The potential of 4D’s approach in curbing antimicrobial resistance among bacterial pathogens

References

• Zhang Z, Zhang Q, Wang T, et al. Assessment of global health risk of antibiotic resistance genes. Nat Commun. 2022 Mar 23 13(1):1553.
   PubMed Web of Science ®Google Scholar
• Hernando-Amado S, Coque TM, Baquero F, et al. Defining and combating antibiotic resistance from One Health and Global Health perspectives. Nat Microbiol. 2019 Sep;4(9):1432–1442.
   PubMed Web of Science ®Google Scholar
• WHO. Global action plan on antimicrobial resistance 2016. cited 05 07 2022. Available from: https://www.who.int/publications/i/item/9789241509763
   Google Scholar
• Knight GM, Glover RE, McQuaid CF, et al. Antimicrobial resistance and COVID-19: intersections and implications. eLife. 2021 Feb 16;10: 10.7554/eLife.64139
   Web of Science ®Google Scholar
• Slama TG, Amin A, Brunton SA, et al. A clinician’s guide to the appropriate and accurate use of antibiotics: the Council for Appropriate and Rational Antibiotic Therapy (CARAT) criteria. Am J Med. 2005 Jul;118(Suppl 7A):1s–6s.
   PubMedGoogle Scholar
• Ma YX, Wang CY, Li YY, et al. Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections. Advanced science. (Weinheim Baden-Wurttemberg Germany): Adv Sci (Weinh). 2020 Jan. Vol. 7. 1. 1901872
   Google Scholar
• Bengoechea JA, Sa Pessoa J. Klebsiella pneumoniae infection biology: living to counteract host defences. FEMS Microbiol Rev. 2019 Mar 1; 43(2):123–144.
   PubMed Web of Science ®Google Scholar
• O’Neill J. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Rev Antimicrob Resist. 2018.
   Google Scholar
• WHO. WHO global priority pathogens list of antibiotic-resistant bacteria 2021 Accessed 05 07 22. Available from: https://www.doherty.edu.au/news-events/news/who-global-priority-pathogens-list-of-antibiotic-resistant-bacteria
   Google Scholar
• Murray CJL, Ikuta KS, Sharara F, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629–655.
   PubMed Web of Science ®Google Scholar
• Rello J, Kalwaje Eshwara V, Lagunes L, et al. A global priority list of the TOp TEn resistant Microorganisms (TOTEM) study at intensive care: a prioritization exercise based on multi-criteria decision analysis. Eur J Clin Microbiol Infect Dis. 2019 ;38(2):319–323.
   PubMed Web of Science ®Google Scholar
• WHO. New Indian Priority Pathogen List to guide discovery of effective antibiotics 2021 cited 05 07 2022. Available from: https://www.who.int/india/news/detail/09-03-2021-new-indian-priority-pathogen-list-to-guide-discovery-of-effective-and-affordable-antibiotics
   Google Scholar
• Moosavian M, Ahmadi K, Shoja S, et al. Antimicrobial resistance patterns and their encoding genes among clinical isolates of Acinetobacter baumannii in Ahvaz, Southwest Iran. MethodsX. 2020 ;7:101031.
   PubMed Web of Science ®Google Scholar
• Razavi Nikoo H, Ardebili A, Mardaneh J. Systematic Review of Antimicrobial Resistance of Clinical Acinetobacter baumannii Isolates in Iran: an Update. Microb Drug Resist. 2017;23(6):744–756.
   PubMed Web of Science ®Google Scholar
• Ebrahim-Saraie HS, Heidari H, Soltani B, et al. Prevalence of antibiotic resistance and integrons, sul and Smqnr genes in clinical isolates of Stenotrophomonas maltophilia from a tertiary care hospital in Southwest Iran. Iran J Basic Med Sci. 2019 Aug;22(8):872–877.
   PubMed Web of Science ®Google Scholar
• Jahansepas A, Aghazadeh M, Rezaee MA, et al. Occurrence of Enterococcus faecalis and Enterococcus faecium in various clinical infections: detection of their drug resistance and virulence determinants. Microbial Drug Resist. 2018;24(1):76–82.
