4,323
Views
36
CrossRef citations to date
0
Altmetric
Discussion Article

Applying U.S. national guidelines for ototoxicity monitoring in adult patients: perspectives on patient populations, service gaps, barriers and solutions

, , ORCID Icon, , , & show all
Pages S3-S18 | Received 26 Jul 2017, Accepted 20 Oct 2017, Published online: 20 Nov 2017

References

  • Abbara, A., S. Lang, O. M. Kon, S. M. Collin, D. Pan, T. Hansel, R. Ravindran, R. Holder, L. John, and R. N. Davidson. 2015. “Weekly Audiograms Pre-Emptively Identify Amikacin Related to Ototoxicity in MDR-TB.” Thorax 70: A1–A254.
  • Alharazneh, A., L. Luk, M. Huth, A. Monfared, P. S. Steyger, A. G. Cheng, and A. J. Ricci. 2011. “Functional Hair Cell Mechanotransducer Channels are Required for Aminoglycoside Ototoxicity.” PLoS One 6: e22347.
  • Al-Malky, G., S. J. Dawson, T. Sirimanna, E. Bagkeris, and R. Suri. 2015. “High-Frequency Audiometry Reveals High Prevalence of Aminoglycoside Ototoxicity in Children with Cystic Fibrosis.” Journal of Cystic Fibrosis 14: 248–254.
  • Amalraj, S., C. Starkweather, C. Nguyen, and A. Naeim. 2009. “Health Literacy, Communication, and Treatment Decision-Making in Older Cancer Patients.” Oncology (Williston Park, N.Y.) 23: 369–375.
  • American Cancer Society. 2016. Cancer Facts & Figures 2016. Atlanta, GA: American Cancer Society.
  • American Academy of Audiology (AAA). 2009. “Position Statement and Clinical Practice Guidelines: Ototoxicity Monitoring.” Accessed 27 January 2017. http://www.audiology.org
  • American Speech-Language-Hearing Association (ASHA). 1994. “Guidelines for the Audiologic Management of Individuals Receiving Cochleotoxic Drug Therapy.” ASHA 36: 11–19.
  • Arora, R., J. S. Thakur, R. K. Azad, N. K. Mohindroo, D. R. Sharma, and R. K. Seam. 2009. “Cisplatin-Based Chemotherapy: Add High-Frequency Audiometry in the Regimen.” Indian Journal of Cancer 46: 311–317.
  • Bass, J. K., and S. P. Bhagat. 2014. “Challenges in Ototoxicity Monitoring in the Pediatric Oncology Population.” Journal of the American Academy of Audiology 25: 760–774; quiz 782–783.
  • Beilefeld, E.C., and D. Henderson. 2011. “Mechanisms of Cisplatin Ototoxicity and Routes for Intervention.” Perspectives on Hearing and Hearing Disorders Research and Diagnostics 15: 3–14.
  • Bertolini, P., M. Lassalle, G. Mercier, M. A. Raquin, G. Izzi, N. Corradini, and O. Hartmann. 2004. “Platinum Compound-Related Ototoxicity in Children: Long-Term Follow-up Reveals Continuous Worsening of Hearing Loss.” Journal of Pediatric Hematology and Oncology 26: 649–655.
  • Black, F. O., C. Gianna-Poulin, and S. C. Pesznecker. 2001. “Recovery from Vestibular Ototoxicity.” Otology & Neurotology 22: 662–671.
  • Blakley, B. W., and S. F. Myers. 1993. “Patterns of Hearing Loss Resulting from Cis-Platinum Therapy.” Otolaryngology Head Neck Surgery 109: 385–391.
  • Bokemeyer, C., C. C. Berger, J. T. Hartmann, C. Kollmannsberger, H. J. Schmoll, M. A. Kuczyk, and L. Kanz. 1998. “Analysis of Risk Factors for Cisplatin-Induced Ototoxicity in Patients with Testicular Cancer.” British Journal of Cancer 77: 1355–1362.
  • Borse, V., R. F. H. Al Aameri, K. Sheehan, S. Sheth, T. Kaur, D. Mukherjea, S. Tupal, et al. 2017. “Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity.” Cell Death & Disease 8: e2921.
