MECHANISM OF ANTIFERTILITY IN MALE RATS TREATED WITH 3-MONOCHLORO-1,2-PROPANEDIOL (3-MCPD)

REFERENCES

• Caflish , C. R. and DuBose , T. D. 1991 . Cadmium-induced changes in luminal fluid pH in testis and epididymis of the rat in vivo . J. Toxicol. Environ. Health , 32 : 49 – 57 .
   PubMedGoogle Scholar
• Cavanagh , J. B. and Nolan , C. C. 1993 . The neurotoxicity of alpha-chlorohydrin in rats and mice: II. Lesion topography and factors in selective vulnerability in acute energy deprivation syndromes . Neuropathol. Appl. Neurobiol. , 19 : 471 – 479 .
   PubMedGoogle Scholar
• Chandler , J. M. , Cohen , G. M. and MacFarlane , M. 1998 . Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver . J. Biol. Chem. , 273 : 10815 – 10818 .
   PubMed Web of Science ®Google Scholar
• Ericsson , R. J. and Youngdale , G. A. 1970 . Male antifertility compounds: structure and activity relationships of U-5897, U-15,646 and related substances . J. Reprod. Fertil. , 21 : 263 – 266 .
   PubMedGoogle Scholar
• Ford , W. C. and Waites , G. M. 1982 . Activities of various 6-chloro-6-deoxysugars and (S) alpha-chlorohydrin in producing spermatocoeles in rats and paralysis in mice and in inhibiting glucose metabolism in bull spermatozoa in vitro . J. Reprod. Fertil. , 65 : 177 – 183 .
   PubMedGoogle Scholar
• Gavrieli , Y. , Sherman , Y. and Bensasson , S. A. 1992 . Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation . J. Cell Biol. , 119 : 493 – 501 .
   PubMed Web of Science ®Google Scholar
• Herak-Kramberger , C. M. , Sabolic , I. , Blanusa , M. , Smith , P. I. , Brown , D. and Breton , S. 2000 . Cadmium inhibits vacuolar H+-ATPase-mediated acidification in the rat epididymis . Biol. Reprod. , 63 : 599 – 606 .
   PubMedGoogle Scholar
• Herak-Kramberger , C. M. , Breton , S. , Brown , D. , Kraus , O. and Sabolic , I. 2001 . Distribution of the vacuolar H+-ATPase along the rat and human male reproductive tract . Biol. Reprod. , 64 : 1699 – 1707 .
   PubMedGoogle Scholar
• Hoyt , J. A. , Fisher , L. F. , Hoffman , W. P. , Swisher , D. K. and Seyler , D. E. 1994 . Utilization of a short-term male reproductive toxicity study design to examine effects of α-chlorohydrin (3-chloro-1,2-propanediol) . Reprod. Toxicol. , 8 : 237 – 250 .
   PubMedGoogle Scholar
• Jones , A. R. 1978 . The antifertility actions of α-chlorohydrin in the male . Life Sci. , 23 : 1625 – 1646 .
   PubMed Web of Science ®Google Scholar
• Jones , R. C. and Murdoch , R. N. 1996 . Regulation of the motility and metabolism of spermatozoa for storage in the epididymis of eutherian and marsupial mammals . Reprod. Fertil. Dev. , 8 : 553 – 568 .
   PubMedGoogle Scholar
• Kim , J. M. , Luo , L. and Zirkin , B. R. 2000 . Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate . Endocrinology , 141 : 1846 – 1853 .
   PubMed Web of Science ®Google Scholar
• Klinefelter , G. R. and Ewing , L. L. 1988 . Optimizing testosterone production by purified adult rat Leydig cells in vitro . In Vitro Cell Dev. Biol. , 24 : 545 – 549 .
   PubMed Web of Science ®Google Scholar
• Laskey , J. W. , Rehnberg , G. L. , Laws , S. C. and Hein , J. F. 1986 . Age-related dose response of selected reproductive parameters to acute cadmium chloride exposure in the male Long-Evans rat . J. Toxicol. Environ. Health , 19 : 393 – 401 .