   PubMed Web of Science ®Google Scholar
• Sulis G, Sayood S, Gandra S. Antimicrobial resistance in low- and middle-income countries: current status and future directions. Expert Rev Anti Infect Ther. 2022 Feb;20(2):147–160.18.
   PubMed Web of Science ®Google Scholar
• Ayukekbong JA, Ntemgwa M, Atabe AN. The threat of antimicrobial resistance in developing countries: causes and control strategies. Antimicrob Resist Infect Control. 2017 ;6(1):47.
   PubMed Web of Science ®Google Scholar
• Zeitouni MO, Al-Moamary MS, Coussa ML, et al. Challenges and recommendations for the management of asthma in the Middle East and Africa. Ann Thorac Med. 2022 Apr-Jun;17(2):71–80.
   PubMed Web of Science ®Google Scholar
• Pokharel S, Raut S, Adhikari B. Tackling antimicrobial resistance in low-income and middle-income countries. BMJ Glob Health. 2019;4(6):e002104.
   PubMed Web of Science ®Google Scholar
• Burki TK. Superbugs: an Arms Race Against Bacteria. Lancet Respir Med. 2018 Sep;6(9):668.
   PubMedGoogle Scholar
• Rello J, Parisella FR, Perez A. Alternatives to antibiotics in an era of difficult-to-treat resistance: new insights. Expert Rev Clin Pharmacol. 2019 ;12(7):635–642.
   PubMed Web of Science ®Google Scholar
• Dedrick RM, Guerrero-Bustamante CA, Garlena RA, et al. Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus. Nat Med. 2019 May;25(5):730–733.
   PubMed Web of Science ®Google Scholar
• Czaplewski L, Bax R, Clokie M, et al. Alternatives to antibiotics-a pipeline portfolio review. Lancet Infect Dis. 2016 Feb;16(2):239–251.
   PubMed Web of Science ®Google Scholar
• He P, Sun Q, Shi L, et al. Rational use of antibiotics in the context of China’s health system reform. BMJ. 2019;365:l4016.
   PubMedGoogle Scholar
• Sulis G, Daniels B, Kwan A, et al. Antibiotic overuse in the primary health care setting: a secondary data analysis of standardised patient studies from India, China and Kenya. BMJ Glob Health. 2020;5(9):e003393.
   PubMed Web of Science ®Google Scholar
• WHO. Promoting rational use of medicines 2020. cited 05 07 2022. Available from: https://www.who.int/activities/promoting-rational-use-of-medicines
   Google Scholar
• Holmes AH, Moore LS, Sundsfjord A, et al. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet. 2016 Jan 9 387(10014):176–187.
   PubMed Web of Science ®Google Scholar
• Roggeveen LF, Guo T, Driessen RH, et al. Right Dose, Right Now: development of AutoKinetics for Real Time Model Informed Precision Antibiotic Dosing Decision Support at the Bedside of Critically Ill Patients. Front Pharmacol. 2020;11:646.
   PubMed Web of Science ®Google Scholar
• Trotter AJ, Aydin A, Strinden MJ, et al. Recent and emerging technologies for the rapid diagnosis of infection and antimicrobial resistance. Curr Opin Microbiol. 2019 Oct;51:39–45.
   PubMed Web of Science ®Google Scholar
• Breijyeh Z, Jubeh B, Karaman R. Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it. Molecules. 2020 Mar 16; 25(6):1340.
   Web of Science ®Google Scholar
• Benkova M, Soukup O, Marek J. Antimicrobial susceptibility testing: currently used methods and devices and the near future in clinical practice. J Appl Microbiol. 2020 Oct;129(4):806–822.
   PubMed Web of Science ®Google Scholar
• Inglis TJJ, Ekelund O. Rapid antimicrobial susceptibility tests for sepsis; the road ahead. J Med Microbiol. 2019 Jul;68(7):973–977.
   PubMed Web of Science ®Google Scholar
• Watkins RR, Bonomo RA, Rello J. Managing sepsis in the era of precision medicine: challenges and opportunities. Expert Rev Anti Infect Ther. 2022 Jun;20(6):871–880.
