Association between circulating unsaturated fatty acid and preeclampsia: a two-sample Mendelian randomization study

References

• Brown MA, Magee LA, Kenny LC, et al. Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice. Hypertension. 2018;72(1):24–43. doi:10.1161/HYPERTENSIONAHA.117.10803.
   PubMed Web of Science ®Google Scholar
• Webster K, Fishburn S, Maresh M, et al. Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance. BMJ. 2019;366:l5119. doi:10.1136/bmj.l5119.
   PubMed Web of Science ®Google Scholar
• MacDonald TM, Walker SP, Hannan NJ, et al. Clinical tools and biomarkers to predict preeclampsia. EBioMedicine. 2022;75:103780. doi:10.1016/j.ebiom.2021.103780.
   PubMed Web of Science ®Google Scholar
• Abalos E, Cuesta C, Grosso AL, et al. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):1–7. doi:10.1016/j.ejogrb.2013.05.005.
   PubMed Web of Science ®Google Scholar
• Gestational hypertension and preeclampsia: ACOG practice bulletin summary, number 222. Obstet Gynecol. 2020;135(6):1492–1495.
   PubMed Web of Science ®Google Scholar
• Wadhwani NS, Narang AS, Mehendale SS, et al. Reduced maternal erythrocyte long chain polyunsaturated fatty acids exist in early pregnancy in preeclampsia. Lipids. 2016;51(1):85–94. doi:10.1007/s11745-015-4098-5.
   PubMed Web of Science ®Google Scholar
• Herlambang H, Puspasari A, Maharani C, et al. Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis. BMC Pregnancy Childbirth. 2022;22(1):8. doi:10.1186/s12884-021-04313-3.
   PubMed Web of Science ®Google Scholar
• Burchakov DI, Kuznetsova IV, Uspenskaya YB. Omega-3 long-chain polyunsaturated fatty acids and preeclampsia: trials say “no,” but is it the final word? Nutrients. 2017;9(12):1364. doi:10.3390/nu9121364.
   PubMed Web of Science ®Google Scholar
• Bakouei F, Delavar MA, Mashayekh-Amiri S, et al. Efficacy of n-3 fatty acids supplementation on the prevention of pregnancy induced-hypertension or preeclampsia: a systematic review and meta-analysis. Taiwan J Obstet Gynecol. 2020;59(1):8–15. doi:10.1016/j.tjog.2019.11.002.
   PubMed Web of Science ®Google Scholar
• Li SN, Liu YH, Luo ZY, et al. The association between dietary fatty acid intake and the risk of developing preeclampsia: a matched case-control study. Sci Rep. 2021;11(1):4048. doi:10.1038/s41598-021-83674-3.
   PubMed Web of Science ®Google Scholar
• Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017;318(19):1925–1926. doi:10.1001/jama.2017.17219.
   PubMed Web of Science ®Google Scholar
• Davies NM, Holmes MV, Davey Smith G. Reading mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362:k601. doi:10.1136/bmj.k601.
   PubMed Web of Science ®Google Scholar
• Richmond RC, Davey Smith G. Mendelian randomization: concepts and scope. Cold Spring Harb Perspect Med. 2022;12(1):a040501. doi:10.1101/cshperspect.a040501.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Bäck M, Rees JMB, et al. Body mass index and body composition in relation to 14 cardiovascular conditions in UK biobank: a Mendelian randomization study. Eur Heart J. 2020;41(2):221–226. doi:10.1093/eurheartj/ehz388.
   PubMed Web of Science ®Google Scholar
• Azizi-Tabesh G, Sadeghi H, Farhadi A, et al. The obesity associated FTO gene polymorphism and the risk of preeclampsia in Iranian women: a case-control study. Hypertens Pregnancy. 2023;42(1):2210685.
   PubMed Web of Science ®Google Scholar
• Peng X, He D, Peng R, et al. Associations between IGFBP1 gene polymorphisms and the risk of preeclampsia and fetal growth restriction. Hypertens Res. 2023;46(9):2070–2084. doi:10.1038/s41440-023-01309-8.
   PubMedGoogle Scholar
• He D, Peng X, Xie H, et al. Genetic variations in angiotensinogen gene and risk of preeclampsia: a pilot study. J Clin Med. 2023;12(4):1509. doi:10.1038/s41440-023-01309-8.
   PubMed Web of Science ®Google Scholar
• Lawlor DA, Harbord RM, Sterne JA, et al. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27(8):1133–1163. doi:10.1002/sim.3034.
   PubMed Web of Science ®Google Scholar
• Staley JR, Blackshaw J, Kamat MA, et al. PhenoScanner: a database of human genotype-phenotype associations. Bioinformatics. 2016;32(20):3207–3209. doi:10.1093/bioinformatics/btw373.
   PubMed Web of Science ®Google Scholar
• Burgess S, Thompson SG, CRP CHD Genetics Collaboration. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011;40(3):755–764. doi:10.1093/ije/dyr036.
   PubMed Web of Science ®Google Scholar
• Papadimitriou N, Dimou N, Tsilidis KK, et al. Physical activity and risks of breast and colorectal cancer: a mendelian randomisation analysis. Nat Commun. 2020;11(1):597. doi:10.1038/s41467-020-14389-8.
   PubMed Web of Science ®Google Scholar
• Chen Y, Lyu S, Xiao W, et al. Sleep traits causally affect the brain cortical structure: a mendelian randomization study. Biomedicines. 2023;11(8):2296. doi:10.3390/biomedicines11082296.