  • Brewer, C. B., and K. A. King. 2017. “Clinical Trials, Grading Scales, and the Audiologist’s Role in Therapeutic Decision Making.” International Journal of Audiology.
  • Brungart, D., J. Schurman, D. Konrad-Martin, K. Watts, and J. Buckey. 2017. “Ototoxicity Monitoring: Tablet-Based Testing.” International Journal of Audiology.
  • Cass, S. P. 1991. “Role of Medications in Otological Vertigo and Balance Disorders.” Seminars in Hearing 12: 257–269.
  • Children’s Oncology Group (COG). 2008. “Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers – Version 3.0.” Accessed 27 January 2017. http://www.survivorshipguidelines.org
  • Common Terminology for Criteria for Adverse Events (CTCAE v3.0). 2006. National Institutes of Health. Accessed 25 May 2013. http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf
  • Common Terminology Criteria for Adverse Events (CTCAE v4.03). 2010. “National Institutes of Health.” Accessed 27 January 2017. https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf
  • Conrad, D. J., A. E. Stenbit, E. M. Zettner, I. Wick, C. Eckhardt, and G. Hardiman. 2008. “Frequency of Mitochondrial 12s Ribosomal RNA Variants in an adult Cystic Fibrosis Population.” Pharmacogenetics and Genomics 18: 1095–1102.
  • Cross, C. P., S. Liao, Z. D. Urdang, P. Srikanth, A. C. Garinis, and P. S. Steyger. 2015. “Effect of Sepsis and Systemic Inflammatory Response Syndrome on Neonatal Hearing Screening Outcomes Following Gentamicin Exposure.” International of Journal of Pediatric Otorhinolaryngology 79: 1915–1919.
  • Cystic Fibrosis Foundation (CFF). 2017. “About Cystic Fibrosis.” Accessed 27 January 2017. https://www.cff.org/What-is-CF/About-Cystic-Fibrosis/
  • Dalton, D. S., K. J. Cruickshanks, B. E. K. Klein, R. Klein, T. L. Wiley, and D. M. Nondahl. 2003. “The Impact of Hearing Loss on Quality of Life in Older Adults.” Gerontologist 43: 661–668.
  • Damschroder, L. J., D. C. Aron, R. E. Keith, S. R. Kirsh, J. A. Alexander, and J. C. Lowery. 2009. “Fostering Implementation of Health Services Research Findings into Practice: A Consolidated Framework for Advancing Implementation Science.” Implementation Science 4: 50.
  • Dille, M. F., D. Konrad-Martin, F. Gallun, W. J. Helt, J. S. Gordon, K. M. Reavis, and G. W. Bratt. 2010. “Tinnitus Onset Rates from Chemotherapeutic Agents and Ototoxic Antibiotics: Results of a Large Prospective Study.” Journal of the American Academy of Audiology 21: 409–417.
  • Dille, M. F., G. P. McMillan, W. J. Helt, D. Konrad-Martin, and P. Jacobs. 2015. “A Store-and-Forward Tele-Audiology Solution to Promote Efficient Screenings for Ototoxicity During Cisplatin Cancer Treatment.” Journal of the American Academy of Audiology 26: 750–760.
  • Ding, D., B. L. Allman, and R. Salvi. 2012. “Review: Ototoxic Characteristics of Platinum Antitumor drugs.” Anatomical Record (Hoboken) 295: 1851–1867.
  • Dreisbach, L., M. Ho, E. Reid, and J. Siegel. 2017. “Effects of Oxaliplatin, Carboplatin, and Cisplatin Across Treatment on High-Frequency Objective and Subjective Auditory Measures in Adults.” Perspectives of the ASHA Special Interest Groups 2: 17–36.
  • Drobnic, M. E., P. Sune, J. B. Montoro, A. Ferrer, R. Orriols. 2005. “Inhaled Tobramycin in Non-cystic Fibrosis Patients with Bronchiectasis and Chronic Bronchial Infection with Pseudomonas aeruginosa.” Annals of Pharmacotherapy 39: 39–44.