   PubMed Web of Science ®Google Scholar
• Singhal C, Bruno JG, Kaushal A, et al. Recent Advances and a Roadmap to Aptamer-Based Sensors for Bloodstream Infections. ACS Appl Bio Mater. 2021 May 17; 4(5):3962–3984.
   PubMedGoogle Scholar
• Li P, Zhang D, Li H, et al. Establishment and Application of Multiplex PCR for Simultaneously Detecting Escherichia coli, Salmonella, Klebsiella pneumoniae, and Staphylococcus aureus in Minks. Front Vet Sci. 2020;7:588173.
   PubMed Web of Science ®Google Scholar
• Nomura F, Tsuchida S, Murata S, et al. Mass spectrometry-based microbiological testing for blood stream infection. Clin Proteom. 2020 ;17(1):14.
   PubMed Web of Science ®Google Scholar
• Louie M, Cockerill FR. 3rd. Susceptibility testing. Phenotypic and genotypic tests for bacteria and mycobacteria. Infect Dis Clin North Am. 2001 Dec;15(4):1205–1226.
   PubMed Web of Science ®Google Scholar
• Rello J, Kalwaje Eshwara V, Conway-Morris A, et al. Perceived differences between intensivists and infectious diseases consultants facing antimicrobial resistance: a global cross-sectional survey. Eur J Clin Microbiol Infect Dis. 2019 ;38(7):1235–1240.
   PubMed Web of Science ®Google Scholar
• Zetts RM, Garcia AM, Doctor JN, et al. Primary Care Physicians’ Attitudes and Perceptions Towards Antibiotic Resistance and Antibiotic Stewardship: a National Survey. Open Forum Infect Dis. 2020 Jul;7(7):ofaa244.
   PubMed Web of Science ®Google Scholar
• Erdem H, Hargreaves S, Ankarali H, et al. Managing adult patients with infectious diseases in emergency departments: international ID-IRI study. J Chemother. 2021;33(5):302–318.
   PubMed Web of Science ®Google Scholar
• Secunda KE, Hart JL. One guideline may not fit all: tailored evidence may improve critical care delivery. Ann Am Thorac Soc. 2022 Aug;19(8):1273–1274.
   PubMed Web of Science ®Google Scholar
• Luyt C-E, Bréchot N, Trouillet J-L, et al. Antibiotic stewardship in the intensive care unit. Crit Care. 2014 ;18(5):480.
   PubMed Web of Science ®Google Scholar
• Cogen JD, Faino AV, Onchiri F, et al. Clinical outcomes of antipseudomonal versus other antibiotics among children with cystic fibrosis without Pseudomonas aeruginosa. Ann Am Thorac Soc. 2022 Aug;19(8):1320–1327.
   PubMed Web of Science ®Google Scholar
• El-Sokkary R, Erdem H, Kullar R, et al. Self-reported antibiotic stewardship and infection control measures from 57 intensive care units: an international ID-IRI survey. J Infect Public Health. 2022 ;15(9):950–954.
   PubMedGoogle Scholar
• Doron S, Davidson LE. Antimicrobial stewardship. Mayo Clin Proc. 2011 Nov;86(11):1113–1123.
   PubMed Web of Science ®Google Scholar
• Aggarwal D, Kanitkar T, Narouz M, et al. Clinical utility and cost-effectiveness of bacterial 16S rRNA and targeted PCR based diagnostic testing in a UK microbiology laboratory network. Sci Rep. 2020 May 14 10(1):7965.
   PubMed Web of Science ®Google Scholar
• Volland H, Dortet L, Bernabeu S, et al. Development and multicentric validation of a lateral flow immunoassay for rapid detection of MCR-1-producing enterobacteriaceae. J Clin Microbiol. 2019 May;57(5):e01454–18.
   PubMed Web of Science ®Google Scholar
• Takahashi MK, Tan X, Dy AJ, et al. A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers. Nat Commun. 2018;9(1):3347.
