–30
  • Lord G M, Matarese G, Howard J K, Baker R J, Bloom S R, Lechler R I. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897–901
  • Howard J K, Lord G M, Matarese G, Vendetti S, Ghatei M A, Ritter M A, Lechler R I, Bloom S R. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 1999; 104: 1051–1059
  • Hu E, Liang P, Spiegelman B M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697–10703
  • Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996; 221: 286–289
  • Nakano Y, Tobe T, Choi-Miura N H, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem (Tokyo) 1996; 120: 803–812
  • Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20: 1595–1599
  • Fruebis J, Tsao T S, Javorschi S, Ebbets-Reed D, Erickson M R, Yen F T, Bihain B E, Lodish H F. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001; 98: 2005–2010
  • Berg A H, Combs T P, Du X, Brownlee M, Scherer P E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001; 7: 947–953
  • Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7: 941–946
  • Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999; 100: 2473–2476
  • Okamoto Y, Arita Y, Nishida M, Muraguchi M, Ouchi N, Takahashi M, Igura T, Inui Y, Kihara S, Nakamura T, et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res 2000; 32: 47–50
  • Kazumi T, Kawaguchi A, Sakai K, Hirano T, Yoshino G. Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure. Diabetes Care 2002; 25: 971–976
  • Matsubara M, Maruoka S, Katayose S. Decreased plasma adiponectin concentrations in women with dyslipidemia. J Clin Endocrinol Metab 2002; 87: 2764–2769
  • Tsao T S, Murrey H E, Hug C, Lee D H, Lodish H F. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 2002; 277: 29359–29362
  • Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, et al. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem 2003; 278: 40352–40363
  • Pajvani U B, Du X, Combs T P, Berg A H, Rajala M W, Schulthess T, Engel J, Brownlee M, Scherer P E. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 2003; 278: 9073–9085
  • Tsao T S, Tomas E, Murrey H E, Hug C, Lee D H, Ruderman N B, Heuser J E, Lodish H F. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem 2003; 278: 50810–50817
  • Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, Funahashi T, Matsuzawa Y. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res 2004; 94: e27–e31
  • Yoon B H, Romero R, Moon J B, Shim S S, Kim M, Kim G, Jun J K. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2001; 185: 1130–1136
  • Romero R, Emamian M, Quintero R, Wan M, Hobbins J C, Mazor M, Edberg S. The value and limitations of the Gram stain examination in the diagnosis of intraamniotic infection. Am J Obstet Gynecol 1988; 159: 114–119
  • Romero R, Jimenez C, Lohda A K, Nores J, Hanaoka S, Avila C, Callahan R, Mazor M, Hobbins J C, Diamond M P. Amniotic fluid glucose concentration: a rapid and simple method for the detection of intraamniotic infection in preterm labor. J Obstet Gynecol 1990; 163: 968–974
  • Romero R, Quintero R, Nores J, Avila C, Mazor M, Hanaoka S, Hagay Z, Merchant L, Hobbins J C. Amniotic fluid white blood cell count: a rapid and simple test to diagnose microbial invasion of the amniotic cavity and predict preterm delivery. Am J Obstet Gynecol 1991; 165: 821–830
  • Hotamisligil G S, Shargill N S, Spiegelman B M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87–91
  • Hotamisligil G S, Arner P, Caro J F, Atkinson R L, Spiegelman B M. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409–2415
  • Pradhan A D, Manson J E, Rifai N, Buring J E, Ridker P M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001; 286: 327–334
  • Sartipy P, Loskutoff D J. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci USA 2003; 100: 7265–7270
  • Mazurek T, Zhang L, Zalewski A, Mannion J D, Diehl J T, Arafat H, Sarov-Blat L, O'Brien S, Keiper E A, Johnson A G, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003; 108: 2460–2466
  • Koenig W, Sund M, Frohlich M, Fischer H G, Lowel H, Doring A, Hutchinson W L, Pepys M B. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 1999; 99: 237–242