  • Durrant, J. D., C. V. Palmer, and T. Lunner. 2005. “Analysis of Counted Behaviors in a Single-Subject Design: Modeling of hearing-Aid Intervention in Hearing-Impaired Patients with Alzheimer's Disease.” International Journal of Audiology 44: 31–38.
  • Egelund, E. F., K. P. Fennelly, and C. A. Peloquin. 2015. “Medications and Monitoring in Nontuberculous Mycobacteria Infections.” Clinics in Chest Medicine 36: 55–66.
  • Engdahl, B., K. Tambs, H. M. Borchgrevink, and H. J. Hoffman. 2005. “Screened and Unscreened Hearing Threshold Levels for the Adult Population: Results from the Nord-Trøndelag Hearing Loss Study.” International Journal of Audiology 44: 213–230.
  • Fausti, S. A., J. A. Henry, W. J. Helt, D. S. Phillips, R. H. Frey, D. Noffsinger, and V. D. Larson. 1999. “An Individualized, Sensitive Frequency Range for Early Detection of Ototoxicity.” Ear and Hearing 20: 497–505.
  • Fausti, S. A., W. J. Helt, D. S. Phillips, J. S. Gordon, G. W. Bratt, K. M. Sugiura, and D. Noffsinger. 2003. “Early Detection of Ototoxicity Using 1/6th-Octave Steps.” Journal of the American Academy of Audiology 14: 444–450.
  • Fee, W. E. Jr. 1980. “Aminoglycoside Ototoxicity in the Human.” Laryngoscope 90: 1–19.
  • Ferlay, J., I. Soerjomataram, M. Ervik, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray. 2013. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon: International Agency for Research on Cancer.
  • Forge, A., and J. Schacht. 2000. “Aminoglycoside Antibiotics.” Audiology & Neurootology 5: 3–22.
  • Frank, T. 2001. “High-Frequency (8 to 16 kHz) Reference Thresholds and Intrasubject Threshold Variability Relative to Ototoxicity Criteria Using a Sennheiser HDA 200 Earphone.” Ear and Hearing 22: 161–168.
  • Frank, T., and L. E. Dreisbach. 1991. “Repeatability of High-Frequency Thresholds.” Ear and Hearing 12: 294–295.
  • Frisina, R. D., H. E. Wheeler, S. D. Fossa, S. L. Kerns, C. Fung, H. D. Sesso, and P. O. Monahan. 2016. “Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer.” Journal of Clinical Oncology 34: 2712–2720.
  • Garinis, A. C., A. Cornell, G. Allada, K. P. Fennelly, R. J. Maggiore, and D. Konrad-Martin. 2017a. “Ototoxicity Monitoring Through the Eyes of the Treating Physician: Perspectives from Pulmonology and Medical Oncology.” International Journal of Audilogy. doi: 10.1080/14992027.2017.1381769
  • Garinis, A. C., C. Cross, P. Srikanth, K. Carroll, M. P. Feeney, D. H. Keefe, L. L. Hunter, et al. 2017b. “The Cumulative Effects of Intravenous Antibiotic Treatments on Hearing in Patients with Cystic Fibrosis.” Journal of Cystic Fibrosis 16: 401–409.
  • Genther, D. J., J. Betz, S. Pratt, K. R. Martin, T. B. Harris, S. Satterfield, D. C. Bauer, et al. 2015. “Association Between Hearing Impairment and Risk of Hospitalization in Older Adults.” Journal of the American Geriatrics Society 63: 1146–1152.
  • Gratton, M. A., R. J. Salvi, B. A. Kamen, and S. S. Saunders. 1990. “Interaction of Cisplatin and Noise on the Peripheral Auditory System.” Hearing Research 50: 211–223.
  • Handelsman, J. A. 2017. “Vestibulotoxicity: Strategies for Clinical Diagnosis and Rehabilitation.” International Journal of Audiology.
  • Hartmann, J. T., and H. P. Lipp. 2003. “Toxicity of Platinum Compounds.” Expert Opinion on Pharmacotherapy 4: 889–901.
  • Hashino, E., and M. Shero. 1995. “Endocytosis of Aminoglycoside Antibiotics in Sensory Hair Cells.” Brain Research 704: 135–140.
