Effectiveness of transcutaneous vagus nerve stimulation for the treatment of tinnitus: an interventional prospective controlled study

References

• Adamchic, I., T. Toth, C. Hauptmann, M. Walger, B. Langguth, I. Klingmann, and P. A. Tass. 2017. “Acute Effects and After-Effects of Acoustic Coordinated Reset Neuromodulation in Patients with Chronic Subjective Tinnitus.” NeuroImage. Clinical 15:541–558. doi:10.1016/j.nicl.2017.05.017.
   PubMed Web of Science ®Google Scholar
• Adcock, K. S., C. Chandler, E. P. Buell, B. R. Solorzano, K. W. Loerwald, M. S. Borland, and C. T. Engineer. 2020. “Vagus Nerve Stimulation Paired with Tones Restores Auditory Processing in a Rat Model of Rett Syndrome.” Brain Stimulation 13 (6):1494–1503. doi:10.1016/j.brs.2020.08.006.
   PubMed Web of Science ®Google Scholar
• Berthoud, H. R., and W. L. Neuhuber. 2000. “Functional and Chemical Anatomy of The Afferent Vagal System.” Autonomic Neuroscience 85 (1–3):1–17. doi:10.1016/S1566-0702(00)00215-0.
   PubMed Web of Science ®Google Scholar
• Bremner, J. D., N. Z. Gurel, M. T. Wittbrodt, M. H. Shandhi, M. H. Rapaport, J. A. Nye, B. D. Pearce, V. Vaccarino, A. J. Shah, J. Park, et al. 2020. “Application of Noninvasive Vagal Nerve Stimulation To Stress-Related Psychiatric Disorders.” Journal of Personalized Medicine 10 (3):119. doi:10.3390/jpm10030119.
   PubMed Web of Science ®Google Scholar
• Budd, R. J., and R. Pugh. 1995. “The Relationship Between Locus of Control, Tinnitus Severity, and Emotional Distress in A Group of Tinnitus Sufferers.” Journal of Psychosomatic Research 39 (8):1015–1018. doi:10.1016/0022-3999(95)00512-9.
   PubMed Web of Science ®Google Scholar
• Buell, E. P., M. S. Borland, K. W. Loerwald, C. Chandler, S. A. Hays, C. T. Engineer, and M. P. Kilgard. 2019. “Vagus Nerve Stimulation Rate and Duration Determine Whether Sensory Pairing Produces Neural Plasticity.” Neuroscience 406:290–299. doi:10.1016/j.neuroscience.2019.03.019.
   PubMed Web of Science ®Google Scholar
• Chae, J.-H., Z. Nahas, M. Lomarev, S. Denslow, J. P. Lorberbaum, D. E. Bohning, and M. S. George. 2003. “A Review of Functional Neuroimaging Studies of Vagus Nerve Stimulation (Vns).” Journal of Psychiatric Research 37 (6):443–455. doi:10.1016/S0022-3956(03)00074-8.
   PubMed Web of Science ®Google Scholar
• Cima, R. F. F., B. Mazurek, H. Haider, D. Kikidis, A. Lapira, A. Noreña, and D. J. Hoare. 2019. “A Multidisciplinary European Guideline For Tinnitus: Diagnostics, Assessment, and Treatment.” HNO 67 (Suppl 1):10–42. doi:10.1007/s00106-019-0633-7.
   PubMedGoogle Scholar
• Davis, A., and A. Refaie. 2000. “Epidemiology of tinnitus.” In Handbook of tinnitits, 1–23. San Diego, CA: Singular Publishing Group.
   Google Scholar
• De Ridder, D., S. Vanneste, B. Langguth, and R. Llinas. 2015. “Thalamocortical Dysrhythmia: A Theoretical Update in Tinnitus.” Frontiers in Neurology 6:124. doi:10.3389/fneur.2015.00124.