   PubMed Web of Science ®Google Scholar
• Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through egger regression. Int J Epidemiol. 2015;44(2):512–525. doi:10.1093/ije/dyv080.
   PubMed Web of Science ®Google Scholar
• Burgess S, Thompson SG. Erratum to: interpreting findings from Mendelian randomization using the MR-egger method. Eur J Epidemiol. 2017;32(5):391–392. doi:10.1007/s10654-017-0276-5.
   PubMed Web of Science ®Google Scholar
• Verbanck M, Chen CY, Neale B, et al. Publisher correction: detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(8):1196–1196. doi:10.1038/s41588-018-0164-2.
   PubMed Web of Science ®Google Scholar
• Skytte HN, Christensen JJ, Gunnes N, et al. Metabolic profiling of pregnancies complicated by preeclampsia: a longitudinal study. Acta Obstet Gynecol Scand. 2023;102(3):334–343. doi:10.1111/aogs.14505.
   PubMedGoogle Scholar
• Nandi A, Wadhwani N, Randhir K, et al. Association of vitamin D with fatty acids in pregnancy. Prostaglandins Leukot Essent Fatty Acids. 2020;157:102030. doi:10.1016/j.plefa.2019.102030.
   PubMed Web of Science ®Google Scholar
• Colvin BN, Longtine MS, Chen B, et al. Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts. Reproduction. 2017;153(4):369–380. doi:10.1530/REP-16-0576.
   PubMed Web of Science ®Google Scholar
• Wang Y, Walsh SW, Kay HH. Placental tissue levels of nonesterified polyunsaturated fatty acids in normal and preeclamptic pregnancies. Hypertens Pregnancy. 2005;24(3):235–245. doi:10.1080/10641950500281118.
   PubMed Web of Science ®Google Scholar
• Firouzabadi FD, Shab-Bidar S, Jayedi A. The effects of omega-3 polyunsaturated fatty acids supplementation in pregnancy, lactation, and infancy: an umbrella review of meta-analyses of randomized trials. Pharmacol Res. 2022;177:106100. doi:10.1016/j.phrs.2022.106100.
   PubMed Web of Science ®Google Scholar
• Lim WY, Chong M, Calder PC, et al. Relations of plasma polyunsaturated fatty acids with blood pressures during the 26th and 28th week of gestation in women of Chinese, Malay, and Indian ethnicity. Medicine (Baltimore). 2015;94(9):e571.). doi:10.1097/MD.0000000000000571.
   PubMed Web of Science ®Google Scholar
• Devarshi PP, Grant RW, Ikonte CJ, et al. Maternal omega-3 nutrition, placental transfer and fetal brain development in gestational diabetes and preeclampsia. Nutrients. 2019;11(5):1107. doi:10.3390/nu11051107.
   PubMed Web of Science ®Google Scholar
• Abdelrahman MA, Osama H, Saeed H, et al. Impact of n-3 polyunsaturated fatty acid intake in pregnancy on maternal health and birth outcomes: systematic review and meta-analysis from randomized controlled trails. Arch Gynecol Obstet. 2023;307(1):249–262. doi:10.1007/s00404-022-06533-0.
   PubMed Web of Science ®Google Scholar
• Qiu C, Sanchez SE, Larrabure G, et al. Erythrocyte omega-3 and omega-6 polyunsaturated fatty acids and preeclampsia risk in Peruvian women. Arch Gynecol Obstet. 2006;274(2):97–103. doi:10.1007/s00404-006-0140-4.
   PubMedGoogle Scholar
• Mahomed K, Williams MA, King IB, et al. Erythrocyte omega-3, omega-6 and trans fatty acids in relation to risk of preeclampsia among women delivering at Harare maternity hospital, Zimbabwe. Physiol Res. 2007;56(1):37–50. doi:10.33549/physiolres.930859.
   PubMed Web of Science ®Google Scholar
• Achamrah N, Ditisheim A. Nutritional approach to preeclampsia prevention. Curr Opin Clin Nutr Metab Care. 2018;21(3):168–173. doi:10.1097/MCO.0000000000000462.
   PubMed Web of Science ®Google Scholar
• Kulkarni AV, Mehendale SS, Yadav HR, et al. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. Prostaglandins Leukot Essent Fatty Acids. 2011;84(1–2):51–55. doi:10.1016/j.plefa.2010.09.005.
   PubMed Web of Science ®Google Scholar
• Mathew SA, Bhonde RR. Omega-3 polyunsaturated fatty acids promote angiogenesis in placenta derived mesenchymal stromal cells. Pharmacol Res. 2018;132:90–98. doi:10.1016/j.phrs.2018.04.002.
   Google Scholar
• Khaire AA, Thakar SR, Wagh GN, et al. Placental lipid metabolism in preeclampsia. J Hypertens. 2021;39(1):127–134. doi:10.1097/HJH.0000000000002596.
   Google Scholar
• Yang Y, Wang Y, Lv Y, et al. Dissecting the roles of lipids in preeclampsia. Metabolites. 2022;12(7):590. doi:10.3390/metabo12070590.
   PubMed Web of Science ®Google Scholar
• Ou M, Zhang Q, Zhao H, et al. Polyunsaturated fatty acid diet and upregulation of lipoxin A4 reduce the inflammatory response of preeclampsia. J Proteome Res. 2021;20(1):357–368. doi:10.1021/acs.jproteome.0c00439.
   PubMed Web of Science ®Google Scholar