Study on identification of a three-microRNA panel in serum for diagnosing neonatal early onset sepsis

References

• Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, et al. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223–230. doi: 10.1016/S2213-2600(18)30063-8.
   PubMed Web of Science ®Google Scholar
• Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390(10104):1770–1780. doi: 10.1016/S0140-6736(17)31002-4.
   PubMed Web of Science ®Google Scholar
• Sofouli GA, Tsintoni A, Fouzas S, et al. Early diagnosis of late-onset neonatal sepsis using a sepsis prediction score. Microorganisms. 2023;11(2):235. doi: 10.3390/microorganisms11020235.
   PubMed Web of Science ®Google Scholar
• Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141(4):1202–1207. doi: 10.1016/j.jaci.2017.08.034.
   PubMed Web of Science ®Google Scholar
• Barichello T, Generoso JS, Singer M, et al. Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review. Crit Care. 2022;26(1):14. doi: 10.1186/s13054-021-03862-5.
   PubMed Web of Science ®Google Scholar
• Fatmi A, Chabni N, Cernada M, et al. Clinical and immunological aspects of microRNAs in neonatal sepsis. Biomed Pharmacother. 2022;145:112444. doi: 10.1016/j.biopha.2021.112444.
   PubMed Web of Science ®Google Scholar
• Jouza M, Bohosova J, Stanikova A, et al. MicroRNA as an early biomarker of neonatal sepsis. Front Pediatr. 2022;10:854324. doi: 10.3389/fped.2022.854324.
   PubMed Web of Science ®Google Scholar
• Dhas BB, Dirisala VR, Bhat BV. Expression levels of candidate circulating microRNAs in early-onset neonatal sepsis compared with healthy newborns. Genomics Insights. 2018;11:1178631018797079. doi: 10.1177/1178631018797079.
   Web of Science ®Google Scholar
• Singh M, Alsaleem M, Gray CP. Neonatal sepsis. Treasure Island (FL): StatPearls Publishing, StatPearls Publishing LLC; 2023.
   Google Scholar
• Satar M, Ozlü F. Neonatal sepsis: a continuing disease burden. Turk J Pediatr. 2012;54(5):449–457.
   PubMed Web of Science ®Google Scholar
• Li M, Huang X, Zhuo Q, et al. Clinical significance of miR-129-5p in patients with neonatal sepsis and its regulatory role in the LPS-induced inflammatory response. Bosn J Basic Med Sci. 2021;22(2):185–190. doi: 10.17305/bjbms.2020.5184.
   PubMed Web of Science ®Google Scholar
• EL-Khazragy N, Mohamed NM, Mostafa MF, et al. miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis. Diagn Microbiol Infect Dis. 2023;107(3):116053. doi: 10.1016/j.diagmicrobio.2023.116053.
   PubMed Web of Science ®Google Scholar
• Lou Y, Huang Z. microRNA-15a-5p participates in sepsis by regulating the inflammatory response of macrophages and targeting TNIP2. Exp Ther Med. 2020;19(4):3060–3068. doi: 10.3892/etm.2020.8547.
   PubMed Web of Science ®Google Scholar
• Hong X, Li S, Wang J, et al. Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p. BMC Immunol. 2021;22(1):29. doi: 10.1186/s12865-021-00419-7.
   PubMed Web of Science ®Google Scholar
• Xu G, Mo L, Wu C, et al. The miR-15a-5p-XIST-CUL3 regulatory axis is important for sepsis-induced acute kidney injury. Ren Fail. 2019;41(1):955–966. doi: 10.1080/0886022X.2019.1669460.
   PubMed Web of Science ®Google Scholar
• Qiu Y, Yu Y, Qin XM, et al. CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p. J Cell Mol Med. 2021;25(17):8244–8260. doi: 10.1111/jcmm.16738.
   PubMed Web of Science ®Google Scholar
• Liu C, Xue J, Xu B, et al. Exosomes derived from miR-146a-5p-enriched mesenchymal stem cells protect the cardiomyocytes and myocardial tissues in the polymicrobial sepsis through regulating MYBL1. Stem Cells Int. 2021;2021:1530445. doi: 10.1155/2021/1530445.
   PubMed Web of Science ®Google Scholar
• Yu J, Xue J, Liu C, et al. MiR-146a-5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7. J Biochem Mol Toxicol. 2022;36(10):e23151. doi: 10.1002/jbt.23151.
   PubMed Web of Science ®Google Scholar
• Wang S, Yang Y, Suen A, et al. Role of extracellular microRNA-146a-5p in host innate immunity and bacterial sepsis. iScience. 2021;24(12):103441. doi: 10.1016/j.isci.2021.103441.
   PubMed Web of Science ®Google Scholar
• Fu M, Zhang K. MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis. Bioengineered. 2021;12(1):2550–2562. doi: 10.1080/21655979.2021.1935405.
   PubMed Web of Science ®Google Scholar
• Hong J, Mo S, Gong F, et al. lncRNA-SNHG14 plays a role in acute lung injury induced by lipopolysaccharide through regulating autophagy via miR-223-3p/Foxo3a. Mediators Inflamm. 2021;2021:7890288. doi: 10.1155/2021/7890288.
   PubMed Web of Science ®Google Scholar
• Tan J, Fan J, He J, et al. Knockdown of LncRNA DLX6-AS1 inhibits HK-2 cell pyroptosis via regulating miR-223-3p/NLRP3 pathway in lipopolysaccharide-induced acute kidney injury. J Bioenerg Biomembr. 2020;52(5):367–376. doi: 10.1007/s10863-020-09845-5.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Chen L, Xu P, et al. Gene correlation network analysis to identify regulatory factors in sepsis. J Transl Med. 2020;18(1):381. doi: 10.1186/s12967-020-02561-z.
   PubMed Web of Science ®Google Scholar
• Tian J, Cui X, Sun J, et al. Exosomal microRNA-16-5p from adipose mesenchymal stem cells promotes TLR4-mediated M2 macrophage polarization in septic lung injury. Int Immunopharmacol. 2022;111:109078. doi: 10.1016/j.intimp.2021.107835.
   PubMed Web of Science ®Google Scholar
• He YX, Huang BL, Yang YY, et al. MicroRNA-16-5p exacerbates sepsis by upregulating aerobic glycolysis via SIRT3-SDHA axis. Cell Biol Int. 2022;46(12):2207–2219. doi: 10.1002/cbin.11908.
   PubMed Web of Science ®Google Scholar
• Gao M, Yu T, Liu D, et al. Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1. Clin Sci. 2021;135(2):347–365. doi: 10.1042/CS20200573.
   PubMed Web of Science ®Google Scholar
• Chen YL, Xie YJ, Liu ZM, et al. Omega-3 fatty acids impair miR-1-3p-dependent Notch3 down-regulation and alleviate sepsis-induced intestinal injury. Mol Med. 2022;28(1):9. doi: 10.1186/s10020-021-00425-w.
   PubMed Web of Science ®Google Scholar