   Web of Science ®Google Scholar
• Dobie, R. A. 2004. “Overview: Suffering from tinnitus.” In Tinnitus: Theory and Management, 1–7. Lewiston, NY: BC Decker Inc.
   Google Scholar
• Dohrmann, K., N. Weisz, W. Schlee, T. Hartmann, and T. Elbert. 2007. “Neurofeedback For Treating Tinnitus.” Progress in Brain Research 166:473–485. doi:10.1016/S0079-6123(07)66046-4.
   PubMed Web of Science ®Google Scholar
• Eggermont, J. J., and L. E. Roberts. 2004. “The Neuroscience of Tinnitus.” Trends in Neurosciences 27 (11):676–682. doi:10.1016/j.tins.2004.08.010.
   PubMed Web of Science ®Google Scholar
• Engineer, C. T., N. D. Engineer, J. R. Riley, J. D. Seale, and M. P. Kilgard. 2015. “Pairing Speech Sounds with Vagus Nerve Stimulation Drives Stimulus-Specific Cortical Plasticity.” Brain Stimulation 8 (3):637–644. doi:10.1016/j.brs.2015.01.408.
   PubMed Web of Science ®Google Scholar
• Engineer, N. D., J. R. Riley, J. D. Seale, W. A. Vrana, J. A. Shetake, S. P. Sudanagunta, M. S. Borland, and M. P. Kilgard. 2011. “Reversing Pathological Neural Activity Using Targeted Plasticity.” Nature 470 (7332):101–104. doi:10.1038/nature09656.
   PubMed Web of Science ®Google Scholar
• Frangos, E., J. Ellrich, and B. R. Komisaruk. 2015. “Non-Invasive Access To The Vagus Nerve Central Projections Via Electrical Stimulation of The External Ear: Fmri Evidence in Humans.” Brain Stimulation 8 (3):624–636. doi:10.1016/j.brs.2014.11.018.
   PubMed Web of Science ®Google Scholar
• Groves, D. A., and V. J. Brown. 2005. “Vagal Nerve Stimulation: A Review of Its Applications and Potential Mechanisms That Mediate Its Clinical Effects.” Neuroscience and Biobehavioral Reviews 29 (3):493–500. doi:10.1016/j.neubiorev.2005.01.004.
   PubMed Web of Science ®Google Scholar
• Hays, S. A., R. L. Rennaker, and M. P. Kilgard. 2013. “Targeting Plasticity with Vagus Nerve Stimulation To Treat Neurological Disease.” Progress in Brain Research 207:275–299. doi:10.1016/B978-0-444-63327-9.00010-2.
   PubMed Web of Science ®Google Scholar
• Henry, J. A. 2016. “Measurement” of Tinnitus.” Otology & Neurotology 37 (8):e276–e285. doi:10.1097/MAO.0000000000001070.
   PubMed Web of Science ®Google Scholar
• Khanna, A., A. Pascual-Leone, C. M. Michel, and F. Farzan. 2015. “Microstates in Resting-State Eeg: Current Status and Future Directions.” Neuroscience and Biobehavioral Reviews 49:105–113. doi:10.1016/j.neubiorev.2014.12.010.
   PubMed Web of Science ®Google Scholar
• Kochilas, H. L., A. T. Cacace, A. Arnold, M. D. Seidman, and W. B. Tarver. 2020. “Vagus Nerve Stimulation Paired with Tones For Tinnitus Suppression: Effects on Voice and Hearing.” Laryngoscope Investigative Otolaryngology 5 (2):286–296. doi:10.1002/lio2.364.
   PubMed Web of Science ®Google Scholar
• Kreuzer, P. M., M. Landgrebe, M. Resch, O. Husser, M. Schecklmann, F. Geisreiter, T. B. Poeppl, S. J. Prasser, G. Hajak, R. Rupprecht, et al. 2014. “Feasibility, Safety and Efficacy of Transcutaneous Vagus Nerve Stimulation in Chronic Tinnitus: An Open Pilot Study.” Brain Stimulation 7 (5):740–747. doi:10.1016/j.brs.2014.05.003.