  • Mendall M A, Patel P, Ballam L, Strachan D, Northfield T C. C reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. BMJ 1996; 312: 1061–1065
  • Yang R Z, Lee M J, Hu H, Pollin T I, Ryan A S, Nicklas B J, Snitker S, Horenstein R B, Hull K, Goldberg N H, et al. Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med 2006; 3: e287
  • Lundgren C H, Brown S L, Nordt T K, Sobel B E, Fujii S. Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease. Circulation 1996; 93: 106–110
  • Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol 2005; 174: 5789–5795
  • White R T, Damm D, Hancock N, Rosen B S, Lowell B B, Usher P, Flier J S, Spiegelman B M. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J Biol Chem 1992; 267: 9210–9213
  • Gainsford T, Willson T A, Metcalf D, Handman E, McFarlane C, Ng A, Nicola N A, Alexander W S, Hilton D J. Leptin can induce, proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564–14568
  • Wolf A M, Wolf D, Rumpold H, Enrich B, Tilg H. Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun 2004; 323: 630–635
  • Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, Kihara S, Funahashi T, Tenner A J, Tomiyama Y, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000; 96: 1723–1732
  • Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson S L, Ohlsson C, Jansson J O. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 2002; 8: 75–79
  • Uysal K T, Wiesbrock S M, Marino M W, Hotamisligil G S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997; 389: 610–614
  • Ma L J, Mao S L, Taylor K L, Kanjanabuch T, Guan Y, Zhang Y, Brown N J, Swift L L, McGuinness O P, Wasserman D H, et al. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes 2004; 53: 336–346
  • Netea M G, Joosten L A, Lewis E, Jensen D R, Voshol P J, Kullberg B J, Tack C J, van K H, Kim S H, Stalenhoef A F, et al. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 2006; 12: 650–656
  • Matsuki T, Horai R, Sudo K, Iwakura Y. IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J Exp Med 2003; 198: 877–888
  • Weisberg S P, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel R L, Ferrante A W, Jr. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006; 116: 115–124
  • Hirosumi J, Tuncman G, Chang L, Gorgun C Z, Uysal K T, Maeda K, Karin M, Hotamisligil G S. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333–336
  • Weisberg S P, McCann D, Desai M, Rosenbaum M, Leibel R L, Ferrante A W, Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796–1808
  • Xu H, Barnes G T, Yang Q, Tan G, Yang D, Chou C J, Sole J, Nichols A, Ross J S, Tartaglia L A, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821–1830
  • Shoelson S E, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007; 132: 2169–2180
  • Dandona P, Weinstock R, Thusu K, bdel-Rahman E, Aljada A, Wadden T. Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab 1998; 83: 2907–2910
  • Vozarova B, Weyer C, Hanson K, Tataranni P A, Bogardus C, Pratley R E. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res 2001; 9: 414–417
  • Kopp H P, Krzyzanowska K, Mohlig M, Spranger J, Pfeiffer A F, Schernthaner G. Effects of marked weight loss on plasma levels of adiponectin, markers of chronic subclinical inflammation and insulin resistance in morbidly obese women. Int J Obes (Lond) 2005; 29: 766–771
  • McLaughlin T, Abbasi F, Lamendola C, Liang L, Reaven G, Schaaf P, Reaven P. Differentiation between obesity and insulin resistance in the association with C-reactive protein. Circulation 2002; 106: 2908–2912
  • Kopp H P, Kopp C W, Festa A, Krzyzanowska K, Kriwanek S, Minar E, Roka R, Schernthaner G. Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients. Arterioscler Thromb Vasc Biol 2003; 23: 1042–1047
  • Ley K. Physiology of inflammation. Oxford University Press. 2001; 1–10
  • Hotamisligil G S. Inflammation and metabolic disorders. Nature 2006; 444: 860–867
  • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005; 115: 911–919
  • Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000; 102: 1296–1301
  • Bradley R L, Cleveland K A, Cheatham B. The adipocyte as a secretory organ: mechanisms of vesicle transport and secretory pathways. Recent Prog Horm Res 2001; 56: 329–358
