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Original Article

Can flavonoid-rich chocolate modulate arterial elasticity and pathological uterine artery Doppler blood flow in pregnant women? A pilot study

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Pages 2293-2298 | Received 09 May 2017, Accepted 08 Jun 2017, Published online: 28 Jun 2017

References

  • Buijsse B, Feskens EJ, Kok FJ, et al. Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study. Arch Intern Med. 2006;166(4):411–417.
  • Mink PJ, Scrafford CG, Barraj LM, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr. 2007;85(3):895–909.
  • Janszky I, Mukamal KJ, Ljung R, et al. Chocolate consumption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program. J Intern Med. 2009;266(3):248–257.
  • Buijsse B, Weikert C, Drogan D, et al. Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults. Eur Heart J. 2010;31(13):1616–1623.
  • Mostofsky E, Levitan EB, Wolk A, et al. Chocolate intake and incidence of heart failure: a population-based prospective study of middle-aged and elderly women. Circ Heart Fail. 2010;3(5):612–616.
  • Djoussé L, Hopkins PN, North KE, et al. Chocolate consumption is inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr. 2011;30(2):182–187.
  • Hooper L, Kroon PA, Rimm EB, et al. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2008;88(1):38–50.
  • Taubert D, Roesen R, Schömig E. Effect of cocoa and tea intake on blood pressure: a meta-analysis. Arch Intern Med. 2007;167(7):626–634.
  • Ried K, Sullivan T, Fakler P, et al. Does chocolate reduce blood pressure? A meta-analysis. BMC Med. 2010;8:39.
  • Desch S, Schmidt J, Kobler D, et al. Effect of cocoa products on blood pressure: systematic review and meta-analysis. Am J Hypertens. 2010;23(1):97–103.
  • Ried K, Sullivan TR, Fakler P, et al. Effect of cocoa on blood pressure. Cochrane Database Syst Rev. 2012:CD008893.
  • Buitrago-Lopez A, Sanderson J, Johnson L, et al. Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ. 2011;343:d4488. [PubMed: 21875885].
  • Engler MB, Engler MM. The emerging role of flavonoid-rich cocoa and chocolate in cardiovascular health and disease. Nutr Rev. 2006;64(3):109–118.
  • Corti R, Flammer AJ, Hollenberg NK, et al. Cocoa and cardiovascular health. Circulation. 2009;119(10):1433–1441.
  • Rein D, Paglieroni TG, Wun T, et al. Cocoa inhibits platelet activation and function. Am J Clin Nutr. 2000;72(1):30–35.
  • Pearson DA, Holt RR, Rein D, et al. Flavanols and platelet reactivity. Clin Dev Immunol. 2005;12(1):1–9.
  • Selmi C, Mao TK, Keen CL, et al. The anti-inflammatory properties of cocoa flavanols. J Cardiovasc Pharmacol. 2006;47:S163–S171 (discussion: S72–S76).
  • Grassi D, Desideri G, Ferri C. Flavonoids: antioxidants against atherosclerosis. Nutrients. 2010;2(8):889–902.
  • Jia L, Liu X, Bai YY, et al. Short-term effect of cocoa product consumption on lipid profile: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2010;92(1):218–225.
  • Hanhineva K, Törrönen R, Bondia-Pons I, et al. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. 2010;11(4):1365–1402.
  • Grassi D, Desideri G, Necozione S, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008;138(9):1671–1676.
  • Hermann F, Spieker LE, Ruschitzka F, et al. Dark chocolate improves endothelial and platelet function. Heart. 2006;92(1):119–120.
  • Kerimi A, Williamson G. The cardiovascular benefits of dark chocolate. Vascul Pharmacol. 2015;71:11–15.
  • Lilamand M, Kelaiditi E, Guyonnet S, et al. Flavonoids and arterial stiffness: promising perspectives. Nutr Metab Cardiovasc Dis. 2014;24(7):698–704.
  • Grassi D, Desideri G, Necozione S, et al. Cocoa consumption dose-dependently improves flow-mediated dilation and arterial stiffness decreasing blood pressure in healthy individuals. J Hypertens. 2015;33(2):294–303.
  • Grassi D, Desideri G, Necozione S, et al. Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia. Hypertension. 2012;60(3):827–832.
  • Fisher ND, Hughes M, Gerhard-Herman M, et al. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens. 2003;21(12):2281–2286.
  • Brillo E, Di Renzo GC. Chocolate and other cocoa products: effects on human reproduction and pregnancy. J Agric Food Chem. 2015;63(45):9927–9935.
  • Di Renzo GC, Brillo E, Romanelli M, et al. Potential effects of chocolate on human pregnancy: a randomized controlled trial. J Matern Fetal Neonatal Med. 2012;25(10):1860–1867.
