Cardiovascular effects of oxytocin and carbetocin at cesarean section. A prospective double-blind randomized study using noninvasive pulse wave analysis

References

• Hendricks CH, Brenner WE. Cardiovascular effects of oxytocic drugs used post partum. Am J Obstet Gynecol. 1970;108(5):751–760.
   PubMed Web of Science ®Google Scholar
• Carvalho JCA, Balki M, Kingdom J, et al. Oxytocin requirements at elective cesarean delivery: a dose-finding study. Obstet Gynecol. 2004;104(5 Pt 1):1005–1010.
   PubMed Web of Science ®Google Scholar
• Langesaeter E, Rosseland LA, Stubhaug A. Haemodynamic effects of repeated doses of oxytocin during caesarean delivery in healthy parturients. Br J Anaesth. 2009;103(2):260–262.
   PubMed Web of Science ®Google Scholar
• Mukaddam-Daher S, Yin Y-L, Roy J, et al. Negative inotropic and chronotropic effects of oxytocin. Hypertension. 2001;38:292–296.
   PubMed Web of Science ®Google Scholar
• Pinder AJ, Dresner M, Calow C, et al. Haemodynamic changes caused by oxytocin during caesarean section under spinal anaesthesia. Int J Obstet Anesth. 2002;11(3):156–159.
   PubMed Web of Science ®Google Scholar
• Svanström MC, Biber B, Hanes M, et al. Signs of myocardial ischaemia after injection of oxytocin: a randomized double-blind comparison of oxytocin and methylergometrine during caesarean section. Br J Anaesth. 2008;100(5):683–689.
   PubMed Web of Science ®Google Scholar
• Thomas JS, Koh SH, Cooper GM. Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing caesarean section. Br J Anaesth. 2007;98(1):116–119.
   PubMed Web of Science ®Google Scholar
• Jonsson M, Hanson U, Lidell C, et al. ST depression at caesarean section and the relation to oxytocin dose. A randomised controlled trial. BJOG. 2010;117(1):76–83.
   PubMed Web of Science ®Google Scholar
• Moertl M, Friedrich S, Kraschl J, et al. Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: a randomised trial. BJOG. 2011;118(11):1349–1356.
   PubMed Web of Science ®Google Scholar
• Larciprete G, Montagnoli C, Frigo M, et al. Carbetocin versus oxytocin in caesarean section with high risk of post-partum haemorrhage. J Prenat Med. 2013;7:12–18.
   PubMedGoogle Scholar
• Rath W. Prevention of postpartum haemorrhage with the oxytocin analogue carbetocin. Eur J Obstet Gynecol Reprod Biol. 2009;147(1):15–20.
   PubMed Web of Science ®Google Scholar
• Holleboom CAG, Van Eyck J, Koenen SV, et al. Carbetocin in comparison with oxytocin in several dosing regimens for the prevention of uterine atony after elective caesarean section in the Netherlands. Arch Gynecol Obstet. 2013;287(6):1111–1117.
   PubMed Web of Science ®Google Scholar
• Hunter DJS, Schulz P, Wassenaar W. Effect of carbetocin, a long-acting oxytocin analog on the postpartum uterus. Clin Pharmacol Ther. 1992;52(1):60–67.
   PubMed Web of Science ®Google Scholar
• Su L-L, Chong Y-S, Samuel M. Carbetocin for preventing postpartum haemorrhage. In: Su L-L, editor. Cochrane database of systematic review [Internet]. Chichester: John Wiley & Sons, Ltd; 2012. Available from: https://onlinelibrary.wiley.com/10.1002/14651858.CD005457.pub4
   Google Scholar
• Widmer M, Piaggio G, Nguyen TMH, et al. Heat-Stable carbetocin versus oxytocin to prevent hemorrhage after vaginal birth. N Engl J Med. 2018;379(8):743–752.
   PubMed Web of Science ®Google Scholar
• Voon HY, Shafie AA, Bujang MA, et al. Cost effectiveness analysis of carbetocin during cesarean section in a high volume maternity unit. J Obstet Gynaecol Res. 2018;44(1):109–116.
   PubMed Web of Science ®Google Scholar
• Sun H, Xu L, Li Y, et al. Effectiveness and safety of carboxytocin versus oxytocin in preventing postpartum hemorrhage: a systematic review and meta-analysis. J Obstet Gynaecol. 2022;48(4):889–901.
   Google Scholar
• Ai W, Zeng Y, Ma Y, et al. Side-effects of carbetocin to prevent postpartum hemorrhage: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res Perspect. 2021;9:11.
   Web of Science ®Google Scholar
• Rosseland LA, Hauge TH, Grindheim G, et al. Changes in blood pressure and cardiac output during cesarean delivery the effects of oxytocin and carbetocin compared with placebo. Anesthesiology. 2013;119(3):541–551.
   PubMed Web of Science ®Google Scholar
• Pisani I, Tiralongo GM, Gagliardi G, et al. The maternal cardiovascular effect of carbetocin compared to oxytocin in women undergoing caesarean section. Pregnancy Hypertens. 2012;2(2):139–142.