  • Mazaki-Tovi S, Kanety H, Sivan E. Adiponectin and human pregnancy. Curr Diab Rep 2005; 5: 278–281
  • Mazaki-Tovi S, Kanety H, Pariente C, Hemi R, Wiser A, Schiff E, Sivan E. Maternal serum adiponectin levels during human pregnancy. J Perinatol 2007; 27: 77–81
  • Mazaki-Tovi S, Kanety H, Pariente C, Hemi R, Efraty Y, Schiff E, Shoham A, Sivan E. Determining the source of fetal adiponectin. J Reprod Med 2007; 52: 774–778
  • Sivan E, Mazaki-Tovi S, Pariente C, Efraty Y, Schiff E, Hemi R, Kanety H. Adiponectin in human cord blood: relation to fetal birth weight and gender. J Clin Endocrinol Metab 2003; 88: 5656–5660
  • Modan-Moses D, Stein D, Pariente C, Yaroslavsky A, Ram A, Faigin M, Loewenthal R, Yissachar E, Hemi R, Kanety H. Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients. J Clin Endocrinol Metab 2007; 92: 1843–1847
  • Combs T P, Berg A H, Obici S, Scherer P E, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 2001; 108: 1875–1881
  • Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002; 8: 731–737
  • Wulster-Radcliffe M C, Ajuwon K M, Wang J, Christian J A, Spurlock M E. Adiponectin differentially regulates cytokines in porcine macrophages. Biochem Biophys Res Commun 2004; 316: 924–929
  • Schober F, Neumeier M, Weigert J, Wurm S, Wanninger J, Schaffler A, Dada A, Liebisch G, Schmitz G, Aslanidis C, et al. Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release. Biochem Biophys Res Commun 2007; 361: 968–973
  • Kumada M, Kihara S, Ouchi N, Kobayashi H, Okamoto Y, Ohashi K, Maeda K, Nagaretani H, Kishida K, Maeda N, et al. Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation 2004; 109: 2046–2049
  • Masaki T, Chiba S, Tatsukawa H, Yasuda T, Noguchi H, Seike M, Yoshimatsu H, et al. Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice. Hepatology 2004; 40: 177–184
  • Rovin B H, Song H, Hebert L A, Nadasdy T, Nadasdy G, Birmingham D J, Yung Y C, Nagaraja H N. Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus. Kidney Int 2005; 68: 1825–1833
  • Sada K E, Yamasaki Y, Maruyama M, Sugiyama H, Yamamura M, Maeshima Y, Makino H. Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus. J Rheumatol 2006; 33: 1545–1552
  • Paul G, Schaffler A, Neumeier M, Furst A, Bataillle F, Buechler C, Muller-Ladner U, Scholmerich J, Rogler G, Herfarth H. Profiling adipocytokine secretion from creeping fat in Crohn's disease. Inflamm Bowel Dis 2006; 12: 471–477
  • Yamamoto K, Kiyohara T, Murayama Y, Kihara S, Okamoto Y, Funahashi T, Ito T, Nezu R, Tsutsui S, Miyagawa J I, et al. Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. Gut 2005; 54: 789–796
  • Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez-Reino J J, Gualillo O. Changes in plasma levels of fat-derived hormones, adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 2006; 65: 1198–1201
  • Aso Y, Yamamoto R, Wakabayashi S, Uchida T, Takayanagi K, Takebayashi K, Okuno T, Inoue T, Node K, Tobe T, et al. Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin. Diabetes 2006; 55: 1954–1960
  • Abke S, Neumeier M, Weigert J, Wehrwein G, Eggenhofer E, Schaffler A, Maier K, Aslanidis C, Scholmerich J, Buechler C. Adiponectin-induced secretion of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) is impaired in monocytes from patients with type I diabetes. Cardiovasc Diabetol 2006; 5: 17
  • Rovin B H, Song H. Chemokine induction by the adipocyte-derived cytokine adiponectin. Clin Immunol 2006; 120: 99–105
  • Neumeier M, Weigert J, Schaffler A, Wehrwein G, Muller-Ladner U, Scholmerich J, Wrede C, Buechler C. Different effects of adiponectin isoforms in human monocytic cells. J Leukoc Biol 2006; 79: 803–808
  • Pajvani U B, Hawkins M, Combs T P, Rajala M W, Doebber T, Berger J P, Wagner J A, Wu M, Knopps A, Xiang A H. Complex, distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004; 279: 12152–12162
  • Bobbert T, Rochlitz H, Wegewitz U, Akpulat S, Mai K, Weickert M O, Mohlig M, Pfeiffer A F, Spranger J. Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes 2005; 54: 2712–2719
