Physical activity, exercise and adverse cardiovascular outcomes in individuals with pre-existing cardiovascular disease: a narrative review

References

• Mensah GA, Fuster V, Murray CJL, et al. Global Burden of Cardiovascular Diseases and Risks, 1990-2022. J Am Coll Cardiol. 2023 Dec 19;82(25):2350–2473. doi: 10.1016/j.jacc.2023.11.007
   PubMed Web of Science ®Google Scholar
• Mensah GA, Roth GA, Fuster V. The global burden of cardiovascular diseases and risk factors: 2020 and beyond. J Am Coll Cardiol. 2019 Nov 19;74(20):2529–2532.
   PubMed Web of Science ®Google Scholar
• Roth GA, Mensah GA, Fuster V. The global burden of cardiovascular diseases and risks: a compass for global action. J Am Coll Cardiol. 2020 Dec 22;76(25):2980–2981.
   PubMed Web of Science ®Google Scholar
• Vaduganathan M, Mensah GA, Turco JV, et al. The global burden of cardiovascular diseases and risk: a compass for future health. J Am Coll Cardiol. 2022 Dec 20;80(25):2361–2371. doi: 10.1016/j.jacc.2022.11.005
   PubMed Web of Science ®Google Scholar
• Lloyd-Jones DM, Hong Y, Labarthe D, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic impact goal through 2020 and beyond. Circulation. 2010 Feb 2;121(4):586–613. doi: 10.1161/CIRCULATIONAHA.109.192703
   PubMed Web of Science ®Google Scholar
• Lloyd-Jones DM, Allen NB, Anderson CAM, et al. Life’s essential 8: updating and enhancing the American Heart Association’s Construct of Cardiovascular Health: a Presidential Advisory from the American Heart Association. Circulation. 2022 Aug 2;146(5):e18–e43. doi: 10.1161/CIR.0000000000001078
   PubMed Web of Science ®Google Scholar
• World Health Organization. The global action plan on physical activity 2018 - 2030. [cited 2023 Sep 29]. Available from: https://www.who.int/news-room/initiatives/gappa/action-plan
   Google Scholar
• Bull FC, Al-Ansari SS, Biddle S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020 Dec;54(24):1451–1462. doi: 10.1136/bjsports-2020-102955
   PubMed Web of Science ®Google Scholar
• Piercy KL, Troiano RP, Ballard RM, et al. The physical activity guidelines for americans. JAMA. 2018 Nov 20;320(19):2020–2028. 10.1001/jama.2018.14854
   PubMed Web of Science ®Google Scholar
• Sedentary Behaviour Research N. Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours”. Appl Physiol Nutr Metab. 2012, Jun;37(3):540–542. doi: 10.1139/h2012-024
   PubMed Web of Science ®Google Scholar
• Tremblay MS, Aubert S, Barnes JD, et al. Sedentary Behavior Research Network (SBRN) - terminology consensus project process and outcome. Int J Behav Nutr Phys Act. 2017 Jun 10;14(1):75. doi: 10.1186/s12966-017-0525-8
   PubMed Web of Science ®Google Scholar
• American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. 10th ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2017.
   Google Scholar
• Blair SN, Kohl HW, Gordon NF, et al. How much physical activity is good for health? Annu Rev Public Health. 1992;13(1):99–126. doi: 10.1146/annurev.pu.13.050192.000531
   PubMedGoogle Scholar
• Strath SJ, Kaminsky LA, Ainsworth BE, et al. Guide to the assessment of physical activity: clinical and research applications: a scientific statement from the American Heart Association. Circulation. 2013 Nov 12;128(20):2259–79. doi: 10.1161/01.cir.0000435708.67487.da
   PubMed Web of Science ®Google Scholar
• Moxley E, Habtzghi D. A systematic review comparing dose response of exercise on cardiovascular and all-cause mortality. Home Health Care Manag Pract. 2019;31(4):263–273. doi: 10.1177/1084822319831929
   Web of Science ®Google Scholar
• Physical Activity Guidelines Advisory Committee. Physical activity guidelines advisory committee report, 2008 (pp. A1-H14). WA (DC): US Department of Health and Human Services; 2008.