   PubMed Web of Science ®Google Scholar
• Kucia, K., W. Merk, K. Zapalowicz, and T. Medrala. 2019. “Vagus Nerve Stimulation for Treatment Resistant Depression: Case Series of Six Patients – Retrospective Efficacy and Safety Observation After One Year Follow Up.” Neuropsychiatric Disease and Treatment 15:3247–3254. doi:10.2147/NDT.S217816.
   PubMed Web of Science ®Google Scholar
• Kutyba, J., E. Gos, W. W. Jędrzejczak, D. Raj-Koziak, L. Karpiesz, I. Niedziałek, H. Skarżyński, and P. H. Skarżyński. 2022a. “Effectiveness of Tinnitus Therapy Using A Mobile Application.” European Archives of Oto-Rhino-Laryngology 279 (3):1257–1267. doi:10.1007/s00405-021-06767-9.
   PubMed Web of Science ®Google Scholar
• Kutyba, J. J., W. W. Jędrzejczak, E. Gos, D. Raj-Koziak, and P. H. Skarzynski. 2022b. “Chronic Tinnitus and The Positive Effects of Sound Treatment Via A Smartphone App: Mixed-Design Study.” JMIR mHealth and uHealth 10 (4):e33543. doi:10.2196/33543.
   PubMed Web of Science ®Google Scholar
• Lehtimäki, J., P. Hyvärinen, M. Ylikoski, M. Bergholm, J. P. Mäkelä, A. Aarnisalo, U. Pirvola, A. Mäkitie, and J. Ylikoski. 2013. “Transcutaneous Vagus Nerve Stimulation in Tinnitus: A Pilot Study.” Acta Oto-Laryngologica 133 (4):378–382. doi:10.3109/00016489.2012.750736.
   PubMed Web of Science ®Google Scholar
• van Lutterveld, R., I. E. C. Sommer, and J. M. Ford. 2011. “The Neurophysiology of Auditory Hallucinations – A Historical and Contemporary Review.” Frontiers in Psychiatry. 2:28.
   PubMedGoogle Scholar
• Manta, S., J. Dong, G. Debonnel, and P. Blier. 2009. “Enhancement of The Function of Rat Serotonin and Norepinephrine Neurons By Sustained Vagus Nerve Stimulation.” Journal of Psychiatry & Neuroscience 34 (4):272–280.
   PubMed Web of Science ®Google Scholar
• Martins, A. R. O., and R. C. Froemke. 2015. “Coordinated Forms of Noradrenergic Plasticity in The Locus Coeruleus and Primary Auditory Cortex.” Nature Neuroscience 18 (10):1483–1492. doi:10.1038/nn.4090.
   PubMed Web of Science ®Google Scholar
• McFerran, D. J., D. Stockdale, R. Holme, C. H. Large, and D. M. Baguley. 2019. “Why Is There No Cure For Tinnitus?” Frontiers in Neuroscience 13:802. doi:10.3389/fnins.2019.00802
   PubMed Web of Science ®Google Scholar
• Mielczarek, M., J. Michalska, K. Polatyńska, and J. Olszewski. 2016. “An Increase in Alpha Band Frequency in Resting State Eeg After Electrical Stimulation of The Ear in Tinnitus Patients-A Pilot Study.” Frontiers in Neuroscience 10:453.
   PubMed Web of Science ®Google Scholar
• Milner, R., M. Lewandowska, M. Ganc, J. Nikadon, I. Niedziałek, W. W. Jędrzejczak, and H. Skarżyński. 2020. “Electrophysiological Correlates of Focused Attention On Low- and High-Distressed Tinnitus.” PloS One 15 (8):e0236521. doi:10.1371/journal.pone.0236521.
   PubMed Web of Science ®Google Scholar
• Newman, C. W., G. P. Jacobson, and J. B. Spitzer. 1996. “Development of The Tinnitus Handicap Inventory.” Archives of Otolaryngology-Head & Neck Surgery 122 (2):143–148. doi:10.1001/archotol.1996.01890140029007.