   PubMedGoogle Scholar
• Lamy B, Sundqvist M, Idelevich EA. Bloodstream infections – standard and progress in pathogen diagnostics. Clin Microbiol Infect. 2020 ;26(2):142–150.
   PubMed Web of Science ®Google Scholar
• Humphries RM, Kircher S, Ferrell A, et al. The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: report from the clinical and laboratory standards institute methods development and standardization working group. J Clin Microbiol. 2018 Aug;56(8):e00437–18.
   PubMed Web of Science ®Google Scholar
• Benkova M, Soukup O, Marek J. Antimicrobial susceptibility testing: currently used methods and devices and the near future in clinical practice. Journal of Applied Microbiology. 2020;129(4):806–822.
   PubMed Web of Science ®Google Scholar
• Gwinn M, MacCannell D, Armstrong GL. Next-generation sequencing of infectious pathogens. JAMA. 2019 Mar 5; 321(9):893–894.
   PubMed Web of Science ®Google Scholar
• Florio W, Baldeschi L, Rizzato C, et al. Detection of Antibiotic-Resistance by MALDI-TOF Mass Spectrometry: an Expanding Area. Front Cell Infect Microbiol. 2020;10:572909.
   PubMed Web of Science ®Google Scholar
• Dhingra S, Rahman NAA, Peile E, et al. Microbial resistance movements: an overview of global public health threats posed by antimicrobial resistance, and how best to counter. Public Health Front. 2020;8:535668.
   Google Scholar
• Hoyle A, Cairns D, Paterson I, et al. Optimising efficacy of antibiotics against systemic infection by varying dosage quantities and times. PLoS Comput Biol. 2020 Aug;16(8):e1008037.
   PubMed Web of Science ®Google Scholar
• Moser C, Lerche CJ, Thomsen K, et al. Antibiotic therapy as personalized medicine – general considerations and complicating factors. APMIS. 2019 May;127(5):361–371.
   PubMed Web of Science ®Google Scholar
• La Rosa M, Omere C, Redfern T, et al. The impact of low-dose versus high-dose antibiotic prophylaxis regimens on surgical site infection rates after cesarean delivery. Arch Gynecol Obstet. 2020 Jan;301(1):69–73.
   PubMed Web of Science ®Google Scholar
• Ren H, Li X, Ni ZH, et al. Treatment of complicated urinary tract infection and acute pyelonephritis by short-course intravenous levofloxacin (750 mg/day) or conventional intravenous/oral levofloxacin (500 mg/day): prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial. Int Urol Nephrol. 2017 Mar;49(3):499–507.
   PubMed Web of Science ®Google Scholar
• Chen CW, Chen YH, Cheng IL, et al. Comparison of high-dose, short-course levofloxacin treatment vs conventional regimen against acute bacterial infection: meta-analysis of randomized controlled trials. Infect Drug Resist. 2019;12:1353–1361.
   PubMed Web of Science ®Google Scholar
• Hsu PI, Lai KH, Wu CJ, et al. High-dose versus low-dose esomeprazole-based triple therapy for Helicobacter pylori infection. Eur J Clin Invest. 2007 Sep;37(9):724–730.
   PubMed Web of Science ®Google Scholar
• Gjini E, Paupério FFS, Ganusov VV. Treatment timing shifts the benefits of short and long antibiotic treatment over infection. Evol Med Public Health. 2020;2020(1):249–263.
   PubMedGoogle Scholar
• Bhalodi AA, van Engelen TSR, Virk HS, et al. Impact of antimicrobial therapy on the gut microbiome. J Antimicrob Chemother. 2019 Jan 1 74(Supplement_1):i6–i15.
   PubMedGoogle Scholar
• Looft T, Johnson TA, Allen HK, et al. In-feed antibiotic effects on the swine intestinal microbiome. Proceedings of the National Academy of Sciences of the United States of America USA. 2012 Jan 31;109( 5):1691–1696.
   Google Scholar
• Barlam TF, Cosgrove SE, Abbo LM, et al. Implementing an antibiotic stewardship program: guidelines by the infectious diseases society of america and the society for healthcare epidemiology of America. CClin Infect Dis. 2016 May 15 62(10):e51–e77.
