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Review Article

Risk factors for adverse outcomes in twin pregnancies: a narrative review

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Article: 2240467 | Received 27 Apr 2023, Accepted 19 Jul 2023, Published online: 30 Jul 2023

References

  • Black M, Bhattacharya S. Epidemiology of multiple pregnancy and the effect of assisted conception. Semin Fetal Neonatal Med. 2010;15(6):306–312. doi: 10.1016/j.siny.2010.06.004.
  • NICE Guidelines. Twin and triplet pregnancy, 1–61. 2019. Available from: https://www.nice.org.uk/guidance/ng137/resources/twin-and-triplet-pregnancy-pdf-66141724389829.
  • Office for National Statistics. Birth characteristics in England and Wales. Annual live births by sex, ethnicity and month, maternities by place of birth and with multiple births, and stillbirths by age of parents and calendar quarter. 2019. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/bulletins/birthcharacteristicsinenglandandwales/2017.
  • Blondel B, Macfarlane A, Gissler M; PERISTAT Study Group., et al. Preterm birth and multiple pregnancy in European countries participating in the PERISTAT project. BJOG. 2006;113(5):528–535. doi: 10.1111/j.1471-0528.2006.00923.x.
  • Kilby MD, Gibson JL, Ville Y. Falling perinatal mortality in twins in the UK: organisational success or chance? BJOG. 2019;126(3):341–347. doi: 10.1111/1471-0528.15517.
  • Gibson JL, Castleman JS, Meher S, et al. Updated guidance for the management of twin and triplet pregnancies from the national institute for health and care excellence guidance, UK: what’s new that may improve perinatal outcomes? Acta Obstet Gynecol Scand. 2020;99(2):147–152. doi: 10.1111/aogs.13785.
  • Russo FM, Pozzi E, Pelizzoni F, et al. Stillbirths in singletons, dichorionic and monochorionic twins: a comparison of risks and causes. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):131–136. doi: 10.1016/j.ejogrb.2013.06.014.
  • Draper ES, Gallimore ID, Kurinczuk JJ, Kenyon S (Eds.); on behalf of MBRRACE-UK. MBRRACE-UK 2019 perinatal confidential enquiry: stillbirths and neonatal deaths in twin pregnancies. In The infant mortality and morbidity studies, department of health sciences. Leicester: University of Leicester; 2021. Available from: https://www.npeu.ox.ac.uk/assets/downloads/mbrrace-uk/reports/perinatal-report-2020-twins/MBRRACE-UK_Twin_Pregnancies_Confidential_Enquiry.pdf.
  • Windmill H on behalf of Tamba. Twins and multiple births association. Reducing stillbirths in multiple pregnancies and the nhs stillbirth “care bundle.” 2019; 1–10. Available from: https://twinstrust.org/asset/$EA170AD6-F8A5-4F67-A85CE9A6CDE68EB7/#:∼:text=Whilst%20the%20proposed%20care%20bundle,differences%20between%20twins%20and%20singletons.
  • Khalil A, Reed K. Confidential enquiry into stillbirth and neonatal death in twins: key messages for obstetricians and fetal medicine specialists. Ultrasound Obstet Gynecol. 2021;58(6):799–803. doi: 10.1002/uog.23594.
  • Carter EB, Bishop KC, Goetzinger KR, et al. The impact of chorionicity on maternal pregnancy outcomes. Am J Obstet Gynecol. 2015;213(3):390.e1-390–.e7. doi: 10.1016/j.ajog.2015.05.027.
  • Miller JL. Twin to twin transfusion syndrome. Transl Pediatr. 2021;10(5):1518–1529. doi: 10.21037/tp-20-264.
  • D'Antonio F, Odibo A, Berghella V, et al. Perinatal mortality, timing of delivery and prenatal management of monoamniotic twin pregnancy: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2019;53(2):166–174. doi: 10.1002/uog.20100.
  • Murgano D, Khalil A, Prefumo F, et al. Outcome of twin-to-twin transfusion syndrome in monochorionic monoamniotic twin pregnancy: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2020;55(3):310–317. doi: 10.1002/uog.21889.
  • Vedel C, Oldenburg A, Worda K, et al. Short- and long-term perinatal outcome in twin pregnancies affected by weight discordance. Acta Obstet Gynecol Scand. 2017;96(2):233–242. doi: 10.1111/aogs.13062.
  • Cheong-See F, Schuit E, Arroyo-Manzano D, et al. Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ. 2016;354:i4353. doi: 10.1136/bmj.i4353.