  • Hellberg, V., I. Wallin, S. Eriksson, E. Hernlund, E. Jerremalm, M. Berndtsson, S. Eksborg, et al. 2009. “Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity.” Journal of the National Cancer Institute 101: 37–47.
  • Hijri, F. Z., S. Arifi , N. Ouattassi, N. Mellas, and O. El Mesbahi. 2014. “Oxaliplatin-induced ototoxicity in adjuvant setting for colorectal cancer: unusual side effect.” Journal of Gastrointestinal Cancer 45: 106–108.
  • Hilder, T. A., and J. M. Hill. 2009. “Modeling the Loading and Unloading of Drugs into Nanotubes.” Small 5: 300–308.
  • Huth, M. E., A. J. Ricci, and A. G. Cheng. 2011. “Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection.” International Journal of Otolaryngology 2011: 937861.
  • Jereczek-Fossa, B. A., A. Zarowski, F. Milani, and R. Orecchia. 2003. “Radiotherapy-induced Ear Toxicity.” Cancer Treatment Reviews 29: 417–430.
  • Karasawa, T., and P. S. Steyger. 2015. “An Integrated View of Cisplatin-Induced Nephrotoxicity and Ototoxicity.” Toxicology Letters 237: 219–227.
  • Karasawa, T., Q. Wang, Y. Fu, D. M. Cohen, and P. S. Steyger. 2008. “TRPV4 Enhances the Cellular Uptake of Aminoglycoside Antibiotics.” Journal of Cell Science 121: 2871–2879.
  • Kazmierczak, P., H. Sakaguchi, J. Tokita, E. M. Wilson-Kubalek, R. A. Milligan, U. Müller, and B. Kachar. 2007. “Cadherin 23 and Protocadherin 15 Interact to Form Tip-Link Filaments in Sensory Hair Cells.” Nature 449: 87–91.
  • Knight, K. R., D. F. Kraemer, C. Winter, and E. A. Neuwelt. 2007. “Early Changes in Auditory Function as a Result of Platinum Chemotherapy: Use of Extended High-Frequency Audiometry and Evoked Distortion Product Otoacoustic Emissions.” Journal of Clinical Oncology 25: 1190–1195.
  • Knudsen, L. V., M. Oberg, C. Nielsen, G. Naylor, and S. E. Kramer. 2010. “Factors influencing Help Seeking, Hearing Aid Uptake, Hearing Aid Use and Satisfaction with Hearing Aids: A Review of the Literature.” Trends in Amplification 14: 127–154.
  • Kochkin, S., and C. Rogin. 2000. “Quantifying the Obvious: The Impact of Hearing Instruments on the Quality of Life.” Hearing Review 7: 6–34.
  • Kolinsky, D. C., S. S. Hayashi, R. Karzon, J. Mao, and R. J. Hayashi. 2010. “Late Onset Hearing Loss: A Significant Complication of Cancer Survivors Treated with Cisplatin Containing Chemotherapy Regimens.” Journal of Pediatric Hematology/Oncology 32: 119–123.
  • Konrad-Martin, D., G. L. Poling, L. E. Dreisbach, K. M. Reavis, G. P. McMillan, J. A. Lapsley Miller, and L. Marshall. 2016. “Serial Monitoring of Otoacoustic Emissions in Clinical Trials.” Otology & Neurotology 37: e286–94.
  • Konrad-Martin, D., K. E. James, J. S. Gordon, K. M. Reavis, D. S. Phillips, G. W. Bratt, and S. A. Fausti. 2010. “Evaluation of Audiometric Threshold Shift Criteria for Ototoxicity Monitoring.” Journal of the American Academy Audiology 21: 301–314; quiz 357.
  • Konrad-Martin, D., K. M. Reavis, G. P. McMillan, and M. F. Dille. 2012. “Multivariate DPOAE Metrics for Identifying Changes in Hearing: Perspectives from Ototoxicity Monitoring.” International Journal of Audiology 51: S51–S62.
  • Koo, J.-W., L. Quintanilla-Dieck, M. Jiang, J. Liu, Z. D. Urdang, J. J. Allensworth, and C. P. Cross. 2015. “Endotoxemia-Mediated Inflammation Potentiates Aminoglycoside-Induced Ototoxicity.” Science Translational Medicine 7: 298ra118.
