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Original Article

Antibiotic administration reduced intra-amniotic inflammation 7 days after preterm premature rupture of the membranes with intra-amniotic infection

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Article: 2286189 | Received 29 Jun 2023, Accepted 16 Nov 2023, Published online: 28 Nov 2023

References

  • Goldenberg RL, Culhane JF, Iams JD, et al. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75–84. doi: 10.1016/S0140-6736(08)60074-4.
  • Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014;345(6198):760–765. doi: 10.1126/science.1251816.
  • Romero R, Quintero R, Oyarzun E, et al. Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. Am J Obstet Gynecol. 1988;159(3):661–666. doi: 10.1016/s0002-9378(88)80030-9.
  • Oh KJ, Lee KA, Sohn YK, et al. Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 2010;203(3):211.e1–211.e8. doi: 10.1016/j.ajog.2010.03.035.
  • Kacerovsky M, Musilova I, Khatibi A, et al. Intraamniotic inflammatory response to bacteria: analysis of multiple amniotic fluid proteins in women with preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2012;25(10):2014–2019. doi: 10.3109/14767058.2012.671873.
  • Kacerovsky M, Romero R, Stepan M, et al. Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes. Am J Obstet Gynecol. 2020;223(1):114.e1-114–e20. doi: 10.1016/j.ajog.2020.01.043.
  • Yoon BH, Romero R, Park JS, et al. Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol. 1998;179(5):1254–1260. doi: 10.1016/s0002-9378(98)70142-5.
  • Shim SS, Romero R, Hong JS, et al. Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 2004;191(4):1339–1345. doi: 10.1016/j.ajog.2004.06.085.
  • Yoon BH, Romero R, Park JS, et al. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol. 2000;182(3):675–681. doi: 10.1067/mob.2000.104207.
  • Thomson AJ. Care of women presenting with suspected preterm prelabour rupture of membranes from 24(+0) weeks of gestation: green-top guideline; no. 73. BJOG. 2019;126:e152–e166. doi: 10.1111/1471-0528.15803.
  • Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE collaborative group. Lancet. 2001;357(9261):979–988. doi: 10.1067/mob.2000.104207.
  • Mercer B. Antibiotics in the management of PROM and preterm labor. Obstet Gynecol Clin N Am. 2012;39(1):65–76. doi: 10.1016/j.ogc.2011.12.007.
  • Dotters-Katz S. Antibiotics for prophylaxis in the setting of preterm prelabor rupture of membranes. Obstet Gynecol Clin N Am. 2020;47(4):595–603. doi: 10.1016/j.ogc.2020.08.005.
  • Heikkinen T, Laine K, Neuvonen PJ, et al. The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. BJOG. 2000;107(6):770–775. doi: 10.1111/j.1471-0528.2000.tb13339.x.
  • Gomez R, Romero R, Gomez R, et al. Antibiotic administration to patients with preterm premature rupture of membranes does not eradicate intra-amniotic infection. J Matern Fetal Neonatal Med. 2007;20(2):167–173. doi: 10.1080/14767050601135485.
  • Lee MY, Kim MH, Lee WI, et al. Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. Yonsei Med J. 2016;57(5):1271–1275. doi: 10.3349/ymj.2016.57.5.1271.
  • Acosta EP, Grigsby PL, Larson KB, et al. Transplacental transfer of azithromycin and its use for eradicating intra-amniotic ureaplasma infection in a primate model. J Infect Dis. 2014;209(6):898–904. doi: 10.1093/infdis/jit578.
  • Kemp MW, Miura Y, Payne MS, et al. Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy. Antimicrob Agents Chemother. 2014;58(11):6581–6591. doi: 10.1128/AAC.03721-14.
  • Miura Y, Payne MS, Keelan JA, et al. Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection. Antimicrob Agents Chemother. 2014;58(9):5413–20. doi: 10.1128/AAC.03187-14, PMID 24982089.