   PubMed Web of Science ®Google Scholar
• Newman, C. W., S. A. Sandridge, and L. Bolek. 2008. “Development and Psychometric Adequacy of The Screening Version of The Tinnitus Handicap Inventory.” Otology & Neurotology 29 (3):276–281. doi:10.1097/MAO.0b013e31816569c4.
   PubMed Web of Science ®Google Scholar
• Nicastri, M., G. Chiarella, L. V. Gallo, M. Catalano, and E. Cassandro. 2004. “Multidimensional Voice Program (Mdvp) and Amplitude Variation Parameters in Euphonic Adult Subjects.” Acta Otorhinolaryngologica Italica 24 (6):337–341.
   PubMedGoogle Scholar
• Noble, L. J., V. B. Meruva, S. A. Hays, R. L. Rennaker, M. P. Kilgard, and C. K. McIntyre. 2019. “Vagus Nerve Stimulation Promotes Generalization of Conditioned Fear Extinction and Reduces Anxiety in Rats.” Brain Stimulation 12 (1):9–18. doi:10.1016/j.brs.2018.09.013.
   PubMed Web of Science ®Google Scholar
• Park, D. H., S. S. Han, M. Han, S. Park, H. N. Kim, J. Kim, H. Aan, J. Kim, S. Kim, K. Kim, et al. 2022. “A Clinical Trial of A Patient-Customized Virtual Reality Intervention For Tinnitus.” Scientific Reports 12 (1):12441. doi:10.1038/s41598-022-16764-5.
   PubMed Web of Science ®Google Scholar
• Pawlak-Osińska, K., W. Kaźmierczak, H. Kaźmierczak, M. Wierzchowska, and I. Matuszewska. 2013. “Cortical Activity in Tinnitus Patients and Its Modification By Phonostimulation.” Clinics 68 (4):511–515. doi:10.6061/clinics/2013(04)12.
   PubMed Web of Science ®Google Scholar
• Peña, D. F., J. E. Childs, S. Willett, et al. 2014. “Vagus Nerve Stimulation Enhances Extinction of Conditioned Fear and Modulates Plasticity in The Pathway From The Ventromedial Prefrontal Cortex To The Amygdala.” Frontiers in Behavioral Neuroscience. 8:327.
   PubMed Web of Science ®Google Scholar
• Pierzycki, R. H., A. J. McNamara, D. J. Hoare, and D. A. Hall. 2016. “Whole Scalp Resting State Eeg of Oscillatory Brain Activity Shows No Parametric Relationship with Psychoacoustic and Psychosocial Assessment of Tinnitus: A Repeated Measures Study.” Hearing Research 331:101–108. doi:10.1016/j.heares.2015.11.003.
   PubMed Web of Science ®Google Scholar
• Raj-Koziak, D., E. Gos, W. Swierniak, J. J. Rajchel, L. Karpiesz, I. Niedzialek, E. Wlodarczyk, H. Skarzynski, and P. H. Skarzynski. 2018. “Visual Analogue Scales As A Tool For Initial Assessment of Tinnitus Severity: Psychometric Evaluation in A Clinical Population.” Audiology & Neuro-Otology 23 (4):229–237. doi:10.1159/000494021.
   PubMed Web of Science ®Google Scholar
• Redgrave, J., D. Day, H. Leung, P. J. Laud, A. Ali, R. Lindert, and A. Majid. 2018. “Safety and Tolerability of Transcutaneous Vagus Nerve Stimulation in Humans; A Systematic Review.” Brain Stimulation 11 (6):1225–1238. doi:10.1016/j.brs.2018.08.010.
   PubMed Web of Science ®Google Scholar
• Rong, P., J. Liu, L. Wang, R. Liu, J. Fang, J. Zhao, Y. Zhao, H. Wang, M. Vangel, S. Sun, et al. 2016. “Effect of Transcutaneous Auricular Vagus Nerve Stimulation On Major Depressive Disorder: A Nonrandomized Controlled Pilot Study.” Journal of Affective Disorders 195:172–179. doi:10.1016/j.jad.2016.02.031.