   Google Scholar
• Lee IM, Paffenbarger RS Jr. Associations of light, moderate, and vigorous intensity physical activity with longevity. The harvard alumni health study. Am J Epidemiol. 2000 Feb 01;151(3):293–299.
   PubMed Web of Science ®Google Scholar
• Tanasescu M, Leitzmann MF, Rimm EB, et al. Exercise type and intensity in relation to coronary heart disease in men. JAMA. 2002 Oct 23-30;288(16):1994–2000. doi: 10.1001/jama.288.16.1994
   PubMed Web of Science ®Google Scholar
• Chomistek AK, Cook NR, Flint AJ, et al. Vigorous-intensity leisure-time physical activity and risk of major chronic disease in men. Med Sci Sports Exerc. 2012 Oct;44(10):1898–905.
   PubMed Web of Science ®Google Scholar
• Williams PT. Reductions in incident coronary heart disease risk above guideline physical activity levels in men. Atherosclerosis. 2010 Apr;209(2):524–7. doi: 10.1016/j.atherosclerosis.2009.09.018
   PubMed Web of Science ®Google Scholar
• Williams PT. Reduced total and cause-specific mortality from walking and running in diabetes. Med Sci Sports Exerc. 2014;46(5):933–9. doi: 10.1249/MSS.0000000000000197
   PubMed Web of Science ®Google Scholar
• Powell KE, Paluch AE, Blair SN. Physical activity for health: what kind? How much? How intense? On top of what? Annu Rev Public Health. 2011;32(1):349–65. doi: 10.1146/annurev-publhealth-031210-101151
   PubMedGoogle Scholar
• Arem H, Moore SC, Patel A, et al. Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med. 2015 Jun;175(6):959–67.
   PubMed Web of Science ®Google Scholar
• UK Chief Medical Officers’ Physical Activity Guidelines 2019. [cited 2022 Nov 25]. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/832868/uk-chief-medical-officers-physical-activity-guidelines.pdf
   Google Scholar
• Cheng W, Zhang Z, Cheng W, et al. Associations of leisure-time physical activity with cardiovascular mortality: a systematic review and meta-analysis of 44 prospective cohort studies. Eur J Prev Cardiol. 2018 Nov;25(17):1864–1872.
   PubMed Web of Science ®Google Scholar
• Lear SA, Hu W, Rangarajan S, et al. The effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study. Lancet. 2017 Dec 16;390(10113):2643–2654. doi: 10.1016/S0140-6736(17)31634-3
   PubMed Web of Science ®Google Scholar
• Kyu HH, Bachman VF, Alexander LT, et al. Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the global burden of disease study 2013. BMJ. 2016 Aug 9;354:i3857.
   PubMed Web of Science ®Google Scholar
• Gebel K, Ding D, Chey T, et al. Effect of moderate to vigorous physical activity on all-cause mortality in Middle-aged and Older Australians. JAMA Intern Med. 2015 Jun;175(6):970–7.
   PubMed Web of Science ®Google Scholar
• Kunutsor SK, Jae SY, Laukkanen JA. ‘Weekend warrior’ and regularly active physical activity patterns confer similar cardiovascular and mortality benefits: a systematic meta-analysis. Eur J Prev Cardiol. 2023 Feb 14;30(3):e7–e10.
   PubMed Web of Science ®Google Scholar
• Kunutsor SK, Makikallio TH, Seidu S, et al. Physical activity and risk of venous thromboembolism: systematic review and meta-analysis of prospective cohort studies. Eur J Epidemiol. 2020 May;35(5):431–442.
   PubMed Web of Science ®Google Scholar
• Kunutsor SK, Seidu S, Makikallio TH, et al. Physical activity and risk of atrial fibrillation in the general population: meta-analysis of 23 cohort studies involving about 2 million participants. Eur J Epidemiol. 2021 Mar;36(3):259–274.
