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Original Articles

Association of SARS-CoV-2 placental histopathology findings with maternal–fetal comorbidities and severity of COVID-19 hypoxia

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Pages 8412-8418 | Received 12 May 2021, Accepted 03 Sep 2021, Published online: 20 Sep 2021

References

  • Yanqing D, Xiuwu B. Discovered from the autopsy of SARS, analysis of several problems of the new coronavirus infection disease (COVID-19). Chinese J Pathol. 2020;49(4):291–293.
  • Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420–422.
  • Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020;144(7):799–805.
  • Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809–815.
  • Trypsteen W, Van Cleemput J, Snippenberg WV, et al. On the whereabouts of SARS-CoV-2 in the human body: a systematic review. PLOS Pathog. 2020;16(10):e1009037
  • Pettirosso E, Giles M, Cole S, et al. COVID-19 and pregnancy: a review of clinical characteristics, obstetric outcomes and vertical transmission. Aust N Z J Obstet Gynaecol. 2020;60(5):640–659.
  • Huntley BJF, Huntley ES, Di Mascio D, et al. Rates of maternal and perinatal mortality and vertical transmission in pregnancies complicated by severe acute respiratory syndrome coronavirus 2 (SARS-Co-V-2) infection: a systematic review. Obstet Gynecol. 2020;136(2):303–312.
  • Vivanti AJ, Vauloup-Fellous C, Prevot S, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(1):3572.
  • Zhang W, Du RH, Li B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 2020;9(1):386–389.
  • Pulinx B, Kieffer D, Michiels I, et al. Vertical transmission of SARS-CoV-2 infection and preterm birth. Eur J Clin Microbiol Infect Dis. 2020;39(12):2441–2445.
  • Zeng H, Xu C, Fan J, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA. 2020;323(18):1848–1849.
  • Taglauer E, Benarroch Y, Rop K, et al. Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyads. Placenta. 2020;100:69–74.
  • Dong L, Tian J, He S, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020;323(18):1846–1848.
  • Li M, Chen L, Zhang J, et al. The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. PLOS One. 2020;15(4):e0230295.
  • Hecht JL, Quade B, Deshpande V, et al. SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. Mod Pathol. 2020;33(11):2092–2103.
  • Gengler C, Dubruc E, Favre G, et al. SARS-CoV-2 ACE-receptor detection in the placenta throughout pregnancy. Clin Microbiol Infect. 2021;27(3):489–490. Mar
  • Schwartz DA, Morotti D, Beigi B, et al. Confirming vertical fetal infection with coronavirus disease 2019: neonatal and pathology criteria for early onset and transplacental transmission of severe acute respiratory syndrome coronavirus 2 from infected pregnant mothers. Arch Pathol Lab Med. 2020;144(12):1451–1456.
  • Facchetti F, Bugatti M, Drera E, et al. SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of placenta. EBioMedicine. 2020;59:102951 Sep
  • Patanè L, Morotti D, Giunta MR, et al. Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019-positive mothers and neonates at birth. Am J Obstet Gynecol. 2020;2(3):100145.
  • Zhang P, Salafia C, Heyman T, et al. Detection of severe acute respiratory syndrome coronavirus 2 in placentas with pathology and vertical transmission. Am J Obstet Gynecol. 2020;2(4):100197.
  • Menter T, Mertz KD, Jiang S, et al. Placental pathology findings during and after SARS-CoV-2 infection: features of villitis and malperfusion. Pathobiology. 2021;88(1):69–77.
  • Best Rocha A, Stroberg E, Barton LM, et al. Detection of SARS-CoV-2 in formalin-fixed paraffin-embedded tissue sections using commercially available reagents. Lab Invest. 2020;100(11):1485–1489.
  • Valdespino-Vázquez MY, Helguera-Repetto CA, León-Juárez M, et al. Fetal and placental infection with SARS-CoV-2 in early pregnancy. J Med Virol. 2021;93(7):4480–4487.
  • Schwartz DA, Baldewijns M, Benachi A, et al. Hofbauer cells and coronavirus disease 2019 (COVID-19) in pregnancy: molecular pathology analysis of villous macrophages, endothelial cells, and placental findings from 22 placentas infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without fetal transmission. Arch Pathol Lab Med. 2021. DOI:10.5858/arpa.2021-0296-SA