  • De la Calle M, Bartha JL, García L, et al. Women aged over 40 with twin pregnancies have a higher risk of adverse obstetrical outcomes. Int J Environ Res Public Health. 2021;18(24):13117.
  • Xiong QF, Yu ZH, Zhang AL, et al. Impact of maternal age on perinatal outcomes in twin pregnancies: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2022;26(1):99–109.
  • Lean SC, Derricott H, Jones RL, et al. Advanced maternal age and adverse pregnancy outcomes: a systematic review and meta-analysis. PLoS One. 2017;12(10):e0186287. doi: 10.1371/journal.pone.0186287.
  • Wang Y, Shi H, Chen L, et al. Absolute risk of adverse obstetric outcomes among twin pregnancies after in vitro fertilization by maternal age. JAMA Netw Open. 2021;4(9):e2123634. doi: 10.1001/jamanetworkopen.2021.23634.
  • McLennan AS, Gyamfi-Bannerman C, Ananth CV, et al. The role of maternal age in twin pregnancy outcomes. Am J Obstet Gynecol. 2017;217(1):80.e1-80–e8. doi: 10.1016/j.ajog.2017.03.002.
  • Mullins E, Kumar S. Older mothers do not confer greater perinatal risk to dichorionic diamniotic twins. Acta Obstet Gynecol Scand. 2012;91(1):152–154. doi: 10.1111/j.1600-0412.2011.01232.x.
  • Ram M, Berger H, Lipworth H, et al. The relationship between maternal body mass index and pregnancy outcomes in twin compared with singleton pregnancies. Int J Obes (Lond). 2020;44(1):33–44. doi: 10.1038/s41366-019-0362-8.
  • Vinturache A, McKeating A, Daly N, et al. Maternal body mass index and the prevalence of spontaneous and elective preterm deliveries in an irish obstetric population: a retrospective cohort study. BMJ Open. 2017;7(10):e015258. doi: 10.1136/bmjopen-2016-015258.
  • Lucovnik M, Blickstein I, Verdenik I, et al. Maternal obesity in singleton versus twin gestations: a population-based matched case-control study. J Matern Neonatal Med. 2015;28(6):623–625. doi: 10.3109/14767058.2014.928854.
  • Sung SJ, Lee SM, Kim S, et al. The risk of spontaneous preterm birth according to maternal pre-pregnancy body mass index in twin gestations. J Korean Med Sci. 2018;33(13):e103. doi: 10.3346/jkms.2018.33.e103.
  • Al-Obaidly S, Parrish J, Murphy KE, et al. Maternal pre-gravid body mass index and obstetric outcomes in twin gestations. J Perinatol. 2014;34(6):425–428. doi: 10.1038/jp.2014.29.
  • Hildén K, Hanson U, Persson M, et al. Gestational diabetes and adiposity are independent risk factors for perinatal outcomes: a population based cohort study in Sweden. Diabet Med. 2019;36(2):151–157. doi: 10.1111/dme.13843.
  • Hauger MS, Gibbons L, Vik T, et al. Prepregnancy weight status and the risk of adverse pregnancy outcome. Acta Obstet Gynecol Scand. 2008;87(9):953–959. doi: 10.1080/00016340802303349.
  • Salihu HM, Alio AP, Belogolovkin V, et al. Prepregnancy obesity and risk of stillbirth in viable twin gestations. Obesity (Silver Spring). 2010;18(9):1795–1800. doi: 10.1038/oby.2009.479.
  • Flenady V, Wojcieszek AM, Middleton P, et al. Stillbirths: recall to action in high-income countries. Lancet. 2016;387(10019):691–702. doi: 10.1016/S0140-6736(15)01020-X.
  • Rolett A, Kiely JL. Maternal sociodemographic characteristics as risk factors for preterm birth in twins versus singletons. Paediatr Perinat Epidemiol. 2000;14(3):211–218. doi: 10.1046/j.1365-3016.2000.00268.x.
  • Soffer MD, Naqvi M, Melka S, et al. The association between maternal race and adverse outcomes in twin pregnancies with similar healthcare access. J Matern Neonatal Med. 2018;31(18):2424–2428. doi: 10.1080/14767058.2017.1344634.
  • Drassinower D, Timofeev J, Huang CC, et al. Racial disparities in outcomes of twin pregnancies: elective cesarean or trial of labor? Am J Obstet Gynecol. 2014;211(2):160.e1–160.e7. doi: 10.1016/j.ajog.2014.02.014.
  • Jardine J, Walker K, Gurol-Urganci I, et al. Adverse pregnancy outcomes attributable to socioeconomic and ethnic inequalities in England: a national cohort study. Lancet. 2021;398(10314):1905–1912. doi: 10.1016/S0140-6736(21)01595-6.