  • Saftlas AF, Triche EW, Beydoun H, et al. Does chocolate intake during pregnancy reduce the risks of preeclampsia and gestational hypertension? Ann Epidemiol. 2010;20(8):584–591.
  • Triche EW, Grosso LM, Belanger K, et al. Chocolate consumption in pregnancy and reduced likelihood of preeclampsia. Epidemiology. 2008;19(3):459–464.
  • Klebanoff MA, Zhang J, Zhang C, et al. Maternal serum theobromine and the development of preeclampsia. Epidemiology. 2009;20(5):727–732.
  • Bujold E, Leblanc V, Lavoie-Lebel É, et al. High-flavanol and high-theobromine versus low-flavanol and low-theobromine chocolate to improve uterine artery pulsatility index: a double blind randomized clinical trial. J Matern Fetal Neonatal Med. 2016:1–6.
  • von Wowern E, Andersson J, Skarping ID, et al. Association between uterine artery Doppler blood flow changes and arterial wall elasticity in pregnant women. J Matern Fetal Neonatal Med. 2016:1–6.
  • Gudmundsson S, Korszun P, Olofsson P, et al. New score indicating placental vascular resistance. Acta Obstet Gynecol Scand. 2003;82(9):807–812.
  • Mulders LG, Jongsma HW, Wijn PF, et al. The uterine artery blood flow velocity waveform: reproducibility and results in normal pregnancy. Early Hum Dev. 1988;17(1):55–70.
  • Gudmundsson S, Marsál K. Umbilical artery and uteroplacental blood flow velocity waveforms in normal pregnancy – a cross-sectional study. Acta Obstet Gynecol Scand. 1988;67(4):347–354.
  • Sekizuka N, Hasegawa I, Takakuwa K, et al. Scoring of uterine artery flow velocity waveforms in the assessment of fetal growth restriction and/or pregnancy-induced hypertension. J Matern Fetal Invest. 1997;7:197–200.
  • Hernandez-Andrade E, Brodszki J, Lingman G, et al. Uterine artery score and perinatal outcome. Ultrasound Obstet Gynecol. 2002;19(5):438–442.
  • Millasseau SC, Ritter JM, Takazawa K, et al. Contour analysis of the photoplethysmographic pulse measured at the finger. J Hypertens. 2006;24(8):1449–1456.
  • von Wowern E, Östling G, Nilsson PM, et al. Digital photoplethysmography for assessment of arterial stiffness: repeatability and comparison with applanation tonometry. PLoS One. 2015;10(8):e0135659.
  • X-Power Squares Xocai Healthy Chocolate Co. [Internet]; [cited 2017 Apr 04]. Available from: https://www.healthychocolateco.com/products/X-Power-Squares/
  • Takazawa K, Tanaka N, Fujita M, et al. Assessment of vasoactive agents and vascular aging by the second derivative of photoplethysmogram waveform. Hypertension. 1998;32(2):365–370.
  • Everett TR, Mahendru AA, McEniery CM, et al. Raised uterine artery impedance is associated with increased maternal arterial stiffness in the late second trimester. Placenta. 2012;33(7):572–577.
  • Savvidou MD, Kaihura C, Anderson JM, et al. Maternal arterial stiffness in women who subsequently develop pre-eclampsia. PLoS One. 2011;6(5):e18703.
  • Han N, Luo X, Su F. A quantitative investigation of hemodynamic adaptation to pregnancy using uterine artery Doppler ultrasonography and finger photoplethysmography. Hypertens Pregnancy. 2014;33(4):498–507.
  • Brodszki J, Länne T, Laurini R, et al. Vascular mechanical properties and endothelial function in pre-eclampsia with special reference to bilateral uterine artery notch. Acta Obstet Gynecol Scand. 2008;87(2):154–162.
  • Weissgerber TL, Milic NM, Milin-Lazovic JS, et al. Impaired flow-mediated dilation before, during, and after preeclampsia: a systematic review and meta-analysis. Hypertension. 2016;67(2):415–423.
  • Heiss C, Dejam A, Kleinbongard P, et al. Vascular effects of cocoa rich in flavan-3-ols. JAMA. 2003;290(8):1030–1031.
  • Skopiński P, Skopińska-Rózewska E, Sommer E, et al. Chocolate feeding of pregnant mice influences length of limbs of their progeny. Pol J Vet Sci. 2003;6:57–59.
  • Zielinsky P, Busato S. Prenatal effects of maternal consumption of polyphenol-rich foods in late pregnancy upon fetal ductus arteriosus. Birth Defects Res C Embryo Today. 2013;99:256–274.
  • Mogollon JA, Bujold E, Lemieux S, et al. Blood pressure and endothelial function in healthy, pregnant women after acute and daily consumption of flavanol-rich chocolate: a pilot, randomized controlled trial. Nutr J. 2013;12:41.
  • Nile SH, Park SW. Edible berries: bioactive components and their effect on human health. Nutrition. 2014;30(2):134–144.
  • Ulbricht C, Brigham A, Burke D, et al. An evidence-based systematic review of acai (Euterpe oleracea) by the Natural Standard Research Collaboration. J Diet Suppl. 2012;9(2):128–147.

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