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Brief Report

Immunosuppressive therapy with tacrolimus is a potential drug candidate for the prevention of unexplained or preeclamptic stillbirths with Th1-dominant immune states: a case series of five patients

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Article: 2258254 | Received 13 Dec 2021, Accepted 07 Sep 2023, Published online: 13 Sep 2023

References

  • Arck PC, Hecher K. Fetomaternal immune cross-talk and its consequences for maternal and offspring’s health. Nat Med. 2013;19(5):548–556. doi:10.1038/nm.3160.
  • Yang F, Zheng Q, Jin L. Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface. Front Immunol. 2019;10:2317. doi:10.3389/fimmu.2019.02317.
  • Yamaguchi K. Tacrolimus treatment for infertility related to maternal-fetal immune interactions. Am J Reprod Immunol. 2019;81(4):e13097. doi:10.1111/aji.13097.
  • King A, Allan DS, Bowen M, et al. HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells. Eur J Immunol. 2000;30(6):1623–1631. doi:10.1002/1521-4141(200006)30:6 < 1623::AID-IMMU1623 > 3.0.CO;2-M.
  • Hviid TV. HLA-G in human reproduction: aspects of genetics function and pregnancy complications. Hum Reprod Update. 2006;12(3):209–232. doi:10.1093/humupd/dmi048.
  • Tsuda S, Nakashima A, Shima T, et al. New paradigm in the role of regulatory T cells during pregnancy. Front Immunol. 2019;10:573. doi:10.3389/fimmu.2019.00573.
  • Huang N, Chi H, Qiao J. Role of regulatory T cells in regulating fetal-maternal immune tolerance in healthy pregnancies and reproductive diseases. Front Immunol. 2020;11:1023. doi:10.3389/fimmu.2020.01023.
  • Stillbirth Collaborative Research Network Writing Group. Causes of death among stillbirths. JAMA. 2011;306:2459–2468.
  • Aneman I, Pienaar D, Suvakov S, et al. Mechanisms of key innate immune cells in early- and late-onset preeclampsia. Front Immunol. 2020;11:1864. doi:10.3389/fimmu.2020.01864.
  • Wei X, Yang X. The Central role of natural killer cells in preeclampsia. Front Immunol. 2023;14:1009867. doi:10.3389/fimmu.2023.1009867.
  • Nakagawa K, Kwak-Kim J, Ota K, et al. Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. Am J Reprod Immunol. 2015;73(4):353–361. doi:10.1111/aji.12338.
  • Nakagawa K, Kwak-Kim J, Kuroda K, et al. Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures. Am J Reprod Immunol. 2017;78(3). doi:10.1111/aji.12682.
  • Hisano M, Nakagawa K, Kwak-Kim J, et al. Changes in the T-helper 1 and 2 cell populations during pregnancy in tacrolimus-treated women with repeated implantation failure and recurrent pregnancy loss. Hum Fertil. 2022;25(5):975–982. doi:10.1080/14647273.2021.1955415.