   PubMed Web of Science ®Google Scholar
• Salazar, J. W., K. Meisel, E. R. Smith, A. Quiggle, D. B. McCoy, and M. R. Amans. 2019. “Depression in Patients with Tinnitus: A Systematic Review.” Otolaryngology-Head and Neck Surgery 161 (1):28–35. doi:10.1177/0194599819835178.
   PubMed Web of Science ®Google Scholar
• Schlee, W., B. Langguth, T. Kleinjung, et al. 2021. Tinnitus – An Interdisciplinary Approach Towards Individualized Treatment: From Heterogeneity to Personalized Medicine First edition., Amsterdam, Netherlands: Elsevier. Accessed August 31, 2022 https://www.elsevier.com/books/tinnitus-an-interdisciplinary-approach-towards-individualized-treatment/langguth/978-0-12-821586-9.
   Google Scholar
• Schoisswohl, S., M. Schecklmann, B. Langguth, W. Schlee, and P. Neff. 2021. “Neurophysiological Correlates of Residual Inhibition in Tinnitus: Hints For Trait-Like Eeg Power Spectra.” Clinical Neurophysiology 132 (7):1694–1707. doi:10.1016/j.clinph.2021.03.038.
   PubMed Web of Science ®Google Scholar
• Schwippel, T., P. A. Schroeder, A. J. Fallgatter, and C. Plewnia. 2019. “Clinical Review: The Therapeutic Use of Theta-Burst Stimulation in Mental Disorders and Tinnitus.” Progress in Neuro-Psychopharmacology & Biological Psychiatry 92:285–300. doi:10.1016/j.pnpbp.2019.01.014.
   PubMed Web of Science ®Google Scholar
• Scott, B., P. Lindberg, L. Melin, and L. Lyttkens. 1990. “Predictors of Tinnitus Discomfort, Adaptation and Subjective Loudness.” British Journal of Audiology 24 (1):51–62. doi:10.3109/03005369009077842.
   PubMedGoogle Scholar
• Shetake, J. A., N. D. Engineer, W. A. Vrana, J. T. Wolf, and M. P. Kilgard. 2012. “Pairing Tone Trains with Vagus Nerve Stimulation Induces Temporal Plasticity in Auditory Cortex.” Experimental Neurology 233 (1):342–349. doi:10.1016/j.expneurol.2011.10.026.
   PubMed Web of Science ®Google Scholar
• Shim, H. J., M. Y. Kwak, Y.-H. An, D. H. Kim, Y. J. Kim, and H. J. Kim. 2015. “Feasibility and Safety of Transcutaneous Vagus Nerve Stimulation Paired with Notched Music Therapy For The Treatment of Chronic Tinnitus.” Journal of Audiology & Otology 19 (3):159–167. doi:10.7874/jao.2015.19.3.159.
   PubMedGoogle Scholar
• Shivaswamy, T., R. R. Souza, C. T. Engineer, et al. 2022. “Vagus Nerve Stimulation As A Treatment For Fear and Anxiety in Individuals with Autism Spectrum Disorder.” Journal of Psychiatr Brain Science 7:e220007.
   PubMedGoogle Scholar
• Sirois, F. M., C. G. Davis, and M. S. Morgan. 2006. “Learning To Live with What You Can’t Rise Above”: Control Beliefs, Symptom Control, and Adjustment To Tinnitus.” Health Psychology 25 (1):119–123. doi:10.1037/0278-6133.25.1.119.
   PubMed Web of Science ®Google Scholar
• Skarżyński, H., E. Gos, D. Raj-Koziak, and P. H. Skarżyński. 2018. “Skarzynski Tinnitus Scale: Validation of A Brief and Robust Tool For Assessing Tinnitus in A Clinical Population.” European Journal of Medical Research 23 (1):54. doi:10.1186/s40001-018-0347-4.