   PubMedGoogle Scholar
• Li JZ, Winston LG, Moore DH, et al. Efficacy of short-course antibiotic regimens for community-acquired pneumonia: a meta-analysis. Am J Med. 2007 Sep;120(9):783–790.
   PubMed Web of Science ®Google Scholar
• Pinzone MR, Cacopardo B, Abbo L, et al. Duration of antimicrobial therapy in community acquired pneumonia: less is more. Sci World J. 2014;2014:759138.
   Google Scholar
• Hepburn MJ, Dooley DP, Skidmore PJ, et al. Comparison of short-course (5 days) and standard (10 days) treatment for uncomplicated cellulitis. Arch Internal Med. 2004 Aug 9-23 164(15):1669–1674.
   PubMedGoogle Scholar
• Bernard L, Dinh A, Ghout I, et al. Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial. Lancet. 2015 Mar 7 385(9971):875–882.
   PubMed Web of Science ®Google Scholar
• Sawyer RG, Claridge JA, Nathens AB, et al. Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med. 2015 May 21 372(21):1996–2005.
   PubMed Web of Science ®Google Scholar
• Katchman EA, Milo G, Paul M, et al. Three-day vs longer duration of antibiotic treatment for cystitis in women: systematic review and meta-analysis. Am J Med. 2005 Nov;118(11):1196–1207.
   PubMed Web of Science ®Google Scholar
• Falagas ME, Vouloumanou EK, Matthaiou DK, et al. Effectiveness and safety of short-course vs long-course antibiotic therapy for group a β-hemolytic streptococcal tonsillopharyngitis: a meta-analysis of randomized trials. Mayo Clin Proc. 2008;83(8):880–889.
   PubMed Web of Science ®Google Scholar
• Kyriakidou KG, Rafailidis P, Matthaiou DK, et al. Short- versus long-course antibiotic therapy for acute pyelonephritis in adolescents and adults: a meta-analysis of randomized controlled trials. Clin Ther. 2008 Oct;30(10):1859–1868.
   PubMed Web of Science ®Google Scholar
• Dimopoulos G, Matthaiou DK, Karageorgopoulos DE, et al. Short- versus long-course antibacterial therapy for community-acquired pneumonia: a meta-analysis. Drugs. 2008;68(13):1841–1854.
   PubMed Web of Science ®Google Scholar
• Eliakim-Raz N, Yahav D, Paul M, et al. Duration of antibiotic treatment for acute pyelonephritis and septic urinary tract infection– 7 days or less versus longer treatment: systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2013 Oct;68(10):2183–2191.
   PubMed Web of Science ®Google Scholar
• Haider BA, Saeed MA, Bhutta ZA. Short-course versus long-course antibiotic therapy for non-severe community-acquired pneumonia in children aged 2 months to 59 months. Cochrane Database Syst Rev. 2008 Apr 16(2). Cd005976. 10.1002/14651858.CD005976.pub2
   Web of Science ®Google Scholar
• Scher KS. Studies on the duration of antibiotic administration for surgical prophylaxis. Am Surg. 1997 Jan;63(1):59–62.
   PubMed Web of Science ®Google Scholar
• Altamimi S, Khalil A, Khalaiwi KA, et al. Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev 8 . 2009 Jan 21;(1). DOI: 10.1002/14651858.CD004872.pub2.
   Google Scholar
• Gotfried MH, DeAbate CA, Fogarty C, et al. Comparison of 5-day, short-course gatifloxacin therapy with 7-day gatifloxacin therapy and 10-day clarithromycin therapy for acute exacerbation of chronic bronchitis. Clin Ther. 2001 Jan;23(1):97–107.
   PubMed Web of Science ®Google Scholar
• Sandberg T, Skoog G, Hermansson AB, et al. Ciprofloxacin for 7 days versus 14 days in women with acute pyelonephritis: a randomised, open-label and double-blind, placebo-controlled, non-inferiority trial. Lancet. 2012 Aug 4 380(9840):484–490.