  • Kujawa, S. G., and M. C. Liberman. 2015. “Synaptopathy in the Noise-Exposed and Aging Cochlea: Primary Neural Degeneration in Acquired Sensorineural Hearing Loss.” Hearing Research 330: 191–199.
  • Laplante-Levesque, A., K. J. Brannstrom, E. Ingo, G. Andersson, and T. Lunner. 2015. “Stages of Change in Adults Who Have Failed an Online Hearing Screening.” Ear and Hearing 36: 92–101.
  • Laurell, G., A. Viberg, M. Teixeira, O. Sterkers, and E. Ferrary. 2000. “Blood-Perilymph Barrier and Ototoxicity: An In Vivo Study in the Rat.” Acta Otolaryngology 120: 796–803.
  • Lee, J. E., T. Nakagawa, T. S. Kim, F. Iguchi, T. Endo, Y. Dong, K. Yuki, Y. Naito, S. H. Lee, and J. Ito. 2003. “A Novel Model for Rapid Induction of Apoptosis in Spiral Ganglions of Mice.” Laryngoscope 113: 994–999.
  • Li, H., A. Kachelmeier, D. N. Furness, and P. S. Steyger. 2015. “Local Mechanisms for Loud Sound-Enhanced Aminoglycoside Entry into Outer Hair Cells.” Frontiers in Cell Neuroscience 9: 130.
  • Li, H., and P. S. Steyger. 2011. “Systemic Aminoglycosides Are Trafficked Via Endolymph into Cochlear Hair Cells.” Scientific Reports 1: 159.
  • Li, S., L. Hang, and Y. Ma. 2016. “FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number.” Hearing Research 332: 39–45.
  • Lobarinas, E., R. Salvi, and D. Ding. 2013. “Insensitivity of the Audiogram to Carboplatin Induced Inner Hair Cell Loss in Chinchillas.” Hearing Research 302: 113–120.
  • Lonsbury-Martin, B. L., and G. K. Martin. 2007. Other Ototoxins: Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs, Quinine, and Macrolides. In Pharmacology and Ototoxicity for Audiologists, edited by Campbell, K. C. M, 187–194. Clifton Park, NY: Thomson/Delmar Learning.
  • Malhotra, N. K., R. Aslam, S. P. Lipman, and V. J. Bilski. 2010. “Acute Ototoxicity from a Single Infusion of Oxaliplatin.” Ear, Nose & Throat Journal 89: 258–261.
  • Marcotti, W., S. M. van Netten, and C. J. Kros. 2005. “The Aminoglycoside Antibiotic Dihydrostreptomycin Rapidly Enters Mouse Outer Hair Cells Through the Mechano-Electrical Transducer Channels.” The Journal of Physiology 567: 505–521.
  • McMillan, G. P., D. Konrad-Martin, and M. F. Dille. 2012. “Accuracy of Distortion-Product Otoacoustic Emissions-Based Ototoxicity Monitoring Using Various Primary Frequency Step-Sizes.” International Journal of Audiology 51: 689–696.
  • Minor, L. B. 1999. “Intratympanic Gentamicin for Control of Vertigo in Meniere's Disease: Vestibular Signs that Specify Completion of Therapy.” American Journal of Otology 20: 209–219.
  • Mukherjea, D., and L. P. Rybak. 2011. “Pharmacogenomics of Cisplatin-Induced Ototoxicity.” Pharmacogenomics 12: 1039–1050.
  • Mulrow, C. D., C. Aguilar, J. E. Endicott, M. R. Tuley, R. Velez, W. S. Charlip, M. C. Rhodes, J.A. Hill, and L. A. DeNino. 1990. “Quality-of-Life Changes and Hearing Impairment. A Randomized Trial.” Annals of Internal Medicine 113: 188–194.
  • National Academies of Sciences, Engineering, and Medicine. 2016. Hearing Health Care for Adults: Priorities for Improving Access and Affordability. New York: National Academies Press.