   PubMed Web of Science ®Google Scholar
• Ungvari Z, Fazekas-Pongor V, Csiszar A, et al. The multifaceted benefits of walking for healthy aging: from blue zones to molecular mechanisms. Geroscience. 2023 Jul 26;45(6):3211–3239. doi: 10.1007/s11357-023-00873-8
   PubMed Web of Science ®Google Scholar
• Kim MH, Sung JH, Jin MN, et al. Impact of physical activity on all-cause mortality according to Specific cardiovascular disease. Front Cardiovasc Med. 2022;9:811058. doi: 10.3389/fcvm.2022.811058
   PubMedGoogle Scholar
• Jeong SW, Kim SH, Kang SH, et al. Mortality reduction with physical activity in patients with and without cardiovascular disease. Eur Heart J. 2019 Nov 14;40(43):3547–3555. doi: 10.1093/eurheartj/ehz564
   PubMed Web of Science ®Google Scholar
• Cabanas-Sanchez V, Duarte Junior MA, Lavie CJ, et al. Physical activity and cause-specific cardiovascular mortality among people with and without cardiovascular disease: a cohort study of 0.6 million US adults. Mayo Clin Proc. 2023 Sep 5; doi: 10.1016/j.mayocp.2023.05.028
   PubMedGoogle Scholar
• Bansilal S, Castellano JM, Fuster V. Global burden of CVD: focus on secondary prevention of cardiovascular disease. International Journal Of Cardiology. 2015 Dec;201(Suppl 1):S1–7. doi: 10.1016/S0167-5273(15)31026-3
   PubMedGoogle Scholar
• Vasankari V, Husu P, Vaha-Ypya H, et al. Subjects with cardiovascular disease or high disease risk are more sedentary and less active than their healthy peers. BMJ Open Sport Exerc Med. 2018;4(1):e000363. doi: 10.1136/bmjsem-2018-000363
   PubMedGoogle Scholar
• Cassidy S, Fuller H, Chau J, et al. Accelerometer-derived physical activity in those with cardio-metabolic disease compared to healthy adults: a UK biobank study of 52,556 participants. Acta Diabetol. 2018 Sep;55(9):975–979.
   PubMed Web of Science ®Google Scholar
• Zhao G, Ford ES, Li C, et al. Are United States adults with coronary heart disease meeting physical activity recommendations? Am J Cardiol. 2008 Mar 1;101(5):557–561. doi: 10.1016/j.amjcard.2007.10.015
   PubMed Web of Science ®Google Scholar
• Anderson L, Oldridge N, Thompson DR, et al. Exercise-based cardiac rehabilitation for coronary heart disease: Cochrane Systematic Review and meta-analysis. J Am Coll Cardiol. 2016 Jan 5;67(1):1–12. doi: 10.1016/j.jacc.2015.10.044
   PubMed Web of Science ®Google Scholar
• Balady GJ, Ades PA, Bittner VA, et al. Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond: a presidential advisory from the American heart association. Circulation. 2011 Dec 20;124(25):2951–60. doi: 10.1161/CIR.0b013e31823b21e2
   PubMed Web of Science ®Google Scholar
• Perk J, De Backer G, Gohlke H, et al. European guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European Society of Cardiology and Other Societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur Heart J. 2012 Jul;33(13):1635–701.
   PubMed Web of Science ®Google Scholar
• American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. 10th ed. Philadelphia: Wolters Kluwer; 2017.
   Google Scholar
• Weston KS, Wisloff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med. 2014 Aug;48(16):1227–34. doi: 10.1136/bjsports-2013-092576
   PubMed Web of Science ®Google Scholar
• American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2013.