   PubMed Web of Science ®Google Scholar
• Millasseau SC, Ritter JM, Takazawa K, et al. Contour analysis of the photoplethysmographic pulse measured at the finger. J Hypertens. 2006;24(8):1449–1456.
   PubMed Web of Science ®Google Scholar
• von Wowern E, Östling G, Nilsson PM, et al. Digital photoplethysmography for assessment of arterial stiffness: repeatability and comparison with applanation tonometry. West J, editor. PLoS One. 2015;10(8):e0135659.
   PubMed Web of Science ®Google Scholar
• Rabow S, Olofsson P. Pulse wave analysis by digital photoplethysmography to record maternal hemodynamic effects of spinal anesthesia, delivery of the baby, and intravenous oxytocin during cesarean section. J Matern Neonatal Med. 2017;30(7):759–766.
   PubMed Web of Science ®Google Scholar
• Rabow S, Hjorth U, Schönbeck S, et al. Effects of oxytocin and anaesthesia on vascular tone in pregnant women: a randomised double-blind placebo-controlled study using non-invasive pulse wave analysis. BMC Pregnancy Childbirth. 2018;18(1):453.
   PubMedGoogle Scholar
• Attilakos G, Psaroudakis D, Ash J, et al. Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomised trial. BJOG. 2010;117(8):929–936.
   PubMed Web of Science ®Google Scholar
• American Society of Anesthesiologists - ASA Physical Status Classification System [Internet]; [cited 2017 Sep 21]. Available from: https://www.asahq.org/resources/clinical-information/asa-physical-status-classification-system
   Google Scholar
• Elgendi M. On the analysis of fingertip photoplethysmogram signals. Curr Cardiol Rev. 2012;8(1):14–25.
   PubMedGoogle Scholar
• Elgendi M. Standard terminologies for photoplethysmogram signals. Curr Cardiol Rev. 2012;8(3):215–219.
   PubMedGoogle Scholar
• Boisselle MÈ, Zaphiratos VV, Fortier A, et al. Comparison of carbetocin as a bolus or an infusion with prophylactic phenylephrine on maternal heart rate during cesarean delivery under spinal anesthesia: a double-blinded randomized controlled trial. Can J Anaesth. 2022;69(6):715–725.
   PubMed Web of Science ®Google Scholar
• Heesen M, Carvalho B, Carvalho JCA, et al. International consensus statement on the use of uterotonic agents during caesarean section. Anaesthesia. 2019;74(10):1305–1319.
   PubMed Web of Science ®Google Scholar
• Geeraerts T, Albaladejo P, Declère AD, et al. Decrease in left ventricular ejection time on digital arterial waveform during simulated hypovolemia in normal humans. J Trauma. 2004;56(4):845–849.
   PubMedGoogle Scholar
• Tavakolian K. Systolic time intervals and new measurement methods. Cardiovasc Eng Tech. 2016;7(2):118–125.
   PubMed Web of Science ®Google Scholar
• Alhakak AS, Teerlink JR, Lindenfeld J, et al. The significance of left ventricular ejection time in heart failure with reduced ejection fraction. Eur J Heart Fail. 2021;23(4):541–551.
   PubMed Web of Science ®Google Scholar
• Boudoulas H. Systolic time intervals. Eur Heart J. 1990;11(suppl I):93–104.
   PubMedGoogle Scholar
• Akc GDL, Chamberlain BM, Rgn EJP, et al. Oesophageal doppler monitor (ODM) guided individualised goal directed fluid management (iGDFM) in surgery - a technical review. Deltex Med. 2010;9051–3014:1–12.
   Google Scholar
• Parsonage WA, Zentner D, Lust K, et al. Heart disease and pregnancy: the need for a twenty-first century approach to care…. hear. Lung Circ. 2021;30(1):45–51.
   PubMed Web of Science ®Google Scholar
• Bekkenes M, Jørgensen MM, Flem Jacobsen A, et al. A study protocol for the cardiac effects of a single dose of either oxytocin 2.5 IU or carbetocin 100 µg after caesarean delivery: a prospective randomized controlled multi-centre trial in Norway. F1000Res. 2021;10:973.
   PubMedGoogle Scholar
• Onwochei DN, Owolabi A, Singh PM, et al. Carbetocin compared with oxytocin in non-elective cesarean delivery: a systematic review, meta-analysis, and trial sequential analysis of randomized-controlled trials. Can J Anaesth. 2020;67(11):1524–1534.
   PubMed Web of Science ®Google Scholar
• Onwochei DN, Van Ross J, Singh PM, et al. Carbetocin reduces the need for additional uterotonics in elective caesarean delivery: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. Int J Obstet Anesth. 2019;40:14–23.
   PubMed Web of Science ®Google Scholar
• McKay EC, Counts SE. Oxytocin receptor signaling in vascular function and stroke. Front. Neurosci. 2020;14:1–18.
   PubMed Web of Science ®Google Scholar
• Passoni I, Leonzino M, Gigliucci V, et al. Carbetocin is a functional selective Gq agonist that does not promote oxytocin receptor recycling after inducing β‐arrestin‐independent internalisation. J Neuroendocrinol. 2016;28(4):12363.
   Web of Science ®Google Scholar