Role of amino acid supplementation in the prevention of necrotizing enterocolitis in preterm neonates – a review of current evidences

References

• Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011;364(3):255–264.
   PubMed Web of Science ®Google Scholar
• Holman RC, Stoll BJ, Curns AT, et al. Necrotising enterocolitis hospitalisations among neonates in the United States. Paediatr Perinat Epidemiol. 2006;20(6):498–506.
   PubMed Web of Science ®Google Scholar
• Sia KL, Gold L, Jacobs S, et al. Hospital DRG costing and health services use of very pre-term infants from the ProPrems Neuro study across 10 hospitals in Australia and New Zealand. Value Health. 2014;17(7):A518–A519.
   PubMed Web of Science ®Google Scholar
• Lin HC, Hsu CH, Chen HL, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics. 2008;122(4):693–700.
   PubMed Web of Science ®Google Scholar
• Lee JS, Polin RA. Treatment and prevention of necrotizing enterocolitis. Semin Neonatol. 2003;8(6):449–459.
   PubMedGoogle Scholar
• Fitzgibbons SC, Ching Y, Yu D, et al. Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg. 2009;44(6):1072–5. (discussion 1075).
   PubMed Web of Science ®Google Scholar
• Papillon S, Castle SL, Gayer CP, et al. Necrotizing enterocolitis: contemporary management and outcomes. Adv Pediatr. 2013;60(1):263–279.
   PubMedGoogle Scholar
• Lemons JA, Bauer CR, Oh W, et al NICHD Neonatal Research Network. Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. Pediatrics. 2001;107(1):E1. doi:10.1542/peds.107.1.e1
   PubMed Web of Science ®Google Scholar
• Wang Q, Dong J, Zhu Y. Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials. J Pediatr Surg. 2012;47(1):241–248.
   PubMed Web of Science ®Google Scholar
• Deshpande G, Rao S, Patole S, et al. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics. 2010;125(5):921–930.
   PubMed Web of Science ®Google Scholar
• AlFaleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Evid-Based Child Health. 2014;9(3):584–671.
   PubMedGoogle Scholar
• Aceti A, Gori D, Barone G, et al. Probiotics for prevention of necrotizing enterocolitis in preterm infants: systematic review and meta-analysis. Ital J Pediatr. 2015;41:89. doi:10.1186/s13052-015-0199-2
   PubMed Web of Science ®Google Scholar
• Dermyshi E, Wang Y, Yan C, et al. The “golden age” of probiotics: a systematic review and meta-analysis of randomized and observational studies in preterm infants. Neonatology. 2017;112(1):9–23.
   PubMed Web of Science ®Google Scholar
• Olsen R, Greisen G, Schrøder M, et al. Prophylactic probiotics for preterm infants: a systematic review and meta-analysis of observational studies. Neonatology. 2016;109(2):105–112.
   PubMed Web of Science ®Google Scholar
• Marc Rhoads J, Wu G. Glutamine, arginine, and leucine signaling in the intestine. Amino Acids. 2009;37(1):111–122.
   PubMed Web of Science ®Google Scholar
• Faintuch J, Aguilar PB, Nadalin W. Relevance of N-acetylcysteine in clinical practice: fact, myth or consequence? Nutrition. 1999;15(2):177–179.
   PubMed Web of Science ®Google Scholar
• Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J. 1998;336(1):1–17.
   PubMed Web of Science ®Google Scholar
• Bertolo RFP, Brunton JA, Pencharz PB, et al. Arginine, ornithine, and proline interconversion is dependent on small intestinal metabolism in neonatal pigs. Am J Physiol Endocrinol Metab. 2003;284(5):E915–E922.
   PubMed Web of Science ®Google Scholar
• Morris SM Jr. Regulation of enzymes of the urea cycle and arginine metabolism. Annu Rev Nutr. 2002;22:87–105.
