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Review

HCV in Egypt, prevention, treatment and key barriers to elimination

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Pages 345-350 | Received 31 Oct 2017, Accepted 02 Mar 2018, Published online: 11 Mar 2018

References

  • Ministry of Health, Egypt, El-Zanaty and Associates, Egypt, ICF International. Egypt Health Issues Survey. Cairo, Egypt and Rockville, MD, USA: Ministry of Health and ICF International; 2015.
  • El-Zenati F, Way A. Knowledge and prevalence of Hepatitis C. Egypt demographic and health survey 2008. [ONLINE]. [cited 2017 Oct 10]. Available from: https://dhsprogram.com/pubs/pdf/FR220/FR220.pdf
  • Strickland G. Liver disease in Egypt: hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors. Hepatology. 2006;43(5):915–922.
  • Rao MR, Naficy AB, Darwish MA, et al. Further evidence for association of hepatitis C infection with parenteral schistosomiasis treatment in Egypt. BMC Infect Dis. 2002;2:29. 24.
  • Frank C, Mohamed M, Strickland GT, et al. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet. 2000;355(9207):887–891.
  • Hajarizadeh B, Grebely J, Dore GJ. Epidemiology and natural history of HCV infection. Nat Rev Gastroenterol Hepatol. 2013;10(9):553–562.
  • Elbaz T, El-Kassas M, Esmat G. New era for management of chronic hepatitis C virus using direct antiviral agents: a review. Expert Opin Drug Saf. 2016 Dec;15(12):1643–1652.
  • El Raziky M, Fathalah W, El-Akel W, et al. The effect of peginterferon alpha-2a vs. peginterferon alpha-2b in treatment of naive chronic HCV genotype-4 patients: a single centre Egyptian study. Hepat Mon. 2013;13:e10069.
  • Esmat G, El Kassas M, Hassany M, et al. How to optimize HCV therapy in genotype 4 patients. Liver Int. 2013 Feb;33(Suppl 1):41–45.
  • El Kassas M, Elbaz T, Hafez E. Safety of direct antiviral agents in the management of hepatitis C. Expert Opin Drug Saf. 2016 Dec;15(12):1643–1652.
  • Centers for Disease Control and Prevention (CDC). Progress toward prevention and control of hepatitis C virus infection–egypt, 2001–2012. MMWR Morb Mortal Wkly Rep. 2012;61:545–549.
  • El-Akel W, El-Sayed MH, El Kassas M, et al. National treatment programme of hepatitis C in Egypt: hepatitis C virus model of care. J Viral Hepat. 2017 Apr;24(4):262–267.
  • Gomaa A, Allam N, Elsharkawy A, et al. Hepatitis C infection in Egypt: prevalence, impact and management strategies. Hepat Med. 2017 May;15(9):17–25.
  • Waked I, Doss W, El-Sayed M, et al. The current and future disease burden of chronic hepatitis C virus infection in Egypt. Arab J Gastroenterol. 2014;15(2):45–52.
  • Estes C, Abdel-Kareem M, Abdel-Razek W, et al. Economic burden of hepatitis C in Egypt: the future impact of highly effective therapies. Aliment Pharmacol Ther. 2015;42(6):696–706.
  • Gower E, Estes CC, Hindman S, et al. Global epidemiology and genotype distribution of the hepatitis C virus. J Hepatol. 2014;61:S45–S57.
  • El Raziky M, Gamil M, Hammad R, et al. Treatment of Hepatitis C genotype 4 patients with simeprevir and sofosbuvir: preliminary results from a phase iia, partially randomised, open-label trial conducted in Egypt (OSIRIS). Abstract ID: 1163. OSIRIS poster, presented at the Liver Meeting®, the Annual Meeting of the American Association for the Study of Liver Diseases. 2015.
  • El-Khayat HR, Fouad YM, Maher M, et al. Efficacy and safety of sofosbuvir plus simeprevir therapy in Egyptian patients with chronic hepatitis C: a real-world experience. Gut. 2017 Nov;66(11):2008–2012.
  • Waked I, Shiha G, Qaqish RB, et al. Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial. Lancet Gastroenterol Hepatol. 2016;1(1):36–44.