   Google Scholar
• Williams CJ, Gurd BJ, Bonafiglia JT, et al. A multi-center comparison of O(2peak) trainability between interval training and moderate intensity continuous training. Front Physiol. 2019;10:19. doi: 10.3389/fphys.2019.00019
   PubMed Web of Science ®Google Scholar
• Yue T, Wang Y, Liu H, et al. Effects of high-intensity interval vs. Moderate-intensity continuous training on cardiac rehabilitation in patients with cardiovascular disease: a systematic review and meta-analysis. Front Cardiovasc Med. 2022;9:845225. doi: 10.3389/fcvm.2022.845225
   PubMed Web of Science ®Google Scholar
• Hannan AL, Hing W, Simas V, et al. High-intensity interval training versus moderate-intensity continuous training within cardiac rehabilitation: a systematic review and meta-analysis. Open Access J Sports Med. 2018;9:1–17. doi: 10.2147/OAJSM.S150596
   PubMed Web of Science ®Google Scholar
• Liou K, Ho S, Fildes J, et al. High intensity interval versus moderate intensity continuous training in patients with coronary artery disease: a meta-analysis of physiological and clinical parameters. Heart Lung Circ. 2016 Feb;25(2):166–74.
   PubMed Web of Science ®Google Scholar
• OCEBM Levels of Evidence Working Group. The oxford 2011 levels of evidence. Oxford Centre for Evidence-Based Medicine. [cited 2020 Oct 8]. Available from: https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence
   Google Scholar
• Moholdt T, Wisloff U, Nilsen TI, et al. Physical activity and mortality in men and women with coronary heart disease: a prospective population-based cohort study in Norway (the HUNT study). Eur J Cardiovasc Prev Rehabil. 2008 Dec;15(6):639–645.
   PubMedGoogle Scholar
• Hamer M, Stamatakis E. Physical activity and mortality in men and women with diagnosed cardiovascular disease. Eur J Cardiovasc Prev Rehabil. 2009 Apr;16(2):156–60. doi: 10.1097/HJR.0b013e32831f1b77
   PubMedGoogle Scholar
• Loprinzi PD, Addoh O. Accelerometer-determined physical activity and all-cause mortality in a national prospective cohort study of adults post-acute stroke. Am J Health Promot. 2018 Jan;32(1):24–27. doi: 10.1177/0890117117720061
   PubMed Web of Science ®Google Scholar
• Stewart RAH, Held C, Hadziosmanovic N, et al. Physical activity and mortality in patients with stable coronary heart disease. J Am Coll Cardiol. 2017 Oct 3;70(14):1689–1700. doi: 10.1016/j.jacc.2017.08.017
   PubMed Web of Science ®Google Scholar
• Biscaglia S, Campo G, Sorbets E, et al. Relationship between physical activity and long-term outcomes in patients with stable coronary artery disease. Eur J Prev Cardiol. 2020 Mar;27(4):426–436.
   PubMed Web of Science ®Google Scholar
• Bakker EA, Lee DC, Hopman MTE, et al. Dose-response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: a cohort study among 142,493 adults from the Netherlands. PLOS Med. 2021 Dec;18(12):e1003845.
   PubMed Web of Science ®Google Scholar
• Buckley BJR, Lip GYH, Thijssen DHJ. The counterintuitive role of exercise in the prevention and cause of atrial fibrillation. Am J Physiol Heart Circ Physiol. 2020 Nov 1;319(5):H1051–H1058.