   PubMed Web of Science ®Google Scholar
• Flynn NE, Meininger CJ, Haynes TE, et al. The metabolic basis of arginine nutrition and pharmacotherapy. Biomed Pharmacother. 2002;56(9):427–438.
   PubMed Web of Science ®Google Scholar
• Briassouli E, Briassoulis G. Glutamine randomized studies in early life: the unsolved riddle of experimental and clinical studies. Clin Dev Immunol. 2012;2012:749189. doi:http://dx.doi.org/10.1155/2012/749189
   PubMedGoogle Scholar
• Newsholme EA, Crabtree B, Ardawi MS. Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance. Q J Exp Physiol. 1985;70(4):473–489.
   PubMed Web of Science ®Google Scholar
• Dilsiz A, Ciftçi I, Aktan TM, et al. Enteral glutamine supplementation and dexamethasone attenuate the local intestinal damage in rats with experimental necrotizing enterocolitis. Pediatr Surg Int. 2003;19(8):578–582.
   PubMed Web of Science ®Google Scholar
• Wang J, Chen L, Li P, et al. Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation. J Nutr. 2008;138(6):1025–1032.
   PubMed Web of Science ®Google Scholar
• Koivusalo A, Kauppinen H, Anttila A, et al. Intraluminal casein model of necrotizing enterocolitis for assessment of mucosal destruction, bacterial translocation, and the effects of allopurinol and N-acetylcysteine. Pediatr Surg Int. 2002;18(8):712–717.
   PubMed Web of Science ®Google Scholar
• Tayman C, Tonbul A, Kosus A, et al. N-acetylcysteine may prevent severe intestinal damage in necrotizing enterocolitis. J Pediatr Surg. 2012;47(3):540–550.
   PubMed Web of Science ®Google Scholar
• Ozdemir R, Yurttutan S, Sarı FN, et al. Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis. J Pediatr Surg. 2012;47(9):1652–1657.
   PubMed Web of Science ®Google Scholar
• Obladen M. Necrotizing enterocolitis −150 years of fruitless search for the cause. Neonatology. 2009;96(4):203–210.
   PubMed Web of Science ®Google Scholar
• Halpern MD, Denning PW. The role of intestinal epithelial barrier function in the development of NEC. Tissue Barriers. 2015;3(1–2):e1000707. doi:10.1080/21688370.2014.1000707
   PubMed Web of Science ®Google Scholar
• Yazji I, Sodhi CP, Lee EK, et al. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci USA. 2013;110(23):9451–9456.
   PubMed Web of Science ®Google Scholar
• Vallance BA, Dijkstra G, Qiu B, et al. Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity. Am J Physiol Gastrointest Liver Physiol. 2004;287(4):G865–G874.
   PubMed Web of Science ®Google Scholar
• Hierholzer C, Kalff JC, Billiar TR, et al. Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2004;286(2):G225–G233.
   PubMed Web of Science ®Google Scholar
• Hackam DJ. Danger at the doorstep: regulation of bacterial translocation across the intestinal barrier by nitric oxide. Crit Care Med. 2011;39(9):2189–2190.
   PubMed Web of Science ®Google Scholar
• Benjamim CF, Silva JS, Fortes ZB, et al. Inhibition of leukocyte rolling by nitric oxide during sepsis leads to reduced migration of active microbicidal neutrophils. Infect Immun. 2002;70(7):3602–3610.
   PubMed Web of Science ®Google Scholar
• Ford HR. Mechanism of nitric oxide-mediated intestinal barrier failure: insight into the pathogenesis of necrotizing enterocolitis. J Pediatr Surg. 2006;41(2):294–299.
   PubMed Web of Science ®Google Scholar
• Li N, Lewis P, Samuelson D, et al. Glutamine regulates Caco-2 cell tight junction proteins. Am J Physiol Gastrointest Liver Physiol. 2004;287(3):G726–G733.
   PubMed Web of Science ®Google Scholar
• Huang Y, Shao XM, Neu J. Immunonutrients and neonates. Eur J Pediatr. 2003;162(3):122–128.
