132
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Maternal/fetal eNOS-Glu298Asp genotypes and their influence on the severity, prognosis, and lipid profile of preeclampsia

, , , , &
Pages 1681-1688 | Received 02 Mar 2017, Accepted 23 Apr 2017, Published online: 09 May 2017

References

  • Sliwa K, Böhm M. Incidence and prevalence of pregnancy-related heart disease. Cardiovasc Res. 2014;101: 554–560.
  • Ahmed R, Dunford J, Mehran R, et al. Pre-eclampsia and future cardiovascular risk among women: a review. J Am Coll Cardiol. 2014;63:1815–1822.
  • Kajantie E, Eriksson JG, Osmond C, et al. Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study. Stroke. 2009;40:1176–1180.
  • Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183:S1–S22.
  • George EM, Granger JP. Recent insights in to the pathophysiology of preeclampsia. Expert Rev Obstet Gynecol. 2010;5:557–566.
  • Sandrim VC, Paley AC, Sertorio JT, et al. Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia. Mol Hum Reprod. 2010;16:506–510.
  • Raffaelli F, Nanetti L, Vignini A, et al. Nitric oxide platelet production in spontaneous miscarriage in the first trimester. Fertil Steril. 2010;93:1976–1982.
  • Pisaneschi S, Strigini FA, Sanchez AM, et al. Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction. PLoS One. 2012;7:452–494.
  • Noris M, Remuzzi G. Physiology and pathophysiology of nitric oxide in chronic renal disease. Proc Assoc Am Physicians. 1999;111:602–610.
  • Rahimi Z, Aghaei A, Rahimi Z, et al. Endothelial nitric oxide synthase (eNOS) 4a/b and G894T polymorphisms and susceptibility to preeclampsia. J Reprod Infertil. 2013;14:184–189.
  • Brown MA, Lindheimer MD, de Swiet M, et al. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy. 2001;20:IX–XIV.
  • Godfrey V, Chan SL, Cassidy A, et al. The functional consequence of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in young healthy volunteers. Cardiovasc Drug Reviews. 2007;25:280–288.
  • Zdoukopoulos N, Doxani C, Messinis IE, et al. Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study. BMC Pregnancy Childbirth. 2011;11:89.
  • Gorchakova O, Koch W, von Beckerath N, et al. Association of a genetic variant of endothelial nitric oxide synthase with the 1 year clinical outcome after coronary stent placement. Eur Heart J. 2003;24:820–827.
  • Myatt L, Brewer A, Brockman DE. The action of nitric oxide in the perfused human fetal-placental circulation. Am J Obstet Gynecol. 1991;164:687–692.
  • Yoshimura T, Yoshimura M, Tabata A, et al. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia. J Soc Gynecol Investig. 2000;7:238–241.
  • Pappa KI, Roubelakis M, Vlachos G, et al. Variable effects of maternal and paternal–fetal contribution to the risk for preeclampsia combining GSTP1, eNOS, and LPL gene polymorphisms. J Matern Fetal Neonatal Med. 2011;24:628–635.
  • Landau R, Xie H-G, Dishy V, et al. No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia. Am J Hypertens. 2004;17:391–394.
  • Chen LK, Huang CH, Yeh HM, et al. Polymorphisms in the endothelial nitric oxide synthase gene may be protective against preeclampsia in a Chinese population. Reproductive Sciences. 2007;14:175–181.
  • The Genetics of Pre-eclampsia (GOPEC) Consortium. Babies, pre-eclamptic mothers and grandparents: a three generation phenotyping study. J Hypertens. 2007;25:849–854.
  • GOPEC Consortium. Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. Am J Hum Genet. 2005;77:127–131.
  • Yaghmaei M, Salimi S, Mokhtari M, et al. Endothelial nitric oxide synthase gene Glu298Asp polymorphism and risk of preeclampsia in South East of Iran. Afr J Biotechnol. 2011;10:10712–10717.
  • Dai B, Liu T, Zhang B, et al. The polymorphism for endothelial nitric oxide synthase gene, the level of nitric oxide and the risk for pre-eclampsia: a meta-analysis. Gene. 2013;519:187–193.
  • Gannoun MBA, Zitouni H, Raguema N, et al. Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs. Gene. 2015;569:303–307.
  • Fairchild TA, Fulton D, Fontana JT, et al. Acidic hydrolysis as a mechanism for the cleavage of the Glu298-Asp variant of human endothelial nitric oxide synthase. J Biol Chem. 2001;276:26674–26679.
  • Tesauro M, Thomson WC, Rogliani P, et al. Intra celular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci USA. 2000;97:2832–2835.
  • Descamps OS, Bruniaux M, Guilmot PF, et al. Lipoprotein metabolism of pregnant women is associated with both their genetic polymorphisms and those of their newborn children. J Lipid Res. 2005;46:2405–2414.
  • Abe K, Nakayama M, Yoshimura M, et al. Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the −786T. C Polymorphism. Pharmacogenet Genomics. 2005;15:329–336.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.