   PubMed Web of Science ®Google Scholar
• Pathak RK, Elliott A, Middeldorp ME, et al. Impact of CARDIOrespiratory FITness on arrhythmia recurrence in obese individuals with atrial fibrillation: the CARDIO-FIT study. J Am Coll Cardiol. 2015 Sep 1;66(9):985–96. doi: 10.1016/j.jacc.2015.06.488
   PubMed Web of Science ®Google Scholar
• Proietti M, Boriani G, Laroche C, et al. Self-reported physical activity and major adverse events in patients with atrial fibrillation: a report from the EURObservational Research Programme Pilot survey on atrial fibrillation (EORP-AF) General registry. Europace. 2017 Apr 1;19(4):535–543. doi: 10.1093/europace/euw169
   PubMed Web of Science ®Google Scholar
• Garnvik LE, Malmo V, Janszky I, et al. Physical activity, cardiorespiratory fitness, and cardiovascular outcomes in individuals with atrial fibrillation: the HUNT study. Eur Heart J. 2020 Apr 14;41(15):1467–1475. doi: 10.1093/eurheartj/ehaa032
   PubMed Web of Science ®Google Scholar
• Malmo V, Nes BM, Amundsen BH, et al. Aerobic interval training reduces the burden of atrial fibrillation in the short term: a randomized trial. Circulation. 2016 Feb 2;133(5):466–73. doi: 10.1161/CIRCULATIONAHA.115.018220
   PubMed Web of Science ®Google Scholar
• O’Connor CM, Whellan DJ, Lee KL, et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009 Apr 8;301(14):1439–50. doi: 10.1001/jama.2009.454
   PubMed Web of Science ®Google Scholar
• Lawler PR, Filion KB, Eisenberg MJ. Efficacy of exercise-based cardiac rehabilitation post-myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Am Heart J. 2011 Oct;162(4):571–584 e2. doi: 10.1016/j.ahj.2011.07.017
   PubMed Web of Science ®Google Scholar
• Dibben G, Faulkner J, Oldridge N, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2021 Nov 6;11(11):CD001800. doi: 10.1002/14651858.CD001800.pub4
   PubMedGoogle Scholar
• Chair SY, Zou H, Cao X. Effects of exercise therapy for adults with coronary heart disease: a Systematic Review and Meta-analysis of Randomized Controlled Trials. J Cardiovasc Nurs. 2021 Jan;36(1):56–77. doi: 10.1097/JCN.0000000000000713
   PubMed Web of Science ®Google Scholar
• Andersen K, Farahmand B, Ahlbom A, et al. Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study. Eur Heart J. 2013 Dec;34(47):3624–31.
   PubMed Web of Science ®Google Scholar
• La Gerche A, Burns AT, Mooney DJ, et al. Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur Heart J. 2012 Apr;33(8):998–1006.
   PubMed Web of Science ®Google Scholar
• Mohlenkamp S, Lehmann N, Breuckmann F, et al. Running: the risk of coronary events: prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Eur Heart J. 2008 Aug;29(15):1903–10.
   PubMed Web of Science ®Google Scholar
• Myrstad M, Nystad W, Graff-Iversen S, et al. Effect of years of endurance exercise on risk of atrial fibrillation and atrial flutter. Am J Cardiol. 2014 Oct 15;114(8):1229–33. doi: 10.1016/j.amjcard.2014.07.047
   PubMed Web of Science ®Google Scholar
• Petek BJ, Churchill TW, Moulson N, et al. Sudden Cardiac Death in National Collegiate Athletic Association Athletes: a 20-year study. Circulation. 2024 Jan 9;149(2):80–90. doi: 10.1161/CIRCULATIONAHA.123.065908
   PubMed Web of Science ®Google Scholar
• Morita H, Asada ST, Miyamoto M, et al. Significance of exercise-related ventricular arrhythmias in patients with Brugada syndrome. J Am Heart Assoc. 2020 Dec;9(23):e016907.
   PubMed Web of Science ®Google Scholar
• Schnohr P, O’Keefe JH, Marott JL, et al. Dose of jogging and long-term mortality: the Copenhagen city heart study. J Am Coll Cardiol. 2015 Feb 10;65(5):411–9. doi: 10.1016/j.jacc.2014.11.023
   PubMed Web of Science ®Google Scholar
• Lee DC, Pate RR, Lavie CJ, et al. Leisure-time running reduces all-cause and cardiovascular mortality risk. J Am Coll Cardiol. 2014 Aug 5;64(5):472–81. doi: 10.1016/j.jacc.2014.04.058
   PubMed Web of Science ®Google Scholar
• Armstrong ME, Green J, Reeves GK, et al. Frequent physical activity may not reduce vascular disease risk as much as moderate activity: large prospective study of women in the United Kingdom. Circulation. 2015 Feb 24;131(8):721–729. doi: 10.1161/CIRCULATIONAHA.114.010296
   PubMed Web of Science ®Google Scholar
• Heidbuchel H, Hoogsteen J, Fagard R, et al. High prevalence of right ventricular involvement in endurance athletes with ventricular arrhythmias. Role of an electrophysiologic study in risk stratification. Eur Heart J. 2003 Aug;24(16):1473–1480.
