NEONATAL EXPOSURE TO DI(N-BUTYL) PHTHALATE (DBP) ALTERS MALE REPRODUCTIVE-TRACT DEVELOPMENT

REFERENCES

• Barlow , N. J. and Foster , P. M. D. 2003 . Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate . Toxicol. Pathol. , 34 : 319 – 410 .
   Google Scholar
• Barlow , N. J. , Phillips , S. L. , Wallace , D. G. , Sar , M. , Gaido , K. W. and Foster , P. M. D. 2003 . Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate . Toxicol. Sci. , 73 : 431 – 451 .
   PubMed Web of Science ®Google Scholar
• Barlow , N. J. , McIntyre , B. S. and Foster , P. M. D. 2004 . Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate . Toxicol. Pathol. , 32 : 79 – 90 .
   PubMed Web of Science ®Google Scholar
• Blount , B. C. , Silva , M. J. , Caudill , S. P. , Needham , L. L. , Pirkle , J. L. , Sampson , E. J. , Lucier , G. W. , Jackson , R. J. and Brock , J. W. 2000 . Levels of seven urinary phthalate metabolites in a human reference population . Environ. Health Perspect. , 108 : 979 – 982 .
   PubMed Web of Science ®Google Scholar
• Brandt , K. 1985 . Final report on the safety assessment of dibutyl phthalate, dimethyl phthalate, and diethyl phthalate . J. Am. Coll. Toxicol. , 4 : 267 – 303 .
   Google Scholar
• Cammack , J. N. , White , R. D. , Gordon , D. , Gass , J. , Hecker , L. , Conine , D. , Bruen , U. S. , Friedman , M. , Echols , C. , Yeh , T. Y. and Wilson , D. M. 2003 . Evaluation of reproductive development following intravenous and oral exposure to DEHP in male neonatal rats . Int. J. Toxicol. , 22 : 159 – 174 .
   PubMed Web of Science ®Google Scholar
• Clark , J. D. , Raggatt , P. R. and Edwards , O. M. 1992 . Abnormalities of the hypothalamo-pituitary-gonadal axis after head injury . Clin. Endocrinol. , 36 : 481 – 485 .
   PubMedGoogle Scholar
• Creasy , D. M. , Foster , J. R. and Foster , P. M. 1983 . The morphological development of di-n-pentyl phthalate induced testicular atrophy in the rat . J. Pathol. , 139 : 309 – 321 .
   PubMedGoogle Scholar
• Department of Health and Human Services . 2003 . Department of Health and Human Services, Centers for Disease Control and Prevention, Second National Report on Human Exposure to Environmental Chemicals. NCEH Pub No. 02-0716
   Google Scholar
• Dostal , L. A. , Chapin , R. E. , Stefanski , S. A. , Harris , M. W. and Schwetz , B. A. 1988 . Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and recovery of fertility as adults . Toxicol. Appl. Pharmacol. , 95 : 104 – 121 .
   PubMed Web of Science ®Google Scholar
• Foster , P. M. D. , Thomas , L. V. , Cook , M. W. and Gangolli , S. D. 1980 . Study of the testicular effects and changes in zinc expression produced by some n-alkyl phthalates in the rat . Toxicol. Appl. Pharmacol. , 54 : 392 – 398 .
   PubMed Web of Science ®Google Scholar
• Foster , P. M. D. , Cook , M. W. , Thomas , L. V. , Walters , D. G. and Gangolli , S. D. 1983 . Differences in urinary metabolic profile from di-n-butyl phthalate-treated rats and hamsters. A possible explanation for species differences in susceptibility to testicular atrophy . Drug Metab. Dispos. , 11 : 59 – 61 .
   PubMed Web of Science ®Google Scholar
• Foster , P. M. D. , Mylchreest , E. , Gaido , K. W. and Sar , M. 2001 . Effects of phthalate esters on the developing reproductive tract of male rats. Human . Reprod. Update , 7 : 231 – 235 .