   PubMedGoogle Scholar
• Skarzynski, P. H., D. Raj-Koziak, J. J Rajchel, A. Pilka, A. W. Wlodarczyk, and H. Skarzynski. 2017. “Adaptation of The Tinnitus Handicap Inventory Into Polish and Its Testing on A Clinical Population of Tinnitus Sufferers.” International Journal of Audiology 56 (10):711–715. doi:10.1080/14992027.2017.1319080.
   PubMed Web of Science ®Google Scholar
• Souza, D. d S., A. A. Almeida, S. M. D. S. Andrade, D. G. d S. Machado, M. Leitão, T. G. Sanchez, and M. R. D. d Rosa. 2020. “Transcranial Direct Current Stimulation Improves Tinnitus Perception and Modulates Cortical Electrical Activity in Patients with Tinnitus: A Randomized Clinical Trial.” Neurophysiologie Clinique 50 (4):289–300. doi:10.1016/j.neucli.2020.07.002.
   PubMed Web of Science ®Google Scholar
• Stegeman, I., H. M. Velde, P. A. J. T. Robe, R. J. Stokroos, and A. L. Smit. 2021. “Tinnitus Treatment By Vagus Nerve Stimulation: A Systematic Review.” PLoS One 16 (3):e0247221. doi:10.1371/journal.pone.0247221.
   PubMed Web of Science ®Google Scholar
• Suk, W. C., S. J. Kim, D. S. Chang, and H. Y. Lee. 2018. “Characteristics of Stimulus Intensity in Transcutaneous Vagus Nerve Stimulation For Chronic Tinnitus.” The Journal of International Advanced Otology 14 (2):267–272. doi:10.5152/iao.2018.3977.
   PubMed Web of Science ®Google Scholar
• Tyler, R., A. Cacace, C. Stocking, B. Tarver, N. Engineer, J. Martin, A. Deshpande, N. Stecker, M. Pereira, M. Kilgard, et al. 2017. “Vagus Nerve Stimulation Paired with Tones For The Treatment of Tinnitus: A Prospective Randomized Double-Blind Controlled Pilot Study in Humans.” Scientific Reports 7 (1):11960. doi:10.1038/s41598-017-12178-w.
   PubMedGoogle Scholar
• Vanneste, S., J. Martin, R. L. Rennaker, and M. P. Kilgard. 2017. “Pairing Sound with Vagus Nerve Stimulation Modulates Cortical Synchrony and Phase Coherence in Tinnitus: An Exploratory Retrospective Study.” Scientific Reports 7 (1):17345. doi:10.1038/s41598-017-17750-y.
   PubMedGoogle Scholar
• Yakunina, N., S. S. Kim, and E.-C. Nam. 2018. “Bold Fmri Effects of Transcutaneous Vagus Nerve Stimulation in Patients with Chronic Tinnitus.” PLoS One 13 (11):e0207281. doi:10.1371/journal.pone.0207281.
   PubMed Web of Science ®Google Scholar
• Yakunina, N., S. S. Kim, and E.-C. Nam. 2017. “Optimization of Transcutaneous Vagus Nerve Stimulation Using Functional Mri.” Neuromodulation 20 (3):290–300. doi:10.1111/ner.12541.
   PubMed Web of Science ®Google Scholar
• Yakunina, N., and E.-C. Nam. 2021. “Direct and Transcutaneous Vagus Nerve Stimulation For Treatment of Tinnitus: A Scoping Review.” Frontiers in Neuroscience 15:680590. doi:10.3389/fnins.2021.680590.
   PubMed Web of Science ®Google Scholar
• Yanagihara, N. 1967. “Significance of Harmonic Changes and Noise Components in Hoarseness.” Journal of Speech and Hearing Research 10 (3):531–541. doi:10.1044/jshr.1003.531.
   PubMedGoogle Scholar