  • Ramsey PS, Vaules MB, Vasdev GM, et al. Maternal and transplacental pharmacokinetics of azithromycin. Am J Obstet Gynecol. 2003;188(3):714–718. doi: 10.1067/mob.2003.141.
  • Sutton AL, Acosta EP, Larson KB, et al. Perinatal pharmacokinetics of azithromycin for cesarean prophylaxis. Am J Obstet Gynecol. 2015;212(6):812.e1–812.e6. doi: 10.1016/j.ajog.2015.01.015.
  • Hassan S, Romero R, Hendler I, Gomez R, Khalek N, Espinoza J, et al. A sonographic short cervix as the only clinical manifestation of intra-amniotic infection.J Perinat Med. 2006;34(1):13–9. doi: 10.1515/JPM.2006.002.
  • Lee SJ, Ahn JW, Lee JY, et al. Maternal azithromycin administration eradicates intra-amniotic ureaplasma infection: the first human case report. J Obstet Gynaecol. 2016;36(2):259–260. doi: 10.3109/01443615.2015.1049250.
  • Yoon BH, Romero R, Park JY, et al. Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2019;221(2):142.e1–142.e22. doi: 10.1016/j.ajog.2019.03.018.
  • Oh KJ, Romero R, Park JY, et al. Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency. Am J Obstet Gynecol. 2019;221(2):140.e1–140.e18. doi: 10.1016/j.ajog.2019.03.017.
  • Lewis DF, Fontenot MT, Brooks GG, et al. Latency period after preterm premature rupture of membranes: a comparison of ampicillin with and without sulbactam. Obstet Gynecol. 1995;86(3):392–395. doi: 10.1016/0029-7844(95)00181-P.
  • Lee J, Romero R, Kim SM, et al. A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. J Matern Fetal Neonatal Med. 2016;29(5):707–720. doi: 10.3109/14767058.2015.1020293.
  • Lee J, Romero R, Kim SM, et al. A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM. J Matern Fetal Neonatal Med. 2016;29(17):2727–2737. doi: 10.3109/14767058.2015.1103729.
  • Namba F, Hasegawa T, Nakayama M, et al. Placental features of chorioamnionitis colonized with ureaplasma species in preterm delivery. Pediatr Res. 2010;67(2):166–172. doi: 10.1203/PDR.0b013e3181c6e58e.
  • Ito K, Akai K, Nishiumi F, et al. Ability of Ureaplasma parvum to invade mouse sperm, fertilize eggs through infected sperm, and impair mouse sperm function and embryo development. F S Sci. 2021;2(1):13–23. doi: 10.1016/j.xfss.2020.12.003.
  • Musilova I, Andrys C, Holeckova M, et al. Interleukin-6 measured using the automated electrochemiluminescence immunoassay method for the identification of intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2020;33(11):1919–1926. doi: 10.1080/14767058.2018.1533947.
  • Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48(3):452–458. doi: 10.1038/bmt.2012.244.
  • Romero R, Yoon BH, Mazor M, et al. A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 1993;169(4):839–851. doi: 10.1016/0002-9378(93)90014-a.
  • Tita AT, Hauth JC, Grimes A, et al. Decreasing incidence of postcesarean endometritis with extended-spectrum antibiotic prophylaxis. Obstet Gynecol. 2008;111(1):51–56. doi: 10.1097/01.AOG.0000295868.43851.39.
  • Skeith AE, Niu B, Valent AM, et al. Adding azithromycin to cephalosporin for cesarean delivery infection prophylaxis: a cost-effectiveness analysis. Obstet Gynecol. 2017;130(6):1279–1284. doi: 10.1097/AOG.0000000000002333.
  • Jabs C, Giroux M, Minion J, et al. Evaluation of adjunctive azithromycin prophylaxis in women undergoing cesarean delivery in a setting with low baseline incidence of surgical site infection. J Obstet Gynaecol Can. 2021;43(9):1062–1068.e2. doi: 10.1016/j.jogc.2020.12.016.
  • Pierce SL, Bisson CM, Dubois ME, et al. Clinical effectiveness of adding azithromycin to antimicrobial prophylaxis for cesarean delivery. Am J Obstet Gynecol. 2021;225(3):335.e1-7–e7. doi: 10.1016/j.ajog.2021.05.023.
  • Tita AT, Szychowski JM, Boggess K, et al. Adjunctive azithromycin prophylaxis for cesarean delivery. N Engl J Med. 2016;375(13):1231–1241. doi: 10.1056/NEJMoa1602044.