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Letter to the Editor

Response to article – alternative interpretation of “there is reduced immunohistochemical staining of placental aromatase in severe neonatal opioid withdrawal syndrome”

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Article: 2183469 | Received 06 Nov 2022, Accepted 15 Feb 2023, Published online: 02 Mar 2023

References

  • Townsel C, Odukoya E, Rae J, et al. There is reduced immunohistochemical staining of placental aromatase in severe neonatal opioid withdrawal syndrome. J Matern Fetal Neonatal Med. 2022;2:1–7.
  • Nanovskaya TN, Deshmukh SV, Nekhayeva IA, et al. Methadone metabolism by human placenta. Biochem Pharmacol. 2004;68(3):583–591.
  • Deshmukh SV, Nanovskaya TN, Ahmed MS. Aromatase is the major enzyme metabolizing buprenorphine in human placenta. J Pharmacol Exp Ther. 2003;306(3):1099–1105.
  • Jones HE, Kaltenbach K, Heil SH, et al. Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med. 2010;363(24):2320–2331.
  • Zharikova OL, Deshmukh SV, Nanovskaya TN, et al. The effect of methadone and buprenorphine on human placental aromatase. Biochem Pharmacol. 2006;71(8):1255–1264.