  • Opondo C, Gray R, Hollowell J, et al. Joint contribution of socioeconomic circumstances and ethnic group to variations in preterm birth, neonatal mortality and infant mortality in England and Wales: a population-based retrospective cohort study using routine data from 2006 to 2012. BMJ Open. 2019;9(7):e028227. doi: 10.1136/bmjopen-2018-028227.
  • Zeitlin J, Mortensen L, Prunet C, et al. Socioeconomic inequalities in stillbirth rates in Europe: measuring the gap using routine data from the Euro-Peristat project. BMC Pregnancy Childbirth. 2016;16(1):15. doi: 10.1186/s12884-016-0804-4.
  • Penn N, Oteng-Ntim E, Oakley LL, et al. Ethnic variation in stillbirth risk and the role of maternal obesity: analysis of routine data from a london maternity unit. BMC Pregnancy Childbirth. 2014;14(1):404. doi: 10.1186/s12884-014-0404-0.
  • Heazell AEP, Budd J, Smith LK, et al. Associations between social and behavioural factors and the risk of late stillbirth – findings from the midland and North of England stillbirth case-control study. BJOG. 2021;128(4):704–713. doi: 10.1111/1471-0528.16543.
  • Smith LK, Manktelow BN, Draper ES, et al. Trends in the incidence and mortality of multiple births by socioeconomic deprivation and maternal age in England: population-based cohort study. BMJ Open. 2014;4(4):e004514. doi: 10.1136/bmjopen-2013-004514.
  • Wisborg K, Kesmodel U, Henriksen TB, et al. Exposure to tobacco smoke in utero and the risk of stillbirth and death in the first year of life. Am J Epidemiol. 2001;154(4):322–327. doi: 10.1093/aje/154.4.322.
  • Pollack H, Lantz PM, Frohna JG. Maternal smoking and adverse birth outcomes among singletons and twins. Am J Public Health. 2000;90(3):395–400.
  • Rydhstroem H, Källén K. The effect of maternal smoking on birth weight in twin pregnancies. Early Hum Dev. 1996;46(1-2):43–53. doi: 10.1016/0378-3782(96)01739-2.
  • Orlebeke JF, Boomsma DI, Van Baal GCM, et al. Effect of maternal smoking on birth weight of twins: a study from the dutch twin register. Early Hum Dev. 1994;37(3):161–166. doi: 10.1016/0378-3782(94)90074-4.
  • Inde Y, Satomi M, Iwasaki N, et al. Maternal risk factors for small-for-gestational age newborns in japanese dichorionic twins. J Obstet Gynaecol Res. 2011;37(1):24–31. doi: 10.1111/j.1447-0756.2010.01301.x.
  • Cooperstock MS, Tummaru R, Bakewell J, et al. Twin birth weight discordance and risk of preterm birth. Am J Obstet Gynecol. 2000;183(1):63–67. doi: 10.1016/S0002-9378(00)55604-X.
  • Goldenberg RL, Iams JD, Miodovnik M, et al. The preterm prediction study: risk factors in twin gestations. National institute of child health and human development Maternal-Fetal medicine units network. Am J Obstet Gynecol. 1996;175(4 Pt 1):1047–1053. doi: 10.1016/s0002-9378(96)80051-2.
  • Wisborg K, Henriksen TB, Secher NJ. Maternal smoking and gestational age in twin pregnancies. SOBS. 2001;80(10):926–930. doi: 10.1080/791200708.
  • Ferraretti AP, Goossens V, De Mouzon J, et al. Assisted reproductive technology in Europe, 2008: results generated from european registers by ESHRE. Hum Reprod. 2012;27(9):2571–2584. doi: 10.1093/humrep/des255.
  • McDonald SD, Han Z, Mulla S, et al. Preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses. Eur J Obstet Gynecol Reprod Biol. 2009;146(2):138–148. doi: 10.1016/j.ejogrb.2009.05.035.
  • Wang AY, Safi N, Ali F, et al. Neonatal outcomes among twins following assisted reproductive technology: an Australian population-based retrospective cohort study. BMC Pregnancy Childbirth. 2018;18(1):320. doi: 10.1186/s12884-018-1949-0.
  • Pandian Z, Bhattacharya S, Templeton A. Review of unexplained infertility and obstetric outcome: a 10 year review. Hum Reprod. 2001;16(12):2593–2597. doi: 10.1093/humrep/16.12.2593.