  • Obermair, A., P. Speiser, M. Thoma, A. Kaider, H. Salzer, C. Dittrich, and P. Sevelda. 1998. “Prediction of Toxicity But Not of Clinical Course by Determining Carboplatin Exposure in Patients with Epithelial Ovarian Cancer Treated with a Combination of Carboplatin and Cisplatin.” International of Journal Oncology 13: 1023–1030.
  • Oh, S. Y., N. Wasif, M. C. Garcon, G. Rodriguez, and M. W. Saif. 2013. “Ototoxicity associated with oxaliplatin in a patient with pancreatic cancer.” Journal of Periodontology 14: 676–679.
  • Orriols, R., J. Roig, J. Ferrer, G. Sampol, A. Rosell, A. Ferrer, and A. Vallano. 1999. “Inhaled Antibiotic Therapy in Non-Cystic Fibrosis Patients with Bronchiectasis and Chronic Bronchial Infection by Pseudomonas aeruginosa.” Respiratory Medicine 93: 476–480.
  • Paken, J., C. D. Govender, M. Pillay, and V. Sewram. 2016. “Cisplatin-Associated Ototoxicity: A Review for the Health Professional.” Journal of Toxicology 2016: 1809394.
  • Prescott, W. A., Jr. 2014. “A Survey of Extended-Interval Aminoglycoside Dosing Practices in United States Adult Cystic Fibrosis Programs.” Respiratory Care 59: 1353–1359.
  • Priest, E. R., and N. J. Vogelzang. 1991. “Optimal Drug Therapy in the Treatment of Testicular Cancer.” Drugs 42: 52–64.
  • Reavis, K. M., G. McMillan, D. Austin, F. Gallun, S. A. Fausti, J. S. Gordon, W. J. Helt, and D. Konrad-Martin. 2011. “Distortion-Product Otoacoustic Emission Test Performance for Ototoxicity Monitoring.” Ear and Hearing 32: 61–74.
  • Riedemann, L., C. Lanvers, D. Deuster, U. Peters, J. Boos, H. Jürgens, and A. am Zehnhoff-Dinnesen. 2008. “Megalin Genetic Polymorphisms and Individual Sensitivity to the Ototoxic Effect of Cisplatin.” The Pharmacogenomics Journal 8: 23–28.
  • Saunders, G. H., M. T. Frederick, S. Silverman, and M. Papesh. 2013. “Application of the Health Belief Model: Development of the Hearing Beliefs Questionnaire (HBQ) and its Associations with Hearing Health Behaviors.” International Journal of Audiology 52: 558–567.
  • Schuknecht, H. F., and M. R. Gacek. 1993. “Cochlear Pathology in Presbycusis.” Annals of Otology, Rhinology and Laryngology 102: 1–16.
  • Schwade, N. D. 2000. Pharmacology in Audiology Practice. In Audiology Diagnosis, edited by Roeser, R. J., M. Valente, and H. Hosford-Dunn, 139–162. New York: Thieme.
  • Schweitzer, V. G. 1993. “Cisplatin-Induced Ototoxicity: The Effect of Pigmentation and Inhibitory Agents.” Laryngoscope 103, 1–52.
  • Stepanyan, R. S., A. A. Indzhykulian, A. C. Vélez-Ortega, E. T. Boger, P. S. Steyger, T. B. Friedman, and G. I. Frolenkov. 2011. “TRPA1-Mediated Accumulation of Aminoglycosides in Mouse Cochlear Outer Hair Cells.” Journal of the Association for Research in Otolaryngology 12: 729–740.
  • Tang, H.-Y., E. Hutcheson, S. Neill, M. Drummond-Borg, M. Speer, and R. L. Alford. 2002. “Genetic Susceptibility to Aminoglycoside Ototoxicity: How Many Are at Risk?” Genetic Medicine 4: 336–345.
  • Tono, T., K. Kiyomizu, K. Matsuda, S. Komune, S. Usami, S. Abe, and H. Shinkawa. 2001. “Different Clinical Characteristics of Aminoglycoside-Induced Profound Deafness with and without the 1555 A->G Mitochondrial Mutation.” Journal of Otorhinolaryngology and its Related Specialities 63: 25–30.