   PubMed Web of Science ®Google Scholar
• Fukuoka , M. , Kobayashi , T. and Hayakawa , T. 1995 . Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. Part 5. Testicular iron depletion and levels of ferritin, haemoglobin and transferrin in the bone marrow, liver and spleen . J. Appl. Toxicol. , 15 : 379 – 386 .
   PubMed Web of Science ®Google Scholar
• Gray , L. E. Jr. , Wolf , C. , Lambright , C. , Mann , P. , Price , M. , Cooper , R. L. and Ostby , J. 1999 . Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p-DDE, and ketoconazole) and toxic substances during sexual differentiation produces diverse profiles of reproductive malformations in the male rat . Toxicol. Ind. Health , 15 : 94 – 118 .
   PubMed Web of Science ®Google Scholar
• Gray , L. E. Jr. , Ostby , J. , Furr , J. , Wolf , C. J. , Lambright , C. , Parks , L. , Veeramachaneni , D. N. , Wilson , V. , Price , M. , Hotchkiss , A. , Orlando , E. and Guillette , L. 2001 . Effects of environmental antiandrogens on reproductive development in experimental animals . Human Reprod. Update , 7 : 248 – 264 .
   PubMed Web of Science ®Google Scholar
• Group , E. F. Jr. 1986. . Environmental fate and aquatic toxicology studies on phthalate esters . Environ. Health Perspect. , 65 : 337 – 340 .
   PubMed Web of Science ®Google Scholar
• Higuchi , T. T. , Palmer , J. S. , Gray , L. E. Jr. and Veeramachaneni , D. N. R. 2003 . Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure . Toxicol. Sci. , 72 : 301 – 313 .
   PubMed Web of Science ®Google Scholar
• Kassim , N. M. , McDonald , S. W. , Reid , O. , Bennett , N. K. , Gilmore , D. P. and Payne , A. P. 1997 . The effects of pre- and postnatal exposure to the nonsteroidal antiandrogen flutamide on testis descent and morphology in the Albino Swiss rat . J. Anat. , 190 : 577 – 588 .
   PubMed Web of Science ®Google Scholar
• Kavlock , R. , Boekelheide , K. , Chapin , R. , Cunningham , M. , Faustman , E. , Foster , P. , Golub , M. , Henderson , R. , Hinberg , I. , Little , R. , Seed , J. , Shea , K. , Tabacova , S. , Tyl , R. , Williams , P. and Zacharewski , T. 2002 . NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate . Reprod. Toxicol. , 16 : 721 – 734 .
   PubMed Web of Science ®Google Scholar
• Kelce , W. R. and Wilson , E. M. 1997 . Environmental antiandrogens: Developmental effects, molecular mechanisms, and clinical implications . J. Mol. Med. , 75 : 198 – 207 .
   PubMed Web of Science ®Google Scholar
• Kohn , M. C. , Parham , F. , Masten , S. A. , Portier , C. J. , Shelby , M. D. , Brock , J. W. and Needham , L. L. 2000 . Human exposure estimates for phthalates . Environ. Health Perspect. , 108 : 440 – 442 .
   PubMed Web of Science ®Google Scholar
• Maness , S. C. , McDonnell , D. P. and Gaido , K. W. 1998 . Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells . Toxicol. Appl. Pharmacol. , 151 : 135 – 142 .
   PubMed Web of Science ®Google Scholar
• Mylchreest , E. and Foster , P. M. 2000 . DBP exerts its antiandrogenic activity by indirectly interfering with androgen signaling pathways . Toxicol. Appl. Pharmacol. , 168 : 174 – 175 .
   Google Scholar
• Mylchreest , E. , Cattley , R. C. and Foster , P. M. D. 1998 . Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism? . Toxicol. Sci. , 43 : 47 – 60 .