   PubMed Web of Science ®Google Scholar
• Batty GD, Shipley MJ, Marmot M, et al. Leisure time physical activity and coronary heart disease mortality in men symptomatic or asymptomatic for ischaemia: evidence from the Whitehall study. J Public Health Med. 2003 Sep;25(3):190–6.
   PubMedGoogle Scholar
• Mons U, Hahmann H, Brenner H. A reverse J-shaped association of leisure time physical activity with prognosis in patients with stable coronary heart disease: evidence from a large cohort with repeated measurements. Heart. 2014 Jul;100(13):1043–9. doi: 10.1136/heartjnl-2013-305242
   PubMed Web of Science ®Google Scholar
• Williams PT, Thompson PD. Increased cardiovascular disease mortality associated with excessive exercise in heart attack survivors. Mayo Clin Proc. 2014 Sep;89(9):1187–94. doi: 10.1016/j.mayocp.2014.05.006
   PubMed Web of Science ®Google Scholar
• Tran ZV, Weltman A, Glass GV, et al. The effects of exercise on blood lipids and lipoproteins: a meta-analysis of studies. Med Sci Sports Exerc. 1983;15(5):393–402. doi: 10.1249/00005768-198315050-00009
   PubMed Web of Science ®Google Scholar
• Leaf DA. The effect of physical exercise on reverse cholesterol transport. Metabolism. 2003 Aug;52(8):950–7. doi: 10.1016/S0026-0495(03)00147-1
   PubMed Web of Science ®Google Scholar
• Wen H, Wang L. Reducing effect of aerobic exercise on blood pressure of essential hypertensive patients: a meta-analysis. Medicine (Baltimore). 2017 Mar;96(11):e6150. doi: 10.1097/MD.0000000000006150
   PubMed Web of Science ®Google Scholar
• Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology. 2002 Sep;13(5):561–8. doi: 10.1097/00001648-200209000-00012
   PubMed Web of Science ®Google Scholar
• Colberg SR, Sigal RJ, Yardley JE, et al. Physical Activity/Exercise and diabetes: a position statement of the American diabetes association. Diabetes Care. 2016 Nov;39(11):2065–2079.
   PubMed Web of Science ®Google Scholar
• Fiuza-Luces C, Santos-Lozano A, Joyner M, et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat Rev Cardiol. 2018 Dec;15(12):731–743.
   PubMed Web of Science ®Google Scholar
• Franklin BA, Thompson PD, Al-Zaiti SS, et al. Exercise-related acute cardiovascular events and potential deleterious adaptations following long-term exercise training: placing the risks into perspective-an update: a scientific statement from the American heart association. Circulation. 2020 Mar 31;141(13):e705–e736. doi: 10.1161/CIR.0000000000000749
   PubMed Web of Science ®Google Scholar
• Di Francescomarino S, Sciartilli A, Di Valerio V, et al. The effect of physical exercise on endothelial function. Sports Med. 2009;39(10):797–812. doi: 10.2165/11317750-000000000-00000
   PubMed Web of Science ®Google Scholar
• Hambrecht R, Fiehn E, Weigl C, et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation. 1998 Dec 15;98(24):2709–15. doi: 10.1161/01.CIR.98.24.2709
   PubMed Web of Science ®Google Scholar
• Aengevaeren VL, Mosterd A, Sharma S, et al. Exercise and coronary atherosclerosis: observations, explanations, relevance, and clinical management. Circulation. 2020 Apr 21;141(16):1338–1350. doi: 10.1161/CIRCULATIONAHA.119.044467
   PubMed Web of Science ®Google Scholar
• Chen H, Chen C, Spanos M, et al. Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics. Signal Transduct Target Ther. 2022 Sep 1;7(1):306. doi: 10.1038/s41392-022-01153-1
   PubMed Web of Science ®Google Scholar
• Moreira JBN, Wohlwend M, Wisloff U. Exercise and cardiac health: physiological and molecular insights. Nat Metab. 2020 Sep;2(9):829–839. doi: 10.1038/s42255-020-0262-1
   PubMedGoogle Scholar
• Mucke M, Ludyga S, Colledge F, et al. Influence of regular physical activity and fitness on stress reactivity as measured with the trier social stress test protocol: a systematic review. Sports Med. 2018 Nov;48(11):2607–2622.