  • Theunissen, E. A. R., S. C. J. Bosma, C. L. Zuur, R. Spijker, S. van der Baan, W. A. Dreschler, J. P. de Boer, A. J. Balm, and C. R. Rasch. 2015. “Sensorineural Hearing Loss in Patients with Head and Neck Cancer After Chemoradiotherapy and Radiotherapy: A Systematic Review of the Literature.” Head and Neck 37: 281–292.
  • Thomas, A. J., D. W. Hailey, T. M. Stawicki, P. Wu, A. B. Coffin, E. W. Rubel, D. W. Raible, J. A. Simon, and H. C. Ou. 2013. “Functional Mechanotransduction is Required for Cisplatin-Induced Hair Cell Death in the Zebrafish Lateral Line.” Journal of Neuroscience 33: 4405–4414.
  • Torre, L. A., F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal. 2015. “Global Cancer Statistics, 2012.” CA Cancer Journal of Clinics 65: 87–108.
  • Tran Ba Huy, P., P. Bernard, and J. Schacht. 1986. “Kinetics of Gentamicin Uptake and Release in the Rat. Comparison of Inner Ear Tissues and Fluids with Other Organs. The Journal of Clinical Investigation 77: 1492–1500.
  • Van der Walt, H. 2002. “Too Close for Comfort: Emotional Ties Between Nurse and Patients.” In Reflective Practice: Psychodynamic Ideas in the Community, edited by Swartz, L., K. Gibson, and T. Gelman. Cape Town: Human Sciences Research Council.
  • van Ruijven, M. W., J. C. de Groot, S. F. Klis, and G. F. Smoorenburg. 2005. “The Cochlear Targets of Cisplatin: An Electrophysiological and Morphological Time-Sequence Study.” Hearing Research 205: 241–248.
  • Vasquez, R., and Mattucci, K. F. 2003. “A Proposed Protocol for Monitoring Ototoxicity in Patients Who Take Cochleo- or Vestibulotoxic Drugs.” Ear, Nose & Throat Jounal 82: 181–184.
  • Vaughan, N. E., S. A. Fausti, S. Chelius, D. Phillips, W. Helt, and J. A. Henry. 2002. “An Efficient Test Protocol for Identification of a Limited, Sensitive Frequency Test Range for Early Detection of Ototoxicity.” Journal of Rehabilitation Research & Development 39: 567–574.
  • Vietor, N. O., and B. J. George. 2012. “Oxaliplatin-induced hepatocellular injury and ototoxicity: A review of the literature and report of unusual side effects of a commonly used chemotherapeutic agent.” Journal of Oncology Pharmacy Practice 18: 355–359.
  • Weaver, A., S. Flemming, J. Kish, H. Vandenberg, J. Jacob, J. Crissman, and M. Al-Sarraf. 1982. “Cis-platinum and 5-Fluorouracil as Induction Therapy for Advanced Head and Neck Cancer.” American Journal of Surgery 144: 445–448.
  • Wiley, T. L., K. J. Cruickshanks, D. M. Nondahl, and T. S. Tweed. 2000. “Self-reported Hearing Handicap and Audiometric Measures in Older Adults.” Journal of the American Academy of Audiology 11: 67–75.
  • Wright, C. G., and S. D. Schaefer. 1982. “Inner Ear Histopathology in Patients Treated with Cis-Platinum.” Laryngoscope 92: 1408–1413.
  • Zuur, C. L., Y. J. Simis, E. A. Lamers, A. A. Hart, W. A. Dreschler, A. J. Balm, and C. R. Rasch. 2009. “Risk Factors for Hearing Loss in Patients Treated with Intensity-Modulated Radiotherapy for Head-and-Neck Tumors.” International Journal of Radiation Oncology, Biology, and Physics 74: 490–496.
  • Zuur, C. L., Y. J. Simis, P. E. Lansdaal, A. A. Hart, C. R. Rasch, J. H. Schornagel, W. A. Dreschler, et al. 2007. “Risk Factors of Ototoxicity After Cisplatin-Based Chemo-Irradiation in Patients with Locally Advanced Head-and-Neck Cancer: A Multivariate Analysis.” International Journal of Radiation Oncology, Biology, and Physics 68: 1320–1325.