   PubMed Web of Science ®Google Scholar
• Lee , B. M. 2002 . Safety and risk assessment of 3-monochloro-1,2-propanediol (3-MCPD) . J. Toxicol. Public Health , 18 : 1 – 11 .
   Google Scholar
• Levine , N. and Kelly , H. 1978 . Measurement of pH in the rat epididymis in vivo . J. Reprod. Fertil. , 52 : 333 – 335 .
   PubMedGoogle Scholar
• Lynch , B. S. , Bryant , D. W. , Hook , G. J. , Nestmann , E. R. and Munro , I. C. 1998 . Carcinogenicity of monochloro-1,2-propanediol (α-chlorohydrin, 3-MCPD) . Int. J. Toxicol. , 17 : 47 – 78 .
   Web of Science ®Google Scholar
• Mortimer , D. , Shu , M. A. and Tan , R. 1986 . Standardisation and quality control of sperm concentration and sperm motility counts in semen analysis . Hum. Reprod. , 1 : 299 – 303 .
   PubMed Web of Science ®Google Scholar
• Ohkubo , T. , Hayashi , T. , Watanabe , E. , Endo , H. , Goto , S. , Endo , O. , Mizoguchi , T. and Mori , Y. 1995 . Mutagenicity of chlorohydrins . Nippon Suisan Gkkaishi (Jpn.) , 61 : 596 – 601 .
   Google Scholar
• Saksena , S. K. and Lau , I. E. 1979 . Effect of cadmium chloride on testicular steroidogenesis and the fertility of rats . Endocrinology , 74 : 6 – 12 .
   Google Scholar
• Silhankova , L. , Smid , F. , Cerna , M. , Davidek , J. and Velisek , J. 1982 . Mutagenicity of glycerol chlorohydrins and of their esters with higher fatty acids present in protein hydrolysates . Mutat. Res. , 103 : 77 – 81 .
   PubMed Web of Science ®Google Scholar
• Song , H. S. and Lee , B. M. 2002 . Analysis of 3-monochloro-1,2-propanediol (3-MCPD) in soy sauce products in Korea . J. Toxicol. Public Health , 18 : 191 – 194 .
   Google Scholar
• Staley , K. , Blaschke , A. J. and Chun , J. 1997 . Apoptotic DNA fragmentation is detected by a semiquantitative ligation-mediated PCR of blunt ends . Cell Death Diff. , 4 : 66 – 75 .
   PubMed Web of Science ®Google Scholar
• Stolzenberg , S. J. and Hine , C. H. 1979 . Mutagenicity of halogenated and oxygenated three-carbon compounds . J. Toxicol. Environ. Health , 5 : 1149 – 1158 .
   PubMed Web of Science ®Google Scholar
• Stolzenberg , S. J. and Hine , C. H. 1980 . Mutagenicity of 2- and 3-carbon halogenated compounds in the Salmonella/mammalian microsome test . Environ. Mutagen. , 2 : 59 – 66 .
   PubMedGoogle Scholar
• Sunahara , G. , Perrin , I. and Marchessini , M. 1993 . Carcinogenicity study on 3-monochloropropane-1,2-diol (3-MCPD) administered in drinking water to Fischer 344 rats , Lausanne, , Switzerland : Research & Development . Report RE-SR93003 submitted to WHO by Nestec Ltd.
   Google Scholar
• Velisek , J. , Davidek , J. , Hajslova , J. , Kubelka , V. , Janiceck , G. and Mankova , B. 1978 . Chlorohydrins in protein hydrolysates . Z. Lebensm. Unters. Forsch. , 167 : 241 – 244 .
   PubMedGoogle Scholar
• Woods , J. and Garside , D. A. 1996 . An in vivo and in vitro investigation into the effects of α-chlorohydrin on sperm motility and correlation with fertility in the Han Wistar rat . Reprod. Toxicol. , 10 : 199 – 207 .
   PubMedGoogle Scholar
• Yamada , T. , Inoue , T. , Sato , A. , Yamagishi , K. and Sato , M. 1995 . Effects of short-term administration of α-chlorohydrin on reproductive toxicity parameters in male Sprague-Dawley rats . J. Toxicol. Sci. , 20 : 195 – 206 .
   PubMedGoogle Scholar