   PubMed Web of Science ®Google Scholar
• Grimble RF. Immunonutrition. Curr Opin Gastroenterol. 2005;21(2):216–222.
   PubMed Web of Science ®Google Scholar
• van de Poll MC, Siroen MP, van Leeuwen PA, et al. Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism. Am J Clin Nutr. 2007;85(1):167–172.
   PubMed Web of Science ®Google Scholar
• Zafarullah M, Li WQ, Sylvester J, et al. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci. 2003;60(1):6–20.
   PubMed Web of Science ®Google Scholar
• Manzoni P, Rinaldi M, Cattani S, et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial. JAMA. 2009;302(13):1421–1428.
   PubMed Web of Science ®Google Scholar
• Ofek Shlomai N, Deshpande G, Rao S, et al. Probiotics for preterm neonates: what will it take to change clinical practice? Neonatology. 2014;105(1):64–70.
   PubMed Web of Science ®Google Scholar
• Dvorak B, Halpern MD, Holubec H, et al. Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol. 2002;282(1):G156–G164.
   PubMed Web of Science ®Google Scholar
• Feng J, El-Assal ON, Besner GE. Heparin-binding epidermal growth factor-like growth factor decreases the incidence of necrotizing enterocolitis in neonatal rats. J Pediatr Surg. 2006;41(1):144–149. (discussion 144).
   PubMed Web of Science ®Google Scholar
• Nowicki PT, Dunaway DJ, Nankervis CA, et al. Endothelin-1 in human intestine resected for necrotizing enterocolitis. J Pediatr. 2005;146(6):805–810.
   PubMed Web of Science ®Google Scholar
• Ohtsuka Y, Okada K, Yamakawa Y, et al. ω-3 fatty acids attenuate mucosal inflammation in premature rat pups. J Pediatr Surg. 2011;46(3):489–495.
   PubMed Web of Science ®Google Scholar
• Garg BD, Balasubramanian H, Kabra NS. Physiological effects of prebiotics and its role in prevention of necrotizing enterocolitis in preterm neonates. J Matern Fetal Neonatal Med. 2017;31:1–8.
   PubMed Web of Science ®Google Scholar
• Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg. 1978;187(1):1–7.
   PubMed Web of Science ®Google Scholar
• Amin HJ, Zamora SA, McMillan DD, et al. Arginine supplementation prevents necrotizing enterocolitis in the premature infant. J Pediatr. 2002;140(4):425–431.
   PubMed Web of Science ®Google Scholar
• Polycarpou E, Zachaki S, Tsolia M, et al. Enteral l-arginine supplementation for prevention of necrotizing enterocolitis in very low birth weight neonates: a double-blind randomized pilot study of efficacy and safety. JPEN J Parenter Enteral Nutr. 2013;37(5):617–622.
   PubMed Web of Science ®Google Scholar
• EL-Shimi MS, Awad HA, Abdelwahed MA, et al. Enteral l-arginine and glutamine supplementation for prevention of NEC in preterm neonates. Int J Pediatr. 2015;2015:856091. doi:10.1155/2015/856091
   PubMedGoogle Scholar
• Neu J, Roig JC, Meetze WH, et al. Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J Pediatr. 1997;131(5):691–699.
   PubMed Web of Science ®Google Scholar
• Vaughn P, Thomas P, Clark R, et al. Enteral glutamine supplementation and morbidity in low birth weight infants. J Pediatr. 2003;142(6):662–668.
   PubMed Web of Science ®Google Scholar
• Van den Berg A, van Elburg RM, Westerbeek EA, et al. Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial. Am J Clin Nutr. 2005;81(6):1397–1404.
   PubMed Web of Science ®Google Scholar
• Van Zwol A, Van den Berg A, Huisman J, et al. Neurodevelopmental outcomes of very low-birth-weight infants after enteral glutamine supplementation in the neonatal period. Acta Paediatr. 2008;97(5):562–567.