   PubMed Web of Science ®Google Scholar
• Mylchreest , E. , Sar , M. , Cattley , R. C. and Foster , P. M. D. 1999 . Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide . Toxicol. Appl. Pharmacol. , 156 : 81 – 95 .
   PubMed Web of Science ®Google Scholar
• Mylchreest , E. , Wallace , D. G. , Cattley , R. C. and Foster , P. M. D. 2000 . Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation . Toxicol. Sci. , 55 : 143 – 151 .
   PubMed Web of Science ®Google Scholar
• Ohsako , S. , Kubota , K. , Kurosawa , S. , Takeda , K. , Qing , W. , Ishimura , R. and Tohyama , C. 2003 . Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide . J. Reprod. Dev. , 49 : 275 – 290 .
   PubMed Web of Science ®Google Scholar
• Parks , L. G. , Ostby , J. S. , Lambright , C. R. , Abbott , B. D. , Klinefelter , G. R. , Barlow , N. J. and Gray , L. E. Jr. 2000 . The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat . Toxicol. Sci. , 58 : 339 – 349 .
   PubMed Web of Science ®Google Scholar
• Prins , G. S. and Birch , L. 1997 . Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes . Endocrinology , 138 : 1801 – 1809 .
   PubMed Web of Science ®Google Scholar
• Regadara , J. , Martinez-Garcia , F. , Gonzalez-Peramato , P. , Serra , A. , Nistal , M. and Suarez-Quian , C. 2001 . Androgen receptor expression in Sertoli cells as a function of seminiferous tubule maturation in the human cryptorchid testis . J. Clin. Endocrinol. Metab. , 86 : 413 – 421 .
   PubMedGoogle Scholar
• Rejfer , J. and Walsh , P. C. 1977 . Hormonal regulation of testicular descent: experimental and clinical observations . J. Urol. , 118 : 985 – 990 .
   PubMedGoogle Scholar
• Rulli , S. B. , Gonzalez-Calvar , S. I. , Campo , S. and Calandra , R. S. 1995 . Effects of two non-steroidal antiandrogens on testicular function in prepubertal rats . J. Androl. , 16 : 225 – 232 .
   PubMedGoogle Scholar
• Sharpe , R. M. , Fisher , J. S. , Millar , M. M. , Jobling , S. and Sumpter , J. P. 1995 . Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production . Environ. Health Perspect. , 103 : 1136 – 1143 .
   PubMed Web of Science ®Google Scholar
• Shultz , V. D. , Phillips , S. , Sar , M. , Foster , P. M. and Gaido , K. W. 2001 . Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate . Toxicol. Sci. , 64 : 233 – 242 .
   PubMed Web of Science ®Google Scholar
• Teirlynck , O. , Kaufman , J. M. , Bogaert , M. G. and Roels , H. 1988 . Testicular toxicity induced by single dosing of di- and mono-(2-ethylhexyl) phthalate in the rat . Toxicol. Lett. , 40 : 85 – 91 .
   PubMed Web of Science ®Google Scholar
• Tsai , E. M. , Wang , S. C. , Lee , J. N. and Hung , M. C. 2001 . Akt activation by estrogen in estrogen receptor-negative breast cancer cells . Cancer Res. , 61 : 8390 – 8392 .
   PubMed Web of Science ®Google Scholar
• A. , Wellejus , M. , Dalgaard and S. , Loft . 2002 . Oxidative DNA damage in male wistar rats exposed to di-n-butyl phthalate. . J. Toxicol. Environ. Health , 65 : 813 – 824 .
   Google Scholar
• Williams , K. , McKinnell , C. , Saunders , P. T. , Walker , M. , Fisher , J. S. , Turner , K. J. , Atanassova , N. and Sharpe , M. 2001 . Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: Evidence for importance of the androgen–oestrogen balance and assessment of the relevance to man . Hum. Reprod. Update , 7 : 236 – 247 .
   PubMed Web of Science ®Google Scholar