  • Lopez-Bermejo A, Fernandez-Real J M, Garrido E, Rovira R, Brichs R, Genaro P, Bach C, Cabrero D, Kihara S, Funahashi T, et al. Maternal soluble tumour necrosis factor receptor type 2 (sTNFR2) and adiponectin are both related to blood pressure during gestation and infant's birthweight. Clin Endocrinol (Oxf) 2004; 61: 544–552
  • Retnakaran R, Hanley A J, Raif N, Connelly P W, Sermer M, Zinman B. Reduced adiponectin concentration in women with gestational diabetes: a potential factor in progression to type 2 diabetes. Diabetes Care 2004; 27: 799–800
  • McLachlan K A, O'Neal D, Jenkins A, Alford F P. Do, adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. Diabetes Metab Res Rev 2006; 22: 131–138
  • Kautzky-Willer A, Pacini G, Tura A, Bieglmayer C, Schneider B, Ludvik B, Prager R, Waldhausl W. Increased plasma leptin in gestational diabetes. Diabetologia 2001; 44: 164–172
  • Kirwan J P, Hauguel-De M S, Lepercq J, Challier J C, Huston-Presley L, Friedman J E, Kalhan S C, Catalano P M. TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes 2002; 51: 2207–2213
  • Chen D, Fang Q, Chai Y, Wang H, Huang H, Dong M. Serum resistin in gestational diabetes mellitus and early postpartum. Clin Endocrinol (Oxf) 2007; 67: 208–211
  • Krzyzanowska K, Krugluger W, Mittermayer F, Rahman R, Haider D, Shnawa N, Schernthaner G. Increased visfatin concentrations in women with gestational diabetes mellitus. Clin Sci (Lond) 2006; 110: 605–609
  • Lewandowski K C, Stojanovic N, Press M, Tuck S M, Szosland K, Bienkiewicz M, Vatish M, Lewinski A, Prelevic G M, Randeva H S. Elevated serum levels of visfatin in gestational diabetes: a comparative study across various degrees of glucose tolerance. Diabetologia 2007; 50: 1033–1037
  • Ranheim T, Haugen F, Staff A C, Braekke K, Harsem N K, Drevon C A. Adiponectin is reduced in gestational diabetes mellitus in normal weight women. Acta Obstet Gynecol Scand 2004; 83: 341–347
  • Worda C, Leipold H, Gruber C, Kautzky-Willer A, Knofler M, Bancher-Todesca D. Decreased plasma adiponectin concentrations in women with gestational diabetes mellitus. Am J Obstet Gynecol 2004; 191: 2120–2124
  • Thyfault J P, Hedberg E M, Anchan R M, Thorne O P, Isler C M, Newton E R, Dohm G L, deVente J E. Gestational diabetes is associated with depressed adiponectin levels. J Soc Gynecol Investig 2005; 12: 41–45
  • Tsai P J, Yu C H, Hsu S P, Lee Y H, Huang I T, Ho S C, Chu C H. Maternal plasma adiponectin concentrations at 24 to 31 weeks of gestation: negative association with gestational diabetes mellitus. Nutrition 2005; 21: 1095–1099
  • Cortelazzi D, Corbetta S, Ronzoni S, Pelle F, Marconi A, Cozzi V, Cetin I, Cortelazzi R, Beck-Peccoz P, Spada A. Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies. Clin Endocrinol (Oxf) 2007; 66: 447–453
  • Hendler I, Blackwell S C, Mehta S H, Whitty J E, Russell E, Sorokin Y, Cotton D B. The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia. Am J Obstet Gynecol 2005; 193: 979–983
  • McCarthy J F, Misra D N, Roberts J M. Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration. Am J Obstet Gynecol 1999; 180: 731–736
  • Fasshauer M, Waldeyer T, Seeger J, Schrey S, Ebert T, Kratzsch J, Lossner U, Bluher M, Stumvoll M, Faber R, et al. Serum levels of the adipokine visfatin are increased in preeclampsia. Clin Endocrinol (Oxf) 2008; 69: 69–73
  • Conrad K P, Miles T M, Benyo D F. Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 1998; 40: 102–111
  • Chen D, Dong M, Fang Q, He J, Wang Z, Yang X. Alterations of serum resistin in normal pregnancy and pre-eclampsia. Clin Sci (Lond) 2005; 108: 81–84
  • Haugen F, Ranheim T, Harsem N K, Lips E, Staff A C, Drevon C A. Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression. Am J Physiol Endocrinol Metab 2006; 290: E326–E333
  • Ramsay J E, Jamieson N, Greer I A, Sattar N. Paradoxical elevation in adiponectin concentrations in women with preeclampsia. Hypertension 2003; 42: 891–894
  • Kajantie E, Kaaja R, Ylikorkala O, Andersson S, Laivuori H. Adiponectin concentrations in maternal serum: elevated in preeclampsia but unrelated to insulin sensitivity. J Soc Gynecol Investig 2005; 12: 433–439

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