   PubMed Web of Science ®Google Scholar
• Kline CE. The bidirectional relationship between exercise and sleep: implications for exercise adherence and sleep improvement. Am J Lifestyle Med. 2014 Nov;8(6):375–379. doi: 10.1177/1559827614544437
   PubMedGoogle Scholar
• Nambiema A, Lisan Q, Perier MC, et al. Healthy sleep score and incident cardiovascular diseases: the Paris prospective study III (PPS3). Eur Heart J. 2022;43(Supplement_2). doi: 10.1093/eurheartj/ehac544.2451
   Google Scholar
• Schneider RH, Grim CE, Rainforth MV, et al. Stress reduction in the secondary prevention of cardiovascular disease: randomized, controlled trial of transcendental meditation and health education in blacks. Circ Cardiovasc Qual Outcomes. 2012 Nov;5(6):750–8.
   PubMed Web of Science ®Google Scholar
• Mikus CR, Boyle LJ, Borengasser SJ, et al. Simvastatin impairs exercise training adaptations. J Am Coll Cardiol. 2013 Aug 20;62(8):709–14. doi: 10.1016/j.jacc.2013.02.074
   PubMed Web of Science ®Google Scholar
• Shave R, Baggish A, George K, et al. Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications. J Am Coll Cardiol. 2010 Jul 13;56(3):169–76. doi: 10.1016/j.jacc.2010.03.037
   PubMed Web of Science ®Google Scholar
• Thompson PD, Franklin BA, Balady GJ, et al. Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association Council on Nutrition, physical activity, and metabolism and the Council on clinical cardiology. Circulation. 2007 May 1;115(17):2358–68. doi: 10.1161/CIRCULATIONAHA.107.181485
   PubMed Web of Science ®Google Scholar
• Vogel B, Acevedo M, Appelman Y, et al. The lancet women and cardiovascular disease commission: reducing the global burden by 2030. Lancet. 2021 Jun 19;397(10292):2385–2438. doi: 10.1016/S0140-6736(21)00684-X
   PubMed Web of Science ®Google Scholar
• Bucciarelli V, Mattioli AV, Sciomer S, et al. The impact of physical activity and inactivity on cardiovascular risk across Women’s lifespan: an updated review. J Clin Med. 2023 Jun 28;12(13):4347. doi: 10.3390/jcm12134347
   PubMed Web of Science ®Google Scholar
• Knuuti J, Wijns W, Saraste A, et al. 2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020 Jan 14;41(3):407–477. doi: 10.1093/eurheartj/ehz425
   PubMed Web of Science ®Google Scholar
• Pelliccia A, Sharma S, Gati S, et al. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J. 2021 Jan 1;42(1):17–96. doi: 10.1093/eurheartj/ehaa605
   PubMed Web of Science ®Google Scholar
• Virani SS, Newby LK, Arnold SV, et al. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association/American College of Cardiology Joint Committee on clinical practice guidelines. Circulation. 2023 Aug 29;148(9):e9–e119. doi: 10.1161/CIR.0000000000001168
   PubMed Web of Science ®Google Scholar
• Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227–3337. doi: 10.1093/eurheartj/ehab484
   PubMed Web of Science ®Google Scholar
• Abreu A, Frederix I, Dendale P, et al. Standardization and quality improvement of secondary prevention through cardiovascular rehabilitation programmes in Europe: the avenue towards EAPC accreditation programme: a position statement of the secondary prevention and rehabilitation Section of the European Association of Preventive Cardiology (EAPC). Eur J Prev Cardiol. 2021 May 14;28(5):496–509. doi: 10.1177/2047487320924912
   PubMed Web of Science ®Google Scholar
• Ruivo J, Moholdt T, Abreu A. Overview of cardiac rehabilitation following post-acute myocardial infarction in European Society of Cardiology member countries. Eur J Prev Cardiol. 2023 Jul 12;30(9):758–768.
   PubMed Web of Science ®Google Scholar