  • Omar H, El Akel W, Elbaz T, et al. Generic daclatasvir plus sofosbuvir, with or without ribavirin, in treatment of chronic hepatitis C: real-world results from 18378 patients in Egypt. Aliment Pharmacol Ther. 2017;1–11.
  • Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med. 2013;368:1878–1887.
  • Lange CM, Zeuzem S. Perspectives and challenges of interferon-free therapy for chronic hepatitis C. J Hepatol. 2013;58:583–592.
  • Doss W, Shiha G, Hassany M, et al. Sofosbuvir plus ribavirin for treating Egyptian patients with hepatitis C genotype 4. J Hepatol. 2015;63(3):581–585.
  • Ruane PJ, Ain D, Stryker R, et al. Sofosbuvir plus ribavirin for the treatment of chronic genotype 4 hepatitis C virus infection in patients of Egyptian ancestry. J Hepatol. 2015;62:1040–1046.
  • Kowdley KV, Lawitz E, Crespo I, et al. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment naıve patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet. 2013;381:2100.
  • Alessandra M, Valeria P. Overall efficacy and safety results of sofosbuvir-based therapies in Phase II and III studies. Dig Liver Dis. 2014;46:S179–85.
  • European Association for the Study of the Liver. EASL recommendations on treatment of hepatitis C 2014. J Hepatol. 2014;61:373–395.
  • AASLD/IDSA HCV Guidance Panel. Hepatitis C guidance: AASLD IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus. Hepatology. 2015;62:932–954.
  • Sulkowski MS, Gardiner DF, Rodriguez-Torres M, et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med. 2014;370(3):211–221.
  • Gao M, Nettles RE, Belema M, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010;465(7294):96–100.
  • Boglione L, Pinna SM, Cardellino CS, et al. Treatment with daclatasvir and sofosbuvir for 24 weeks without ribavirin in cirrhotic patients who failed first-generation protease inhibitors. Infection. 2017 Feb;45(1):103–106.
  • Moshyk A, Martel MJ, Tahami Monfared AA, et al. Cost-effectiveness of daclatasvir plus sofosbuvir-based regimen for treatment of hepatitis C virus genotype 3 infection in Canada. J Med Econ. 2016;19(2):181–192.
  • Pol S, Bourliere M, Lucier S, et al. Safety and efficacy of daclatasvir-sofosbuvir in HCV genotype 1-mono-infected patients. J Hepatol. 2016;pii: S0168-8278(16)30486-X.
  • Luetkemeyer AF, McDonald C, Ramgopal M, et al. 12 weeks of daclatasvir in combination with sofosbuvir for HIV-HCV coinfection (ALLY-2 Study): efficacy and safety by HIV combination antiretroviral regimens. Clin Infect Dis. 2016;62(12):1489–1496.
  • Gevers TJ, Burger D, Schipper-Reintjes E, et al. Full-dose sofosbuvir and daclatasvir for chronic hepatitis C infection in haemodialysis patients. Neth J Med. 2016;74(5):225–227.
  • Poordad F, Schiff ER, Vierling JM, et al. Daclatasvir with sofosbuvir and ribavirin for hepatitis C virus infection with advanced cirrhosis or post-liver transplantation recurrence. Hepatology. 2016;63(5):1493–1505.
  • Welzel TM, Petersen J, Herzer K, et al. Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort. Gut. 2016 Nov;65(11):1861–1870.
  • Kandeel A, Genedy M, El-Refai S, et al. The prevalence of HCV infection in Egypt 2015: implications for future policy on prevention and treatment. Liver Int. 2016;37:45–53.
  • Elsharkawy A, Fouad R, El Akel W, et al. Sofosbuvir-based treatment regimens: real life results of 14 409 chronic HCV genotype 4 patients in Egypt. Aliment Pharmacol Ther. 2017;45(5):681–687.
  • Elgharably A, Gomaa AI, Crossey MM, et al. Hepatitis C in Egypt - past, present, and future. Int J Gen Med. 2016;20(10):1–6.
  • Walker CM. Designing an HCV vaccine: a unique convergence of prevention and therapy? Curr Opin Virol. 2017 Apr;23:113–119.

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