  • Helmerhorst FM, Perquin DAM, Donker D, et al. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ. 2004;328(7434):261–264. doi: 10.1136/bmj.37957.560278.EE.
  • Koudstaal HW, Bruinse Helmerhorst FM, Vermeiden JPW, et al. Obstetric outcome of twin pregnancies after in-vitro fertilization: a matched control study in four dutch university hospitals. Hum Reprod. 2000;15(4):935–940. doi: 10.1093/humrep/15.4.935.
  • Moise J, Laor A, Armon Y, et al. The outcome of twin pregnancies after IVF. Hum Reprod. 1998;13(6):1702–1705. doi: 10.1093/humrep/13.6.1702.
  • Moini A, Shiva M, Arabipoor A, et al. Obstetric and neonatal outcomes of twin pregnancies conceived by assisted reproductive technology compared with twin pregnancies conceived spontaneously: a prospective follow-up study. Eur J Obstet Gynecol Reprod Biol. 2012;165(1):29–32. doi: 10.1016/j.ejogrb.2012.07.008.
  • Palomba S, Santagni S, Gibbins K, et al. Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors. A comprehensive review. Reprod Biomed Online. 2016;33(5):612–628. doi: 10.1016/j.rbmo.2016.08.007.
  • Domingues AP, Dinis SR, Belo A, et al. Impact of induced pregnancies in the obstetrical outcome of twin pregnancies. Fertil Steril. 2014;101(1):172–177. doi: 10.1016/j.fertnstert.2013.09.026.
  • Vasario E, Borgarello V, Bossotti C, et al. IVF twins have similar obstetric and neonatal outcome as spontaneously conceived twins: a prospective follow-up study. Reprod Biomed Online. 2010;21(3):422–428. doi: 10.1016/j.rbmo.2010.04.007.
  • Fitzsimmons BP, Bebbington MW, Fluker MR. Perinatal and neonatal outcomes in multiple gestations: assisted reproduction versus spontaneous conception. Am J Obstet Gynecol. 1998;179(5):1162–1167. doi: 10.1016/s0002-9378(98)70125-5.
  • Heazell AEP, Budd J, Li M, et al. Alterations in maternally perceived fetal movement and their association with late stillbirth: findings from the midland and North of England stillbirth case-control study. BMJ Open. 2018;8(7):e020031. doi: 10.1136/bmjopen-2017-020031.
  • Efkarpidis S, Alexopoulos E, Kean L, et al. Case-control study of factors associated with intrauterine fetal deaths. MedGenMed. 2004;6(2):53.
  • Sterpu I, Pilo C, Koistinen IS, et al. Risk factors for poor neonatal outcome in pregnancies with decreased fetal movements. Acta Obstet Gynecol Scand. 2020;99(8):1014–1021. doi: 10.1111/aogs.13827.
  • Samueloff A, Evron S, Sadovsky E. Fetal movements in multiple pregnancy. Am J Obstet Gynecol. 1983;146(7):789–792. doi: 10.1016/0002-9378(83)91079-7.
  • Aboellail MAM, Kanenishi K, Mori N, et al. Ultrasound study of fetal movements in singleton and twin pregnancies at 12-19 weeks. J Perinat Med. 2018;46(8):832–838. doi: 10.1515/jpm-2017-0158.
  • Levy M, Kovo M, Izaik Y, et al. Reduced fetal movements is twin pregnancies and the association with adverse neonatal outcomes. Eur J Obstet Gynecol Reprod Biol. 2020;246:165–168. doi: 10.1016/j.ejogrb.2020.01.050.
  • McCarthy CM, Meaney S, O'Donoghue K. Perinatal outcomes of reduced fetal movements: a cohort study. BMC Pregnancy Childbirth. 2016;16(1):169. doi: 10.1186/s12884-016-0964-2.
  • Retnakaran R, Shah BR. Impact of twin gestation and fetal sex on maternal risk of diabetes during and after pregnancy. Diabetes Care. 2016;39(8):e110–1–e111. doi: 10.2337/dc16-0825.
  • Hiersch L, Berger H, Okby R, et al. Gestational diabetes mellitus is associated with adverse outcomes in twin pregnancies. Am J Obstet Gynecol. 2019;220(1):102.e1–102.e8. doi: 10.1016/j.ajog.2018.10.027.
  • Mcgrath RT, Hocking SL, Scott ES, et al. Outcomes of twin pregnancies complicated by gestational diabetes: a meta-analysis of observational studies. J Perinatol. 2017;37(4):360–368. doi: 10.1038/jp.2016.254.