   PubMed Web of Science ®Google Scholar
• de Kieviet JF, Oosterlaan J, van Zwol A, et al. Effects of neonatal enteral glutamine supplementation on cognitive, motor and behavioural outcomes in very preterm and/or very low birth weight children at school age. Br J Nutr. 2012;108(12):2215–2220.
   PubMed Web of Science ®Google Scholar
• de Kieviet JF, Oosterlaan J, Vermeulen RJ, et al. Effects of glutamine on brain development in very preterm children at school age. Pediatrics. 2012;130(5):e1121–e1127.
   PubMed Web of Science ®Google Scholar
• Korkmaz A, Yurdakök M, Yiğit S, et al. Long-term enteral glutamine supplementation in very low birth weight infants: effects on growth parameters. Turk J Pediatr. 2007;49(1):37–44.
   PubMed Web of Science ®Google Scholar
• Sevastiadou S, Malamitsi-Puchner A, Costalos C, et al. The impact of oral glutamine supplementation on the intestinal permeability and incidence of necrotizing enterocolitis/septicemia in premature neonates. J Matern Fetal Neonatal Med. 2011;24(10):1294–1300.
   PubMed Web of Science ®Google Scholar
• Pawlik D, Lauterbach R, Hurkała J, et al. The effects of enteral administration of glutamine enriched solution in very low birth weight infants on reducing the symptoms of feeding intolerance. A prospective, randomized pilot study. Med Wieku Rozwoj. 2012;16(3):205–211.
   PubMedGoogle Scholar
• Lacey JM, Crouch JB, Benfell K, et al. The effects of glutamine-supplemented parenteral nutrition in premature infants. JPEN J Parenter Enter Nutr. 1996;20(1):74–80.
   PubMedGoogle Scholar
• Thompson SW, McClure BG, Tubman TRJ. A randomised controlled trial of parenteral glutamine in ill very low birth weight neonates. J Parenter Enter Nutr. 2003;37:550–553.
   Google Scholar
• Poindexter BB, Ehrenkranz RA, Stoll BJ, et al. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics. 2004;113(5):1209–1215.
   PubMed Web of Science ®Google Scholar
• Bober-Olesiñska K, Kornacka MK. Effects of glutamine supplemented parenteral nutrition on the incidence of necrotizing enterocolitis, nosocomial sepsis and length of hospital stay in very low birth weight infants. Med Wieku Rozwoj. 2005;9(3Pt1):325–333.
   Google Scholar
• Wang Y, Tao YX, Cai W, et al. Protective effect of parenteral glutamine supplementation on hepatic function in very low birth weight infants. Clinical Nutrition. 2010;29(3):307–311.
   PubMed Web of Science ®Google Scholar
• Ahola T, Lapatto R, Raivio KO, et al. N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: a randomized controlled trial. J Pediatr. 2003;143(6):713–719.
   PubMed Web of Science ®Google Scholar
• Mohamad Ikram I, Quah BS, Noraida R, et al. A randomised controlled trial of glutamine-enriched neonatal parenteral nutrition in Malaysia. Singapore Med J. 2011;52(5):356–360.
   PubMed Web of Science ®Google Scholar
• Li ZH, Wang DH, Dong M. Effect of parenteral glutamine supplementation in premature infants. Chinese Medical Journal. 2007;120(2):140–144.
   PubMed Web of Science ®Google Scholar
• Poindexter BB, Langer JC, Dusick AM, et al. Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome. J Pediatr. 2006;148(3):300–305.
   PubMed Web of Science ®Google Scholar
• Shah PS, Shah VS, Kelly LE. Arginine supplementation for prevention of necrotising enterocolitis in preterm infants. Cochrane Database Syst Rev. 2017;4:CD004339. doi:10.1002/14651858.CD004339.pub4
   PubMed Web of Science ®Google Scholar
• Moe-Byrne T, Brown JVE, McGuire W. Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2016;4:CD001457. doi:10.1002/14651858.CD001457.pub6
   PubMed Web of Science ®Google Scholar