  • Roberts DJ, Edlow AG, Romero RJ, et al. SPECIAL REPORT: a standardized definition of placental infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH/NICHD) SARS-CoV-2 placental infection workshop. Am J Obstet Gynecol. 2021. DOI:10.1016/j.ajog.2021.07.029
  • Schwartz DA, Baldewijns M, Benachi A, et al. Chronic histiocytic intervillositis with trophoblast necrosis is a risk factor associated with placental infection from coronavirus disease 2019 (COVID-19) and intrauterine maternal-fetal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in live-born and stillborn infants. Arch Pathol Lab Med. 2021;145(5):517–528.
  • Patberg ET, Adams T, Rekawek P, et al. Coronavirus disease 2019 infection and placental histopathology in women delivering at term. Am J Obstet Gynecol. 2021;224(4):382.e1–382.e18.
  • Redline RW, Ravishankar S. Fetal vascular malperfusion, an update. APMIS. 2018;126(7):561–569.
  • Ernst LM. Maternal vascular malperfusion of the placental bed. APMIS. 2018;126(7):551–560.
  • Shanes ED, Mithal LB, Otero S, et al. Placental pathology in COVID-19. Am J Clin Pathol. 2020;154(1):23–32.
  • Hosier H, Farhadian SF, Morotti RA, et al. SARS-CoV-2 infection of the placenta. J Clin Invest. 2020;130(9):4947–4953.
  • Smithgall MC, Liu-Jarin X, Hamele-Bena D, et al. Third-trimester placentas of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive women: histomorphology, including viral immunohistochemistry and in-situ hybridization. Histopathology. 2020;77(6):994–999.
  • Prabhu M, Cagino K, Matthews KC, et al. Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York city: a prospective cohort study. BJOG. 2020;127(12):1548–1556.
  • Hsu AL, Guan M, Johannesen E, et al. Placental SARS-CoV-2 in a pregnant woman with mild COVID-19 disease. J Med Virol. 2021;93(2):1038–1044.
  • Girolamo RD, Khalil A, Alameddine S, et al. Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021:100468.
  • Zhang P, Heyman T, Greechan M, et al. Maternal, neonatal and placental characteristics of SARS-CoV-2 positive mothers. J Matern Fetal Neonatal Med. 2021:1–9.
  • Debelenko L, Katsyv I, Chong AM, et al. Trophoblast damage with acute and chronic intervillositis: disruption of placental barrier by SARS-CoV-2. Hum Pathol. 2021;109:69–79.
  • Cribiù FM, Erra R, Pugni L, et al. Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission. J Clin Invest. 2021;131(6):e145427.
  • Racicot K, Mor G. Risks associated with viral infections during pregnancy. J Clin Invest. 2017;127(5):1591–1599.
  • Gulersen M, Prasannan L, Tam H, et al. Histopathologic evaluation of placentas after diagnosis of maternal severe acute respiratory syndrome coronavirus 2 infection. Am J Obstet Gynecol. 2020;2(4):100211.
  • Khong TY, Mooney EE, Ariel I, et al. Sampling and definitions of placental lesions: Amsterdam placental workshop group consensus statement. Arch Pathol Lab Med. 2016;140(7):698–713.
  • Baergen RN, Heller DS. Placental pathology in covid-19 positive mothers: preliminary findings. Pediatr Dev Pathol. 2020;23(3):177–180.
  • Chen X, Zhao B, Qu Y, et al. Detectable serum severe acute respiratory syndrome coronavirus 2 viral load (RNAemia) is closely correlated with drastically elevated interleukin 6 level in critically ill patients with coronavirus disease 2019. Clin Infect Dis. 2020;71(8):1937–1942.
  • Kreis NN, Ritter A, Louwen F, et al. A message from the human placenta: structural and immunomodulatory defense against SARS-CoV-2. Cells. 2020;9(8):1777.
  • Garrido-Pontnou M, Navarro A, Camacho J, et al. Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise. Mod Pathol. 2021;34(9):1704–1709.
  • Lu-Culligan A, Chavan AR, Vijayakumar P, et al. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Medicine. 2021;2(5):591–610.e10.
  • Rebutini PZ, Zanchettin AC, Stonoga ETS, et al. Association between COVID-19 pregnant women symptoms severity and placental morphologic features. Front Immunol. 2021;12:685919.
  • Oakes MC, Kernberg AS, Carter EB, et al. Pregnancy as a risk factor for severe coronavirus disease 2019 using standardized clinical criteria. Am J Obstet Gynecol. 2021;3(3):100319.
  • Sharps MC, Hayes DJL, Lee S, et al. A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection. Placenta. 2020;101:13–29.
  • Tasca C, Rossi RS, Corti S, et al. Placental pathology in COVID-19 affected pregnant women: a prospective case-control study. Placenta. 2021;110:9–15.

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