   PubMed Web of Science ®Google Scholar
• Bouglé A, Tuffet S, Federici L, et al. Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. Intensive Care Med. 2022 Jul;48(7):841–849.
   PubMed Web of Science ®Google Scholar
• Bae M, Jeong Y, Bae S, et al. Short versus prolonged courses of antimicrobial therapy for patients with uncomplicated Pseudomonas aeruginosa bloodstream infection: a retrospective study. J Antimicrob Chemother. 2021 Dec 24 77(1):223–228.
   PubMed Web of Science ®Google Scholar
• Deshpande A, Richter SS, Haessler S, et al. De-escalation of empiric antibiotics following negative cultures in hospitalized patients with pneumonia: rates and outcomes. Clin Infect Dis. 2021 Apr 26 72(8):1314–1322.
   PubMed Web of Science ®Google Scholar
• Schmidt-Hieber M, Teschner D, Maschmeyer G, et al. Management of febrile neutropenia in the perspective of antimicrobial de-escalation and discontinuation. Expert Rev Anti Infect Ther. 2019 ;17(12):983–995.
   PubMed Web of Science ®Google Scholar
• De Waele JJ, Schouten J, Beovic B, et al. Antimicrobial de-escalation as part of antimicrobial stewardship in intensive care: no simple answers to simple questions—a viewpoint of experts. Intensive Care Med. 2020 ;46(2):236–244.
   PubMed Web of Science ®Google Scholar
• Mathieu C, Pastene B, Cassir N, et al. Efficacy and safety of antimicrobial de-escalation as a clinical strategy. Expert Rev Anti Infect Ther. 2019 ;17(2):79–88.
   PubMed Web of Science ®Google Scholar
• Thursky K. Use of computerized decision support systems to improve antibiotic prescribing. Expert Rev Anti Infect Ther. 2006 Jun;4(3):491–507.
   PubMedGoogle Scholar
• Palma P, Rello J. Precision medicine for the treatment of sepsis: recent advances and future prospects. Expert Rev Precis Med Drug Dev. 2019 ;4(4):205–213.
   Web of Science ®Google Scholar
• van Duijn Pj, Verbrugghe W, Jorens PG, et al. The effects of antibiotic cycling and mixing on antibiotic resistance in intensive care units: a cluster-randomised crossover trial. Lancet Infect Dis. 2018 Apr;18(4):401–409.
   PubMed Web of Science ®Google Scholar
• Gorsline CA, Staub MB, Nelson GE, et al. Antimicrobial de-escalation in patients with high-risk febrile neutropenia: attitudes and practices of adult hospital care providers. Ashe. 2021;1(1):e22.
   Google Scholar
• Rahal JJ, Urban C, Horn D, et al. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA. 1998 Oct 14 280(14):1233–1237.
   PubMed Web of Science ®Google Scholar
• Sid Ahmed MA, Abdel Hadi H, Abu Jarir S, et al. Impact of an antimicrobial stewardship programme on antimicrobial utilization and the prevalence of MDR Pseudomonas aeruginosa in an acute care hospital in Qatar. JAC-Antimicrob Resist. 2020;2(3). 10.1093/jacamr/dlaa050.
   PubMedGoogle Scholar
• WHO. World Antimicrobial Awareness Week (WAAW) 2021. cited 08 07 2022. Available from: https://www.who.int/campaigns/world-antimicrobial-awareness-week/2021#:~:text=World%20Antimicrobial%20Awareness%20Week%20(WAAW,Resistance%20(AMR)%20Awareness%20champions.
   Google Scholar
• Kaplan JB. Antibiotic-Induced Biofilm Formation. Int J Artif Organs. 2011 Sep;34(9):737–751.
   PubMed Web of Science ®Google Scholar
• Imran M, Smith H. A model of optimal dosing of antibiotic treatment in biofilm. Math Biosci Eng. 2014;11(3):547–571.
   PubMed Web of Science ®Google Scholar
• Leone M, Martin C. How to break the vicious circle of antibiotic resistances? Curr Opin Crit Care. 2008 Oct;14(5):587–592.
   PubMed Web of Science ®Google Scholar