  • Lai FY, Johnson JA, Dover D, et al. Outcomes of singleton and twin pregnancies complicated by pre-existing diabetes and gestational diabetes: a population-based study in Alberta, Canada, 2005-11. J Diabetes. 2016;8(1):45–55. doi: 10.1111/1753-0407.12255.
  • González NLG, Goya M, Bellart J, et al. Obstetric and perinatal outcome in women with twin pregnancy and gestational diabetes. J Matern Neonatal Med. 2012;25(7):1084–1089. doi: 10.3109/14767058.2011.622009.
  • Buhling KJ, Henrich W, Starr E, et al. Risk for gestational diabetes and hypertension for women with twin pregnancy compared to singleton pregnancy. Arch Gynecol Obstet. 2003;269(1):33–36. doi: 10.1007/s00404-003-0483-z.
  • Simoes T, Queiros A, Correia L, et al. Gestational diabetes mellitus complicating twin pregnancies. J Perinat Med. 2011;39(4):437–440.
  • Dave ED, Bodnar LM, Vani K, et al. Perinatal outcomes in twin pregnancies complicated by gestational diabetes. Am J Obstet Gynecol MFM. 2021;3(5):100396. doi: 10.1016/j.ajogmf.2021.100396.
  • Luo ZC, Simonet F, Wei SQ, et al. Diabetes in pregnancy may differentially affect neonatal outcomes for twins and singletons. Diabet Med. 2011;28(9):1068–1073. doi: 10.1111/j.1464-5491.2011.03366.x.
  • Okby R, Weintraub AY, Sergienko R, et al. Gestational diabetes mellitus in twin pregnancies is not associated with adverse perinatal outcomes. Arch Gynecol Obstet. 2014;290(4):649–654. doi: 10.1007/s00404-014-3272-y.
  • Foeller ME, Zhao S, Szabo A, et al. Neonatal outcomes in twin pregnancies complicated by gestational diabetes compared with non-diabetic twins. J Perinatol. 2015;35(12):1043–1047. doi: 10.1038/jp.2015.133.
  • Giorgione V, Melchiorre K, O'Driscoll J, et al. Maternal echocardiographic changes in twin pregnancies with and without pre-eclampsia. Ultrasound Obstet Gynecol. 2022;59(5):619–626. doi: 10.1002/uog.24852.
  • Sibai BM, Hauth J, Caritis S, et al. Hypertensive disorders in twin versus singleton gestations. Am J Obstet Gynecol. 2000;182(4):938–942. doi: 10.1016/s0002-9378(00)70350-4.
  • Aviram A, Berger H, Abdulaziz KE, et al. Outcomes associated with hypertensive disorders of pregnancy in twin compared with singleton gestations. Obstet Gynecol. 2021;138(3):449–458. doi: 10.1097/AOG.0000000000004506.
  • Laine K, Murzakanova G, Sole KB, et al. Prevalence and risk of pre-eclampsia and gestational hypertension in twin pregnancies: a population-based register study. BMJ Open. 2019;9(7):e029908. doi: 10.1136/bmjopen-2019-029908.
  • Foo JY, Mangos GJ, Brown MA. Characteristics of hypertensive disorders in twin versus singleton pregnancies. Pregnancy Hypertens. 2013;3(1):3–9. doi: 10.1016/j.preghy.2012.05.005.
  • Day MC, Barton JR, O'Brien JM, et al. The effect of fetal number on the development of hypertensive conditions of pregnancy. Obstet Gynecol. 2005;106(5 Pt 1):927–931. doi: 10.1097/01.AOG.0000182578.82926.9c.
  • Santema JG, Koppelaar I, Wallenburg HCS. Hypertensive disorders in twin pregnancy. Eur J Obstet Gynecol Reprod Biol. 1995;58(1):9–13. doi: 10.1016/0028-2243(94)01982-d.
  • Hayes-Ryan D, Meaney S, Hodnett A, et al. The maternal and perinatal implications of hypertensive disorders of pregnancy in a multiple pregnancy cohort. Acta Obstet Gynecol Scand. 2020;99(4):525–536. doi: 10.1111/aogs.13774.
  • Hehir MP, Breathnach FM, McAuliffe FM, et al. Gestational hypertensive disease in twin pregnancy: influence on outcomes in a large national prospective cohort. Aust N Z J Obstet Gynaecol. 2016;56(5):466–470. doi: 10.1111/ajo.12483.
  • Gulati N, Mackie FL, Cox P, et al. Cause of intrauterine and neonatal death in twin pregnancies (CoDiT): development of a novel classification system. BJOG. 2020;127(12):1507–1515. doi: 10.1111/1471-0528.16291.